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The 6th Annual Evercore ISI HealthCONx Conference

Nov 29, 2023

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Hi, everybody. I am Elizabeth Anderson. I'm Evercore's healthcare technology and distribution analyst, and I am very pleased to be joined by IQVIA. We have Ron Bruehlman, the EVP and CFO of the organization, who many of you know, and also Nick Childs as well from IR, who is sitting there, and Gustavo as well. So perfect. Thank you so much. So maybe as we take a look at the business, I think, you know, hot topics have been sort of the current demand environment. This probably is no surprise to anyone in this room.

So, if we take TAS, and we break it into sort of the four large buckets that you guys have highlighted, we have, like, analytics and consulting, we have the info services, real-world evidence, and the tech business, how do we think about the sort of pharma spending demand environment, specifically in each of these, in these segments and where—what you're seeing?

Ron Bruehlman
EVP and CFO, IQVIA

Right. Well, the demand environment has become an issue because you've seen our growth rate slow down some in the TAS business, and it hasn't been uniform across the TAS business. But we have seen about two-thirds of large pharma announce in one way or another that they're looking to make some budget cuts, and it's typically focused on short cycle promotional spending, and things of that nature. So the business has been most affected of ours, and we've talked about this quite a bit, is the consulting and analytics business.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Mm-hmm.

Ron Bruehlman
EVP and CFO, IQVIA

A lot of that work flows out of new product launches, which have been good, and ultimately, we think a lot of the work is gonna get done, but it's also deferrable sort of work, and.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah

Ron Bruehlman
EVP and CFO, IQVIA

... we've definitely seen a slowdown there. It's even gone negative in terms of growth rates a couple of quarters, and that's a business that's been most affected. But ultimately, we think it'll come back because it involves issues like profiling, segmentation, targeting of doctors, launch planning, and things of that nature, that needs to get done. Now, another part of our business that's kind of you would call discretionary, at least in timing in nature, is parts of the Real-World Evidence business. We think about Real-World Evidence sometimes as being a regulatory requirement, and in, say, a third to a half the cases it is, but there's also a large percentage of that business which is discretionary in nature. It provides a good return, we believe, for our pharma clients over time, but can also be deferred.

You know, for instance, getting drugs onto formularies... doing real-world evidence to get drugs on the formulary or to support new indications, things of that nature. So that business has, I think, started to be affected some too. The portion of our business that is less affected is our core data business, which is about 30% of the TAS business, and that's pretty much fundamental to what pharma needs to do on a kind of day-to-day basis is track how their sales are going. And, of course, we have a very strong position there. And, yeah, on the margin, we can sometimes see pharma customers adjust their spending some there, you know, frequency of data and things of that nature, but that's held up very well for us.

Then last, you mentioned the tech business, and that tends to be a little bit longer cycle business. You might get some delays in decision-making from clients, but typically hasn't been as affected. So to summarize, it's been really the shorter cycle, discretionary parts of the business, consulting and analytics, and parts of the Real-World Evidence business where we've seen the biggest impact.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. And maybe specifically on the Real-World Evidence business, is part of that impact, to point out, sort of, cyclically driven or sort of spending slowdown driven, is that also in part like a, driven by IRA and sort of like ex-US product expansion, or is that doesn't really, hasn't really played into the demand for that?

Ron Bruehlman
EVP and CFO, IQVIA

Well, you would say IRA shouldn't have an impact yet. I mean, the first impacts don't happen until 2025, but it has forced, I think, our clients to kind of re-look at their portfolio and decide, you know, put some things on pause, perhaps, and decide where they want to spend their money. So it's very hard to to tie it directly to IRA, but we think that there is, there is likely some impact there.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Okay. No, that certainly makes sense. So then as we think about, you know, obviously, you have the shorter-term demand environment dynamics, and then the longer-term, still very positive, trends in that business. How do you think about your investment priorities for TAS over the next couple of years?

Ron Bruehlman
EVP and CFO, IQVIA

Well, we think that there's still areas that we would like to fill in and grow more, where we have, you know, we have a large market potential, and we haven't penetrated as much as we would like. For instance, we've done a couple of deals recently in the real-world evidence area. One, a company called QualityMetric, that has kind of standardized forms and templates for investigators and for pharma professionals in the real-world evidence space to gather data from clients... excuse me, from patients-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Mm-hmm

Ron Bruehlman
EVP and CFO, IQVIA

... in a standardized fashion that meets the requirements of Real-World Evidence generation. And QualityMetric has over a hundred of these standardized forms that are used, and is really kind of the gold standard in the industry. We also have made some acquisitions, and that would be what I would consider, like, patient centricity area. We've also been growing some and putting some money into medical affairs. You know, you think the communications between pharma and clients, you know, healthcare professionals would be relatively straightforward, but they're actually highly regulated, what you can say and what you can't say, how you have to present. You know, evidence generation is one thing. Evidence dissemination has to follow some fairly strict rules.

So the process for vetting data being disseminated to healthcare professionals in the real-world space is pretty time-consuming, and we made a recent acquisition in Europe of a company that has found a way to shorten that process. And they've found that they can take up to 90% of the time out of the process of vetting and getting information ready for dissemination. You know, it's amazing when you think about average over 60 days that it takes sometimes to get data in a form that can be disseminated to healthcare professionals, and they've gotten it down to around 10 days. So that's just another example of an area that we're investing in. We're investing more in the MedTech area. This has historically been an area where there's been less activity.

We have a decent-sized business there, but in relation to our pharma business, it's pretty small. We think there's a lot of growth opportunity there, and selectively, we'll be making acquisitions in the tech area. So you know, both a combination of internal development and acquisitions will be our investment focus across those areas, like real-world evidence, medical and scientific affairs, tech. And you know, in the real-world evidence, there's also finding new data sets as well. So that's another area because there's always more data to capture there.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah. It does sound like an interesting mix of sort of new capacity expansions, both in terms of your internal investments and M&A, and then also productivity and tools, both for you guys internally and on the client side. That's a fair way to sort of characterize that?

Ron Bruehlman
EVP and CFO, IQVIA

You know, before I forget, there was another thing that's important, too, and that's digital marketing. We've seen pharma, you know, historically it has been very focused on the sales rep model of approaching healthcare professionals. Now it's getting harder for reps to get in and see docs, and you have a younger generation of doctors that are more comfortable with digital communications. So we've made some investment in those areas in digital marketing that have been very helpful to us, and you're gonna see us continue to invest there as well. That's another big area of investment.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. And if we talk about those digital and marketing investments for a second, where, where are you sort of seeing increased spend? Like, how... Is it like, where are you seeing, like, the most effective channels in, in your experience?

Ron Bruehlman
EVP and CFO, IQVIA

In what? For digital marketing?

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah.

Ron Bruehlman
EVP and CFO, IQVIA

Well, look, we have a company that, DMD, that has basically opt-in consent from healthcare professionals to be able to market directly to them based online, based on their usage of journals and what they're researching in journals and so forth. So I think that kind of very targeting advertising is important. I mean, we've been doing you know, Googles of the world and others, have been doing very targeted online marketing for years and years. I think, the, you know, life sciences is just catching up in that area, and that, that's a big area of growth. And so how you serve up advertising and how you do outreach to healthcare professionals based on their very specific interest, what they're researching, is a big area of growth.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it, and even in the current and demand environment, that's something that sort of pharma-

Ron Bruehlman
EVP and CFO, IQVIA

It's-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

is still continuing to spend on.

Ron Bruehlman
EVP and CFO, IQVIA

It's still, still growing. I mean, you know, even that has slowed a little bit versus what it was previously, but you're still talking about strong double-digit growth in that area. It's just relative growth has slowed a little bit as our clients have pulled in their budgets a little.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. Okay, that makes sense. Okay, maybe talking about R&DS a little bit, as you move to sort of through the fourth quarter and the end year, how do we think about RFP flow? Is that continuing to sort of, you know, be the sort of similar to third-quarter levels? Is there any sort of standouts in terms of therapeutic areas or service types or anything like that to call out?

Ron Bruehlman
EVP and CFO, IQVIA

What I would say is, from the start is that RFP flow remains strong. You know, it was strong through the first nine months of this year and remains good into the fourth quarter. We haven't seen any softening of overall demand, demand indicators. Now, if you look at it by kind of area, you can break it down. You can say, "Okay, well, you know, by customer segment, what are you seeing?" We're seeing growth. Now, it'll vary quarter to quarter, RFP flow and bookings, but we're seeing growth in everything from small pharma, emerging biopharma, mid-size pharma up through large pharma, and so there's been growth in all of those segments.

I know there's been a lot of concern about EBP, but we just have not seen a slowdown, and we've been pretty consistent with that since the issue first popped up more than two years ago. By therapeutic area, of course, as we've gotten beyond COVID, we're seeing, we have seen the emphasis shift back towards more traditional therapeutic areas. But the big growth areas are oncology, rare diseases, neurology, and surprisingly cardiology, and surprisingly to me, maybe not to others. Cardiology remains very strong. You'd think that's a pretty mature field, but it really isn't. There's quite a lot going on there as well. But in general, what you tend to find is that the emphasis has shifted towards more complicated sorts of trials than in the past.

And then last, there's kind of an FSP versus full service that we've talked about, that over the last couple of years, we've seen a shift, a gradual shift, in the percentage growth towards more FSP versus full service, at least among large pharma. Now, the flip side of it is EBP is pretty much-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Full service

Ron Bruehlman
EVP and CFO, IQVIA

... exclusively full service, and that's growing nicely, so that provides a bit of an offset, but there has been some shift there. But by any metric that you look at, it, everything remains strong. I think our book-to-bill in the third quarter was 1.24. 12-month rolling is slightly over 1.3. And, you know, looking encouraging as we proceed into fourth quarter.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. Okay, that's very helpful. As we think about the past rounds of pharma restructuring, how do you think about, like, what do you think the right way is to think about the timeline between, you know, when an internal restructuring is announced and we start to see, you know, spending cuts as well as, you know, potentially opportunities where, you know, IQVIA could help reduce costs in clinical trials?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah, look, it's interesting. There is no set timeline for how pharma budget cuts tend to affect clinical trials. A clinical trial business is inherently a long-cycle business. It has a lot of momentum. Certainly, trials that are in flight generally are not affected. Every now and then, pharma will look, relook at its portfolio and say, "Okay, we're gonna halt this clinical trial 'cause we wanna change our emphasis to a different therapeutic area," or something like that, but generally not. And in fact, I'm fond of quoting this statistic. We went back and took a look back to the year 2000 of revenues among publicly traded CROs.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Mm-hmm

Ron Bruehlman
EVP and CFO, IQVIA

... and through multiple cycles, economic cycles, some of them pretty bad during the past, you know, 25 years or so. And what we found is that no given year did the CRO industry, publicly traded as a whole, have a year of negative growth. So, the long cycle nature of the business tends to dampen those ups and downs quite a bit. It's not that pharma doesn't make changes, it's not that they don't reassess their portfolio, but the changes tend to flow through to the CROs pretty slowly. Where you see the quicker flow through is on the TAS side of the business and promotion and marketing spend, where when things get tight at pharma, for whatever reason, be it...

Well, you know, some of the things that have happened recently, coming off kind of a peak of COVID revenue to where COVID vaccine work is, and therapeutics work has dried up, the concern about a recession, higher interest rates, you know, all the things. And then also just, you know, the Inflation Reduction Act, concern about that. All those things kind of weighing on pharma and causing them to pull in a little bit. The first place they seem to go is towards the short cycle sort of spending, the things that you can have an immediate impact, you can cut your budgets immediately. Now, the way it'll often happen is, we've been through this cycle numerous times, is our pharma customers, particularly large pharma, will come to us and say, "We really wanna, you know, tighten our belts.

We wanna make some budget cuts. We need some help from all of our suppliers. And they'll, you know, start throwing out numbers for you to hit. And you know, if I hadn't been in this business in a while, it could cause a bit of a panic mode 'cause you think, "Gee, how are we gonna absorb these kinds of hits?" But that's not the way it typically happens. We have contracts in place and so forth, and we go back and we try to help our customers. But very often we do that by saying, "Look, we'll save you $X million or whatever, but here's how I think we can do it most effectively.

You know, help us consolidate some more of your spend with us, or we can insource or you can outsource some of your work to you. We can take cost out that way." And there are a lot of different ways of kind of skinning that cat. So those are some of the discussions we're involved in right now with our clients. But we also find that, you know, that what ends up happening is they just cut their spend too. So that's why you saw the growth rate in TAS drop off from high single digits, low double digits, down into the low single-digit range, was because, you know, that part of the way they save money is just by either cutting or deferring discretionary projects in the commercialization area.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. No, that makes sense. 'Cause it occurs to me that we tend to have the same sort of panic when we go through, like, large pharma M&A, if it happens to be, like, a customer set of yours or somebody. It's like, go through this initial panic, consolidate, they kind of reorganize, and then, you know, I think there are sort of been historically, like, interesting opportunities over the longer term from that perspective.

Ron Bruehlman
EVP and CFO, IQVIA

That's true, and I would say, actually, the mergers tend to have a pretty immediate impact. We haven't seen a lot of those, but if you go back-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Right

Ron Bruehlman
EVP and CFO, IQVIA

... to the first decade of the two thousands, you know, late, there were a number of large mergers there, and what'll end up happening. And that's when we were just, at least the commercial side of the business, was just IMS. They're buying data from, you know, two different companies buying data are now buying it once in overlapping therapeutic areas, or they're, you know, they're cutting duplication and spending. You also find that sometimes patent or LOEs or patent expiries tend to trigger reductions in spending as well. You know, there have been some major ones over time, but when, for instance, Pfizer lost exclusivity on Lipitor, you know, that had a huge impact on them, and obviously, they're gonna pull in from a spending standpoint.

But that's, you know, more than a decade in the rearview mirror.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah. No, for sure. Maybe thinking sort of that growth and that demand about it, how do we think about TAS and the segment gross margin line, you know, in this environment? Like, how fast does the growth really need to be to generate gross margin expansion? Is that not really, or is that not really the right way to think about it? And are there any additional sort of levers you can pull, depending on, you know, if growth continues to be slower in the near term?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah, I would say that the gross margins in TAS tend to be affected most by product mix. We have the highest margins typically in our data contracts. Our consulting and analytics can be very nice business as well. Within the tech business, the license part is good margins, the implementation, not so much. Real-world evidence, it varies. If it's you know, data-generated or it's syndicated sort of stuff, it can be high margin. If it's just doing health economics outcome research with expensive researchers, it's just marking up labor. So kinda the mix within that business tends to be what determines the gross margin as much as anything.

Yeah, there's a volume impact, clearly, because when you have higher volume, you have higher utilization, particularly of consultants and people like that, so that's helpful in the gross margin. Where you see the biggest volume impact, though, is actually when you get down to the EBITDA line, because the SG&A is where you get your leverage. And so what we've been doing as the business has pulled in some is we've been very aggressive about taking costs out of the SG&A line. And honestly, that's where we would have to continue to look if it doesn't bounce back. Now, we expect it will bounce back. Why? Because there's a pipeline of work there that we think pharma will wanna do, that they've been deferring.

The new drug approvals are up substantially versus their 5-year average, so there are lots of those there. And there tends to be a cyclicality to the pharma spending that we've seen. It doesn't last five years. It's, you know, it's kinda 1 to 18 months to 2-year sort of thing before it bounces back. But with-- having said that, I would caution that we see it as being more likely a second-half 2024 bounce back in growth rates rather than a first-half bounce back in growth rates, 'cause these trends tend to have a little bit of momentum.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah. No, that makes sense. So is it possible, like, given what you just said about the gross margin line, or maybe we could talk about EBITDA, if you'd prefer, that if you have, like, you know, the data services is less affected and, like, the analytics and consult modified, that that could just sort of help to offset that sort of broader decline in that from, like, a mix perspective?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah. Oh, for sure, that, you know, to the extent, in an odd kind of way, the extent that the data becomes less of a drag from a mix standpoint because, you know, it's growing low single digits, and previously, everything else was growing high single digits or double digits. Yes, as those other parts slow down, data becomes less of a mixed drag. It's kind of an odd phenomenon. So there, there's always a lot going on beneath the gross margin line. I mean, even FX affects gross margins, where your cost is, where your revenue is. So it's a bit of a puzzle to sort it out sometimes. But overall, if you focus on what we've done at the EBITDA line for it, you know, we don't...

You know, we have segment disclosure for, you know, for operating income, but that's also got a lot of things in it that are, you know, that are non-GAAP add-backs. But if you look at our overall, EBITDA margin, we've had about 70 basis points of margin expansion this year, and we're projecting roughly 50 next year. So we've been able to overcome those impacts so far.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. And how do we think of, I think you talked about some of the levers in TAS on the, on the OpEx line. Are those sort of similar in R&DS too, or is, is that, is there some other way you would sort of differentiate the potential cost opportunity if that business were to slow more?

Ron Bruehlman
EVP and CFO, IQVIA

Well, the distinction in the R&DS side is that in TAS, we can adjust pricing pretty quickly. In the R&DS business, it tends to lag, and sometimes that works to your advantage, and sometimes it works against you. Recently, it's worked against us because during the COVID period, we saw, like others, a lot of pressure on attrition, labor costs, that we had to absorb because we didn't have the ability to go back and adjust contracts. The contracts in the R&DS business run 4-5 years, and they, for clinical trials, and the pricing is typically set with annual escalators that are tied to historical rates of inflation. So if inflation is running at 2% in 2019 when you price a contract, you're gonna get a 2% escalator, even if your labor, you know, costs are up 8%.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Mm-hmm.

Ron Bruehlman
EVP and CFO, IQVIA

So what's happened over time is that we've gradually been rolling off some of the you know, the contracts that have been negatively infected, affected by inflation, and there's more and more that we're burning off that has the new rate cards, higher labor rates in it. So it's so gradual, it's been a tailwind for us in margins. Now, the other side of it is, you have FSP growing a little bit faster than full service, and FSP is substantially lower margin than full service. So, you know-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah

Ron Bruehlman
EVP and CFO, IQVIA

... net-net, our R&DS margins have held up well, but, those are two of the kind of countervailing forces.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. And maybe just we're sort of 2 years into the sort of higher inflation period, and, you know, if we think about the typical trial being sort of 3.5-4 years in length, is that the right way to think about it, that we're sort of, like, 50% of the way through this sort of, like, rate card increase, roughly?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah. Roughly-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah

Ron Bruehlman
EVP and CFO, IQVIA

... roughly, 50% through the increase, correct.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. Okay, and then how do we think about sort of employee retention versus, you know, I think that had been sort of slowly improving earlier in the year. Now, we have this sort of demand environment. Are there any sort of changes to how to think about that, or is that kind of continuing to improve, as we think about the end of this year?

Ron Bruehlman
EVP and CFO, IQVIA

Well, I think it got worse. The worst point for attrition was, I want to say it was third quarter of 2021, where-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Mm-hmm

Ron Bruehlman
EVP and CFO, IQVIA

... it peaked at over 20% annual labor attrition. It came down from that point forward to the end of last year. It got down to pre-pandemic levels, around 12%, and it's been bouncing around that area since. So we've kind of returned to normal versus what we used to see. So those pressures are largely behind us. Now, there are pockets of the business that remain competitive, particularly in the clinical trial area, CRAs and so forth, but not to the extent that they were previously, and even among CRAs and project leads and people like that, attrition has come down substantially. So that's been very helpful. It's returned to...

You know, wage increases have returned to more of a normal, what you would expect, and of course, with inflation settling down, that, that's, that's helpful as well. In addition to getting past that COVID surge, just inflation coming down. So that's, that's not a big issue for us right now. We're just, as you pointed out, still working through some of the backlog, issues in R&DS. And like I said, that can work either way. It may be that two or three years from now, we'll get some benefit out of having some higher inflation rates baked into our contracts.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Mm-hmm.

Ron Bruehlman
EVP and CFO, IQVIA

It's gone both directions for us in the past.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. No, that makes sense. You know, obviously, I think we've, you know, you've talked about and on prior calls, you've talked about that sort of shifting FSP mix in pharma versus in the biotech segment. How do we think about sort of like where that could go or kind of like the ceiling of that? Is that kind of like. You know, and obviously, it's been accelerating recently, but like, I don't know. I'm just trying to understand, like, where you sort of think, either from prior cycles experience or not, like, where that could go over time.

Ron Bruehlman
EVP and CFO, IQVIA

Well, let me, let me put some numbers around it, 'cause we get this question from time to time. If you look at the business or R&DS revenues, including pass-throughs, FSP work is across the entire R&DS business is about 15% of our revenues. If you do it just on pure services, that is, before pass-throughs, it's about 20%, give or take, of the business. So I mean, the business is still predominantly full service work. Now, we have seen over the past couple of years that tick up a few percentage points, and you can see in the RFP flow, it's slightly higher for FSP work than for full service work in comparison to what our revenues are. So that's kind of a leading indicator that it's gonna continue to go up.

How much longer? It's hard to say. We've seen this be a trend that's reversed itself, swung like a pendulum sometimes within the industry. Some of the large pharma clients decide, well, when their budgets are getting a little tough, maybe I can save some money by bringing the work in-house. And then they later decide, "Well, this isn't really our core competency. We're not as efficient here as we want to be, or we don't have the expertise for some of these trials, so we want to outsource some." So I don't see it as being a long-term, secular trend based on what's happened in the past, which is we've seen it be like a pendulum going back and forth. But right now, the movement is definitely towards more FSP work on the margin.

Keep in mind, too, that you're talking about having a backlog of, you know, $28 billion and 4-5 years to burn off through a trial on average. So these shifts tend to be relatively gradual within the business.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

If we think about that... Thank you, that's really helpful context. If we think about, like, the peak to trough, like, where has FSP ever been at its highest versus lowest? Like, we're just trying to think of the magnitude of that swing.

Ron Bruehlman
EVP and CFO, IQVIA

That's a great question, and I don't have the answer to that. Has it ever been significantly higher or lower than kind of, we'll call it, the 20% service work it is right now? I don't know the... Nick, have you ever seen any stats on that?

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

I want to hold you to it. I'm just trying to think of, like, relative- Is it like, it's been 10-30, like, you know, it's been 18-22? I'm just trying to, like, gauge that magnitude.

Ron Bruehlman
EVP and CFO, IQVIA

Moving more towards the peak now.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah.

Ron Bruehlman
EVP and CFO, IQVIA

We're getting back to some of the highest levels that we've seen.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah.

Ron Bruehlman
EVP and CFO, IQVIA

On the low side, I can't tell you how low it ever went, but, you know, the data, the data I've seen is—I think you're kind of in that 15-25 is kind of the band that-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah

Ron Bruehlman
EVP and CFO, IQVIA

- we've seen.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Okay.

Ron Bruehlman
EVP and CFO, IQVIA

We can, we can definitely pull that and look into it.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah, I was just trying to understand, like, the relative... Because I know we spend, as you say, so much time talking about this, but I'm just trying to understand, you know, make sure I'm understanding it versus its relative importance to your-

Ron Bruehlman
EVP and CFO, IQVIA

Yeah

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

... to your business. And obviously, you pointed out some of the countervailing trends on the biotech side as well.

Ron Bruehlman
EVP and CFO, IQVIA

Yeah, yeah. Right, exactly. EBP is entirely full service, and over time should grow faster. We see it definitely growing faster.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. Obviously, you know, hot topic of the last couple of weeks, you guys have restructure- you know, refinanced-

Ron Bruehlman
EVP and CFO, IQVIA

Mm-hmm

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

... a bunch of your debt. Can you sort of give us an update as to how do things stand now? And then how do we think about, like, your interest expense on an ongoing basis?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah, we, I, you know, there was a lot of concern expressed by both the sell side and the buy side about some of our near-term maturities and our exposure on the interest rates and refinancing, and I think we took a really nice step in the past month to alleviate some of those concerns. We had two big issuances. We did $1.25 billion of senior secured notes that were 5-year notes, and then we followed that with $1.5 billion of term loans, both U.S. dollar denominated. Now, we swapped those to euros, and we got a fixed rate on those euro swaps of, you know, if you average out the two, but just shy of 4.9%, which was better than the rates we were paying on the debt.

Now, you may say, "Okay, but you took on euro exposure doing that," but that isn't a concern, first off, because part of what we did was we refinanced... We, we took out a big slug of euro term loans. It was about $1.2 billion that was due in March of 2024. We also did take out some U.S. dollar term loans that were due in 2025, but, we have plenty of euro earnings that, that operate as a natural hedge of that euro interest expense, or the euro interest expense, operates as a natural hedge of those euro earnings. And so right now, our euro/dollar net borrowing mix is around 50/50, but it's very, very comfortable for us.

So two things we were able to do: One, we were able to take out near-term maturities, our 2024 maturities, and a good chunk of our 2025 maturities. We were able to get a very favorable rate, and that will help us keep interest expense flat to slightly up, maybe next year. Flattish, call it, next year, given where the market sees rates going right now. And previous to that, we were looking at it actually going up because, you know, you would have a full year impact of 2024 rate increases going through. We have a swap rolling off next year. So we were looking at interest expense going up next year. Now probably flattish to maybe up a tad.

It really, in the latter, depends on what happens with short-term rates, 'cause we'll still have about 20% of our portfolio that's on a debt portfolio, that's on a variable rate basis, post these swaps that we just did.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. And can you talk about the FX cost mix? Obviously, you just talked about the matching of the interest expense in euros to the cost basis. Can you just remind us what percentage of your cost base is in euros?

Ron Bruehlman
EVP and CFO, IQVIA

I don't think we've disclosed that per se. Let's just say, it's considerable, and I would... Really, I think what's, you know, our, our biggest country probably for cost, UK, we have a substantial amount of cost. But that's obviously pound and not euro. You know, we have a fair amount of cost in euro region. We have a lot in India, we have a lot in Philippines. So our, our, our cost base, some in Argentina, our cost base is spread out around the world, and we haven't disclosed the exact percentages of that. But we do have a substantial European business, I want to say, you know, in excess of 30% of our overall revenues. It generates a lot of profitability, and that's what we're...

You know, those earnings are what we hedge with our euro interest expense.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. One more thing maybe on the Europe, versus sort of the U.S. and ex-elsewhere. Like, is the demand environment from, like, pharma or biotech, like, different by geography, or you would say it's pretty similar? I mean, obviously, many of these pharma companies are global in nature, so maybe that's the less relevant, but I just wanted to see if tease out.

Ron Bruehlman
EVP and CFO, IQVIA

You know, it's interesting. We have seen more pressure in our U.S. business in the TAS than we have seen in Europe. U.S. companies—I mean, our pharma companies tend to make more money in the U.S. than they do in Europe because the pricing umbrella there, so-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah

Ron Bruehlman
EVP and CFO, IQVIA

... when times are a little tougher, then that's probably where they cut back first. So I'd say the pricing environment is one of the big differences, and of course, the IRA is going to affect pharma in the U.S. It doesn't affect pharma pricing so much overseas, but the U.S. business does support R&D for the world, so it's not like the IRA wouldn't have an effect on overall, you know, global pharma outlook.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. And I think, you know, as Ari mentioned the call, sort of continued sort of leverage levels that sort of we should continue to think about those as, like, broadly consistent going forward with where you currently are?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah, we're at about, on a net leverage ratio, we're at about, 3.5 times, net debt being 3.5 times trailing 12-month EBITDA. And yeah, that should remain there, or over time, let's say, through the end of 2025, should actually naturally drift downwards some-

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Sure

Ron Bruehlman
EVP and CFO, IQVIA

... just as EBITDA continues to grow. But around 3.5, we're very comfortable with that, and no issues servicing the debt. We've been quite a bit higher in the past, so the nature of our business is such that it can support a fair amount of debt.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Okay, that makes sense. One of the other things you've been talking about over your time in recent years is sort of just like network and capital improvements and continued sort of generation of free cash flow. How do we think about sort of like where you are in that journey, and sort of where do you see the opportunities to improve that over the next, let's call it six to 12 months?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah, and it's interesting that we have made progress there, but some of it is masked by the fact that we went through a period in COVID where there was a lot of very quick burn studies with big upfronts associated with them, and also some of the consulting and analytics work that's on the R&DS side that was done then tends to come up with bigger upfronts. And we burned through a lot of that, and we're in a period now where we're not seeing as much in terms of customer advances, and we're also seeing, because interest rates have risen, our pharma customers, you know, hanging on to their money a little bit more. So collections have been a bit more challenging. But it's something we put a tremendous amount of emphasis on internally.

Also, improving our processes to reduce our unbills. And, you know, some of our investors have picked up on the fact that our unbills have gone up a lot. And the one thing I would caution when you look at that is some of that has to do with the fact that our investigators out in the field for our R&DS business are under pressure in terms of labor. They've been billing more slowly, so they bill investigator fees more slowly, which we in turn bill to our customers more slowly. So there's no cash flow impact. No cash is changing hands, but it shows up as unbilled because we're accruing for the revenue.

So some of that's a bit artificial, but some of it, the unbills have to do with the nature of – and the unbills and the customer advances have to do with the nature of what parts of our business are growing the fastest. Some areas just have better cash flow characteristics than others, where you can, you know, for instance, in consulting and analytics, you can bill more upfront. The data business, you tend to bill more in advance.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Okay. No, that, that makes sense. In terms of that too, maybe sort of relatedly, like, how do you think about your sort of M&A strategy, given sort of, you know, obviously, interest rates and what you're saying with the leverage and also the more assertive FTC environment?

Ron Bruehlman
EVP and CFO, IQVIA

Yeah, I would say the, the FTC, everybody's aware that we're involved in litigation right now around a, a digital marketing acquisition that we're trying to make. So it's something that I think everybody thinks about but doesn't have a major impact on what we pursue. I would say what we're doing is looking to build out areas where we see the opportunity for growth, and I mentioned some of those, the real-world evidence area, being an area of growth. Some of the tech, continuing to do work in digital marketing and things around that nature. We put an emphasis... I think acquisitions have the first call on our capital.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Mm-hmm.

Ron Bruehlman
EVP and CFO, IQVIA

Or, yeah, we're gonna spend a certain amount, you know, call it 4-4.5%, maybe at the outside, 5% of our revenue internally on, you know, various things. It's either gonna be software development's the biggest thing. We also do, you know, spend a lot in the IT area and a certain amount in real estate and so forth. That's not gonna vary much from year to year. What's left over in free cash flow, acquisitions are gonna have the first call then. From time to time, there are gonna be periods where our stock price gets dislocated, and we'll take advantage of that to repurchase shares. So, we'll do both. You know, and on the margin, do we pay down more debt? We'll see. I think it depends upon opportunities.

I don't think we're gonna have. We don't have an explicit strategy of going out and saying, "Okay, we're gonna try to, you know, drive down our leverage to 2.5 turns," or something like that, where we've seen others say. We're comfortable where we are, and if our leverage naturally drifts down over time just 'cause our EBITDA grows, that's fine.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. And have valuations for assets changed much given the current environment, or you think that the people are still anchored on like two or three years ago?

Ron Bruehlman
EVP and CFO, IQVIA

It depends. Valuations of some assets definitely have started to come down. Some of the higher quality stuff, people are still expecting big dollars for it, and it's been a little stickier. The private markets tend to adjust, maybe a little bit more slowly than the public market sometimes, and there's still a lot of PE money sloshing around that can make selected acquisitions difficult to do. So we have to have a pretty big funnel to get down to those acquisitions we can do, and we've walked away from more than a few over valuation concerns, where we just say, "Look, this is what the seller is expecting. This is what the indications we're getting that PE is willing to spend, and we're just not gonna spend that much." And that's okay. That's fine.

But it tends to move fairly slowly. Valuation expectations are coming down, but slowly.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Got it. In the last sort of minute that we have of our time together today, what do you think the least well-understood thing is about IQVIA by investors, or most misunderstood?

Ron Bruehlman
EVP and CFO, IQVIA

Oh, that's a great question. I think, you know, I would've said if we went back a year or so ago, that people didn't focus on us purely as a CRO, and now I think with the TAS business slowing down, so maybe for the wrong reasons, we've gotten more focus there. I think just the resiliency of the growth opportunities we have in our business, in particular, like in the R&DS area, I think a lot of people tend to focus on these very micro things like, okay, you know, this quarter, EBP funding went down a certain point. And I mean, I've been fielding questions about that for the last two years.

Why aren't you guys seeing anything in the R&DS business? We don't quite believe it." And the business has been very resilient, and I think that people tend to underestimate that. And, you know, we keep putting up the numbers and the book-to-bill and everything quarter after quarter, and everything is good, but there still seems to be a lot of skepticism, like, "When's the next shoe gonna drop?" And I just don't see it happening. So right now, I'd say that's the biggest area of misunderstanding in our business, is just how resilient the growth opportunities are within the R&DS business.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Great. Well, thank you so much. I think we're out of time, and appreciate your coming down.

Ron Bruehlman
EVP and CFO, IQVIA

Yeah. Thank you, Elizabeth.

Elizabeth Anderson
Senior Managing Director, Healthcare Technology & Distribution Research, Evercore ISI

Yeah, thanks.

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