Yield10 Bioscience, Inc. (YTENQ)
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Earnings Call: Q3 2023

Nov 14, 2023

Operator

Hello, and welcome to the third quarter 2023 financial results and business update conference call for Yield10 Bioscience. During the call, participants will be in listen-only mode. The presenters will address questions from analysts today. If anyone should require operator assistance during the conference, please press star zero on your telephone keypad. As a reminder, this conference call is being recorded. I would now like to turn the conference call over to your host, Yield10 Vice President of Planning and Corporate Communications, Lynne Brum. Please go ahead.

Lynne Brum
VP of Planning and Corporate Communications, Yield10 Bioscience

Thank you, Sarah, and good afternoon, everyone. Welcome to the Yield10 Bioscience third quarter 2023 conference call. Joining me on the call today are President and CEO, Dr. Oliver Peoples; Vice President of Research and Chief Science Officer, Dr. Kristi Snell; and Chief Accounting Officer, Chuck Haaser. Earlier at noon, Yield10 issued our third quarter 2023 financial results. This press release, as well as slides of today's presentation, are available on the Investor Relations Events section of our website at yield10bio.com. Let's turn to slide two. Please note that as part of our discussion today, management will be making forward-looking statements. These statements are not guarantees of future performance, and therefore you should not place undue reliance on them. Investors are also cautioned that statements are not strictly historical, constitute forward-looking statements.

Such forward-looking statements are subject to a number of risks and uncertainties that could cause the actual to differ materially from those anticipated. These risks include risks and uncertainties detailed in Yield10's filings with the SEC. The company undertakes no obligation to update any forward-looking statements in order to reflect events or circumstances that may arise after the date of this conference call. And I'll turn the call over to Ollie.

Oliver Peoples
President and CEO, Yield10 Bioscience

Thanks, Lynne. Good afternoon, everyone, and thanks for joining our call. Let's now turn to slide three. We're making solid progress in our technology and business plans to launch Camelina as a platform crop with a focus on the biofuel feedstock market and the high-value market for omega-3 oils. Using different Camelina varieties, both products can be produced in a closed-loop value chain, which encompasses contracting with growers and oilseed crushers and securing offtake agreements with end users for the different oils. Today, we'll provide an update on recent accomplishments in our Camelina seed genetics to biofuel platform, our progress developing herbicide-tolerant Camelina varieties, provide an update on our omega-3 Camelina program, present the third quarter financials, key milestones. We will then open the call to questions. Let's now turn to slide four, Progress on key 2023 business goals.

Over the course of 2023, we've achieved numerous milestones on the path towards commercializing Camelina as a platform crop for biofuels, deploying herbicide tolerance and producing high-value omega-3 fatty acids in Camelina. In biofuels, our key commercial goal in 2023 has been to demonstrate the value chain from Yield10 Camelina seed to commercial offtake of Camelina grain to a customer. An important goal has been achieved, as we've generated cash proceeds from seed shipments to growers and from grain shipments to a biofuel player. In 2024, we intend to continue to deliver grain for use in biofuel based on the winter Camelina grower contracts we signed this fall. As this is a key area for partnership, we are continuing to progress discussions to form additional partnerships in biofuels.

A year ago, we signed a 1-year extension of our research and option agreement with Rothamsted to complete the omega-3 Camelina program, which had been delayed due to COVID restrictions in the U.K. We've made good progress with our omega-3 Camelina platform in 2023, including developing project timelines and a launch plan for the first product, EPA omega-3 oil. A few weeks ago, we announced that we've exercised our option to finalize an exclusive global commercial license with Rothamsted. Shortly thereafter, we announced the signing of an LOI for a partnership with BioMar Group, one of the largest aquafeed producers in the world, and I'm pleased to let you know that we have recently initiated seed scale-up activities for the omega-3 EPA Camelina line in Chile. The EPA line produces up to 20% EPA in the seed oil.

Going into 2024, we anticipate the production of pilot quantities of the purified EPA oil for business development purposes and potentially larger scale field production of EPA Camelina to support our commercial development activities. Let's now turn to slide five, Establishing Camelina production. Our business plan is based on using advanced genetics to develop Camelina as a platform crop for producing oil, meal, and specialty products. Today, there is a significant opportunity in the biofuels market, where vegetable oil is processed into sustainable aviation fuel and renewable diesel. Significant new demand for feedstock oils is being generated as new refineries are coming online and as new environmental commitments are being made to utilize these cleaner fuels across the globe.

Based on our partner discussions, we believe the biofuel sector recognizes that there is going to be a divergence of supply and demand at some point, but it's not yet clear when exactly this will happen. For 2023, we contracted approximately 2,000 acres of winter and spring Camelina for production in Canada and in the U.S. In Canada, we engaged growers in southern Alberta, in northern Alberta in the Peace River region, in Saskatchewan, and Manitoba. In the U.S., we contract growers in Idaho and Montana. We are very pleased with the level of grower engagement we had. Growers shared their insights on the crop, whether on-farm practices or opportunities they see for how they could use the crop in their rotations and comparative economics.

In particular, the growers had strong, positive feedback on the types of herbicide-tolerant varieties Yield10 is developing and how those could significantly expand the opportunity and add value for them. We were also very pleased with the performance of our current Camelina varieties. For example, our WDH2 winter variety is very robust in cold temperatures, and planted seed shows a built-in fail-safe mechanism, whereby if seed did not germinate in the fall, it survived winter and germinated in the spring. Both our winter and spring varieties require some moisture to germinate, but then demonstrate excellent drought tolerance over the growing season. For example, we had a 160-acre field in Southern Alberta that received just 1.5 inches of rain over the entire season, but over twice the yield of neighboring mustard and canola crops grown under the same drought conditions.

Camelina also showed good pest resistance, in particular to flea beetles and in some areas, grasshoppers, which are pests in other oilseed crops such as canola and mustard. During the third quarter of 2023, our contracted growers harvested their winter and spring Camelina fields, setting in motion the steps in the value chain from planting, harvest, grain delivery to an offtake customer. Photos in this slide illustrate the steps of the value chain we established in Western Canada. In the third quarter of 2023, we contracted with existing and new growers and planted winter acres for harvest in summer of 2024. As you can see in the photo to the right, there's already been snow cover on that crop in Canada. The same closed-loop value chain can be used with our omega-3 Camelina varieties for the production of omega-3 oils in the future.

I will now turn the call over to Kristi for an update on the development of HT and stacked HT Camelina varieties.

Kristi Snell
VP of Research and Chief Science Officer, Yield10 Bioscience

Thanks, Ollie, and good afternoon, everyone. Let's turn to slide six. A couple of years ago, we prioritized the development of herbicide-tolerant Camelina to provide farmers with a robust weed control package, supporting the broad adoption of the crop in North America. We have been waiting for regulatory responses from USDA-APHIS and the Environmental Protection Agency to enable the use of glufosinate for control of broadleaf weeds with our engineered Camelina lines. We hoped that we would receive responses from the agencies before year-end, and I'm delighted this afternoon that we heard we received a positive response from USDA-APHIS, stating that our glufosinate-tolerant line is not considered regulated by the agency. Growers have provided us with positive feedback on the potential of using glufosinate-tolerant Camelina in their rotations.

Historically, incorporation of herbicide tolerance traits, including glufosinate tolerance into canola, helped transform it from a marginal crop to a major crop grown on millions of acres, and we believe Camelina has the potential to follow a similar path. We have demonstrated tolerance to applications of glufosinate in three seasons of successful field tests of our lead spring HT Camelina variety. One main objective of our 2023 field testing was to collect and analyze the data on the seed composition of the herbicide-tolerant lines compared to controls. Samples have been harvested for these analyses. This is required for a data package to verify the safety of the meal for animal feed through a self-determination process. We also intend to voluntarily submit this package to FDA in 2024.

With field data in hand and seed scale-up activities underway, we remain on track to launch our first herbicide-tolerant Camelina variety as early as 2025. Let's now turn to slide seven. Over the course of 2023, we made good progress with the development of stacked herbicide tolerance in spring and winter Camelina. Our stacked herbicide-tolerant Camelina exhibits tolerance to over-the-top applications of glufosinate for broadleaf weed control, as well as tolerance to Group 2 herbicides in soil. Camelina is very sensitive to Group 2 residues, thus, the Group 2 trait is important to provide Camelina with tolerance to SU and IMI herbicides that may remain in the soil from a previous season's crop. This past summer, we reported encouraging data from our spring field trials, demonstrating robust stacked herbicide tolerance in multiple events.

The photos on the slide show examples of events with stacked herbicide tolerance that have survived herbicide treatments. Little to no growth of control plants was observed in plants without the stacked HT trait in plots labeled with red dots on the slides. We are currently analyzing agronomic data from the spring field trials and are measuring seed yield and seed oil content. We expect to choose the best lead and backup lines to move forward in our pipeline. In our winter 2023 field tests, we are testing for the first time, several candidate stacked HT winter Camelina lines. Here, too, we plan to choose the best lead and backup lines to move forward in our pipeline based on field test results. Earlier in 2023, we filed a request for regulatory status review, or RSR, with USDA-APHIS to determine if the stacked trait is exempt from regulation.

I am pleased to say that we also received a response this afternoon from USDA-APHIS, stating that our HT stack is not considered regulated by the agency. We believe that stacked herbicide-tolerance lines will be a win-win for growers and Yield10, since the trait will allow robust weed control for farmers, potentially increasing yield and revenue, and providing tolerance to soil residues of previously applied Group 2 herbicides. This is expected to result in broad expansion of acres available for Camelina planting. Let's now turn to slide eight. As shown in the figure on the right of the slide, our stacked herbicide-tolerant E3902 is a highly engineered Camelina plant. The molecular stack in this plant is a result of the use of a variety of tools. The oil content trait in E3902, which improves seed oil content by 5%, was achieved by editing eight genes.

We previously determined that the resulting genome-edited E3902 line is not considered a regulated article with the submission to USDA under the former Am I Regulated process. To incorporate stacked herbicide tolerance, we inserted a gene that confers tolerance to glufosinate-containing herbicides when expressed in a plant. We also inserted another mutated gene that, when expressed in a plant, confers tolerance to IMIs and SUs, both Group 2 herbicides. Modern biotech tools allow the straightforward stacking of traits, and we believe that the U.S. science-driven regulatory process is favorable for Camelina with stacked traits, as evidenced by our recent positive decision from USDA, stating that our HT stack is not considered regulated by the agency. Our EPA8 Camelina is also based on a molecular stack of genes, enabling EPA production in the oil.

We are utilizing molecular stacking to deploy new traits in Camelina, with the aim to deliver ongoing enhancements to crop performance, which, if achieved, would bring enhanced revenue and margin to the crop. Our strategy is to create a pipeline of highly engineered elite Camelina varieties to deliver ongoing performance improvements in agronomics, yield, oil content, meal profile, and other desirable attributes. We are deploying these novel traits through genome editing, traditional genetic modifications, and breeding to create new Camelina varieties. For example, we are deploying combinations of traits for additive effects, where we are evaluating performance traits such as C3004, C3007, and C3020, and others, to drive ongoing improvements to plant vigor, seed yield, and oil content. As we create new engineered Camelina varieties, we intend to protect our Camelina varieties through plant variety protection and patent filings.

I'd like to acknowledge the tremendous efforts of the Yield10 technology team. Their continued diligent efforts have produced the elite herbicide-tolerant Camelina germplasm that forms the foundation of our commercial Camelina pipeline for production of feedstock oils for biofuels. These herbicide-tolerant lines are expected to provide the elite Camelina germplasm background for high-level production of omega-3 oils and, in the future, PHA bioplastics. In the months ahead, we look forward to further field testing our lead commercial quality herbicide-tolerant Camelina lines, advancing the omega-3 oil technology platform, and we seek to secure favorable regulatory decisions for our elite Camelina products. I'll now hand the call back to Ollie.

Oliver Peoples
President and CEO, Yield10 Bioscience

Thanks, Kristi. Let's now turn to slide nine, the omega-3 market opportunity. We secured the rights to the omega-3 Camelina technology from Rothamsted in 2020, because we believe that the omega-3 oils containing EPA and DHA fatty acids represent a very significant, differentiated, and growing market opportunity. These omega-3 fatty acids are essential to aquaculture feed and human nutrition. As we've highlighted before, there continues to be major global supply constraints and disruptions in oil produced from ocean-harvested fish. It's been reported recently that the cancellation of the first Peruvian anchovy harvest earlier this year cost the industry $1 billion. While the second anchovy harvest is going forward, the authorized catch is about 25% below 2022 levels, which is expected to extend the supply constraint on the industry.

We are also seeing positive developments on the regulatory front, with Norway, the largest producer of farmed salmon, recently approving the use of a GMO omega-3 oil from Nuseed. They produce a DHA-containing oil in canola. As a result of continuing supply constraints, as well as evidence of a more receptive regulatory environment, we are seeing increased third-party interest in alternative sources like the camelina omega-3 platform. Based on the technology developed by Rothamsted, we believe that producing omega-3 fatty acids in camelina represents a potential game changer for the omega-3 and salmon farming industries by enabling a plant-based, predictable supply of this high-value nutrition ingredient. Based on our successful collaboration with Professor Jonathan Napier's team at Rothamsted, we recently executed our exclusive option to an exclusive commercial license to the omega-3 camelina.

Reflecting industry interest in new sources of omega-3, we also recently signed a letter of intent with BioMar Group, a global aquafeed producer and industry leader, to develop a collaboration on the production of omega-3 for this market. Let's now turn to slide 10, with an overview of the omega-3 Camelina development status. On the regulatory front, we filed an RSR with USDA in the third quarter for the EPA8 Camelina line, which produces oil with up to 20% EPA content. And we are preparing a second RSR filing for an omega-3 Camelina line that produces both EPA and DHA at levels similar to Northern Hemisphere fish oil. Using the RSR process for regulatory approval by USDA-APHIS under the SECURE Rule, we see a promising path to production of omega-3 in the U.S. We recently began scaling up EPA Camelina seed to support business development activities....

Potentially additional planting in 2024. The EPA8 oil will also have use in aquafeed formulations as it is closer to commercial production and we can reblend it with algal DHA oil. Rothamsted has also developed and extensively tested the omega-3 Camelina DHA1 line, which contains 10% EPA and 10% DHA in the oil. Published results on aquafeed studies carried out in previous Rothamsted collaborations with BioMar have shown that the DHA1 oil can serve as a drop-in replacement for fish oil. Human clinical studies, also published, have shown this oil to be an effective alternative to fish oil in the human diet. We look forward to completing the commercial license with Rothamsted and working to form partnerships with BioMar and others to advance omega-3 Camelina towards commercialization. Chuck, over to you.

Chuck Haaser
Chief Accounting Officer, Yield10 Bioscience

Thanks, Ollie, and good afternoon, everyone. Let's turn to slide 11, third quarter results. We ended the third quarter of 2023 with $2.8 million in cash and cash equivalents. During our third quarter of 2023, we raised $3.7 million in a public offering of units consisting of common shares and warrants. We expect that our cash on hand, including the proceeds from the offering, will support our operations into December of 2023. We are engaged in a dedicated and ongoing effort to secure additional funds in the very near term in order to continue our operations. Our net operating cash used for operating activities was $2.6 million for the third quarter of 2023, as compared to $2.7 million for the third quarter of last year.

For the full year 2023, we continue to expect total net cash usage in the range of $12.5-$13 million to fund our operations, including remaining payments to our growers for the first Camelina grain harvest. Let's now review the third quarter and year-to-date operating results. For the third quarter of 2023, Yield10 reported a net loss of $3.7 million, or $0.41 per share, as compared to a net loss of $3.5 million, or $0.71 per share, for the third quarter of the previous year. And as expected, due to the completion of our Department of Energy grant during our first quarter of this year, we did not report grant revenue during the third quarter of 2023.

We did report $0.1 million in grant revenue in the third quarter of 2022. R&D expenses were $2.2 million during the third quarter of 2023, and during the third quarter of 2023, we recorded our first $100,000 in payments received or due to us from shipments of seed and harvested grain to growers and off-take partners as an offset to R&D expense. R&D expenses in the third quarter of 2022 were $2.1 million. General and administrative expenses were consistent between the two years, at $1.5 million for the third quarter of both 2023 and 2022.

For the nine months ended September 30th, 2023, the company reported a net loss of $11.2 million, or $0.70 per share, compared to a net loss of $10.3 million, or $2.09 per share, during the first nine months of the previous year. Year-to-date grant revenue during 2023 and 2022 from the completed DOE grant were $0.1 million and $0.4 million, respectively. Research and development expenses were $6.4 million and $5.9 million during the nine months ended September 30th, 2023, and September 30th, 2022, respectively. G&A expenses were $4.9 million and $4.7 million during each of those periods. For more details on our financial results, I ask you to please refer to our earnings release. Ollie, back to you.

Oliver Peoples
President and CEO, Yield10 Bioscience

Thanks, Chuck. Let's now come to slide 12, upcoming milestones. Before getting into the upcoming milestones, I'd like to comment on the accomplishments of the Yield10 team, including the hot-off-the-press news we received from USDA this afternoon. Congratulations to the entire Yield10 technology team, who, under Kristi's leadership, have demonstrated compelling capabilities in the development and regulatory approval of advanced Camelina varieties developed using genetic engineering. On the commercial side, we have set up a value chain in biofuels requiring seed production and grower engagement, and charted a path to use Camelina as a platform crop to produce omega-3 fatty acids based on our collaboration with Rothamsted. For the biofuel market, we are continuing partnership discussions across the biofuel value chain to support ramping up acreage of Camelina to produce low-carbon feedstock oil for that market.

As we work to realize our vision of leading the industry in the commercialization of differentiated Camelina varieties, our focus is on introducing HT and stacked HT Camelina varieties that are well suited to farm rotations in North America. I was thrilled to hear from Kristi this afternoon that we have received regulatory clearance for HT and stacked HT Camelina. This is not only a major milestone for Yield10, but also a major milestone for Camelina as a new crop. These positive regulatory outcomes bode well, not only for the pending review of our EPA Camelina RSR, but also for the DHA1 RSR we are preparing and for the performance traits in our pipeline. We are building seed inventory over the winter in South America to support grower contracts. We believe that omega-3 products represent a wide array of commercial opportunities.

These essential fatty acids are used in aquaculture feed, pet food, pharmaceuticals, nutraceuticals, and even cosmetics. We look forward to completing the commercial license with Rothamsted and working with BioMar and others to form a partnership to produce omega-3 oil for use in aquafeed. There have been some recent patent awards and notices of allowance for filings in our IP portfolio over the last few months as we continue to expand and build our intellectual property portfolio. With that, I'd like to turn the call back over to Lynne for questions.

Lynne Brum
VP of Planning and Corporate Communications, Yield10 Bioscience

Thanks, Ollie. And Sarah, we're ready for questions.

Operator

Thank you. If you have a question, it is star one on your telephone keypad. If you wish to withdraw your question, simply press star one again.

Your first question comes from the line of Ben Klieve with Lake Street Capital Markets. Your line is open.

Ben Klieve
Senior Equity Research Analyst, Lake Street Capital Markets

All right, thanks for taking my questions. In your prepared remarks, you noted that you were continuing to progress the biofuel partnerships. But there was no mention made of Marathon, Mitsubishi, or American in your prepared remarks. I'm wondering, first of all, if you could give us an update on the status of these three relationships. Are they all ongoing, or have any of those parties exited discussions with you?

Oliver Peoples
President and CEO, Yield10 Bioscience

So, I'm not gonna get into too many details, but no one has exited at this point. And we have indicated that we are in extensive discussions in the biofuel space with other parties. And so it's a very busy area, as you can imagine. I think the issue, of course, is, as a small company, working with these giants to get things to the point where we are mutually agree on the path forward, and that's what we're working on. So nothing has changed with those guys.

Ben Klieve
Senior Equity Research Analyst, Lake Street Capital Markets

Okay. Well, that's, that's good to hear. And the follow-up to that, to your comment right there, I mean, I'm wondering. I appreciate you're not going to get into specifics, but I'm wondering if on a high level, you can talk about, you know, kind of what the barriers, if any, have been to converting these, you know, relationships to a commercial or investment, or a formal investment. You know, is there any kind of broad characterization that you can help make to, you know, give us confidence that these are, you know, going to be reaching a successful completion here soon?

Oliver Peoples
President and CEO, Yield10 Bioscience

No, I think we remain very optimistic that we will achieve a successful partnership. Obviously, that takes two of us to agree on the structure, the funding, and how we go about this. So no, we don't, we can't really provide color on individual ones. But I would say overall, the interest remains very strong. There's been new players come to the table, which is great, but ultimately it's a matter of getting the time and the decisions made within those organizations to essentially go forward on the path that we want to go forward on. So, you know, we can't really provide too much color on individual companies.

Ben Klieve
Senior Equity Research Analyst, Lake Street Capital Markets

Okay. Fair enough. Last one for me, and then I'll get back in line. You called out $100,000 of Camelina grain deliveries that were recognized as an offset to R&D in the quarter. Can you talk about the level of inventories of grain you have today or, you know, grain that's expected to arrive here soon, and, you know, for future delivery over the next quarter or over the next year? And if those are going to be recognized as revenue or as continued still as R&D offsets.

Oliver Peoples
President and CEO, Yield10 Bioscience

So, I think, you know, obviously, you know, we're in that sort of gray zone between revenue and reimbursement, and obviously we're working with the audit group to make sure that we stay on the right side of the fence on that. So, I'm not sure we can provide much more color. We do have additional grain and/or oil in hand, but we're trying to essentially, you know, use that strategically versus simply to make a quick sale. I mean, we have avenues to sell that "or get reimbursed for it," if you like. But our goal is to leverage that oil for other purposes, and we have discussions ongoing regarding a more strategic use of that material.

Chuck Haaser
Chief Accounting Officer, Yield10 Bioscience

Holly, I think we've also indicated publicly, we've completed the harvest from the first two seasons.

Oliver Peoples
President and CEO, Yield10 Bioscience

Yeah, we've completed the harvest, and that's basically where we are.

Kristi Snell
VP of Research and Chief Science Officer, Yield10 Bioscience

And I would add to that, Ben, that, you know, as we talked about, seed scale-up as well, you know, we're positioning, you know, across our portfolio of existing Camelina lines that are commercial, as well as the HT and stacked HT that are coming behind it, to build inventory to support those, launches that we're anticipating. So that's also part of the picture to, you know, be able to have sufficient seed for grower contracts.

Chuck Haaser
Chief Accounting Officer, Yield10 Bioscience

Yep.

Ben Klieve
Senior Equity Research Analyst, Lake Street Capital Markets

Yeah. No, fair enough, and that, that's a, an important calculus to make, at, at this stage, so, understood on all, on all accounts. All right, well, that's, that does it for me. Thanks for taking my questions, and I'll get back in line.

Operator

Okay, thanks, Ben. Your next question comes from the line of Anthony Vendetti with Maxim Group. Your line is open.

Jeremy Pearlman
Senior Research Associate and Equity Analyst, Maxim Group

Hi, thanks for taking the question. This is actually Jeremy on the line for Anthony. Just, one quick question: Is there any overlap between all, all these different segments that you're in? Meaning, is there a limit to when you grow something, you, you sort of, you know, have to focus on growing a Camelina for, let's say, for the crushers or for the herbicide tolerance, or is, are they separate, and you could really just keep growing each, each segment of your business-

Oliver Peoples
President and CEO, Yield10 Bioscience

Yeah. No, no, no

Jeremy Pearlman
Senior Research Associate and Equity Analyst, Maxim Group

You know, exponentially?

Oliver Peoples
President and CEO, Yield10 Bioscience

The way to think about it, Jeremy, is that, you know, the first generation was obviously the lines, for example, WH2, that we started the grain contracting with, or the E3902. Obviously, what's going to happen is those lines will be... generation two, generation three. So they will—they'll all ultimately end up HT. It's just that it takes time to transition through this process of scale up with non-engineered lines and ultimately replace those with the engineered lines, which have higher value, higher productivity, better integration into crop rotations. And that will be a continuous process, just like Bayer or Corteva or any of the big seed companies does. There's a continuous improvement process in place.

Jeremy Pearlman
Senior Research Associate and Equity Analyst, Maxim Group

Okay, understood. Thank you. And then just one last question. You mentioned that you think you can get commercialization for the herbicide-stacked Camelina, herbicide-tolerant Camelina in 2025. What does that, y ou know what? I know it's a little early, but what does that commercialization look like to you? Like, how does that play out?

Oliver Peoples
President and CEO, Yield10 Bioscience

Well, I mean, obviously, in terms of commercialization, and I'll let Kristi speak to the technology because it's a pretty big accomplishment for a small company. It, you know, really fundamentally, what it's going to come down to, we've got other steps in the regulatory process to go through. The biggest one and the most expensive one from the point of view of the development is really the USDA-APHIS, because obviously, if you're doing this work under permitted conditions, it's very expensive. And there's a lot of restrictions and regulations around, as there should be, until they deregulate it, because they believe it's safe. So, I think the reality of it is that we're gonna move forward with this, and I think we have a great project coming up.

We know from the farmers they want this, but we need to make sure we check all the boxes in 2025. By that time, we'll also built up quite a bit of, I don't wanna use the word inventory, but available seed for larger scale planting, as well as generate the grower interest in using it. We know the grower interest is very, very strong, but obviously, we've got more work to do in 2024 to get to that point.

Kristi Snell
VP of Research and Chief Science Officer, Yield10 Bioscience

Do you wanna talk a little about the-

Jeremy Pearlman
Senior Research Associate and Equity Analyst, Maxim Group

All right. Oh, yeah, you can talk. Yeah. No, great.

Kristi Snell
VP of Research and Chief Science Officer, Yield10 Bioscience

Well, I guess all I can say is that our lead event for the glufosinate tolerance is very robust in this field, and, you know, it's ideal for approval for regulatory agencies. So the team has done a great job in constructing that event and evaluating it.

Jeremy Pearlman
Senior Research Associate and Equity Analyst, Maxim Group

Okay. All right. Thank you. I'll hop back in the queue.

Operator

Once again, ladies and gentlemen, if you have a question, it is star one. Your next question comes from the line of Noel Parks with Tuohy Brothers. Your line is open.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Hi, good afternoon.

Kristi Snell
VP of Research and Chief Science Officer, Yield10 Bioscience

Hi.

Oliver Peoples
President and CEO, Yield10 Bioscience

Hi, Noel.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Hi, sorry, just having a little, little problem with my phone options. Just a second. Sorry.

Kristi Snell
VP of Research and Chief Science Officer, Yield10 Bioscience

Okay.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Okay, I think I'm back. I was just wondering if you were just talking about glufosinate tolerance. But I was wondering if you could maybe just drill down a bit more into feedback from growers from the most recent harvest and looking towards the next crops. And I'm sort of thinking in terms of if any of the feedback you've gotten, say, year to date has, you know, really made any changes in terms of where you're headed in product development?

Oliver Peoples
President and CEO, Yield10 Bioscience

Yeah. No, I think I saw it. So I can kinda give you kind of a broad, kinda sweeping overview of that. I think, I think in general, obviously, there's a pretty bad drought in that area of North America this year. And so I think the number one thing was actually, compared to the other crops that I'm growing in my farm, this thing looks really very good. It's very, obviously very robust to drought conditions. It does require water, but it's very robust.

I think the other aspect of it, of course, is that as they look at the rotations, and we talk to them about the herbicide tolerance we're developing, that's when they get very excited about it because they see ways to leverage that herbicide tolerance just as a way to better manage their rotations, and that's another very encouraging thing.

And so I think in general, you know, I would say the feedback is they remain very interested. And one thing we did see, and at least coming from our commercial team, was a lot more interest from the growers in planting spring Camelina in 2024 because of some of the challenges we had with some of the other crops. So that was interesting to see. Now, the back end of 2023, of course, you've had a drought for many months, and so the soil is very, very dry, and so we actually backed off on some of the winter planting just because of the drought conditions in some areas, recognizing that that's probably the right thing to do at this stage while we bring forward these next generations of lines. So strong interest at some.

It's definitely got the attention of the growers, no question about that. The growers are also, as I said, very excited about the prospects for the glufosinate tolerant Camelina, and in the stacked Camelina, because if they're using these Group 2s in a, you know, a significant share of their acreage, that, those acreages, those acres are just not available for planting Camelina immediately after.

So, they're definitely giving feedback. They're working on the right things. We're doing the right thing. Not to be negative at anybody, but one of them did tell me that if we had been doing glyphosate, they'd have thrown us off the farm, because of some of the weed issues they've seen. So, you know, they're pretty vocal. They have strong opinions and very smart people because, of course, being a farmer is not easy. So, yeah.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Sure.

Oliver Peoples
President and CEO, Yield10 Bioscience

It's clear that we're working on the right thing. It's clear we've got to do it right. This first step with USDA-APHIS indicating the science is absolutely solid, and they don't see really any risk. The next step is obviously just what we believe is getting the data on the meal and demonstrating it's safe. So I think the way I look at it going forward, it's all about two things: It's about safety, and it's about science. You get the science right and get the safety right, and then make sure it's adding value for the grower, and that's the way we're focusing on, you know, developing our new products.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Great. Thanks for that detail. And then sort of heading to another part of the value chain, I wondered, as you've continued talking with various parties about partnership, could you generally characterize what discussions with the integrated oil companies or the downstream and refining companies are these days? I'm just-- Well, two things. I'm kinda curious about their attention span. And part of that is that they're, in my mind, they've been in their general sort of ESG decarbonization portfolios, they've made some, some of them have made some fairly puzzling investments, I'd say, over the last couple of quarters. And also I recognize that they can also tend to be kind of bureaucratic, which means it can take a while to get consensus on things.

Oliver Peoples
President and CEO, Yield10 Bioscience

Yeah.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Anything you'd like to say about that would be great.

Oliver Peoples
President and CEO, Yield10 Bioscience

Yeah. So I think it's, let me just juxtapose two things. So we are really pushing forward right now on two different oil products, and it's absolutely crystal clear to the entire biofuel sector that if you add 9.5 billion gallons of new vegetable oil demand by 2030, and the entire soybean and canola crop only produces around 8.5 billion gallons today, assuming we just stopped eating it, then guess what?

The math tells you there's going to be a disconnect.

So everybody knows this. Everybody understands that. Of course, then you get into the challenges around an, you know, very large or obviously bureaucratic organizations with really smart people, I mean, very, very smart people. But of course, they don't have the domain space in agriculture, farming seed genetics. So of course t hat is a hurdle.

And then you've got the hurdle of this small company in Woburn, Massachusetts just basically indicating that they're gonna get-- basically gonna go and do what Bayer and Monsanto did and be successful at it. And by the way, we just demonstrated we can be.

So we kind of have to show them we can do this because of course, there is definitely an issue there. But I think when I look at the whole space, I would say the entire sector knows this is gonna be a crunch. They've been pretty open in the discussions with us that they know alternative oilseeds, particularly winter oilseeds, are gonna be critical for the future of low carbon intensity biofuel feedstocks. And then you get into the nuts and bolts of how do we make that happen? And that's where the learning experience just takes time. It just takes time.

Like everyone else in the sector, they want to turn a tap. They just want to turn a valve, and the pipe willm pour out Camelina oil.

Well, it doesn't work that way.

There's these pieces that have to be pressed.

There's the seed, the farmer, there's the crusher. You know and so, but they're getting their head around it. And they're, and some of these things that you've seen with CoverCress and Bunge and Bayer, and obviously Chevron, I mean, that's happening. It's happening. It just takes time. And you've got to get the circumstances right, you've got to get the location right. So I think we're making phenomenal progress for a small, small company. But then if you kind of look at that and say, "Well, how does that compare to what's going on in omega-3s?" Well, guess what? That disconnect between supply and demand has happened to that industry in a massive role.

You know, we've heard estimates that fish oil prices, which used to be $2,000 a ton, are $9,000 a ton. Oh, and by the way, if you want to use algal systems to produce this, to make 20,000 tons, you have to invest $200 million, if you look at the Veramaris investment that went into-

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Wow!

Oliver Peoples
President and CEO, Yield10 Bioscience

The facility in Blair, Nebraska. So, so when you look at the two things, they're obviously quite different. It's fundamentally the same technology, the same herbicide technology, the same Camelina. The difference is, the Omega-3 has been modified, further modified to make this much higher value oil.

And the market demand there is literally off the charts. So very different, but all based on the same technology, based on all of the investment we've made in new varieties and herbicide tolerance and the partnership with Rothamsted. The difference being, we announced we're executing the exclusive option, and within a few weeks, we've got an agreement in place with BioMar, and I can tell you that we've had a lot of interest from a number of others. So it's just a different dynamic because that industry knows the need is here, we have to solve the problem, and so they're moving faster than the biofuel guys.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Got it. Thanks. And just one last thing, kind of touches on what you were just talking about. As you look ahead to the need to build inventory to support grower contracts, I'm just thinking, does that imply any capital investment on your part down the road? And if so, is that a particular timeframe, or can you sort of use leased facilities, equipment, et cetera, to handle that?

Oliver Peoples
President and CEO, Yield10 Bioscience

Yeah. So in terms of that, I mean, really, you know, the issue is, at some point, it'll be a question of working, you know, working capital associated with our planting seed inventory.

That's what it's going to be. I mean, that, that'll be it. But of course, you know, the whole idea that we have with this value chain is to have offtake for the product, the oil and the meal, lined up ahead of time. So essentially, the transfer of the grain from the grower to the processing facility or to the storage facility, they get paid, and we get paid, and we pay them. So you know, it's, it can be done fairly seamlessly. That's what we've basically been doing with this arrangement we have in Western Canada ultimately, as it goes, you know, the business may likely evolve into different business models for sure, as it gets big.

Noel Parks
Managing Director, Tuohy Brothers Investment Research

Great. Thanks a lot.

Lynne Brum
VP of Planning and Corporate Communications, Yield10 Bioscience

Okay, Noel, thank you for your questions tonight. They were, they were great.

Oliver Peoples
President and CEO, Yield10 Bioscience

Thank you.

Lynne Brum
VP of Planning and Corporate Communications, Yield10 Bioscience

I think, Ollie, I'll turn the call back to you for closing remarks.

Oliver Peoples
President and CEO, Yield10 Bioscience

I'd like to personally thank all of you for joining us on the call tonight, and especially our shareholders for your continued support. I want to thank everybody at Yield10 for contributions that are keeping us on track to reach our commercial and product development goals. Have a nice evening.

Operator

Thank you, everyone, for joining.

Lynne Brum
VP of Planning and Corporate Communications, Yield10 Bioscience

Thank you.

Operator

You may now disconnect. My apologies. Go ahead.

Lynne Brum
VP of Planning and Corporate Communications, Yield10 Bioscience

That's fine. That's nope. That's what-

Operator

Thank you.

Lynne Brum
VP of Planning and Corporate Communications, Yield10 Bioscience

We're doing. We're going to disconnect now, Noel. Thank you.

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