Company Description
Alector, Inc., a late-stage clinical biotechnology company, develops therapies that is focused on counteracting the devastating progression of neurodegenerative diseases.
The company’s products under development include Latozinemab (AL001), an investigational human recombinant monoclonal antibody designed to elevate progranulin (PGRN), a protein encoded by the granulin (GRN) gene that regulates lysosomal function, neuronal survival, and inflammation in the brain.
Its lead PGRN-elevating candidate is being developed for the potential treatment of frontotemporal dementia with a granulin gene mutation (FTD-GRN) which is caused by heterozygous loss-of-function (LOF) mutations in the GRN gene and results in PGRN haploinsufficiency and is in Phase 3 clinical trial.
It also develops AL101/GSK4527226 that is in Phase 2 clinical trial for the treatment of neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases.
In addition, the company’s preclinical and research pipeline products include ADP037-ABC, a proprietary anti-amyloid beta (Aβ) antibody paired with proprietary ABC for the treatment of AD; ADP050-ABC, a GCase replacement therapy paired with proprietary ABC for GBA gene mutation carriers with Parkinson’s disease and Lewy body dementia; ADP056, a Reelin modulator designed to block tau pathology and promote synaptic function in AD; and ADP063-ABC and ADP064-ABC that are therapeutic candidates paired with proprietary ABC that target tau pathology in AD through distinct approaches.
It has a strategic collaboration agreement with GlaxoSmithKline plc for the development and commercialization of progranulin-elevating monoclonal antibodies, including latozinemab and AL101 to treat neurodegenerative diseases.
The company was founded in 2013 and is headquartered in South San Francisco, California.
| Country | United States |
| Founded | 2013 |
| IPO Date | Feb 7, 2019 |
| Industry | Biotechnology |
| Sector | Healthcare |
| Employees | 238 |
| CEO | Arnon Rosenthal |
Contact Details
Address: 131 Oyster Point Boulevard, Suite 600 South San Francisco, California 94080 United States | |
| Phone | 415 231 5660 |
| Website | alector.com |
Stock Details
| Ticker Symbol | ALEC |
| Exchange | NASDAQ |
| Stock Type | Common Stock |
| Fiscal Year | January - December |
| Reporting Currency | USD |
| IPO Price | $19.00 |
| CIK Code | 0001653087 |
| CUSIP Number | 014442107 |
| ISIN Number | US0144421072 |
| Employer ID | 82-2933343 |
| SIC Code | 2836 |
Key Executives
| Name | Position |
|---|---|
| Dr. Arnon Rosenthal Ph.D. | Co-Founder, Chief Executive Officer and Director |
| Dr. Saraswati Kenkare-Mitra Ph.D. | President and Head of Research and Development |
| Dr. Marc Grasso M.D. | Chief Financial Officer, Principal Financial Officer and Principal Accounting Officer |
| Dr. Gary Romano M.D., Ph.D. | Chief Medical Officer |
| Katie Hogan | Senior Director of Corporate Communication and Investor Relations |
| Danielle Pasqualone J.D., Ph.D. | General Counsel |
| Clare Hunt M.B.A. | Chief People Officer |
| Kristina Cutter M.P.H. | Chief Regulatory, Pharmacovigilance, and Quality Assurance Officer |
| Virginia DeJesus-Rueff M.B.A. | Chief of Staff and Head of Strategy |
| Neil Berkley M.B.A., M.S. | Chief Business Officer |
Latest SEC Filings
| Date | Type | Title |
|---|---|---|
| Mar 10, 2025 | 8-K | Current Report |
| Feb 28, 2025 | 144 | Filing |
| Feb 28, 2025 | 144 | Filing |
| Feb 28, 2025 | 144 | Filing |
| Feb 28, 2025 | 144 | Filing |
| Feb 26, 2025 | S-8 | Securities to be offered to employees in employee benefit plans |
| Feb 26, 2025 | 10-K | Annual Report |
| Feb 26, 2025 | 8-K | Current Report |
| Jan 10, 2025 | 8-K | Current Report |
| Dec 6, 2024 | SC 13G | Statement of acquisition of beneficial ownership by individuals |