Orchid Pharma Limited (NSE:ORCHPHARMA)
India flag India · Delayed Price · Currency is INR
720.00
+16.55 (2.35%)
May 11, 2026, 3:29 PM IST
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Q2 24/25

Nov 11, 2024

Operator

Ladies and gentlemen, good day and welcome to Orchid Pharma Limited Q2 FY 2025 earnings conference call hosted by Systematix Institutional Equities. As a reminder, all participant lines will be in the listen-only mode, and there will be an opportunity for you to ask questions after the presentation concludes. Should you need assistance during the conference call, please signal an operator by pressing star, then zero on a touch-tone phone. Please note that this conference is being recorded. I now hand the conference over to Mr. Vishal Manchanda from Systematix Institutional Equities. Thank you, and over to you, sir.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Thank you, Dan, and good evening, everyone. On behalf of Systematix Institutional Equities, I welcome you to the Q2 FY 2025 earnings call of Orchid Pharma. We thank the Orchid Pharma management for giving us an opportunity to host the call today. We have with us the senior management of the company, represented by Mr. Manish Dhanuka, Managing Director, Mr. Mridul Dhanuka, Full-Time Director, and Mr. Sunil Kumar Gupta, Chief Financial Officer. I'll now hand over the call to the company management for opening remarks. Over to you, sir.

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Thank you. Thank you so much, Vishal. Good evening, ladies and gentlemen. I'm Manish Dhanuka, Managing Director of Orchid Pharma Limited, and I'm delighted to welcome you to our discussion on the results for the second quarter of financial year 2025. First, let's review the financial performance for the Q2. Our sales for this quarter reached INR 222.7 crores, and our EBITDA for the quarter was INR 37.5 crores. As we analyze cumulative performance, we believe it is more meaningful to compare results on a cumulative basis for the half-year ending. For the first half of financial year 2024, our sales totaled at INR 467.1 crores, reflecting a 22% increase over the first half of financial year 2024. This growth reflects the positive momentum toward our efforts for business development and regaining of our customer base.

Our overall EBITDA for the first half of 2025 was INR 78.6 crores, making a significant increase from INR 54.7 crores in the first half of last year. This improvement is a testament to our continued focus on cost control, productivity, and efficiency. The operating EBITDA for the same period was INR 66.8 crores, marking a 39% increase over the last year EBITDA for the first half. This quarter has been really eventful as many of our projects and initiatives have transitioned from planning to reality. Of course, it's early days, but we are pleased with these initial developments. I'm pleased to report that Orblicef, our drug product for Enmetazobactam-Cefepime combination, was successfully launched in the Indian market during the last week of September. Orblicef holds a special place as the first drug discovered in India, now commercialized in the EU and approved in the U.S. market.

With our marketing partnership with Cipla, we expect good momentum to sales in the coming months. We are optimistic that Orblicef will make a significant impact on the healthcare landscape as the initial microbiological results on the Indian strains are very promising. On the sales front, I'm pleased to report that our Enmetazobactam sales have officially begun in the EU market. While the initial numbers are insignificant as the sales started just recently, we are encouraged by this initial progress. Much like in cricket, the account has been opened. In the United States, however, we still await news of developments. We remain optimistic and eager to see forward movement in this important revenue stream as we continue to monitor the landscape closely.

On another note, I would like to address an update regarding our Orchid's filing of Ceftazidime Avibactam . This filing has received some observations from the U.S. FDA.

As per our consultant, the cited deficiencies were not of a serious nature, and we are now generating data to address these points promptly. We are currently working to remove the noted deficiencies and expect to be filed within this quarter. Now, for some updates on our key projects. I'm pleased to share that our small capacity enhancement project has been commissioned ahead of schedule. We have already completed validation batches, and this additional capacity will start contributing to sales in the coming months. This project provides the added production capability required to support our growth and meet the increasing demand of our products. Additionally, I am pleased to report that we have successfully broken ground on our 7-ACA projects as scheduled on the auspicious day of Ganesh Chaturthi.

While initial progress was slow due to extended rains this year, we are now expecting work to move forward at a swift pace. We are excited to continue advancing this important project. Looking ahead, I'm optimistic about the future. Our achievements in the first half of 2025, coupled with the steady progress on key projects and strategic initiatives, position Orchid Pharma well for ongoing project growth and value creation. We remain dedicated to operational excellence and disciplined execution, which will continue to guide us as we seize new opportunities and address the challenges that lie ahead. In closing, I want to thank all our stakeholders, employees, investors, and partners for your unwavering support and trust in Orchid Pharma. Together, we will continue to build on our successes and reach even greater heights in the years to come. Thank you for your attention.

I now welcome your questions and look forward to our productive discussion. Thank you.

Operator

Thank you. We will now begin the question- and- answer session. Anyone who wishes to ask a question may press star and one on their touch-tone telephone. If you wish to remove yourself from the question queue, you may press star and two. Participants are requested to use handsets while asking a question. Ladies and gentlemen, we will wait for a moment while the question queue assembles. First question is from the line of Vivek Patel from Ficom Family Office. Please go ahead.

Vivek Patel
Equity Research Analyst, Ficom Family Office

Very good evening, sir. I'm hoping I'm audible.

Operator

Yep.

Vivek Patel
Equity Research Analyst, Ficom Family Office

Great. I just had two quick questions on Cefiderocol firstly. What would be the potential size of this drug given that Shionogi will be expanding this out of the U.S. and Europe to 135 low-income countries? Secondly, what would be the risk for this drug as another prominent company is also developing a competing drug which they claim to be better than Cefiderocol? That's it from myself. Thank you.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Thanks, Vivek, for your question. With respect to the potential, what we believe is 100 million doses potential is there for this particular product, as about 1.6 million people out of the 5 million people who died due to AMR in 2019 can be cured by Cefiderocol. That's a very, very large number. What does it translate to? Value is questionable, as I stated before, because the cost of treatment is very high, currently standing at INR 1 million per patient. It's yet to be seen how much of that theoretical potential actually converts to a market number. On your second question, with respect to the competition developing another product, I'm not sure which particular company and product you're talking about, but this problem is so large.

Like I said, 5 million people died in 2019, and it's expected by 2030 this number is expected to rise to 10 million. We need more and more drugs to tackle this menace of antimicrobial resistance. So I welcome any development in that area. I don't think any such number is going to reduce the possible sales potential of this product.

Vivek Patel
Equity Research Analyst, Ficom Family Office

Thanks so much. Thank you. All the best.

Operator

Thank you. A reminder to all the participants that you may press star and one to ask a question. Participants who wish to ask a question may press star and one. A reminder to all participants that you may press star and one to ask a question. The next question is from the line of Ankur Chadha, who is an individual investor. Please go ahead.

Hello.

Yeah.

Hi. So I have a question on the future prospects of Orchid Pharma beyond what's already in the public domain. So we have four or five big projects in the next 3-4 years.

I do understand. Could you come a bit close to your handset?

Is it better?

Yes, sir.

Yeah. So see, we've got these three or four big projects in the next three to four years. Exblifep, which is the new chemical entity that the new drug, then we have this Cefiderocol, and then there's the other and the related developments in the cephalosporin domain, and there are 7-ACA projects. So that takes care of our growth for the next three to four years. I just wanted to understand from the management what is the future beyond that, what sort of domains we would be working in. You mentioned in one of your previous conference calls regarding Orchid will try to become an expert in fermentation-based R&D and drug development. Could you just give an overview of what do you see happens after three or four years when all these projects have come on stream and you're looking for a future beyond that?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Yeah. Thanks for your question. Now, see, we are going ahead with further research, and there are very few companies involved in the space of cephalosporins. And most of the newer molecules that are going off patent are in the injectable space, and Orchid is very well poised in this space to be one of the leaders. So our R&D in that, also our focus on R&D in that space continues, and we will be going ahead with doing the process development for the newer molecules, which go off patent after these few projects that are going on stream at present.

At the same time, I feel that by setting up the 7-ACA projects, we would have gained a significant insight into the fermentation technology, and that will probably create a launch platform for us to develop further molecules because not too many companies in India have the capabilities to develop products on fermentation. So I think that will definitely pave the way for further development. But as of now, we have got our hands full, and we are focusing on executing the projects in hand while trying to identify the newer opportunities.

Okay. Thank you. Thank you for your answer.

Operator

Thank you. A reminder to all participants that you may press star and one to ask a question. The next question is from the line of Vidit Shah from Spark Private Wealth Management . Please go ahead.

Vidit Shah
Equity Research Analyst, Spark PWM Private Limited

Hello. Good evening, and thanks for taking my questions. Just two questions from me. One was around our R&D efforts. So do we have any more products not in the near future, but at least with a 5-6 year horizon, such as Enmetazobactam, which we are looking to innovate completely out of India? And if so, what sort of fields or what sort of treatments are we looking to get in?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Yeah. You see, there are molecules that we have identified. There is a molecule which is going off patent just before and after this Cefiderocol in various markets, depending on which market you are looking at. Then there are various opportunities with respect to Ceftazidime and Avibactam, which we recently identified because we have developed a molecule which is a non-infringing polymorph and non-infringing process. So besides the U.S., there are opportunities that lie in other regulated markets like Europe, Brazil, etc., where the patent for the patented morph is still existent till the early 2030s. So we are now looking at those opportunities and discussing with customers for launching this particular product with a non-infringing process in markets like Europe and Brazil. So it's not just about the molecule. It's about different markets present opportunities at different times.

We are very hopeful that with our capabilities, we can demonstrate properly the Cefiderocol project. We will get opportunities to work with a lot of innovators as well to manufacture the products for them. We are quite hopeful of these opportunities.

Vidit Shah
Equity Research Analyst, Spark PWM Private Limited

Okay. Understood. And could you just help us with an update on the Enmetazobactam royalties from Europe that we've started to get? What is the quantum of these royalties, and what is the overall market size in Europe per se for Enmetazobactam?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

The sales just started. The royalties amount is very significant. We are happy that the sales have started. And with respect to the amount, I think we are bound by the confidentiality agreement with Allecra. So, we have not been able to disclose the amount.

Vidit Shah
Equity Research Analyst, Spark PWM Private Limited

But how big is Europe as a market overall?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

So it's again difficult for an NCE because, as I've explained earlier, there is not much experience. India as a country has experts on NCE. Our long-term estimate for the lifetime sale for this product is $2 billion-$3 billion, which has U.S. and Europe and China combined. This is the same estimate which I said three years ago. I don't think I have any better information to quantify the market. It will depend on what price the product is launched at, the price elasticity, and the competing products present at that particular point of time. So it's difficult to say what could be the possible market, especially when Orchid is not responsible for selling the product.

Vidit Shah
Equity Research Analyst, Spark PWM Private Limited

Okay. Understood. So thanks so much for taking these questions. And all the best. Thank you.

Operator

Thank you. The next question is from the line of Nikhil Upadhyay from SIMPL. Please go ahead.

Nikhil Upadhyay
Fund Manager, SIMPL

Yeah. Hi. Good evening. I hope I'm audible.

Operator

Yeah, Nikhil, we can hear you.

Nikhil Upadhyay
Fund Manager, SIMPL

Yeah. And congratulations on our steady growth, which we've been delivering. So great job. Two or three questions. One is, can you share what would be the mix for first half between regulated and non-regulated markets in terms of revenue?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah, sure. It remains similar, 40%-60%, regulated 40% and emerging 60%.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. And see, we've been consistently growing at 15%-20%. And what I understand is our top three molecules had a larger concentration. So is this growth more coming from newer molecules, or are we gaining share in our top three molecules? Some insights, if you can share, what is playing out for us?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. Actually, Nikhil, because our growth percentage at 20% is a very large number now on a large base for our cephalosporin products per se. So obviously, if we don't continue to grow over there, we would not be able to demonstrate these numbers. Having said that, we are working on more niche opportunities to try and focus on them to get a higher growth there. So depending on product to product, there are some products which are showing more promise, and their percentage growth is faster probably than the largest three molecules. But at the same time, they have not that much an impact on overall if you look at one or two products out of those to say what is the reflection on the number.

These three products are the largest, and in the near future, I don't think any other product is going to dethrone them of the top three positions. These three will continue to be the largest products for Orchid in the near future as well.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. Secondly, on this capacity addition, post this, what would be our net capacity addition with this new CapEx which we have commissioned ?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. In terms of kg, it is difficult to say the number because the product and the capacity is fungible. For example, if we talk about the sterile products, I have explained if we make in the same capacity, we can make a product which is $1,000 per kg that we can make maybe one ton. And if it is $100 a kg, it will make five tons. But in terms of the growth, we have talked about that for the next year, couple of years, we don't need a CapEx to fund that. This CapEx should be sufficient to supply to that growth. But if you want another term, if we talk about some base molecule, although it will not give you much reflection, it could be a 15%-20% kind of capacity addition on the overall side.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. Now, coming to Orblicef , two questions. Anything on China? Because we've been waiting in terms of the trials which had to happen in China and all, but there is no news, anything on the internet of what's happening. So any idea where are we stuck and how is Allecra thinking about it? Because it's also an opportunity lost for us if the product does not get launched.

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Yeah. I agree with you. We've had a couple of discussions with Allecra's MD. They are as confused as we are. Very difficult to get information from China. I agree. And we're discussing with the partners, but no development that we would like to disclose at this time.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. And in India, any sense when the commercial launch can happen? Because approval is almost nine months. We've got the approval. Any sense, if you can share, what is happening there and what's taking so much time?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

So all I can say is that they have shared some confidentiality agreement with their partners evaluating the project, and we're keeping our fingers crossed. Don't have any information beyond that.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. And when we launched this product in India, I know it's still initial days, but when our MRs are going and talking to the hospitals versus the competitive product, what's the sense we are getting? How are doctors responding to the product versus the existing product which is there? Any feedback you can share?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Yeah, so there is a lot of encouraging response from the doctors when our people explain the product to them. They are willing to give audience to our sales team and our clinical team, and they have been doing trials on some of the strains that are resistant in India, and the feedback that we have got is that the molecule works well against the existing empirical therapy space of antibiotics, and the biggest advantage that we are trying to convince doctors is that it can spare Meropenem for the more resistant bacteria and for providing longevity to Meropenem against resistance, so these are the two major advantages, and we feel encouraged from just one month of sales. I think the molecule should do well.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

There's always excitement in the market with respect to an Indian-developed product. How does that translate to actual on-the-ground? That will take a couple of quarters to actually see how many doctors adopt. Because it's a question of life and death, right? Doctors really want to do a dipstick. It's not an anti-allergy medicine which you give and say whether it works or not. Building confidence on their patients on a couple of cycles and then prescribing it would be their method of progress, I would believe.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. And lastly, how many specialists or hospitals we would have covered till now? If you can just share. And similarly, when we also have a tie-up with Cipla, so how does the marketing regions get split between two of us? Our same MR can go two MRs can go to the same doctor or hospital. Some pointers, if you can share, how are you going about on the marketing side here along with?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

On the reach numbers, I won't be able to share anything with you. But both Orchid and Cipla will be selling in the same market. There is no geographical division between the companies as to Orchid can sell to certain hospitals and they can sell to the certain hospitals. Both companies can go and sell. At the end, for Orchid as a company, it does not matter because Orchid's product only is selling in the market. The idea is, how do we make sure that this world-class new generation product is available to maximum number of patients? And with that idea, only we have partnered with Cipla. So it is in the interest of Orchid. Whoever sells in the end, it would be great. Although we would like to have a relevant share from the AMS team on this business.

We believe in tier one cities, we should be able to make a good impact.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. And is it a royalty charge with Cipla, or is it a profit share with Cipla? Any idea you can give?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. It's a combination of both.

Nikhil Upadhyay
Fund Manager, SIMPL

Okay. Okay. Yeah. Okay, sure. Thanks. I'll come back.

Operator

Thank you. Thank you. A reminder to all the participants that you may press star and one to ask a question. The next question is from the line of Narendra from WhiteOak Capital. Please go ahead.

Narendra Gangan
Fund Manager, WhiteOak Capital

Hello, sir. Can you hear me?

Operator

Yeah, Narendra.

Narendra Gangan
Fund Manager, WhiteOak Capital

Yes, we can. Sir, can you share any early data on the basis of Enmetazobactam used in India, wherever the limited number of patients is surgery, in terms of clinical or microbiological cure which has been achieved?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. We've been asked by the SEC to do a Phase IV. I don't think we will be able to share data before those studies are complete as such. But I can share the clinical trial data which is globally accepted based on which we have received the Phase IV. The product was compared with Pip-Taz of over 1,000 patients, and our product had an efficacy of 79% compared to 59% of Pip-Taz. So this particular.

Narendra Gangan
Fund Manager, WhiteOak Capital

I'm aware I thought post marketing means…

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. Because it just started. We have received the approval from SEC to do the Phase IV on X number of patients. Once we have that data and that is in public domain, only then I'll be able to share some number one.

Narendra Gangan
Fund Manager, WhiteOak Capital

Sir, have you marketed in only limited hospitals or regions, or is it pan-India?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

It has to be pan-India. Both Orchid and Cipla have partnered for this reason only to leverage Cipla's distribution network and also Orchid's new model of Orchid AMS, which is antimicrobial solution. Obviously, Cipla's reach is much larger than Orchid, and we expect the product to be available pan-India. We have already started distribution from Orchid and Cipla both across the country. But since it's early days, the sales was only just started in the last week of September. It will take some time. Like I said, doctors will do some trials. They will see the performance of their product on their patients. So it will take some time to find trials.

Narendra Gangan
Fund Manager, WhiteOak Capital

Sir, what would be the overall treatment cost per patient in India with Enmetazobactam? Approximate number.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

So it's.

Narendra Gangan
Fund Manager, WhiteOak Capital

Just for a 10-day course, what will be the approximate price per patient?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

It's similar to other molecules, maybe 10%-15% higher than other standard products that are used for similar kind of therapies.

Narendra Gangan
Fund Manager, WhiteOak Capital

Okay. Thank you.

Operator

Thank you. A reminder to all the participants that you may press star and one to ask a question. The next question is from the line of Ishita Jain from Ashika Group. Please go ahead.

Ishita Jain
Equity Research Analyst, Ashika Group

Hi. Am I audible?

Operator

Yes.

Ishita Jain
Equity Research Analyst, Ashika Group

Hi. So my first question is on the FDA inspection. Can you remind us when was the last FDA inspection, and when are we expecting the next one?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Last FDA inspection was in July 2019. We are expecting them anytime, and we are ready for them to come. Although we don't have any information from them as yet, when are they going to come?

Ishita Jain
Equity Research Analyst, Ashika Group

Okay. Got it. My second question is on the 7-ACA timeline for the PLI. Could you throw some light on how does the payout schedule work for the PLI in case of, I mean, the contract we have gotten a bit delayed? So just to get some color on that.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. Sure. So on paper, nothing has changed. Whatever was the original approval, it stays like that. In face-to-face conversations with government officials, they have assured us that, "Don't worry. It is all there." They have given examples of Aurobindo who has delayed it even beyond the timeline of the written policy. But what we have understood is nobody has received any formal letter from the government that this policy is extended, and this is the now new payout period. So there are only verbal assurances to everyone at this point of time.

Ishita Jain
Equity Research Analyst, Ashika Group

Got it. I thought Aurobindo's penicillin plant was fully operational.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. They have announced the operation, but it is after the timeline as written in the original policy. So I don't have a copy of their letter. It is only my estimate that the timeline would have expired from their original letter. But you would probably know better from their conference calls.

Ishita Jain
Equity Research Analyst, Ashika Group

Right. Got it. And just to know how much we have spent from our books on the 7-ACA plant?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Sorry?

Ishita Jain
Equity Research Analyst, Ashika Group

What is our spend on the 7-ACA plant?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Till now, you mean?

Ishita Jain
Equity Research Analyst, Ashika Group

Yeah.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. Mr. Sunil Gupta , can you please answer this question? The exact spend till now in the OBPL subsidiary?

Sunil Gupta
CFO, Orchid Pharma Limited

It is around INR 35 crores.

Ishita Jain
Equity Research Analyst, Ashika Group

How much are we planning on spending until fully operational?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

About INR 700 crores.

Ishita Jain
Equity Research Analyst, Ashika Group

Got it. And if you could just reiterate the timeline on this.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. So nothing has changed since last time. In August, we had talked about a commissioning of April 26th. So it's early to say the construction is fully going to begin now. So right now, we don't see any major change. We will only know after a couple of quarters how things are actually progressing and if we encounter some new hurdles.

Ishita Jain
Equity Research Analyst, Ashika Group

Got it. And just last question. So far, sorry to keep harping on Enmetazobactam, but in the U.S., Allecra has partnered already on the marketing?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

So I am as aware as probably you are. Whatever is in public domain, only that they share. I talked about in an earlier call that Allecra is a German company, right? They are very, you can say, straight-jacketed about what is written in the agreement. Only that information we get. So probably if you are on the internet, you may find out earlier than I do that they have done the deal.

Ishita Jain
Equity Research Analyst, Ashika Group

Got it. Okay. All right. Just was trying to figure out since approval has come, no collaboration has been announced for the marketing partner in the U.S. Okay. Thank you so much. I'll get back in touch with you.

Operator

Thanks. Thank you. A reminder to all the participants that you may press star and one to ask a question. The next question is from the line of Sanjay Kumar from iThought Financial Consulting. Please go ahead.

Sanjay Kumar
Co-Fund Manager, iThought Financial Consulting

Hi, sir. Thanks for the opportunity. On Enmetazobactam, now that we've launched it, do we have a revised estimate of number of patients in India? Or the other way to look at it is you take hospitals with 500+ beds and let's say 500 hospitals. So any revised estimate for Enmetazobactam market size in India?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

So, market size estimates we have not given as the product and as a company. We don't talk about product-wide market. So since we have not given anything earlier, the vision would be difficult to give. So unfortunately, I can't say this. We have given a guidance of AMS sales, and this would be part of that only.

Manish Dhanuka
Managing Director, Orchid Pharma Limited

The only good thing is that we've got a wider coverage of indications like UTIs, pneumonia, and bacteremia. So that should definitely increase the horizon of the patient population. But maybe the medical team will be able to understand in the next few quarters.

Sanjay Kumar
Co-Fund Manager, iThought Financial Consulting

Okay. And you mentioned that while we are talking to doctors, they're doing tests against meropenem. But our global clinical trials were done versus Pip-Taz, right? And we don't have data on how Enmetazobactam is performing in relation to meropenem. So are doctors okay to willing to explore using Enmetazobactam as meropenem-sparing drug?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

No, you see, as per the policy of the ICMR, Meropenem is supposed to be a reserved drug. So when a patient enters a hospital, the doctors are not supposed to inject Meropenem to the patients. They are supposed to reserve it because it is definitely supposed to be a superior drug, and it is supposed to be reserved for a more aggressive form of infections. So the purpose of launching this drug is that it has just enhanced the capability of an existing cephalosporin spectrum. So it does not actually provide any increase to the resistance factor. And it should be used before Meropenem. So the idea is that it is Meropenem-sparing. So that Meropenem's life gets increased and the development of resistance against Meropenem gets delayed.

So what the doctors are doing is they are testing the drug against the strains which they find to be difficult to cure with the existing first generation of antibiotics. And that's where we have found from the clinicians that the results are encouraging.

Sanjay Kumar
Co-Fund Manager, iThought Financial Consulting

Got it. Got it. Thank you, sir. That's it from my side.

Operator

Thank you. A reminder to all the participants that you may press star and one to ask a question. The next question is from the line of Gaurav Lakhotia from Nuvama. Please go ahead.

Gaurav Lakhotia
Equity Research Analyst, Nuvama Group

Hi, so I wanted to know if there is any update on Ceftaroline and Cefovecin.

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Yeah. So we would be taking some engineering versions of Ceftaroline soon. Ceftaroline, we are still looking for a partner for the U.S. market.

Gaurav Lakhotia
Equity Research Analyst, Nuvama Group

Okay. Thank you. My second question is on bookings. So I wanted to know the oral versus sterile split for Q2 and the domestic business revenues for Q2?

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah, so oral versus sterile split remains same as our long-term guidance, so 30% sterile, 70% oral, and domestic business also remains similar at 22%.

Gaurav Lakhotia
Equity Research Analyst, Nuvama Group

Oh, okay. Thank you.

Operator

Thank you. A reminder to all participants that you may press star and one to ask a question. Participants who wish to ask a question may press star and one. The next question is from the line of Vamsi Krishna Hota from Systematix. Please go ahead.

Vamsi Hota
Equity Research Analyst, Systematix Institutional Equities

Hi, sir. Thanks for the opportunity. Am I audible?

Operator

Yeah.

Vamsi Hota
Equity Research Analyst, Systematix Institutional Equities

Yes, sir. So two questions. So firstly, when it comes to the revenues, there is a sequential down of about 8.9%. What would be the factors that are contributing to this? And secondly, I think Orchid is also foraying into branded formulation segment, especially in India, with about launch of 30+ molecules. So any update on that also would be helpful. Thank you.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Yeah. On the first question, we've always maintained Orchid should not be looked at as a sequential kind QoQ of a company. Always compare Orchid as a cumulative last year versus cumulative this year. So in the last call, there was one question I'd answered because we grew by more than 35% last quarter that this kind of performance cannot be continued. It is just that each of those shipments are maybe 5% of Orchid's revenue could be one shipment in a quarter. So if that goes in one quarter last day, a few days left, let's say on June 30th , then it is Q1 or first July Q2. So that kind of shift can happen. So QoQ number is never relevant for Orchid because its seasonal markets are different.

There is not going to be any pattern, or I will not be able to share any data how it is worse or not worse. I would encourage you to look at only cumulative numbers. On the second question on AMS, I'm happy to say that we have launched the AMS division again in the last week of September of this quarter. The products are available in the market, although it's too early to talk about any numbers. Doctors are appreciating our concept, and we are getting time largely because we are the only company which has ever invented a product which is now approved worldwide. With that, we are getting good, at least admission or seat at the table for discussion with the doctors.

Vamsi Hota
Equity Research Analyst, Systematix Institutional Equities

Thank you, sir. All the best.

Operator

Thank you. Thank you. A reminder to all participants that you may press star and one to ask a question. Participants who wish to ask a question may press star and one. The next question is from the line of Vishal Manchanda from Systematix Institutional Equities. Please go ahead.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Yeah. Hi. Thanks for the opportunity. Sir, on the new oral block, could you guide how long can you take to ramp it up to full utilization?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

So the block is fully up and ready for the production, but it will depend on how we are able to generate sales. So there's nothing to do with respect to the manufacturing part. We will keep on increasing production as we can generate sales.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

All right. And so you won't have visibility in terms of kind of orders from clients. So it will develop over time, and then you would ramp it up.

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Yeah. You see, I mean, it takes some time to become an approved vendor in the pharmaceutical industry when you go to meet a customer. And that process has been going on for some time, which has resulted in growth over the last three, four years. But we have to continue with that initiative and difficult to say customer to customer how long it takes.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Right. So if you produce too much, there is selling pressure, which brings the pressure on the pricing and profitability. And we have always maintained Orchid is never the company to do that first. So we would only like to sell in the market what is the demand rather than flooding the market with material and resulting in a price drop.

Mridul Dhanuka
Whole-Time Director, Orchid Pharma Limited

Right.

Manish Dhanuka
Managing Director, Orchid Pharma Limited

The B2B companies can't generate demand, right? You just have to follow the demand.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Got it. And for the second one on Enmetazobactam, would you know the price in Europe? What's the per patient price there?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

That's a good question. We would like to find out. Don't have that information yet, but we'd like to find out. Maybe next time.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Got it. Got it. And just one more on would you have a number on how much is Dhanuka doing currently?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Yeah. Mr. Gupta, can you give me a sales number?

Sunil Gupta
CFO, Orchid Pharma Limited

Sales number? In the first six months, our sales was INR 275 crores.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Okay. And it's broadly flat on a YoY basis?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

I think on a six-monthly basis, there is a growth. But last year, I think we did INR 550 crores. So if you see on annual basis, we are expecting maybe 5% growth, not significant. Yeah.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Margin should be EBITDA margin should be double digit here?

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Single digit. It's still single digit. Yeah.

Vishal Manchanda
SVP of Institutional Research, Systematix Institutional Equities

Okay. Okay. Got it, sir. That's all from my side. Thank you very much.

Operator

Thank you. A reminder to all participants that you may press star and one to ask a question. A reminder to all participants that you may press star and one to ask a question. Are there any further questions from the participants? I now hand the conference over to the management for closing comments.

Manish Dhanuka
Managing Director, Orchid Pharma Limited

Thank you, Systematix. We would like to thank each and every one of you for your participation. Your questions always provide a different perspective to the management, and it's an opportunity for us to learn. We look forward to our continued engagements in the future as well. Thank you.

Operator

Thank you. On behalf of Systematix Institutional Equities, that concludes this conference. Thank you for joining us, and you may now disconnect your lines.

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