For medical devices at Bank of America. Thanks for joining AtriCure presentation this morning with Michael Carrel, CEO. I will hand it off to him for the presentation. Thanks.
All right. Do we have the presentation? Nope, that's not me. Well, as we're waiting for the presentation, my name is Mike Carrel, President and CEO AtriCure. thank you to B of A for having us here today, as we wait for the presentation to kinda come up. There we go. Awesome. I could do a little jig for everybody if I want to. I don't think so. I've done TikTok before. In case you're wondering, I have done TikTok with my daughters. It's really funny. It works. There we are. All right. Well, again, Mike Carrel AtriCure. again, thank you to B of A for having us here today. Let's see how quick I can get through the forward-looking statements.
For those of you that don't know, I look around and I see many people that AtriCure incredibly well out there today, but for those of you that don't know, we're really focused on helping those patients that have really complex forms of atrial fibrillation. We've gotten into the space of also improving pain after surgery with a non-opioid cryo device that has actually helped out thousands and thousands of patients around the world. Every one of the markets that I'm gonna talk about today are multi-billion-dollar markets. These are large market opportunities that we're going AtriCure is actually number one in the markets that we go after. One of the unique things AtriCure is that we are creating and building these markets.
These are large markets with lots of patients that can benefit from it, and we are focused on building both the technology and the clinical data behind it to really support going after those markets. In addition to that, we've got a strong portfolio that I'm gonna walk you through of both that innovation and the clinical science that kind of supports it, which obviously sets us up for a bright future. I could just talk on the slide. Okay. This is a trick to see if I've memorized all the slides. I can just give the presentation without the slides, I think. Well, you know, I can talk AtriCure all day, so I'll kind of go down and try to walk you through kind of AtriCure story a bit.
Let me hit first on the first item on there. There we are. Okay. Large market. All right. Hitting on a large market. Atrial fibrillation affects. It says 37 million people on this slide. It's really affecting more than 55 million people around the world nowadays. These numbers keep getting updated every year because just more and more people around the world are getting atrial fibrillation, and it, unfortunately, is not getting treated. There are 7 billion people in the world. People are living longer, and our hearts were not made to necessarily live that long. As a result, people are getting and going into atrial fibrillation. One of our KOLs on the EP side says every one of us are going to get AFib at some point in time in our life if we live long enough.
It's a disease that every one of us is gonna get to some degree. Why is that? Because the heart begins to break down. Some of us may not live to that point, but quite frankly, it is a debilitating disease. Why is it debilitating? It's debilitating because it causes strokes, first and foremost. You've got a 5 to 6 more likely chance of getting a stroke if you have AFib because, and you've heard this probably if you sit in all the other conversations, when you go into those into AFib, your heart is not beating smoothly. As a result, blood is pooling. It pools in your left atrial appendage. That causes emboli. Those emboli cause stroke, thus leading to a increased view of stroke on that front.
Let's get on to our dedication and foundation of success here. I mentioned this earlier. These are the pillars by AtriCure has founded and built our business on, and they're incredibly important. First, I believe you've gotta build innovative technologies that differentiate and push the market. You've gotta continue to make it smaller, less invasive, and help these patients out with innovative technologies. We've done that. As I mentioned before, we're really number one in the markets, every one of the markets that we have. In addition to that, it's great to build great technology, AtriCure has done. On top of that, you have to actually build clinical science to support that innovation. You have to make major investments to demonstrate that that actually is going to help patients out in the long term.
You have to continue to look at how large is that market. Are we gonna serve a market that's gonna make sense? In our case, that is. What you've seen AtriCure is also incredibly durable growth. Over the last 10 years, we've achieved strong double-digit growth, and this year we just raised our guidance recently into the high teens, where we're in that kind of 17% or so range. Increased it quite dramatically over the course of the last several years. What you're really gonna get from us more than anything else is super consistent type of growth. In large markets. What about the innovations? If you look at continuous innovation over time, we've got innovation in really 2 different fronts. One is on the ablation side. You use our technology for these complicated to treat patients.
These are usually long-standing, persistent patients that have been in atrial fibrillation for more than a year, and we've developed number one technology in there. All the way to the right, you can see we have not stopped innovating from the Isolator Clamp, excuse me, over on the left that was kind of introduced back in the late 2000s all the way up to EnCompass clamp that just came out. EnCompass clamp is opening up a brand-new market for us and is driving growth that we've never seen before in open cardiac surgery, an area that people said was dying a long time ago. That has enabled us to help patients out that are not getting treated today. I'll go into that in a moment. In addition to that, you can see we've continued to invest in AtriClip franchise.
AtriClip is what manages the left atrial appendage. It basically takes it out of commission. It amputates it in a very easy way so the surgeon doesn't have to cut and try to sew it back together, which is very complicated to do in that part of the heart. You can see the continuous innovation that we've actually achieved there over the course of the last 10 years that's been in existence, and we've implanted over AtriClips in that period of time. The number one player in the appendage management business. As I mentioned, in addition to making sure that you've got great technology, which I just showed you've also got to be able to demonstrate clinical evidence with it. We've invested heavily in clinical trials and clinical evidence.
Some of the items that we've invested, you can see in 2011, we were able to get the ABLATE trial. Now, that seems like a long time ago, that literally opened up the market. At that time, only 10% of patients were getting treated when they went cardiac surgery, when it should have been 100% of those AFib patients. Today, that number is up to almost 30% because why? We got the label. We were able to get guidelines changed. That led to training and education, which led to an improvement. Now, you're probably asking over 10 years, why can't that go and why didn't that go to 100%? Very logical question. That's where EnCompass clamp comes in. There's two big pushbacks that we get.
At 30%, it's a technically difficult procedure to add on to another cardiac surgery case. EnCompass clamp makes it really simple. We took a 30 - 40 minute procedure and we brought that down. We brought that procedure down and showed in our trial during that time. Why do I put that up there? Because it demonstrates that that arm was actually a very strong arm, that it was appropriate, and that there really is a dramatic improvement in these patients. CCAF was a trial that just happened in Europe and just closed out and was actually utilizing our technology in our TT approach, which is actually coming from the sides. It demonstrated that if you do a back-wall ablation in a randomized fashion, this was also randomized, you get another 100% almost improvement.
It's about 82% improvement catheter by itself versus catheter plus doing the back wall with our other technology. Again, demonstrating that the combination of epicardial and endocardial ablation really does improve the results for these patients. What's really exciting now as we move forward is some trials that we're doing to continue to expand our markets. The one I'm going to hit on real quickly, and I'm not going to talk too much detail about it, is the one all the way to the right, which is our LeAAPS trial. Our LeAAPS trial is the largest cardiac surgery trial that has ever been run. It's 6,500 patients. Right now, almost 50% of the patients that undergo cardiac surgery that have AFib have their appendage managed. Now, that should be 100%. We've made a lot of progress. We're at 50%.
What about those other two-thirds of patients that undergo cardiac surgery that don't have AFib? We believe that you can reduce the stroke rate by putting AtriClip on. We're running this trial, 6,500 patients, 250 sites, global trial, to demonstrate that almost every patient around the globe should get AtriClip. how many patients is that? It's like 1.5 million patients every year that undergo cardiac surgery. I've seen numbers at 1 million. I've seen numbers at 2 million. Let's just call it 1.5 million patients around the globe, and if we can demonstrate that by putting a clip on, you can reduce the stroke rates, that is a huge help to those patients and society overall.
I'm not going to go into detail on all these slides because I know I'm short for time, and, but this is kind of an overview of our cardiac surgery market. It's about a billion-dollar overall market. It's a combination of the AFib. This is just $1 billion in the U.S., and you can obviously multiply that on a global basis. I talked about EnCompass clamp, and I talked about AtriClip and the LeAAPS trial that are really going to demonstrate our ability to grow that market. These are real numbers. These are absolute markets that we can win in, and right now, we're number one, and we're going to continue to invest both in the technology and the clinical science to get there. I talked already about the details around the clinical data supporting going after the hybrid market.
It's a huge market. There are 45% of the patients that have atrial fibrillation have long-standing persistent atrial fibrillation. There's only one company in the world that has a label and has proven randomized controlled data to show that if you use our technology, it will actually work and improve these patients' lives, and that's the technology AtriCure. we're investing heavily to continue to expand and build out this market and to really get those surgeons and EPs and electrophysiologists to work together to really help a patient population that today is not getting served.
Finally, on pain management, for those that don't know our story very well, there's about 150,000 thoracotomies that happen around the globe, or I'm sorry, in the United States every year. 150,000. It's an incredibly painful procedure because what you're doing is you're going in through the ribs and you've got nerves that go right there. When you spread that, your nerves get really angry. We have our cryoprobe that freezes it and temporarily kills the nerve. It works because it freezes the inside, but not the sheath on the outside, so that the nerves can regenerate and grow back. The beauty of it is it lasts about 4 to 6 weeks so that they can recover more quickly, get back to work more quickly, take less opioids.
Those are the goals of reducing that pain management. We did a trial, as I mentioned before, that showed that you can see substantial improvement in recovery time. We still have to do the work to go after an opioid label to show that you can actually reduce opioids post when you leave the hospital. We're seeing that in many single centers and single-center studies that they're showing a significant reduction in the opioid use in this patient population that's utilizing it. Big opportunity for us and been growing incredibly fast. You multiply that out, and it's an over $5 billion market opportunity globally. We just reported our first quarter results. We beat by about $5.9 million. We raised by a similar amount, about $5 million, on both the top and the bottom line.
We showed EBITDA profitability in the quarter. You're starting to see the scale of our business really come together, come to fruition after a lot of these major investments. What's great is that we're not gonna stop making major investments. We're committed to getting that $2 million in EBITDA profitability and growing it going forward as we look to 2024 and beyond. You've seen that we've had great growth over the many years. It was 25%+ growth in the first quarter. We feel really good about the year coming ahead as well. I talked briefly about the guidance. In addition to that, I've got six seconds to tell you that we're committed to many other things in our business.
I'm really proud of the fact that, if you look at our board, you look at the investments that we've made in ESG, it's not something that we just say on a podium, but we've actually won the Nasdaq award for small cap companies that have been committed to DE&I throughout the company, both at the board level and throughout. That's something that we're really committed to AtriCure as well, we're proud of that fact. With that, I see it's hit 0. Thank you for your time. I appreciate it. Have a great one.