Good afternoon. My name is Annie, and I will be your conference operator today. At this time, I would like to After the speakers' presentation, there will be a question and answer session. Please be advised that today's conference is being recorded. I will now turn the call over to Mr.
Tommy Thomas, Vice President of Investor Relations. Mr. Thomas, you may begin the conference.
Thank you, operator, and good afternoon, everyone. Thank you for joining us on today's call. Our speakers today are Michael Stubblefield, President and Chief Executive Officer and Tom Sloczek, Executive Vice President and Chief Financial Officer. The press release and a presentation accompanying this call are available on our Investor website at ir.avantorsciences.com. A replay of this webcast will also be made available on our website after the call.
Following our prepared remarks, we will open up the line for questions. During this call, we will be making some forward looking statements within the meaning of the federal securities laws, including statements regarding events or developments that we believe or anticipate may occur in the future. These forward looking statements are
subject to a number
of risks and uncertainties, including those set forth in our SEC filings. Actual results might differ materially from any forward looking statements that we make today. These forward looking statements speak only as of the day that they are made. We do not assume any obligation to update these forward looking statements whether as a result of new information, future events and developments or otherwise. This call will include a discussion of non GAAP measures.
A reconciliation of these non GAAP measures can be found in the appendix to the presentation. With that, I will now turn the call over to Michael.
Michael? Thanks, Tommy, and good afternoon, everyone. I appreciate you joining us today. I'm starting on Slide 3. Avantor's Q1 results provide a terrific start to the year and underscore the value of our fully integrated business model and the relevance of our diversified portfolio.
Driven by the Avantor business system, we delivered strong results across all core financial metrics. We achieved 13.5 percent organic revenue growth and our core growth rate excluding COVID tailwinds improved for the 3rd consecutive quarter. We continue to play a critical role in providing solutions and services to support the global response to the COVID-nineteen pandemic, and these COVID tailwinds accounted for approximately 700 basis points of growth in the quarter. We realized substantial EBITDA growth, expanded margins more than 300 basis points and more than doubled adjusted EPS. Additionally, our leverage position continues to rapidly improve and we received upgrades from all 3 rating agencies in the quarter.
On April 12, we announced a definitive agreement to acquire Ritter GmbH and its affiliates, a technology leader in high precision consumables, expanding our proprietary offering for diagnostic and drug discovery workflows. I will share more details about the transaction in a moment. We continue to actively invest in biopharm production capacity, supporting our core business as well as COVID-nineteen vaccine production. This quarter, we advanced several important expansion initiatives, including projects at our Morrisville, North Carolina and Devons, Massachusetts facilities. We're also adding a second European single use facility in the Netherlands.
In total, we will increase our single use manufacturing footprint by 30% and double our cleanroom space in the United States and Europe. We remain focused on driving innovation and growth across our core businesses and recently enhanced offering with the launch of J. T. Baker, Bakerbond chromatography columns to support downstream protein purification. These new columns have unique selectivity and enable higher purification performance across a wide range of platforms.
Consistent with our integrated discovery to delivery model, Avantra's resins are available to support scientists from early phase discovery to full scale production and will drive long term recurring revenues across multiple biopharma therapies. In our advanced technology platform, we created a unique space grade silicone formulation that was used on the Lockheed Martin aeroshell, which helped protect NASA's latest rover, Perseverance, during the descent into the Martian atmosphere earlier this year. Our silicone materials performed a critical role in protecting Perseverance from extreme heat and particulate contamination, a great example of our proven ability to customize solutions for the most stringent and demanding applications. Looking forward, we expect our end markets to steadily improve throughout the year. Growth in April has kept pace with the Q1 and the order book in our longer cycle businesses, including biopharma production continues to grow.
Based on these favorable market dynamics and our strong Q1 performance, we are raising our full year revenue, EBITDA and EPS guidance. We will share details on this in a few minutes. Moving on to Slide 4, I'd like to reiterate some of the highlights from the announcement of our definitive agreement to acquire Ritter GmbH and its affiliates. Ritter is a fast growing technology leader in high precision consumables for automated liquid handling in clinical and research applications. We've noted in prior presentations that M and A offers opportunities to accelerate growth, enhance our portfolio of proprietary offerings, and ultimately provide more comprehensive workflow driven solutions for our customers.
In that context, Rooter's platform is an excellent strategic fit with Avantor as it addresses all these dimensions and applications and end markets that we know well. Additionally, our combined businesses share similar characteristics, including a highly recurring specification driven revenue profile. One important element of this acquisition is the attractive end market dynamics and the addition of approximately $7,000,000,000 in total addressable market in application areas such as clinical diagnostics, drug development and clinical trials. We're excited to bring together Ritter's proprietary offerings and manufacturing capabilities with Avantor's broad reach and deep customer relationships to generate incremental growth and margin expansion. The transaction is expected to close in the Q3 and we anticipate that it will be immediately accretive to adjusted earnings per share.
For further information about the acquisition, please see the recorded presentation on the Investors section of our website. Turning to Slide 5 of the presentation, I'd like to summarize our Q1 financial results. Organic revenues increased 13.5%. All regions and all product groups experienced double digit organic growth. Overall performance continues to be driven by our biopharma end market where organic revenue growth once again exceeded 20%.
We are encouraged to see several leading indicators that point to the ongoing recovery of our end markets, particularly in the United States, including the resumption of clinical trial activities, the return of scientists and researchers to R and D labs and the rebound in elective surgical procedures. Importantly, our elective procedure related revenues returned to pre pandemic levels in the quarter. COVID-nineteen related tailwinds contributed approximately 700 basis points of revenue growth. We play a critical role in providing solutions and services to support COVID-nineteen testing workflows, head to toe personal protective equipment and customized materials needed to produce vaccines and therapies. There was continued demand for our testing and PPE solutions during the quarter and we realized a significant step up in the contribution from our support of vaccine production.
We are proud to play a role in the global COVID-nineteen response and we see opportunities to participate in future mRNA and viral vector based vaccines and therapies for other applications. Adjusted EBITDA in the quarter was up 38%, leading to adjusted earnings per share growth of 101 percent to $0.35 Our EBITDA margin growth continues to reflect the impact of volume growth, productivity and the favorable mix from our proprietary offerings. Tom will provide more details on adjusted EBITDA and EPS growth in just a few minutes. We generated $112,000,000 in free cash flow in the quarter and are reiterating our full year free cash flow guidance of over 800,000,000 dollars Our cash performance and earnings momentum enabled a reduction to our adjusted net leverage from 4 times EBITDA at the end of last year to 3.5x EBITDA at the end of the Q1. We now expect our leverage to remain under 4x throughout the year even after we close on Ritter.
You will recall that our launch target is 2 to 4 times EBITDA. In summary, our results reflect our resilient portfolio, relevant market position and unwavering focus on execution. As always, we remain committed to building trusted and collaborative relationships with our customers and driving a culture of continuous improvement and execution through the Avantor business system. With that, let me turn it over to Tom.
Thank you, Michael, and good afternoon, everyone. Slide 6 shows our organic revenue growth by end market and product group for the quarter. Biopharma representing approximately 50% of our revenue experienced double digit growth in the Q1. Our biopharma production business grew over 30% in Q1, driven by strong contributions from both chemicals and single use technologies. Our lab products business also experienced strong growth in chemicals, consumables and equipment driven by positive trends in R and D activity.
Healthcare, which represents approximately 10% of our revenue, also experienced double digit organic revenue growth. Strength was driven by continued COVID testing momentum and a strong rebound of elective procedures. As Michael mentioned, we saw our medical implants business for elective procedures return to pre pandemic levels in Q1. Education and government representing approximately 15% of our revenue experienced mid teens organic revenue growth in the Q1. Growth was driven by strength in government COVID related sales and an incremental improvement in education as more university research activities resumed.
Advanced Technologies and Applied Materials representing approximately 25% of our revenue declined by about 1% in the Q1. This business continues to show modest signs of improvement and we are encouraged by macroeconomic signals pointing us to a broader industrial recovery. We saw strong contributions in the quarter from both our EMEA industrial sector and our microelectronics business, offset by weakness in other sectors, including food and beverage. By product group, all our product categories experienced double digit revenue growth, including our proprietary materials and consumables, driven by strong demand for our biopharma production platform. Notably, equipment and instrumentation experienced a significant recovery to double digit growth, consistent with industry trends and reflecting an increase in CapEx investments as lab activities resumed.
Let's move to Slide 7. Looking at growth from a regional perspective, Americas, which represents approximately 60% of global sales, reported 14.6 percent organic revenue growth and sequential improvement in daily rate of sales from the Q4. Highlights were double digit growth in biopharma, including approximately 40% growth in biopharma production and greater than 20% growth in healthcare, driven by hospital and clinical reference lab customers as well as the rebound in medical implants used in elective procedures. Education and government grew double digits driven by COVID related government purchases and education growth from COVID diagnostic demand. Europe, which represents approximately 30 5% of global sales, reported 10.1 percent organic revenue growth.
Growth was driven by biopharma with biopharma production growing double digits. We also experienced continued COVID diagnostic tailwinds given ongoing COVID challenges in the European region. Healthcare and education and government both experienced double digit growth supported by recovery in elective procedures and strong consumable sales. EMEA, representing approximately 5% of global sales, reported 27.2% organic revenue growth driven by biopharma as well as a moderate comparable given the early impact of COVID in the region in 2020. Our biopharma business in EMEA grew nearly 70% in the quarter and our order book has grown significantly, reflecting strong demand for both chemicals and single use products.
On the right hand side of the slide, you can see the expansion of our core growth rate, meaning organic growth less the estimated COVID tailwinds versus Q1 last year, rising from approximately 4% to approximately 7% this quarter. As Michael noted, this represents the 3rd consecutive quarter of acceleration. This trend reflects positive end market trends as well as the resilience of our business model and relevance of our market position. Slide 8 has our segment results. Americas reported 24.3% in adjusted margin rate, approximately 320 basis points higher as compared to the prior period.
Key drivers include strong volume and productivity, ongoing favorable mix driven by growth in proprietary materials and consumables and commercial excellence. Europe reported a 20.2 percent adjusted EBITDA margin rate approximately 3.30 basis points higher as compared to the prior period. We continue to experience favorable margin impacts from strong volume, productivity and commercial excellence. EMEA reported a 22.7 percent adjusted EBITDA margin rate, approximately 500 basis points higher as compared to the prior period, driven by strong volume growth in proprietary biopharma materials and productivity. Turning to Slide 9, let me start with our Q1 adjusted EBITDA.
We achieved approximately 34% growth in adjusted 300 basis points of margin expansion. As I indicated on the prior slide, all three regions achieved strong margin expansion, reflecting volume growth, productivity, commercial excellence, discretionary cost containment and modest mix tailwinds. These mix tailwinds are tied to strong growth in biopharma production and proprietary consumables as well as return to growth in our biomaterials offering, partially offset by strong equivalent and instrument growth. Regarding earnings per we achieved approximately 101% growth in our adjusted EPS for the quarter. Primary drivers were strong operating performance, ongoing reduction in interest expense from our deleveraging and refinancing and improvement in our income tax rate to 22.4%.
We continue to forecast a 24% tax rate for the full year. Turning to free cash flow. As Michael mentioned, we generated 112,000,000 dollars of free cash flow in the Q1 compared to 240,000,000 in the Q1 of 2020. The year over year difference primarily relates to the timing of interest payments, investments in working capital and CapEx to support our growth strategy and higher incentive compensation payments related to our strong 2020 performance. We are reiterating our full year free cash flow guidance of over 800,000,000 Moving to Slide 10, as Michael indicated, we are raising our guidance for the full year to reflect strong Q1 performance, improving end markets and COVID-nineteen dynamics.
Based on the outlook for our core business together with COVID-nineteen tailwinds of approximately $350,000,000 to $450,000,000 we are now guiding to 6% to 9% organic growth for 2021 as compared to the original 4% to 7% guidance. Reported growth guidance is approximately 8% to 11% for the year. Growth in April has kept pace with the Q1, but we do expect moderation in growth rates in the second half of twenty twenty one given the extraordinarily strong comparables in the second half of twenty twenty. We are also increasing our adjusted EBITDA margin expansion expectations to be approximately 75 basis points versus the original 50 basis points. This improvement reflects our strong first quarter results, continuation of higher growth in our proprietary offerings, productivity and commercial excellence.
Also, as global economies begin to open up, we are including in our outlook a return of certain operating costs such as travel and entertainment in the second half of twenty twenty one that were previously put on hold due to the global pandemic. We now anticipate adjusted earnings per share growth of approximately 40%, up from our previous guidance of approximately 30%. This guidance reflects our strong first quarter results, continued operational improvement, lower interest expense from deleveraging and refinancing, and an effective full year tax rate of 24%. We also maintain a flat share count for guidance purposes. As stated before, we are reiterating our full year free cash flow guidance of over 800,000,000 Our full year outlook is based on ongoing EBITDA growth and lower interest payments with some modest offsets from increased working capital needs to support our growth.
Mentioned the leverage ratio improvement we achieved in Q1 to 3.5 times EBITDA and an expectation that we will remain under 4x EBITDA even after funding the Ritter acquisition. On debt pricing, we are pursuing opportunities to further reduce the cost of our term loans, enabled in part by our credit rating improvements and leverage reduction. We expect to share more details about these repricing actions as well as about the Ritter acquisition financing in the coming weeks. Please note that we have not reflected the impact from the Ritter acquisition in this guidance commentary. This concludes my prepared remarks.
I will now hand the call back over to Michael.
Reflecting on our Q1, we are encouraged by the strong financial results and the continued improvement for growth rate. We continue to execute well as evidenced by our significant margin expansion, EPS growth and deleveraging. We remain steadfast in our focus on executing our long term growth strategy and our definitive agreement to acquire Ritter marks an important milestone in our transformation. We capitalize on our exposure to the attractive biopharma end market by making additional investments to expand our manufacturing capacity. These investments will support vaccine and therapies to combat the COVID-nineteen pandemic and support our growing core business.
Our biopharma order book continues to expand, further underscoring the relevance of our integrated discovery to delivery business model. As we look ahead, we are well positioned for continued growth and expect to deliver strong results for the full year. Avantor's mission of setting science in motion to create a better world has never mattered more. I want to thank you for your interest and investment in Avantor and for your ongoing support. I will now turn it over to the operator to begin the question and answer portion of our call.
We have a question from the line of Tycho Peterson from JPMorgan. Your line is open. You may ask your question.
I'll try to squeeze 2 in. 1st on the COVID tailwinds, obviously, you're bumping the guidance here. Testing tailwinds obviously fading pretty quickly. So can you just talk a little bit about how you're thinking about the relative mix and what's really kind of prompting the increase? And then bioprocess, great numbers.
Just curious, was there any element of stockpiling? And then also how are you thinking about potential kind of mRNA and viral vector therapeutics beyond COVID given your current capacity? Thanks.
Thanks, Tycho. It's Michael. I appreciate the question. And then taking your first question here around the COVID tailwinds. As you noted, we've increased our outlook for the full year by, at the center point, roughly $100,000,000 The mix continues to reflect kind of our original assumptions around the vaccine being 40% to 50% of the total tailwind for the year.
And obviously, we've seen that ramp aggressively Q4 last year and certainly saw it ramping again in Q1 and we anticipate based on the order books and the improved vaccines that are out there for that mix to hold throughout the year. Testing for us was certainly strong in Q1. And as we're into the early days of the Q2, we see it strong, that strength continuing. And in this embedded in our kind of $350,000,000 to $450,000,000 guide on tailwinds for the full year, we would anticipate the diagnostic solutions that we offer in that 40% to 50% of total contribution level. Embedded in that at kind of the midpoint, of course, would still be, as you suggest, an expectation that we would see a decline in the second half of the year, which we've been pretty consistent about that view even in our initial guidance.
How that plays out obviously is a little bit of an unknown with infection rates the way they're at around the world. We're still seeing continued dose strength in that diagnostic workflow. From a bioprocessing perspective, the business continues to run at a very high level. As I mentioned in my prepared remarks, order book has continued to advance at a pretty impressive clip. And it's both vaccine driven as well as continued strength in our core business.
The growth in monoclonal antibody production is continuing at a mid upper teens level around the world, and we're certainly getting our share of that. So well positioned for a fantastic year. And as I mentioned in my remarks, we're focused on significant investments in capacity to continue to keep pace with the growth that we're seeing. We're excited about the expansions to both our chemicals as well as our cleanroom capacity for single use. And innovation continues to be an important thing.
You mentioned mRNA and viral vectors beyond COVID. And I think when you look at the application, particularly with mRNA to other non COVID vaccines, we see that as a real opportunity longer term for the business that will add to an already pretty important addressable market for us. So we're encouraged by not only the momentum in the current business, but we're excited by continued strength of funding as well as the application of some of these technologies to some new indications going forward.
Great. Thank you.
Thank you, sir. We have another question from the line of Derek Nedruin from Bank of America. Your line is open.
Hi, good afternoon. Thanks for taking my question. Basically, it's yes, hi. Basically, it's a little bit of bullet more color on the Tycho just asked. When we sort of think about pacing for COVID for the rest of the year, I mean, can we book it current level?
I mean, it's more of an even I would say it's dropped off and it's more steady rather than a sharp drop off in the back half of
the year. So, kind of looking at it getting to bioprocessing,
is that fair to say? Yes. When you look at the midpoint, Derek had roughly $400,000,000 of hotel wins for the year. And if you look at what we did in Q1, your point about it being relatively consistent throughout the year, I think, is fair. The mix maybe look a little bit different, particularly as we get into the back half of the year.
I think, as I mentioned, Tycho, our expectation would be that the diagnostic testing workflow could be a little bit weaker in the second half of the year than in the first half of the year. And we anticipate continued strength of vaccines. And I think PPE contribution should be relatively stable throughout the year.
Got it. That sort of leads to the question. I mean, should we think about the margin expansion? I mean, you're obviously going to be up year over year. Is the bio correct me, Armando, is the bioprocessation be higher margin than the diagnostics that we that sort of major driver?
When you look at our proprietary materials and consumables solutions, of which most of our production solution will fall into that category. That obviously is the highest margin part of our business. So strength there is certainly an important driver of margins. It goes beyond bioproduction. We've talked a bit about our NuScale platform.
It wasn't lost in my prepared remarks there that we saw that business return to kind of pre pandemic levels in the Q1, which is going to be an important platform for us going forward. But our testing workflows, we do have a fair bit of content on those, both from a chemical standpoint as well as a consumable standpoint. So the margins in that part of our workflow would come in above the group average, Derek.
But even, Derek, when you get to the margin expansion point, there are other factors besides the COVID mix that are driving that for the full year. We've got a really strong open order book beyond COVID, particularly in biopharma production. And those margins are superior to the overall weighted average of outdoor portfolio. So it's a you're right, it's a mix factor, but it's beyond COVID given the growth dynamics in the portfolio.
Thank you, sir. Our next question comes from the line of Ghoshan Kho from Cowen.
Good afternoon and thank you for taking my questions. First on M and A, the Ritter deal. 1, what's your capability given you're going to be well within your target leverage range for the year? 2, beyond financial constraints, how would you characterize the organizational readiness for more? And 3, how would you describe the deal pipeline at this point?
So that's the first topic on M and A. And then on guidance, I was hoping that you'd be able to share more on your assumptions by end market in terms of what's incorporated into revenue guidance for the year. It would be great to get those markets, given there are some signs of cyclical improvement. Thank you. Thank you.
Markets given there are some signs of cyclical improvement? Thank you.
Okay. Thanks, Doug. This is Tom.
Thanks for the question. Yes, so the Vinner deal when it closes, call it early hopefully early to mid July, that will be just north of a $1,000,000,000 of divinity capacity in U. S. Dollars, it's a euro dollar deal. But we think we have the capacity to for the rest of the year to have aggregate spending or spending on individual deals roughly that same number.
So there's somewhere between $1,000,000,000 and $1,500,000,000 capacity for this year. And that when you get into 2022 that continues to grow depending on what we've done. In terms of the organizational readiness I would say that this is the first deal that we've done since the large Avantor VWR deal. But we had a program management office in place that always has winded down because we've completed the addressing of that. But you certainly have the capacity from an integration perspective that we've demonstrated to be able to integrate deals that are 3 times the size of Ritter.
And we've been able to sustain the ongoing business as well doing while generating $300,000,000 of synergies on CBWR. So pretty good track record. And when you go back further, we've kind of sustained that over the years. So I would say there's a fairly high degree of confidence doing simultaneous multiple integrations. I mean, there does come a stretching point, but I don't think we're there.
And I think we consider the capacity discussion in dollars. I think we have the capacity to integrate something of that size. In terms of the deal pipeline, as you know, we're focused and concentrating on areas where we have superior growth rates relative to the Avanter portfolio. And I think the Ritter demonstrates that very nicely. And also that's better overall margin rates both gross margin and EBITDA margin.
That points us to proprietary offerings. And in both the lab space type, some of the diagnostic opportunities as well as in biopharma production would be areas that are of most interest to us. And we're looking for deals that have existing profitability and existing cash flow that will help us to speed up quickly. So we're excited about the continuing flow. All the businesses are engaged, have a regular pipeline review.
We have capacity in that place. In terms of the guidance on the end market, so just to remind you, overall we're guiding to 6% to 9% for the year. And for biopharma in total, that's probably close to high single digits to low double digit kind of growth from a healthcare perspective. It would be similar from an education government perspective that is the area where we're seeing the most improvement year over year given the decline in education last year. So that would be clearly in the double digits.
In terms of advanced technology and applied materials, we're not forecasting a breakout like we're not including massive return to growth just yet. And so you can kind of consider that to be low single digits to mid single digit kind of growth expectations.
Thank you, sir. We do have another question from the line of Vijay Kumar from Evercore. Your line is open. You may ask your question.
Hey, guys. Thanks for taking my question. One on guidance here, Michael, it looks like the base ex COVID, it's about 3.5% to 6.5%. I want to is my math correct on the base assumptions? And the low end, is that just conservatism because I think most of your peers are looking at mid to high?
I'm curious what would cause us to get to the low end?
Yes. Thanks Vijay for the question. I think it's important to recognize firstly, we're out of the gate strong on Q1, 3 straight quarters now of of sequential improvement in the core business. We were down a business day in Q1. If you adjust for that, our core growth rate in Q1 was, call it, 8% to 9% in the quarter.
So really strong performance in the base business. And so a period here, obviously, where the comps on the base business are going to get a little bit easier here at least for the next couple of quarters before you run into a tough comp again in the Q4 here. So when we break down the 6% to 9 percent, Vijay, the midpoint on our COVID tailwinds, you're talking a couple of points of growth. So that probably points you to kind of 4% to 7% or so on the base business.
That's helpful, Michael. And maybe one for you, Tom. Margin performance in the quarter was extremely strong. It looks like proprietary products came in strong, it was mix driven. Why shouldn't that mix effect continue into the back half?
And I'm curious that on the free cash flow side, our guidance wasn't changed, but I mean, that Q1 free cash was very impressive, $240,000,000 that's almost 30% of the annual guide. So was there any timing impact on free cash?
Yes. So just on the margin performance, yes, Q1 was outstanding, 300 basis points improvement on EBITDA, I might say. About half of that came from gross margins and the rest was just really good controls around SG and A spending and the volume leverage on those fixed costs. But between mix and productivity as well as good commercial attention to pricing relative to inflation. You had about 130 basis points or so on gross margin.
You had the rest of the growth on SG and A. I would say that relative to the rest of the year, you have to consider the significance of that. When we printed 15% or so growth in the Q4 of 2020, we created a tough baseline for ourselves. And so Q1 to Q2, as we've said, are going to be the start ones for this year. You will see real strong margin performance as well.
I think in the second half of the year, we won't have quite that the volume leverage, at least as you see it right now. If we're on the upper end of the guide, which knock on wood hopefully will be, then I would expect us to be closer to the kinds of margin expansion that we got in the Q1 and for what you would reasonably expect for the Q2. On free cash flow, Vijay, the number for the Q1 of 2021 was $112,000,000 We were at 2.40 dollars in 2020. So we did have a bit of a decline. I would say it's 2 factors.
1 is just the growth in the business that necessitated investments in working capital. We probably added in the quarter roughly $50,000,000 of inventory as you can see. But when you look at the inventory, the days, the number of days that we have in inventory day sales, it's roughly the same as what we had and what we've been carrying throughout 20 20. So we're in good shape on that. And on receivables, there was a sizable investment, but the March sales relative to last year were up about $100,000,000 And so you would expect to see a significant growth in receivables.
So between receivables and inventory, you did have a bit of dilution on free cash flow, but we think that's going to support the future growth. We also had a couple of other elements. I mentioned that the incentive comp payments, I mean, the payout this year were twice what they were in the Q1 last year. So all in the number that we mentioned also includes investment. Our CapEx continues to be an area of focus.
We mentioned several of the single use investments that may support the growth in that business. All in, we're this is the performance is pretty much what we had expected. We didn't give guidance by quarter. But if we had showed you our plan, you would say that the performance for Q1 was pretty much dead on what we would have expected and that's in line with the 800 for the full year. Could that be better?
I hope so, but we want to kind of get another quarter or so behind us before we're working on this. One other point I mentioned, Vijay, I should mention is, you might you'll recall the refinancings we did last year. As part of those, we ended up moving the interest payment dates from the Q2 and Q4, Q3 and Q3. So we pulled in about $50,000,000 or $60,000,000 of interest payments into the Q1 that were paid last year. So we'll get that back in the second quarter, should be a real strong quarter from a free cash flow perspective and looking forward to making you happy once again non cash with $800,000,000
Thanks for clarifying on the system capital items. Thanks guys.
Okay. Thanks, Andy.
Thank you, sir. We have another question from the line of Jack Meehan from Nephron. Your line is open. You may ask your question.
Great. Yes, and thank you. Good afternoon. Just wondering if you could Just any additional color there? And as you look at 2Q, I think you have some pretty easy third party comps.
Is that right? What's that going to mean for margin in 2Q?
Thanks, Jack. Good to hear from you. On your first question here regarding the strength of both proprietary as well as our 3rd party offerings in the quarter, we'll go into the double digits obviously. I think it reflects things. 1, when you look at the proprietary piece, really towards our bioproduction offering.
So we're tracking strength in both our business there as well as in our in the vaccine production. But as noted, we're also for the first time in the year seeing growth in some of our other important proprietary offerings including our raw materials offering, for example. On the 3rd party side of things, obviously, strength there being driven by a lot of the diagnostic testing workflows. And these are chemicals and consumables, where we have some structurally some strong agreements there that also yield well above group average margins for us. So the growth being driven by kind of return to the lab and the general strength across biopharma and academia and healthcare, but also from a margin standpoint, certainly contributing to the 130 basis point of gross margin expansion that Tom referenced.
So both trends in the quarter were pretty favorable for us.
Great. And as one follow-up on COVID testing, it seems like you're expecting a little bit more durability here than some of your peers. Is there any color you can give around what the international mix you guys have there is? Is that one reason why you're expecting more kind of relative steadiness?
It's a good question, Jack. If you look at where our strength in testing has been, we've probably been a bit stronger throughout the pandemic in Europe than we have in the U. S. And clearly there's a different level of infection rate in Europe that's been persisting there, which we do see continuing. I think we've been pretty consistent in suggesting maybe even contrary to what a lot of the data points that were out there in that we would anticipate a bit of a fall off in the second half of the year.
And that still continues to be modeled into our outlook here. But Q1 probably held up a bit stronger than what we had anticipated. And we're a month into the Q2 and we see continued strength. We do see durability to testing that probably occurs beyond this year. If you look at just the U.
S. And the funding that's going to be available to support testing for K-twelve schools and employers testing plans and getting associates back to work. Just to name a couple of examples, we do think testing is going to be sustainable for the foreseeable future, albeit perhaps a more modest level than what we've seen here at the height of the pandemic.
Thank you, Michael.
Thank you, sir. We have another question from the line of Patrick Donnelly from Citi. Your line is open.
Thanks for taking the question guys. Michael, maybe one for you some of the advanced technology piece, down low single this quarter. I think it had grown at 4Q. I think Tom maybe expected low single digit growth for the year. Can you just talk through it sounds like you guys are encouraged by the macro signals, obviously pointing to a broader recovery.
Can you just talk about the outlook there? How conservative is that low single and what should we be looking for in terms of kind of the macro piece to really suggest things are reflecting higher there?
Yes. Thanks for the question, Patrick. I think firstly, it's important to kind of maybe put that part of our business in context. It's about a quarter of our overall revenues with about half of that being considered to be defensive growth oriented platforms semiconductor exposure. And that piece of the business continues to be pretty resilient.
Our both our proprietary offerings and both our proprietary offerings into semiconductor manufacturing continues to be a strength for us. We then have maybe 10% or so of the business that's linked to more cyclical end markets like petchem oil and gas, food and beverage. Net net, we were down just a tad below flat in absolute terms. I think it was less than 1% off in the quarter. So modest year over year decline, certainly not contributing to the results significantly here.
So I think plus or minus the business is on track from where it's been performing Even in pre COVID times, there's been that part of the business to print kind of low single digits. So PMI is holding up where they're at and outlooks around the world, we would anticipate that business kind of sequentially improving throughout the year and certainly before the end of the year getting to kind of a low single digit level, Patrick.
That's helpful. And then maybe just on the bioproduction expansion, was that always in the plan?
You guys just pulled
it forward a couple of years due to the strength of COVID on the cash flow side as well as the demand? And then secondarily, I think just following up on maybe Tycho's question earlier, how robust is the demand there in terms of your confidence level that this expansion will get filled relatively quickly in terms of the capacity you're building out there? Thank you.
Yes, great questions. So this part of our business, the single use part of the portfolio, we've been describing for a couple of years now is growing north of 20%. And certainly, that's accelerated as we've worked through the pandemic. The base business itself continues to be strong. And then you add to that the demand coming from COVID.
Our single use offerings are very prevalent across these various production of vaccine modalities. So we have an investment plan in place that we definitely have to accelerate to account for the tailwinds that we're seeing. And our order book, which we continue to reference as growing significantly a significant part of that order book growth is in our single use business. And it really is necessary to keep up with the growth as well as to establish more normal lead times for our base business and for our offerings to put the capacity in place. So the capacity will be utilized pretty much instantaneous.
We're hiring ahead of the construction being completed so that when we turn the lights on, we're ready to go with full teams and full shifts that can meet the demand that we do have in place. I referenced in my prepared remarks to help keep up with the demand. Although we're expanding existing facilities, but we were excited this week to announce the addition of a second site there in Europe that we've taken possession of that take us 2 or 3 months to get the facility ready to run. But by certainly by July, we'll be we'll produce single use assembly down to that facility. So team is doing a great job in keeping up with the growth and making sure we've got capacity to sustain it.
Very helpful. Thanks so much.
Thank you, sir. We another question from the line of Luke Astrachart from Barclays. Your line is open. You may ask your question.
Thanks. Just a follow-up on Patrick's question on the capacity expansion. Can you give us an idea how big your single use business is now? And then what we should expect from an incremental sales perspective over the next couple of years as those as that business comes online and that capacity starts filling out?
That part of our business is in probably 20% to 30% of our total production platform and has been growing pre pandemic north of 20%. And obviously, we're seeing tailwinds on top of that this year. But no reason why that type of growth rate won't persist for at least through the midterm here.
Okay. That's helpful. And then lastly on Ritter, I know it has strong diagnostic exposure, precision manufacturing that seems right down the middle for biopharma. Give us a sense of your early strategy here in expanding this customer base. And again, like the incremental opportunity as you guys see it over those 1st couple of years post close?
Yes, we're really excited honestly about the opportunity to bring these manufacturing capabilities into our portfolio, really fits in the sweet spot here of our consumables offering to our automated lab workflows across a number of end markets. You mentioned biopharma. These products are used extensively in the clinical trial workflows as well as in drug discovery. And when you look at our customer set there, we're excited about the ability to expand the offering that Ritter has beyond kind of their core OEM focus that they've had historically. And when you look at kind of the clinical diagnostics exposure that the business has, another area where we've got great customer overlap and great customer exposure here.
And we're selling significant content onto these workflows already. And so the products coming off of later are going to be a straight drop into our channel. Our sales associates are excited to be able to add it along with the rest of the content that they provide. And certainly, our customers, since the announcement, have expressed their excitement for us having this as part of our offering going forward. This is an area that's structurally been constrained throughout the pandemic, but probably even before that.
And having not only the scale and the reach that will bring to it, but the ability to accelerate the investments, expand the business over time is going to be an attractive part of the target here.
Great. Thank you.
Thank you, sir. Next we have Dan Leonard from Wells Fargo. Your line is open. You may ask your question.
Thank you. A couple of one, ripping off Jack's question. Could you characterize your COVID diagnostics exposure in terms of how much is lab based testing versus how much is the point of care testing you distribute? Just as I think all of us are trying to understand the divergent COVID use out there.
Yes, Dan, thanks for the question. So as we've mentioned before, we're going to have offerings that are going to span kind of the 3 major categories of the testing workflow with PCR testing certainly being the most important for us. But we do have significant content on the antigen based tests that are out there
even at the point of care
as you mentioned, both in providing content to OEMs in the production of these tests and these kits as well as in distributing the test kits and the tests themselves. And then as we've said from the beginning, we also have a I think softening for serological testing, which today hasn't had much traction as a workflow. How that plays out longer term is yet to be determined. But today, the proprudents of our exposure would be on PCR and antigen based testing then.
Thank you. And then my follow-up, can you offer more color on your outlook for the APAC region, your strongest region in the quarter? Wondering if you foresee any issues with the COVID outbreak in India or anything else with flagging? Thank you.
No, it's a good question. We're obviously following the developments in the region pretty closely. And obviously, that's from a human perspective, it's obviously tragic to see what's unfolding in India, for example, with the infection rate that we do see there. We see most of the concern fighting centered on India. China continues to be strong.
Southeast Asia around Singapore and Korea continue to be pretty strong, particularly from a vial production standpoint. We have a significant order book to support all three of those regions and would anticipate continued momentum there. India for us is part of what's been a percentage of the overall business today for us. So it's a 3 bars impacts. And I can imagine the return to kind of pre pandemic levels for some of the end markets that we serve that are being spunked a bit here given the outbreak that they're experiencing.
At the same time though, we're seeing obviously very, very strong demand for things like PPE and diagnostic testing solutions, which obviously we're well prepared to provide. So the mix of the business probably unfolds a little bit differently than what we had imagined, but the business continues to run well. But no, we're following it quite closely. So we anticipate continued momentum in the region.
Yes. Just to add a little more color to that, Dan, the 27% in Q1, I wouldn't take that here. As Mike said, it's going to be strong, but we've kind of got it dialed into our numbers just right around double digit type increase for the year for the region. We had a really strong Q2 last year, driven in part by some of the COVID testing that Michael mentioned. And so there are some comp things that we have to that are actually countercyclical to our overall comp for Q2.
So I would expect a really strong overall number for the year, but I would just want to temper your enthusiasm based the Q1, the outstanding Q1 results.
Okay. Thanks both for the color.
Thank you, sir. We do have another question from the line of Desjardins from Morgan Stanley. Your line is open.
Thanks for squeezing me in here. Just one sort of follow-up, Michael, for you on the vaccine front. I mean, there's growing chatter around the need for boosters and so on. Does the vaccine portion of your COVID forecast still essentially only account for the current order books and any sort of future And then second, on a related note, last quarter you had noted that the timing of the vaccine ramp is important. And if it ramps sooner than your capacity does, you may not be able to capture all that sort of upside that you think you're eligible for.
So in light of this recent capacity expansion, etcetera, can you just give us an update on that situation?
Great questions, Tejas. Appreciate you joining the call tonight. From an outlook standpoint, built into the 350 to 450 guide there, at this stage, certainly reflects the approvals that are in place as well as the order book that we do have, which is pretty significant, continued to build aggressively in the quarter. And not only do we have strong orders that extend throughout 2021, but we're also starting to now get orders that are investing for delivery in 2022. So I think on that part of the business, we certainly have good line of sight.
But I think it's becoming almost the prevailing wisdom that there will be a need booster shot this fall to address the various variants and mutations that are out there. And I think you start to see that built into the planning. One of the implications, as you noted, of a strong vaccine ramp is whether or not you have instantaneously enough capacity to support that as well as really robust base business order book. And certainly one of the things that us as well as our peers in this space have been challenged with as we move through the quarter is the so called rated orders status that comes with the vaccine orders that based on the Department of Defense prioritization protocols require you to place those orders at the front of the line. And so there are certainly instances here where some of the core businesses that the delivery dates have had to get pushed out or adjusted to reflect that.
We've had a series of expansions coming online to date, and we have a number of more that are planned throughout the year that will certainly provide relief to some of the balances. But the supply chains across the industry are going to be strained, I suspect, well into next year.
Got it. Super helpful, Michael. And one separate follow-up on your remarks earlier on Advanced Technologies. I'm Materials. How are you thinking about the impact of the semiconductor market supply demand disruption that's underway here and expected to stay with us through 'twenty two?
Could that essentially potentially be a tailwind for you guys for what you do there with the move to the lower nanometer nodes and so on?
Yes. We like that platform an awful lot. And historically, it's been quite resilient and pretty frothy from a growth perspective. It's quite reasonable for that platform to grow high single digits, double digit type levels and it's not often on the strength of that space. And we see that in our numbers.
The business continues to run. We have great technology and a footprint that allows us to serve the growth from the fabs in Asia as well as in the U. S. Here. So certainly one of the strengths of the advanced technology part of our business.
Got it. Super helpful. Thanks so much guys.
Thanks, Ed.
Thank you, sir. There are no further questions at this time. I would like to turn back the call to Mr. Michael Stavridis for the closing remarks.
Thank you again for participating in our call today. I wanted to take the opportunity to make you all aware of our intent to an Analyst and Investor Day on Thursday, September 9. We'll be sharing more details, including registration information on that in the coming weeks. But as we close here this evening, I just want to express my continued gratitude for all of the efforts that our associates are putting in around the world who are living our values every day and helping us live our mission of studying science and mission to create a better world. This team and the resolve and steadfast support of our customers is super critical to our mission and our success.
We're excited about what lies ahead for our business and for Vontor and look forward
to updating you when we
meet next. Until then, take care and be well everyone. Thank you.
Ladies and gentlemen, this concludes today's conference call. You may now disconnect. Thank you for participating.