All right. Good morning, everybody. So it's very much my pleasure to start off the day today with Pfizer's head of R&D, Mikael Dolsten. It's very much my pleasure to welcome him. And Ronen Tamir from Investor Relations is going to start off with just the brief disclaimers.
Thank you, David, and good morning. I just want to make sure that we are all aware that today we're going to make some forward-looking statements which are true for today and the actual result might change materially. I encourage all of you to look at our SEC filing for a full forward-looking statement and disclosures. Thank you.
Wonderful. Well, Michael, thank you very much for being with us here. We very much appreciate it. I thought it would be helpful just for you to set the stage on Pfizer's R&D spending overall. Obviously, the company's gone through transition and has rationalized, refocused, acquired Seagen. But I think setting the stage would be a good place to start, and then we can go from there.
Yeah, thank you, David. Always a pleasure to be with you here. We spend, according to our general statements this year, about $11-$12 billion. And as you know, our revenue base is, you know, approximately maybe $60 billion, so that gives you a sense. We are trying to become more efficient, like every company in every division. So while we have reduced somewhat compared to if you would have added just Pfizer and Seagen, this has been part of our continuous improvement process. It's still one of the largest R&D budgets in the industry, in total. I am responsible for four of the five research and development areas. So my team executes end-to-end vaccines, internal medicine, immune inflammation, and infectious diseases.
We also support through some of the heavy tech platform that we carry, design of small molecules in oncology, safety, medical support in certain aspects. So it's an organization that contains deep platforms and certain disciplines that are focused on therapeutic areas. In total of the 11-12, we are spending on programs, about 60% on the four areas that I lead and about 40% on oncology programs.
Excellent. With respect to your activities, let's turn to what's exciting. What are some of the programs that you're most excited about and that we should be focused on?
Yeah, let me put it into what I call the scientific key value drivers. What are they right now? The first one, it's a legacy strong area, bacterial vaccines. While we have quite recently got our 20-valent novel pneumococcal vaccine approved for adult and pediatrics, we're already moving a fourth generation conjugate vaccines that will contain more serotype and also improved technology forward. We know, as you and others point out, this is an area where more companies are coming in. We have been leading it for; this is our third decade. So while we defend it vigorously, we also have added growth drivers in bacterial vaccines, among them C. difficile, where we have made some great progress and look forward to see that drive bacterial vaccines to new heights.
The second one is the seasonal vaccines that are the more viral vaccines, where, of course, our COVID businesses, with continuous upgrades of that. We have added a flu vaccine that's now in a combination with COVID in a phase III for younger adults. And we have our recently launched RSV vaccine for two indications that also have a significant expansion program, that we can talk more about. The third pillar would be in internal medicine, where we have some efforts on various aspects of weight regulation in human disease. One is cachexia, where I think we are pioneering some efforts. And it's an area increasingly more in need because of many chronic conditions, whether cancer, heart failure, COPD, or aging. And we have ponsegromab that we think could be a multibillion-dollar asset across cancer cachexia, and also heart failure.
Of course, in internal medicine, we have our obesity platform that now lies on three different assets, of which one of them has gotten a lot of attention, danuglipron, where we're now working on a once-daily formulation, after having concluded a phase II trial earlier on a twice-daily. We have other assets in the broader cardiometabolic setting that are in the clinic. And then I would mention benign hematology. It's an area where we started with hemophilia, and we have added sickle cell disease. And we believe that area will be a very significant growth for us. Initially, we launched, through the acquisition of GBT, Oxbryta that's doing well. We are coming with a full-on drug, 601.
We have several assets in hemophilia that are now in very late state of registration, marstacimab that we think will be approved this year, hemophilia B gene therapy in registration, and hemophilia A reading out, likely, you know, in the middle of the year or so. Those were five examples of large growth drivers. We sometimes use the term they can drive mega blockbuster value, which we have defined as $3 billion+. But actually, I think each of these five can drive much bigger value. Of course, they rely on multiple pillars and contain already well-established franchises that we expand.
Excellent. That's a great framework, so thank you. And we only have 22 minutes more, so, I don't know how we're going to go through all that, but, but I'll, I'll, do my best. So, with respect to the vaccine readouts ahead, so what should we be watching and when?
We'll soon have a readout for the RSV 18-59 years. That gives the opportunity to expand from all 60+ to those that have comorbidities, which is pretty common nowadays, unfortunately, among younger people, and play an important role. It's the widest age span of any of the vaccine players that could then reach for the fall season. Of course, we recently shared two-season data that will be published, which looked really good, strong. Otherwise, we have, in addition to RSV, the mod flu data, the phase III trial that's ongoing, that is also reading out this year. It's also in the younger adult population that we think will benefit from combination vaccine. They vaccinate frequently for flu.
They vaccinate less frequently for COVID, which, by combining the two, we think will improve public health and hopefully bring it to a similar level that you see for the older adults. So these are, I would say, some of the things really happening this year in the seasonal vaccine area.
With respect to mod flu, could you just talk about influenza A versus B coverage and, you know, what you had updated on last year and what to watch in coming months? I think the readout is coming relatively soon for that trial.
Yeah. This is the—we call it the second-generation mRNA flu that is combined with the COVID. The first generation showed that the mRNA platform, when used properly, can be very powerful, as it was an event trial that we said was superior to standard of care. And to the best of my knowledge, that hasn't been reported in recent time for any new vaccine in the 18-59 superior to standard of care. Now, that was an event trial, and we had basically few, if any, B cases. And on immune response, our levels against B was lower than standard of care.
Of course, if outcomes contain more than antibody immune levels, but we have made some improvement, reformulated it, and now been able to show in phase II that we have very robust immune response, not just to A but also to B, although B is increasingly less common. And actually, recently, it has been proposed that for next, next season, one of the B strains should be removed. It should be a trivalent vaccine 2A1B. So we feel, because of the improvement, very positive about being able now to generate immune data that's strong for the 2A and the B that will be used. And we rely on a previously robust superior efficacy for the primary endpoint. So that tells me it's possible to make improvement in a disease that has been for a long time, like flu, and we bring it together with the COVID.
What we see is that we can retain the good antibody response for COVID. I think it can be a really nice improvement for the 2025 season when we hope to have it possibly improved, approved, and in the U.S. and worldwide.
Just so I understand the timing, what was the timing of pivoting to the newer version with the better B coverage?
We have been running this event trial over a couple of seasons. So, it's part of our continuous efforts to put in new science. And, the mRNA platform is an area where we at Pfizer constantly improve the mRNA string, the LNPs, and how we package the amount of RNA in LNPs. And as we made an improvement, we transferred it to flu. And we could note, in a phase II trial that, those improvements had particular importance for the B strain. And as the trial from the event trial came, we thought, this brings us an opportunity to take the best what we learned in the first and incorporate with new technology to have what we think could be a best-in-class and a first flu/COVID combo vaccine. It is important. We've seen in the pediatric sector that, you improve vaccination rates when you come with combination vaccines.
And we think that's going to happen now in the adult sector and allow us simplicity, convenience, and access to a larger population.
Excellent. Thank you. And then you had talked about your pioneering work in cachexia. Could you talk about that a little bit more, please?
Yeah. GDF-15 turns out to be a major factor driving a kind of sickness feel and also catabolic metabolism, which means that you are losing weight. You have a poor appetite, poor nutrition status. And 20%-30% of cancer patients, which means the major cancers, do die with cachexia contributing to disease. So we have seen in an earlier smaller clinical trial that we could substantially improve how much they eat, their body weight, their nutritional and functional status. And we think it will be by itself improving long-term outcomes and will make patients more fit for treatments. And we are targeting initially some of the larger cancers that are driving these outcomes, among them lung cancer and pancreatic cancer. And, you know, many regimens today, even those with the immune oncology product, contain chemo backbone.
And this will improve the ability to stand through treatment and be in a better performance status. We're also running in heart failure, where you see similar a cachectic phenotype. You also see it in COPD, which include that some of the muscles involved in breathing are becoming poor because of weight loss. So we think it can be a pretty big area. It's kind of the two ends. Obesity has gotten all the attention, and we want to play there. But also cachexia with an aging population and chronic diseases, we think there's a big opportunity to improve long-term outcomes for patients. It's a very conveniently administered antibody, and it has performed really well in clinical studies. So it has the potential to be simple and easy administered with a, you know, maybe a monthly interval for patients, depending on finalization of dose, et cetera.
One of the next major readouts to watch?
We will have a phase II readout for cancer cachexia this year. That could position us for potential to move to phase III, pending regulatory dialogue. We're already in a phase II trial with heart failure that could follow after that. We are exploring, looking at COPD, just to give you some example of very big diseases where patients are suffering from this. We have gotten interested in cachexia and also have other programs that face what's called geriatric anorexia, the aging population start also to have cachexia as a major problem, limiting their lifespan as they pass, you know, 75. It's a growing population that will be a burden on healthcare and their own well-being. So we think this cachexia is a pretty big phenomenon with different components, whether you are an aging patient or a patient that suffers from chronic disease.
Excellent. That's great. So, maybe we could pivot to the vision for obesity R&D. Obviously, you're, you're working on the potential once, once daily for danuglipron, but you have other efforts as well. So if you could just provide a framework and what to watch, both with respect to when you'll have clarity on the possibility of danuglipron once daily and then other options.
Yeah. First of all, we feel, given our skills in cardiometabolic, that this is an area we're committed to. Our presence in global primary care over a long time positions us well for that. In total, we have three assets that are pure obesity in the clinic and another asset that works on muscle energetics that could also be of great interest in this space. Of the three, two are GLP-1s. One is a validated mechanism for obesity through the peptide therapeutics that are used. That's really our strategy. We use our unique skills to make oral, small, convenient, scalable, a small molecule, and based on principles that have been validated by injectable in this area. And why do we think that's really attractive? Well, it's approaching 1 billion patients worldwide that suffer from obesity.
You have noticed it's really hard to bring manufacturing of peptides to that scale. The need to make devices doesn't make it practical for a broad population of overweight and obesity. The 1 billion is overweight and obesity. But that's really the segment that's addressable now. The overweight often have then comorbidities, cardiovascular, renal, et cetera. With the lead asset that did deliver really robust body weight loss up to 13% over 36 weeks, danuglipron, we are working with a set of once-a-day sustained release formulations that will wrap up around mid-year. We promised first half of the year. We'll be able to look at that and define next steps. We have strong skills in modified release and have brought many drugs into the market.
That makes me encouraged to believe that we can address the once-a-day challenge we put in front of us in a good manner and look forward to get that data and review them and prepare for next step.
Excellent. So when you mentioned the three assets, obviously, one of them is danuglipron. But what are the other two?
The second is another GLP-1 that has some different features, also in the clinic, and looks encouraging when it comes to PK and dose. And the third one, we haven't released the mechanism yet. But it's one of those mechanisms that, you know, have been validated by biologics from companies that are in that space, the type of mechanisms that you hear from Lilly and Novo. And we've been able, I think, by far being the first company to make an oral version of it. So while a drug like the GLP-1, the danuglipron, is a bit ahead as, as it would have a strong number of patients in phase II, plus possibly a, a once-a-day that we've discussed as we approach mid of the year, we could see that as, a potential first entrant.
The second drug would be a nice combination in order to build a portfolio that addresses different types of patients. Some patients may need to lose 10% of body weight and be in a normal spectrum, and it addresses their metabolic dysfunction. Other patients may want to have more body weight loss and may need combo agents. You really see that now from the peptide companies that they play with single-double mechanism of action. We're making progress on a variety of different mechanisms. But these are the two more advanced and more to come, oral version of peptide-validated mechanisms. Again, with this large population of obese patients, just in China as an example, you have 600 million patients overweight and obese. That's a place where an oral drug would thrive.
Of course, in the United States too, where you may have 150 million patients that could be qualified, it would be very hard to satisfy all of those segments with just injectable. And that's why you see us and some other companies pushing into the oral segment to be able to access that larger population.
Excellent. Thank you. So, you mentioned those, second and third, those are both in phase I currently?
The second and third are both in phase, have concluded. One of them have concluded. Phase I is now gearing up for a phase II trial. The second one is just concluding phase I. So it's, it's moving pretty swiftly there with three different assets.
So, just to clarify, the second GLP-1 is gearing up for phase II.
Yeah.
And then the one that you haven't disclosed the mechanism for, that's wrapping up phase I.
No, it's the one that's the novel mechanism is already in the planning for the phase II study.
Okay. The other, the reverse.
It's wrapped up, and it looks like a low-dose, well-behaving, typical, beautiful Pfizer oral drug. And the other GLP-1 beyond danuglipron is just concluding phase I, finalizing the cohort. But whether we and how we would develop that, of course, depends on danuglipron. If we have a QD on that, we may be happy with that and not need the second one. On the other hand, we have seen that the GLP-1 assets play a role in metabolic disease. They may play a role in certain addiction diseases. They may play a role in certain neurological conditions. So we also thought it could be to our advantage to have more than one GLP and be able to combine them with other oral drugs that I spoke about.
Excellent. Yeah.
The second GLP-1 that you have finished phase I and are in phase II, how is that?
No, he mentioned it's the new mechanism that is.
The second one, he said he finished phase I.
We are wrapping up phase I, I said. We haven't.
That's the third one. You're wrapping up phase I.
Yeah.
That's the mechanism you won't have. But the second GLP that you told us is in the clinic, PK done, phase I, and you're in.
We are concluding phase I. So, we haven't.
How is that different from danuglipron? How is that different?
Well, you know, every.
Yeah, for those, there might be some on the webcast. So the question is, for the second phase, for the second GLP-1.
Yeah.
Beyond danuglipron that's wrapping up phase I, how is it different?
Yeah. As I said, danuglipron is the lead drug for us because we have treated more than 1,500 patients, so we know it's safe. Our focus is to get the once-a-day. The second one, I would at this point see more, like you see in all the obesity companies, they're developing multiple drugs for this area, because it will be different needs for different types of patients. And this we may not need a second one at all and decide that we're all fine. There are areas like addiction, the various craving conditions outside body weight. There have been intriguing reports on neurological disease. There are some of the companies running trials in Parkinson's and Alzheimer's. So it gives us just one more card if ever needed. I would focus for now on danuglipron and.
Let's focus on danuglipron. You're finishing up your extended release study. We'll have the results by mid-year.
Yeah.
What about safety? Danuglipron's biggest problem was nausea, vomiting, was very strong, very much. Is that improving with the extended release? That's question one.
Yeah.
That's the tolerability. Tolerability.
Yeah. That's tolerability. Safety is whether you have issues that could stop a drug. Tolerability is how well it affects the patient.
Is the tolerability improving for danuglipron with extended release? That's the first question. Second question, if your weight loss is still 15% with danuglipron and others are coming out with 20%, like orforglipron will be 20% and others even higher, others are coming out with once-a-day, why will anybody use danuglipron long-term?
Yeah. So let me repeat the question. So the question, is twofold. First, how is the extended release going to impact the tolerability?
Yeah.
because there were tolerability issues in the danuglipron data. Then second, if it generates 15% weight loss, will it be competitive with others, or for lotiglipron and potentially combos that could drive greater weight loss?
First of all, we only develop drugs, beyond, of course, the early clinical development that we believe can be differentiated for patients and satisfy needs that are unique for patients, number 1. Number 2 is that, if you look at, for example, semaglutide, which is more modest in weight loss maybe than Mounjaro at certain doses, it had a dramatic effect on cardiovascular outcome and renal. So there is a balance between how much weight you lose and your general health. Too much weight loss leads to muscle impairment. So I'm not sure we should be so simple and think more is always better. We need to look at the holistic taking care of patients. And GLP-1s have effects that are beneficial beyond weight loss. So I wouldn't, you know, lock myself into a box and think about only that.
When it comes to tolerability, please remember we had forced titration in that trial in order to reach and really answer the question, can an oral molecule give 10% or more weight loss? That was our goal. And yes, it could. But it was forced titration. If you look at some of the other studies where they go from forced to allowing physicians and patients to more individualized titration, it improves dramatically tolerability. So there are many ways that you can go from phase II and onwards and improve tolerability. And if you really look at the danu data compared to Altimmune data and the BI data on the GLP-1 glucagon, they are all in the same ballpark of nausea, vomiting, and diarrhea.
We just chose, again, it's a lot how you decide in phase II to generate data fast or have extensive durations of treatment up and down. So I wouldn't focus on that. It's a safe, efficacious drug. Can we get it once a day? We'll put all data together and have the opportunity to discuss our next steps around mid-year. I appreciate your interest, but I want to make sure also David can answer, ask me more questions than just obesity. It's, it's one of our many interesting opportunities.
All right. Last question. The muscle drug, can you give us the mechanism of your muscle-sparing drug? And you have a growth hormone. Others are looking at growth hormone for muscle sparing for you.
Yeah. I mean, that's.
So the question is, on the muscle drug, could you provide more color?
So, you know, the question about muscle punctuates that you need to be careful in how much weight you lose too fast because then you need to be on a muscle-sparing drug. And that's why I said maybe the future isn't just about adding more drugs because you cause side effects, but rather how you use the drugs. No, I will not disclose that it's an oral drug. It's more focused on muscle energetics, how muscle works, than the typical growing muscle drugs that you're referring to. So it's going to be a different one.
The growth hormone no issue.
It's an evolving field, and I would just stay open and see how it, but my primary thinking here is that if you can avoid losing too much muscle too fast, it's far better for the patients than worrying like you do how to rebuild muscle. Okay.
All right. Wonderful. So, maybe we could just move to the fourth-gen PCV candidate. I think you mentioned that it would be adjuvanted. So could you talk a little bit more about its profile? And if it's adjuvanted, would it likely be specifically for adults rather than infants?
So we have developed for bacterial vaccines in general, a set of different adjuvants. For this fourth generation, we have not disclosed whether that particularly contains adjuvant or not. So we have three different toolkits that we deploy on these bacterial conjugate vaccines. If needed, adjuvant. In contrast, the C. difficile vaccine that we work on now, we have included an adjuvant in order to reduce the number of doses needed. And we think it's primarily used in an older population where you need quick to raise antibodies to protect them when they go into hospital or use antibiotics. In the PCV, we have also introduced new conjugation chemistry, a new generation of chemistry that allows you to get stronger, better immunogens and antibody responses.
We're exploring more than one carrier, which means it's not just the CRM proteins, but we only want to give you those examples how we continuously advance our tech platform and that we believe we can improve immune response against old serotypes to get them more effective and add more serotypes. And that's really the profile of the fourth one, more serotypes than the 20 and improving for select serotype. And that brings what we think, a new generation that can be very powerful and can be explored for infants and adults.
Excellent. Well, I think we're out of time. Thank you so much for being with us here today. Appreciate it.
Thank you, as always. Great talking to you, David.
Thank you.