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JPMorgan Healthcare Conference

Jan 9, 2023

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Good morning, everybody. I'm Chris Schott at JP Morgan. It's my pleasure to be hosting a fireside chat with Joaquin Duato, Chairman and CEO of J&J today. Joaquin, Happy New Year and.

Joaquin Duato
Chairman and CEO, J&J

Thank you.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Thanks for thanks for joining us. I thought I might just kick off the conversation. You're about a year into the CEO role. Let's just hear how your top priorities for the company as we think about 2023 and beyond, and kind of what you're most focused on in the role right now.

Joaquin Duato
Chairman and CEO, J&J

Thank you, Chris, and thank you for inviting us, Johnson & Johnson, to participate once again in the conference. The overarching goal for Johnson & Johnson is to be able to deliver sustained growth for patients and shareholders. That's something that we do while being squarely focused on the patient in everything we do, and also working with the values of our credo as we have done during a long period of time. When I think about that, and I think about Johnson & Johnson being one year in the role of CEO, I always wonder, how can we sustain the success and the reputation of Johnson & Johnson during a long period of time, not only in 2022 or 2023, but in this decade and beyond? I always think Johnson & Johnson has to evolve.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

When you think about our decision to separate our consumer business and create two new companies, the new consumer health company and the new Johnson & Johnson around pharmaceuticals and medical technology, you have to think about that in the context of the evolution of Johnson & Johnson to be able to deliver more value and to be more competitive. That's what we are trying to do, deliver more value and be more competitive. My two priorities that I stated back in 2022 were, how are we gonna drive more competitiveness in the new Johnson & Johnson, in medtech and pharmaceuticals? How we are gonna be progressing towards the successful separation of our consumer health business, and I believe, as I'm gonna describe, that we are well on our way for both.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

When it comes to the new Johnson & Johnson and our intent to be market leaders and to deliver above-market growth, we are doing it both from a commercial perspective and also from an innovation perspective. When I look at medtech year-to-date September, our medtech business is growing about 6%. That is, you know, above its competitive composite. I think it's particularly remarkable for a franchise the size of our medtech business with $27 billion. Most of the companies that are growing in that ZIP code of 6%, they are half or a third of the size of Johnson & Johnson. I think it's remarkable the evolution of our medtech business and the type of our market growth that our medtech business is delivering.

When it comes to pharmaceuticals, the year-to-date growth in September was 8%. Clearly, our market growth is the 11 consecutive year that our pharmaceutical group is delivering above-market growth. It's a remarkable performance that has driven consistency around time. From that perspective, competitively, we are doing it in 2022. If I move to how we are executing in our pipeline to continue to sustain this growth into the future, two comments there. One, we have had, some interesting approvals lately in pharmaceuticals with TECVAYLI.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

Our BCMA CD3 bispecific...

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... which is already approved. Also the filing of talquetamab, which is our GPRC5D CD3 bispecific, also in relapsed refractory multiple myeloma, which is gonna create, which I believe is the best multiple myeloma portfolio that we, I'm sure we'll have an opportunity to discuss later.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Absolutely.

Joaquin Duato
Chairman and CEO, J&J

We are executing well in our pipeline in pharmaceuticals in 2022. You know, when I go to medtech, we've been able to continue to advance our pipeline. As a matter of fact, it's not only the number of new product launches in medtech that we have, but also how we have increased our pipeline value in medtech. When it comes to the number of projects in our pipeline that have more than $100 million of net present value, we have more than double during this period. Obviously, in 2022, we also completed the acquisition of Abiomed, which is gonna create a new leg of growth for Johnson & Johnson, a new platform.

We are proud of what we accomplished or we are accomplishing in 2022, both competitively and in our pipeline, being true to the priorities that I stated. The second priority, which is the separation of our consumer health company, which we have announced that we're gonna call Kenvue, by the way. We've made a lot of progress in 2022. We have appointed CEO and CFO designees, a Chairman for the company, Larry Merlo, that used to be the CEO and Chairman of CVS. Since January, we're starting to operate our consumer business as a company within a company at Johnson & Johnson. We have filed with the SEC our S-1 form, in which we indicate that our preferred form for separation, it's an IPO.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

We've made a lot of progress. There's not much I can talk about the consumer separation, as you know, because of the moment we are, but we remain on track for completing the separation and a public market exit in 2023. We have really meet all the milestones that we told The Street that we were gonna accomplish in 2022.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Great. Great. One question I get, with J&J creating a more focused portfolio with the spin, does that help, or can we expect an acceleration in some of your strategic priorities as I think about either pharma or the med tech business?

Joaquin Duato
Chairman and CEO, J&J

Thank you. That's a great question. I normally say that the biggest opportunity for Johnson & Johnson is taking advantage of creating a more focused company around med tech and pharmaceuticals. Moving from a three-sector company to a two-sector company has advantages. It makes Johnson & Johnson a simpler company. It helps us simplifying the company, and when you simplify the company, you make it nimbler, you make it faster, you make it more competitive. For us, it's only an acceleration of the strategic priorities that we have in pharmaceuticals and in med tech that we have outlined.

In pharmaceuticals, we have clearly outlined our goal to be able to continue to grow our market, and we have stated that we plan to grow every single year from until 2025 with positive growth, even in the face of the loss of exclusivity of Stelara, and that we plan to land $60 billion by 2025 in pharmaceuticals. This is gonna be accomplished mainly through the strength of our existing portfolio, and I'm sure we'll have opportunities to discuss about that later.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

Also through the new product launches that I described, like Spravato, Carvykti, TECVAYLI, and then the pipeline that we announced that we have five products that will be launched in this period, which all of them have a peak year sales potential of more than $5 billion. To enumerate those products, Carvykti, our BCMA CAR-T is one of them, followed by the combination of RYBREVANT and lazertinib in EGFR mutant non-small cell lung cancer. RYBREVANT is a bispecific EGFR-c-Met antibody, and lazertinib is an oral EGFR inhibitor. Then the next product, it's our Factor XIa milvexian that I will have the opportunity to talk about that later. Then Nipocalimab, our FcRn antagonist in autoantibody-mediated diseases. Finally, our bladder cancer platform, Taris.

Taris is a drug-eluting device which is implanted in the bladder by cystoscopy that we believe it's going to be able to create a new option for treatment in bladder cancer, which is a very frequent cancer. More than half a million people has bladder cancer unfortunately, it's one that is clearly an underserved area. Those are areas of excitement for us in our in our portfolio in pharmaceuticals. When it comes to med tech, we'll continue with our stated goal of being able to go into higher growth segments. That applies to higher growth segments within our existing markets of surgery, orthopedics, vision, and cardiology, and also higher adjacencies as we have done with Abiomed entering in the heart recovery area. Our focus now in R&D organically is in those areas.

We are trying to identify those areas within our existing markets that are faster growing. For example, when we are talking about orthopedics, we are going into cementless knees, into extremities, into robotics, into areas of the orthopedics market that are faster growing. When we are talking about vision, we're going to presbyopia. We have a new line of techniques, intraocular lenses for cataracts that provide better quality of vision. When we are talking about cardiac ablation, we are launching new treatment and diagnostic catheters. When we are talking about our surgery portfolio, we're trying to digitally enable our stapling and our energy group. That is the type of focus that we are putting in our, in our med tech business.

As I said, I'm very pleased of the cadence of innovation that we have in our med tech business and also on how much we have increased the value of our pipeline in our med tech business. It's really changing the profile of our med tech business. We continue to have our strength in surgery and in orthopedics and our global leadership position there. We are moving into faster growth areas in cardiology and in vision.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah, absolutely. Maybe digging into the pharmaceutical business first. I guess a little over a year ago, you put out this $60 billion target by 2025. Can you maybe just sitting here today, how confident are you in J&J's ability to kind of hit that target? Just thinking about, you know, what's been de-risked, sort of thinking about what the commercial profile or programs have been doing.

Joaquin Duato
Chairman and CEO, J&J

Thank you, and thank you for the question because it's one that...

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah

Joaquin Duato
Chairman and CEO, J&J

get frequently asked. We continue to drive towards our $60 billion goal in pharmaceuticals by 2025. We are confident that we're gonna be able to exceed current expected expectations when it comes to our 2025 sales. you know, I mean, we'll have an opportunity now if you want to talk about the disconnect.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah. I'd love to hear it. Yeah.

Joaquin Duato
Chairman and CEO, J&J

Let me start with the, with the excitement, of the growth areas that I see, right?

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

Let me start with the positives first.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Sure, yeah.

Joaquin Duato
Chairman and CEO, J&J

I mean, where is that growth going to come from?

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

I have said many times that the growth is going to come from mainly through our existing portfolio.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

Through the one that is already de-risked, as you mentioned. That's the key area of growth for us. Our existing portfolio, what products are we talking about? We're talking about, Darzalex continue to grow in first-line multiple myeloma. We are talking about, Tremfya, which continue to grow share in psoriatic arthritis and in psoriasis, and we are well in our way in our clinical development of Tremfya in Crohn's disease and in ulcerative colitis with completion dates of our studies in 2023 and 2024 respectively. We are talking about our pulmonary arterial hypertension portfolio.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... with Uptravi and Opsumit that have been affected by the pandemic.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

They are gonna continue to come back. We are talking about Erleada, which is our androgen receptor antagonist for prostate cancer. Those products are gonna be carrying the bulk of our growth into 2025, mainly through indication expansions that we can discuss later, and also through continue to gain share.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

We're also talking about our new product launches, Spravato.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

Our medicine, our NMDA agonist for treatment and depression, Carvykti, our BCMA CAR-T, and also TECVAYLI, which it's been already approved. Our BCMA CD3 bispecific, most likely the addition of Talquetamab, our other BCMA bispecific. You know, more in the later part of this period we'll have the launches of our some of our $5 billion portfolio products like Nipocalimab-

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... the combination of lazertinib and RYBREVANT and the Taris platform. Those are the reasons to believe on the fact that we will be able to get into this stated goal of $60 billion. If you want, I can go more in detail into every areas.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

I guess I just really one quick one follow up on that. When I think about the disconnect you see versus 2025, it sounds like from the comments, it's maybe more about the expansion of indications for already approved drugs as compared to.

Joaquin Duato
Chairman and CEO, J&J

Yeah

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

The pipeline seems like it's maybe beyond 25 is where that becomes bigger.

Joaquin Duato
Chairman and CEO, J&J

Yeah. I mean-

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Is that fair?

Joaquin Duato
Chairman and CEO, J&J

let me start with the growth areas.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah

Joaquin Duato
Chairman and CEO, J&J

... the biggest area of growth

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... is our multiple myeloma portfolio.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

I think what we have a best-in-class multiple myeloma portfolio. What we're trying to do with our multiple myeloma portfolio is to change the paradigm from treating to progression to treating to cure.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

That is going to encompass, being able to create combinations and treatment sequences that are gonna drive into cure. That's exactly what we are doing now with Carvykti.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

with our CAR-T two studies.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yep.

Joaquin Duato
Chairman and CEO, J&J

One of these studies, CD24 CAR-T, which is treating patients with one-three prior lines of therapy, it's gonna read soon.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

That's gonna give you an idea of how a medicine like Carvykti could move into earlier lines of therapy and could become a mainstay of treatment of multiple myeloma.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

That's a clear area of growth that I think, the Street needs to think about.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Sure.

Joaquin Duato
Chairman and CEO, J&J

how our entire portfolio in multiple myeloma with Darzalex in first line, Carvykti, TECVAYLI, and Talquetamab-

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... cannot be something that is cannibalizing each other, but creating the treatment paradigms which are different by combining and sequencing different medicines there. That's a growth factor that we have to take into consideration. If I continue on the growth side.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah

Joaquin Duato
Chairman and CEO, J&J

It's exciting for me. RYBREVANT plus lazertinib.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

That's an exciting area for us. It's a large area, a first-line EGFR mutant non-small cell lung cancer. We have a phase III study, which is called MARIPOSA, which is comparing lazertinib, plus RYBREVANT versus Tagrisso.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... in first line EGFR mutant non-small cell lung cancer patients. The study will read in 2024. Since it's an event-driven study, there's a potential of an interim analysis in 2023.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay. Great.

Joaquin Duato
Chairman and CEO, J&J

That is a very large market, as you can imagine. We believe that could be a very significant opportunity for us from a growth perspective. If I continue with Nipocalimab, our FcRn antagonist in autoantibody-mediated diseases, again, a large area of opportunity. There's more than 200 million people globally affected by autoantibody-mediated diseases. We are now in phase III in warm autoimmune hemolytic anemia. It may read in 2023 too.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

We may see results of our rheumatoid arthritis study phase II in 2023 too, and we'll see results of our myasthenia gravis study of phase III in 2024. That's another area.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah

Joaquin Duato
Chairman and CEO, J&J

... of excitement that I believe it's gonna be important for us. If I continue in this area, Taris, the Taris platform, that's an area that the Street doesn't even have-

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

I was gonna say, yeah.

Joaquin Duato
Chairman and CEO, J&J

in consideration, right?

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

bladder cancer is a big problem, more than half a million people with bladder cancer. We are already in phase III with Taris, with gemcitabine. Also we have a study that will read in 2023, a phase two one in patients that are undergoing radical cystectomy. You're gonna see more about Taris, and that's gonna help you profile our Taris platform in bladder cancer, which is a clear area of underserved patients. Finally Milvexian.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

We believe that milvexian is gonna be a big opportunity. We are developing milvexian in partnership with BMS. We are going to be moving into phase III in three indications: atrial fibrillation, acute coronary syndrome, and at the same time stroke. Look, coronary disease is one of the major causes of death and hospitalization. I do not need to explain to you what the potential of an oral anticoagulant is, and we see there in milvexian, in our factor XI, the potential of have a medicine that is going to have same or better efficacy than factor Xa with a better bleeding profile, which will enable us to expand into multiple indications. Clearly a very important product for us, milvexian. Those are exciting areas for growth that I think we need to consider.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah

Joaquin Duato
Chairman and CEO, J&J

... let me tell you what I think The Street is missing too.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Sure.

Joaquin Duato
Chairman and CEO, J&J

Because some of these things were known.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

What do I think The Street is missing? Number one, it's missing the potential of our multiple myeloma portfolio.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yep.

Joaquin Duato
Chairman and CEO, J&J

I think it's because The Street is thinking cannibalization, and we are seeing treating to cure and combinations of different products there, and that's the type of clinical data you're going to see. You were at ASH this year.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

You saw the type of clinical studies we have with Carvykti, with TECVAYLI, with talquetamab. They are creating new lines of therapy in this area. I think that will be recognized as time goes by. What is The Street missing too? The Street is missing the potential of Erleada.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

Our androgen receptor antagonist. Erleada is approved in metastatic castrate-sensitive prostate cancer and in non-metastatic castrate-resistant prostate cancer. The next level of growth of Erleada, it's gonna be in high risk, localized or locally advanced prostate cancer, and we have two phase III studies there. One of them is gonna be reading in 2023, the next one in 2024, in patients that are undergoing radiation or prostatectomy, and this is gonna create a new leg of growth for Erleada that is not yet recognized by The Street. The Street is also missing Spravato. You know, Spravato is the one of the only medications approved for treatment of seasonal depression. It has shown significant efficacy very quickly in the first 24 hours and long term.

So far we have not disclosed the sales of Spravato, and you could expect us disclosing sales of Spravato this year, which is going to increase the confidence on Spravato.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

Spravato is another product that The Street is missing. I think The Street is missing the strength of our pulmonary arterial hypertension portfolio, specifically both Uptravi and Opsumit. They were clearly affected by the pandemic because there were less new patients because pulmonologists were occupied diagnosing, and treating, COVID. Now you're gonna see that changing, and you're gonna see a new leg of growth in our pulmonary arterial hypertension portfolio. Finally, there's another disconnect, an easy one-

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... which is with XARELTO, our Factor Xa.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

I mean, The Street is modeling a loss of exclusivity in the short term, and we see the loss of exclusivity of XARELTO more like a second half of the decade event.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

There's a number of things that The Street is missing that we hope will see more in 2023 as we will start to disclose sales of Spravato, most likely sales of CARVYKTI too, that are gonna increase the conviction of The Street on the potential opportunities that we have to be able to drive towards this $60 billion stated goal in 2025.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

It seems like a lot of healthy drivers to offset.

Joaquin Duato
Chairman and CEO, J&J

I hope so.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

... Stelara exposure. Just a couple more on pharma before I go to med tech. I guess one of the questions I have is on business development priorities. It seems like J&J's had a tremendous amount of success, I think, kind of identifying either partnerships or acquisitions of kind of like right after proof of concept and really developing them. Is that still the focus of the organization? Or I guess as we get closer to Stelara, is there maybe more of a focus of looking at things that are closer to market or even in-market assets to acquire?

Joaquin Duato
Chairman and CEO, J&J

External innovation and business development, it's been always a key source of growth for Johnson & Johnson.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

of strength for the company. About 50% of our growth comes from external innovation. We see that continuing into the future.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

just to be clear. We are well equipped in order to be able to identify, onboard, and develop external innovation opportunities. We have a tremendous infrastructure in order to be able to do that. On one hand, we have our innovation centers, that are scouting scientific opportunities in the key hubs in the world, in San Francisco, in Boston, in Oxford, Cambridge, in Shanghai. On the other hand, we have our incubator network that we call JLABS. We have more than 500 companies in residence.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm.

Joaquin Duato
Chairman and CEO, J&J

It's really, you know, another source of insights for us. I mean, when I was driving yesterday, I saw many companies that started in our JLABS incubator network. We have our development corporation, which is one of the oldest and most successful development corporations, and then our business development group.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

When it comes to be able to have the capabilities to identify and onboard opportunities, we are well equipped, and all these teams work in close collaboration with our therapeutic area R&D leaders, and also with our global commercial strategy leads. We are well prepared in order to be able to do that. As you mentioned, our success, and we have many examples of this success, has been in opportunities that we identify earlier on.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

Immediately post proof of concept or before proof of concept, and that we've been able to drive significant growth thanks to that. Now, does it mean that we are averse to other types of M&A opportunities? No, we are not, and we did it in the past with Actelion, and we are open to consider these other type of M&A opportunities. Now, we have a discipline capital allocation strategy and discipline metrics in order to evaluate those opportunities. Normally, these companies that you are referring are already well run do have a fair valuation from The Street and, you know, it's more challenging, and they require higher bar.

We are open for all different kinds of opportunities while we recognize that we have been most successful when we have been able to identify opportunities that were earlier on, that were in a space of high and medical need, that were clearly differentiated, in which we had internal capabilities and expertise for evaluating and developing these medicines, and that they were in the spaces that were not overly crowded.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

That's, our sweet spot, and that's where we will continue to look for opportunities, not averse to larger ones. I want to make a comment on that.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Sure

Joaquin Duato
Chairman and CEO, J&J

... because, you know, it was reported in the press, in a press release, that Johnson & Johnson was one of the companies that was in preliminary discussions, for the acquisition of Horizon Therapeutics, right?

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

You know, I wanted to comment on that. This disclosure was due to the rules of the ID stakeholder board that requires those disclosures. I wanted to explain to you what we did there.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Sure.

Joaquin Duato
Chairman and CEO, J&J

We attended a market presentation.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

Due to these rules, you know, we were in the press release. Now after attending the market presentation, we subsequently decided that this acquisition didn't meet our strategic criteria and, as a consequence, we never entered into diligence, never put a bid for Horizon Therapeutics. I think it's important for investors to understand that. You know, Horizon Therapeutics was not a company that was in the sweet spot of our strategic criteria.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay. Okay. Appreciate that. Switching over to the MedTech business, I know your background is more on the pharma side, but I know from the time you became CEO, you highlighted this as kind of one of your focus areas. I guess share your broader thoughts on the franchise today and, you know, do you feel like you're at a business that's positioned to kind of hit that a kind of above market growth that you've been targeting at this point?

Joaquin Duato
Chairman and CEO, J&J

Yeah. First, you know, I want to eventually be considered also a MedTech person too. I have stated that a very important part of my tenure would be to make sure that our MedTech business is a best in class franchise. Now, the thing is, when I say that, I tell you they are already doing that. I think that's important. I mean, when you look at our growth year to date in September, you know, MedTech is growing more than 6%, which as I said, it's more than the competitive composite. I think that, you know, they have had tremendous evolution from being growing low single digit five years ago to be now in a zip code that only smaller companies are able to achieve.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

This has been a combination of things that I am proud that I see in MedTech. On one hand, you know, they have been able to do very well commercially executing. I mean, when I look at the 12 platforms, now we have 12. Before we had 11. Now with Abiomed, we have 12 platforms of more than $1 billion. In the majority of them, we're holding or gaining share. When I look at our share evolution, and the latest data that I have is still 2021, we have our best share evolution in the last five years. They are commercially executing really well.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

I think that has to be appreciated. That's why they are growing more than the competitive composite.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

I also, I think that we are executing very well in our pipeline and how we are moving our business from markets that are, let's say more stable to markets that are faster growing. As I said before, look, I mean, we're moving our orthopedic business into faster grow areas. We are continued to move our surgery business into robotics and to digitally enable surgeon staplers. We are continue to move our vision business into areas like presbyopia, which is faster growing. We are moving into other markets like with Abiomed that are faster growing. The profile of our MedTech business is also changing-

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... moving into faster growth markets, we plan to continue to enhance that, right? I'm proud of the evolution of our MedTech market, both our MedTech business, how we have been able to improve our commercial execution, how we have been able to improve our cadence of innovation and the new products that we have introduced. I'm confident that, moving into 2023, our MedTech business will continue to deliver competitive growth rates.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

As on that topic of competitive growth rates, it seems like it's been a few years since we've had a normalized year for MedTech. What do you consider kind of a market growth rate as we think about the kind of overall industry going forward?

Joaquin Duato
Chairman and CEO, J&J

That's a good question, and when we think about the evolution of the MedTech market, the normalized growth rates would be somewhere between 4%-6%.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

That I would consider the normalized growth rates.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

The headline for me on the MedTech market, I'm very optimistic about the MedTech market.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

I believe that MedTech is a very healthy area of growth, for the market and for Johnson & Johnson. In the short term, you also have to accept some variability due to the COVID situation. When people ask me to predict that, it's very difficult to predict.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Sure

Joaquin Duato
Chairman and CEO, J&J

... as you know, right?

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

I think we have to be able to live with the variability that we'll have in the short term due to COVID, which is having a lingering impact, not only because of the number of cases and the hospitalization that COVID drives, but also because of the impact in hospital capacity that it creates. We have to live with that variability that COVID introduces. That variability is gonna vary geographically depending on the moment.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yep.

Joaquin Duato
Chairman and CEO, J&J

Overall, the headline for me is that the MedTech market has significant potential. The MedTech market will continue to grow into the future, and it's a great area for Johnson & Johnson to continue to invest.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Great. Talking about the Abiomed acquisition, I guess when you were looking at the range of potential companies the company could add to the portfolio, I guess what brought you to that asset? I guess how does that fit in with your kind of broader priorities within the med tech business?

Joaquin Duato
Chairman and CEO, J&J

Thank you. I mean, Abiomed it was a perfect fit into our strategic desire of entering into adjacencies with higher growth and at the same time with platforms that have, A, playing a significant unmet medical need like heart failure, which is one of the major causes of death and hospitalization. B, has significant durability. Abiomed has a number of pipeline opportunities, both in terms of new devices and new indications that are gonna create significant durability. I would tell you decades-long durability. At the same time, it's an area where Abiomed enjoys a significant competitive advantage. It's years ahead of potential competition. When we think about something to move for the long term-

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

...not only to deliver growth today, but also to create a new leg of growth for Johnson & Johnson into the future, Abiomed really squarely fit that bill. You know, clearly when we were thinking about what was gonna be able to be significant in adding to our portfolio in med tech, that it was gonna be a high-quality company with a high-quality team that was gonna create a new leg of growth for Johnson & Johnson, we didn't have any questions that Abiomed was the right choice. I'm very optimistic about the future of Abiomed within Johnson & Johnson. We just closed the transaction. We have welcomed the Abiomed team into Johnson & Johnson. It's a team that has very similar cultural values to the Johnson & Johnson ones.

I think it's going to be a great cultural fit and a very synergistic acquisition for Johnson & Johnson, in which we are gonna be able to put all our global footprint in order to expand the therapy, but also all our clinical development engine that we have in Johnson & Johnson to support the development of new indications. In this case, there are PMAs with significant clinical development plans that Abiomed has. For us, it's been a reason for optimism to be able to complete a transaction like Abiomed. I think, you know, I tried to telegraph during this year that that was the type of acquisition we were driving through, and this clearly fits squarely what we wanted.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

In terms of, I guess, what's next on business development within medtech, I mean, can we think of another larger transaction like Abiomed, or is it more likely we're gonna see Johnson & Johnson do smaller, more tuck-in type of transactions?

Joaquin Duato
Chairman and CEO, J&J

Thank you. Staying in Abiomed, look, Abiomed, now we are starting with the integration.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

It's gonna be accretive to our growth in med tech year one, and at the same time will be accretive from an earnings perspective to Johnson & Johnson in 2024.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

That's the picture for Abiomed moving forward. When it comes to med tech and M&A or external innovation, I mean, we, as I commented in pharmaceuticals, our sweet spot, it's always going to be in identifying companies that we can create value. Many of them will be tuck-ins. You know, like for example, we have done in extremities with CrossRoads Extremities.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

We'll continue to look for opportunities in that area that would complement our current portfolio. We are also going to be looking for other opportunities that are going to be close to the areas of focus that we have today. We have always believed that being close to our areas of expertise is a success factor, because we are able to identify better what value this company has, and also we are able to add value to expand those therapies. What are our areas of focus? Eye health remains an important area for us. We have a terrific position in contact lenses. We are the number one. We are also now in surgical vision. Eye health is an area of interest for Johnson & Johnson overall.

Orthopedics remains an area of focus for us, identifying higher growth segments within orthopedics. Surgery, specifically robotics, is an important area for us, and we are trying to digitally enable all our portfolio in our surgery space. Finally, cardiovascular. As we have stated, atrial fibrillation is a growth engine for us, and now with the addition of heart failure, but we are continue to look into the cardiovascular space. Those are the areas of focus for us, and we'll continue to be disciplined in looking for opportunities in which we can create value that serve a significant unmet medical need, like heart failure. You know, for investors in which we have a disciplined financial approach consistent with our capital allocation strategy, and that's what we'll continue to apply.

You can expect from us that we will continue to look for opportunities, but we're always going to maintain a disciplined capital allocation and financial discipline when we look at these opportunities.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Great. Maybe turning to the P&L, it seems like we're heading into a year with a lot of moving pieces. I think about, we got the spin, we got the Abiomed acquisition, we've got potential biosimilar Stelara. You've talked a lot about the growth drivers. I guess, how should investors be, I guess, thinking about the pushes and pulls in J&J's business as we go into this coming year?

Joaquin Duato
Chairman and CEO, J&J

Thank you. That's a great question, as you know, we are now working in completing our Q4 results.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

and also in generating what will be our 2023 guidance. We'll have our earnings call, Q4 earnings call in January 24th, I believe. We'll be able to provide more details about that, right? When I think about 2023, when I look at the context that we are in macroeconomically, that I read in the press every day and that the audience, I'm sure, reads in the press every day.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

With the different pulls and pushes that we have there, inflation, higher costs. More specifically as you were discussing, the situation with COVID-19, that we're seeing the situation in China. Broadly, we see also, both in med tech and pharmaceuticals, pressures in price. No VBP in China, austerity measures in Europe, changes in the channel mix in the U.S. I put all that into consideration.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm

Joaquin Duato
Chairman and CEO, J&J

... I see uncertainty moving into 2023. While I remain very confident of the strength of Johnson & Johnson to address these challenging macroeconomic conditions, I have to look realistically at 2023. I have to be cautious about 2023.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

That's the first thing I will tell you.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

I have to be cautious about that. Grounded on the confidence that Johnson & Johnson normally is able to do better in situations where you have macroeconomic challenges, but I have to be prudent about 2023. What do I believe? Look, I think that, you're going to see the med tech market continue to recover, as we discussed before.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yep, yep.

Joaquin Duato
Chairman and CEO, J&J

Especially as the year progresses, fueled by new procedures. I'm optimistic about that. When it comes to pharmaceutical, while I believe pharmaceuticals will have a healthy growth, it may be a softer growth from a market perspective than the past years.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

That's the macro picture that I see for the med tech markets and the pharmaceutical market.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

In that context, what do I see for Johnson & Johnson? I see our pharmaceutical business and our med tech business continue to be able to deliver competitive growth.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

That will be true for medtech, as I described before. We will continue to deliver competitive growth into 2023. That will be true also for pharmaceuticals, where we believe we will be able to drive in 2023 above market growth once again.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

Even in the face of the Stelara loss of exclusivity.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

That's the picture that I see.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yep.

Joaquin Duato
Chairman and CEO, J&J

That's how I see the situation. Now, when I think about 2023, and specifically in pharmaceuticals, you know, I get many questions about how to model 2023.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah.

Joaquin Duato
Chairman and CEO, J&J

... given the all the push and pulls, right? Let me give you some ideas there. Look, on the Stelara loss of exclusivity, look, it's difficult for me to give you a view there. I think there's uncertainty. You know, there's different models that you can use.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

You're gonna see the Humira model. You have the Remicade model, so it would be something in between there.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yep.

Joaquin Duato
Chairman and CEO, J&J

The timing is also uncertain, because we don't have any biosimilar data approved. That would be more for you guys to guess.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah. Range of outcomes there.

Joaquin Duato
Chairman and CEO, J&J

For a range, it comes there. I mean, I see some areas of disconnect.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

For example, I think that, you guys need to take a look at the Remicade erosion curve, which is accelerating globally.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

I think that the Street has to take into consideration the loss of exclusivity in Europe of ZYTIGA and our injectable antipsychotics there.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Mm-hmm.

Joaquin Duato
Chairman and CEO, J&J

That has to be taken into consideration.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Okay.

Joaquin Duato
Chairman and CEO, J&J

At the same time, I see overstated COVID-19 vaccine sales into 2023. We don't see nominal sales or material sales of our vaccine in 2023.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Good point.

Joaquin Duato
Chairman and CEO, J&J

... those are some considerations for modeling that I think The Street.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Yeah

Joaquin Duato
Chairman and CEO, J&J

should look at. Overall, as I said, I'm prudent on 2023, but confident that we'll be able to deliver competitive growth. If I go to my other stated priority, confident that we will be able to complete the separation and the public market exit of our consumer health company. Johnson & Johnson, as I said, it's been always able to do better in terms of macroeconomic uncertainty. I think it was clear in 2022 that we were able to do that. When it comes to capital allocation, which is another question that we get very frequently, in 2022, we hit in all our priorities. We invested in our business.

We were able to increase our dividend for the 60th consecutive year, we plan to continue to increase our dividend, for investors to know, in the new Johnson & Johnson. We also invested in M&A with the acquisition of Abiomed, we did a share repurchase. Very few companies have the strength of the balance sheet and the worth self to be able to hit on all these priorities in a single year with the macroeconomic uncertainty that we see. We did in 2022, I'm confident that we'll be able to do it in 2023 and beyond.

Chris Schott
Managing Director and Senior Equity Research Analyst, JPMorgan

Great. Well, I think we're out of time. Really appreciate those comments. Thanks again for joining us.

Joaquin Duato
Chairman and CEO, J&J

Thank you.

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