Great. Good morning, everyone. Thanks so much for joining us. I'm Salveen Richter, Cover Biotechnology at Goldman Sachs, and really pleased to have the team from Regeneron here with us. We have, at the end, Ryan Crowe, Vice President, Investor Relations, Robert Landry, CFO, and Marion McCourt, Head of Commercial. With that, Ryan, I'm gonna turn it over to you.
Sure. This will be quick. I'd like to remind you that remarks made today may include forward-looking statements about Regeneron. Each forward-looking statement is subject to risks and uncertainties that could cause actual results and events to differ materially from those projected in such statements. A description of material risks and uncertainties can be found in Regeneron's SEC filings. Regeneron does not undertake any obligation to update any forward-looking statements, whether as a result of new information, future events, or otherwise. I think Bob's gonna make a couple opening comments. Then we'll get right to your questions, Salveen.
Sure. Good morning, everyone. Salveen and Goldman Sachs, thank you for inviting Regeneron. This is a conference we do appreciate coming to. Before Salveen jumps into Q&A, I was gonna do kind of three, four minutes, kind of get everybody back to baseline with regards to what's been happening at Regeneron. We had a good Q1. Our net revenue grew 7%, and actually, for DUPIXENT and LIBTAYO, we had kind of all-time highs for both of those products for the quarter, which obviously is very, very promising. I'm sure we'll get into EYLEA a lot. We do have a big PDUFA coming for our eight mg high dose, which is gonna be coming, June 27th is the PDUFA date, and I'm sure Salveen and Marion will talk a lot about that with regards to the commercial anticipation.
With regards to DUPIXENT, continues to do well. It grew 40% on a constant currency basis in Q1. Roughly, we're did $2.5 billion, annualizing now at a $10 billion product. I'm sure that we'll get into some of the specifics on that. You know, again, with regards to DUPIXENT, what people may not know, you know, we're in five different indications. We are the leading new-to-brand prescriptions on all five, and with regards to total prescriptions, we have four of the five indications in which we're number one. Asthma is not the only one, and Marion's working very hard to ensure that we take that away from Xolair. We look forward to that. We do have another, a sixth indication coming up with DUPIXENT for chronic spontaneous urticaria.
Again, it's a pretty big disease. You know, the population is about 300,000 people in the U.S. We have a PDUFA date on October 22nd. Again, that will be our 6th indication. As you probably know, there's a lot of buzz around it. You know, we've got our first readout on COPD in DUPIXENT, which will hopefully be our 7th indication. We read out on our first phase III trial, BOREAS. You know, as Ryan is telling investors, it was the trifecta with regards to being able to hit on FEV1 in asthma and just quality of life and, you know, we very much look forward to getting this drug into a much-needed population. Again, the sizing on that is big.
In the U.S., we think there's 300,000 patients in the G7, 500,000 patients. We very much look forward to that. You know, LIBTAYO, as you may remember or may know, we bought back our 50% rights that we didn't own on July, and Marion McCourt and the team, commercial-wise, we're very happy we did, and the product's doing great. Again, we've reached all-time highs in the Q1 . I think it was up 49% on a worldwide basis. It's annualizing towards $750 million. Again, it's primarily the CSCC indication. We are just getting going with regards to the chemo combo launch, which we got approval in October, November of 2022. We look forward to that to continue to grow. You know, maybe I'll wrap up with regards to ASCO.
We're coming off of ASCO. Salveen covered ASCO for us. You know, we have a BCMA by CD3 that we showed in myeloma, and then certainly we have our LAG-3 fianlimab that we combine it with LIBTAYO, which again, we showed further positive information on both those assets. Moving forward, we do expect to file the BCMA by the end of this year. Again, our IO pipeline, in addition to LIBTAYO doing well, you know, the clinical assets continue to move forward, and we're very, very pleased with how all that's going. With that, Salveen, I'll turn it over to you.
Perfect. Thank you. Let's start with high-dose EYLEA. You've got this June 27th PDUFA coming up, at the same time, there's new FDA guidelines that came out with regard to wet AMD development. Is your PDUFA, I mean, are you at risk of not getting approved here?
Maybe I'll take that one. We certainly have been aligned with the FDA throughout the development process for eight milligram of aflibercept. This goes back several years. This draft wet AMD guidance was issued in February, which happened to be the same month that they accepted our BLA for eight milligram of aflibercept. I think that I'd note that it's still draft. It literally says on the first page of the guidance, "Not for implementation," and we're confident that the submission we made to the FDA is comprehensive, and we remain on track for an on-time decision from them on June 27th.
Great. Me moving forward to the commercial launch situation, can you just remind us the timelines here around the J-code and what's reasonable to expect with regard to use prior to a permanent J-code?
Sure, Salveen. Happy to. You know, reflecting on the aflibercept eight milligram PDUFA date coming up less than two weeks now, on June 27th, potentially. As it relates to J-code, we would then be filing, and I'm assuming the PDUFA date of the June 27, we would make sure we filed and submitted appropriately to CMS.
... by early July, according to their deadline, proper information, so that obviously we would launch with a temporary J-code, and then we would, with that timing of early July, Q2 later, would result in our potentially and likely receiving our permanent J-code for January 1. The launch timing is actually rather nice in terms of being able to move forward with that prior to or early quarter July submission.
And maybe just speak to how you think about use in the window where you don't have the problem.
Delighted to. I do think that, as we launch our new product, the 8-milligram product, you know, it's certainly with a lot of enthusiasm from the retinal community related to what they've seen so far in terms of clinical trial results, in terms of disease control, visual acuity, the safety profile, and then the ever-important improvement in duration and dosing interval. We would anticipate that there will be prescribing in the window of time where we have a temporary J-code. The confidence in the product, confidence in potential reimbursement, certainly we're also going to work very diligently to make sure that we can move from temporary to permanent J-code as quickly as possible to give that added level of confidence.
I do want to be clear in the fact that we'll be working forward with partnering with our customers and the community to support the use of eight milligram as we launch. I also assure you all that we'll be, you know, ready to launch as soon as we have FDA approval.
Great. Marion , could you provide us any details, whatever they may be, with regard to strategy and pricing here? Just a sense of how you think use will play out from the switching dynamic or naive patients.
We're very happy to. As many of you know, we will be giving clarity and specific information on pricing strategy at time of launch. We have a very sophisticated team doing this work and making sure that we do what's right in terms of, you know, patient access and physician prescribing. We'll hold on that until the time of launch, but I will share with you in terms of product positioning and the opportunity for aflibercept eight milligram to assist patients. We do believe that there's an opportunity for patients who might be today on another product, branded or unbranded, in the anti-VEGF category, to have an opportunity of not only the disease control they're looking for and safety, but greater durability being converted or moving over to, at physician discretion, to the aflibercept eight milligram product.
You know, also today, we would see, you know, opposite naive patients, there are situations where, based on patient criteria, physicians might start a patient on Eylea or another product. They might look at our new product, eight milligram, and believe it's a good starting point for a naive patient. I think of our positioning will most certainly be broadly within the anti-VEGF category for existing patients and potentially new patients, but always looking to physician choice and what they think is best for their patients, and supporting that.
Great. Transitioning over to Eylea or low-dose Eylea, on your 1Q earnings call, sales decreased about 4% on a sequential quarterly basis, and this was impacted by a number of factors, including gross to net on the back of competitive pressure. Can you just walk us through when we look at the 4Q earnings and the 1Q earnings? You know, help us understand these dynamics and your strategy to kind of manage these ahead of high dose, the high dose launch, and what this really means for high dose as well.
Sure. In launching our high dose product, it certainly is important to have sophisticated understanding of the anti-VEGF category, our customers, our patient needs. As we reported most recently, Eylea is the, you know, the product within category that has the, you know, certainly highest share in the branded category, about 70%, in the overall market, about 46%. We come into this next launch with a great level of knowledge of the category, how to participate, the competition within the category, and I think it actually bodes quite well for our ability to make an impact with the launch product. As I mentioned, as we reported our last quarter earnings, it is a competitive category. There have been some pricing pressures. You know, there are more products in the category.
There are biosimilars launching, but through that, what I would assure you is that the clinical profile of Eylea is what has allowed for this very robust performance over 12 years in the marketplace. Certainly, we look forward to creating and providing a next standard of care treatment in aflibercept eight milligram.
With regard to the potential to be a new standard of care for high-dose EYLEA, just help us understand your strategy with physicians and patients to be aware of the clinical profile versus the existing competitors?
Sure. I think what, you know, what's important, and we'll roll back in time a little bit in terms of why Eylea made such an impact in the marketplace when launched 12 years ago. It was a combination of the clinical profile, the proven safety as physicians had experience, and it being the product that offered such an effective, safe, and important alternative, and very quickly became, over time, the go-to product. Certainly, when you launch a product, it takes some time for physicians to have experience and to use the product and, you know, to see firsthand how their patients respond. We believe with aflibercept eight milligram, we have a similar opportunity of coming into a marketplace that is more sophisticated, has developed one that we know very, very well, but we certainly are excited.
More importantly, our physician community of retina specialists are very excited about what they've seen in the aflibercept eight milligram clinical data, and then having the opportunity to actually use the product and experience it in their own patients.
Have you gotten a sense from physicians as to where they intend to use high dose?
There's variety in the answer to that. Obviously, we don't know as much as we'll know when the commercial organization is involved in launching the product. My commercial team is not yet involved in, you know, product. That happens after the PDUFA date and a very official launch dynamic. I think we'll have to actually wait and see what the actual prescribing looks like. I can share from working with our medical colleagues and attending some of the clinical meetings, that there is a lot of enthusiasm. Physicians have a variety of patient types in mind.
Any updated thoughts here on how IRA impacts your EYLEA franchise?
I don't think there's any real update there, Salveen. Our view is that the statute is clear, that a new BLA represents a new reference product, and aflibercept eight milligram wouldn't be subject to the negotiation process until after its first 11 years on the market, with that negotiated price implemented no sooner than 13 years after the launch. We've of course, seen the Part D guidance that CMS issued a couple of months ago, which seemed to aggregate products with the same active moiety. I think, you know, we need to wait to see what the Part B guidance could look like. Should they take a similar approach for Part B drugs, so long as there's an aflibercept two milligram biosimilar on the market, we believe that aflibercept-containing products would not be subject to price negotiation because there's biosimilar competition.
We feel pretty well-positioned relative to how the statute reads, and we await the Part B guidance to inform how we're going to move forward.
Great. Our last question here on this franchise with regard to the biosimilars, you know, entering for EYLEA. How do you think the formularies will play out?
Well, you know, it's interesting, and obviously, today there are no biosimilars to aflibercept, but where we have seen biosimilars enter opposite Lucentis, the uptake has been modest. I think, you know, more importantly, we'll be participating in our launch of aflibercept eight milligram. You know, obviously, physicians don't want patients to have more injections in the eye than they need to, and patients also will see that as a very important element of their treatment plan. You know, we'll have to see how that plays out.
Great. ASCO, you recently presented your LAG-3 data in combination with LIBTAYO across three independently advanced melanoma cohorts, including a new cohort of patient who received PD-1 and other systemic therapy in the adjuvant setting. Could you just frame what this data means for you in terms of the opportunity in melanoma and your expansion plans for other settings?
Sure. I think, you know, we remained extremely excited about the potential for fianlimab plus LIBTAYO in melanoma, especially because that's the where we've generated the most data. We've had previous disclosures on response rates in the, in the low 60%. We saw a consistent response in that cohort of patients, which I'll speak to in a moment. That, that kind of a response rate is roughly double that of PD-1 monotherapy in the, in the first line metastatic setting. With, fianlimab, LIBTAYO's median PFS of around 15 months, that's roughly triple that of PD-1 monotherapy. This data also compares very favorably to the end market, LAG-3, PD-1 combination product, where a 43% overall response rate, is in their label and around 10 months of PFS.
Again, we think we have a really strong combination. The data, the new data that we presented at ASCO involved a cohort of patients that had received PD-1 in the adjuvant setting. That really means that these patients had a surgical incision of their melanoma, received a course of PD-1 therapy, but unfortunately, their disease relapsed beyond six months or later, and they were treated in a metastatic setting with fianlimab plus LIBTAYO. In that setting, we saw a response rate of 56%, which is very consistent with those that had no PD-1 experience, and that we think bodes extremely favorably as more and more patients are treated with PD-1 therapy in the adjuvant setting. You know, to summarize, we have a really strong combination.
We're enrolling our metastatic melanoma and adjuvant melanoma studies today. We haven't talked about lung cancer. We didn't have any new data at ASCO in the lung setting. We're also enrolling our pivotal lung studies, now and hope to have that data in two years. A very strong combination. We're excited about it, and certainly, melanoma, looks really good.
You also presented longer-term data for your BCMA targeted bispecifics. Maybe help us understand your updated thinking around this program.
Linvoseltamab is our BCMA by CD3 bispecific. We presented initial data in the go-forward dose back in December at ASH, where I believe the overall response rate was around 64%. At ASCO, a couple of weeks ago, we presented data with additional follow-up, with about six months of follow-up, and response rate reached 71%. We're seeing deeper and broader responses with more follow-up, which is important and what we've seen with other products in this category. We're going to continue to move this program forward, later this year, take a registration-enabling cut of the data with the intent of filing on this data set by the end of this year. When you look cross-trial against other BCMA by CD3 bispecifics.
I think our data stands up pretty well, especially on the toxicity side, where CRS, which is a concern with kind of all CD3 bispecifics, we had almost all grade one CRS events. I think we had only one patient who had a grade three CRS event. A strong safety profile, an efficacy profile that continues to improve with longer follow-up, and a filing to come, hopefully by the end of this year.
When you think of the oncology vertical, there's been significant R&D investment on your part, but there's also a lot of excitement at Regeneron on this vertical, and it's not necessarily reflected or understood by the street. You know, why do you think that is, and in that context, what's coming on the forward that you really think could show, you know, everyone really the potential of this portfolio?
Yeah, you know, I mean, I always struggle with that question, Salveen, in terms of, you know, I think of it like an iceberg, right? I mean, the investors and shareholders only get to see what's above the water, but yet, you know, Marion and Ryan, and myself, we could see everything underneath, which, you know, we think is a gigantic iceberg. Usually, it's just time will tell on these things. I mean, we're. These, you know, as it pertains to, like, Alnylam and Intellia, and things that we made kind of early, really early platform bets, you know, and the bet included, you know, making a kinda equity investment into these companies, too.
We're just now kinda starting to see, you know, the art of the possible in terms of what was in the eyes of George Yancopoulos, our Chief Scientific Officer, and his team back in Tarrytown, with regards to how, you know, what platforms and franchises can do. I just think it's a matter of time, you know, as these things continue to get validated, right? Intellia had another indication of which we have no economics with, kinda validating their platform last week. Certainly, people are following up with regards to Alnylam and, you know, what siRNA is doing. It's just a matter of time before we think our shareholders will see the valuation that we have by having partnerships in these different platforms besides, you know, being the antibody company.
Ryan, could you speak specifically to what we're gonna see on oncology on the forward?
Sure. Yeah. The way I think about oncology at Regeneron, it's really a kinda nice cadence of catalysts to come. This year, we're gonna be filing our CD20 by CD3 bispecific Odronextamab in B-cell lymphomas, and I mentioned earlier, Linvoseltamab, our filing should be complete by the end of this year. We have potential regulatory decisions as early as next year in the hemonc space. The fianlimab data should continue to mature, and we should have incremental updates there in 2024, with our melanoma studies expected to read out in 2025.
Beyond that, you know, we'll be able to have more data on the costim platform, which we haven't really talked about yet, but is one where we've seen data in prostate cancer, an immunologically cold tumor, have really dramatic response rates at some of the higher dose levels that we tested. We're still working on building that program out as we figure out safety and try and figure out the right dose. That's all information to come, either later this year or in the first half of next, but we certainly have a lot going on. I think another program we'll have an update on in the second half of this year is the MUC16 by CD3 in combination with LIBTAYO in advanced ovarian cancer.
We saw monotherapy MUC16 by CD3 data last year at ESMO, where, response rates in the high expressors was pretty impressive. We're hopeful to build on that when we add PD-1 on top of Obimadimab, as it's known.
Okay. Dupixent was approved in 2017, and you've obviously seen this incredible, you know, entry of different indications and the sales ramp that followed. What's next in terms of indications and approvals, and where do you think there's still ability to innovate in the field?
Sure, I'll take a start. I think the important thing to understand with Dupixent, for each of the approved indications today, there's still tremendous opportunity in terms of unmet need. As we go into future indications, as Bob mentioned, you know, we have the chronic spontaneous urticaria coming up with the PDUFA data on October 22nd. We're very excited about the COPD data that, you know, we've shared to date. Salveen, your question was about the future. In COPD, we also have our IL-33, which potentially addresses another different population of COPD patients who've been smokers.
You know, obviously in our scientific platform, we have a lot of opportunity for the future that moves into this area of immunology, and frankly, a very experienced team over many disease states that will be there to be able to commercialize that opportunity and help so many patients.
Could you help us understand how you're thinking about pricing and strategy in the context of competitors? I know Lilly's LIBTAYO is coming up, given their pricing and rebates.
Well, you know, as I think everyone has seen, since time of launch with Dupixent, the pricing strategy in the selected WAC price was highly responsible in terms of affordability for patients, and as we've shown over the course of many years now, payer coverage for incremental indications. You know, in the last year alone, as we've expanded not only indications but age groups and products with the different... Excuse me, indications with a different dosing interval, like eosinophilic esophagitis, which is helping so many patients with unmet need. I think the team has done a very good job of matching needs of patients, prescribers, and also the payers.
as additional products come into the space, for example, with Lilly coming into potentially atopic dermatitis later this year, I will share with you that as other competitors, even the JAK inhibitors, came into category, they actually helped to expand the patient population of patients coming in to seek care from physicians, even when their product was not the product selected. In the case of JAK inhibitors, most, and recognizably, because of black box warnings and DUPIXENT offering not only a highly efficacious, easy-to-use product, but also pronounced safety, where we have indications now even with patients down to six months year of age, which is truly remarkable. I think as another product comes into the category, and specifically Lilly, one of the items I think that remains to be seen is the efficacy of the product, speed of action.
Does half the mechanism of action, you know, result in a different clinical profile and marketplace? We'll have to wait and see on that. You know, obviously, safety always is best determined when a product is actually used in market, but I think the most important thing is to see what is the impact for atopic dermatitis in patients with moderate to severe disease, where Dupixent is indicated in doing so well.
On the COPD indication, do you think just that the pivotal BOREAS study is sufficient here for an approval, or you'd have to wait for the second trial in NOTUS?
That's a tough question to answer at this point. We certainly are very excited about the data to generate, to Bob's earlier comment, which in fact that, you know, 30% improvement in moderate reduction in moderate to severe exacerbations, around an 80 milliliter improvement in FEV1 or lung function, and quality of life for these patients improved. I'll remind you, these patients were already being treated with maximal triplet therapy with LABA, LAMA, and inhaled corticosteroids. They were out of options, and they were still not well controlled. With Dupixent, they felt better, and they were not exacerbating as often. Really a clearly positive data set. Every endpoint in the statistical hierarchy was hit. I'd add that there's high unmet need here.
That COPD is the third leading cause of death in the world. There's a lot of reasons for optimism about potentially getting able to file on a single study. You know, the FDA guidance does call for two randomized controlled studies. We'll see when we have the conversation with them on this data, whether or not there's any flexibility there. Regardless, you know, we're preparing for success and we'll be ready to file should we get the green light from the FDA, and we should get our answer in the next, you know, near future.
I mean, one thing I'll offer on Dupixent that perhaps we didn't cover is that the other really important thing to realize is when patients have type two inflammation or allergic cascade, very often, and I'll go back to atopic dermatitis and asthma, nasal polyps, eosinophilic sinusitis, and all the indications and more, as you know, I can't even rattle them all off at the same time. Allergic cascade actually has a component of type two inflammation, where patients often have more than one condition. It's something that helps the individual patients that, you know, that asthma patient that no longer is suffering from atopic dermatitis. That's something also that's really, really important within the totality of use of Dupixent and the differential of Dupixent from competitors that might be coming into the market for any of the indications.
For Dupixent, can you just discuss the margin expansion we can expect here and then what's been driving that?
Sure. For those that follow closely, you know, we've been waiting for leverage on Dupixent for a while. You know, I mean, this is a product, like I said, it's got five indications going to six indications. COPD will be seven indications, and they're getting rolled out by, you know, Regeneron and Sanofi around the world. There's a, you know, as you'd expect, there's a lot of launch costs involved in all of this. We're finally coming to a point where we have a good baseline, you know, set of costs that are there, and we're starting to see the leverage come, you know, whether it be 300, 400, 500 basis points, you know, on a kind of year-over-year basis with regards to the operating margin of Dupixent, which has been really, really tremendous on that.
What I've been talking about a little bit, and I think what Salveen is alluding to, is that on top of all that, we've actually, and we're in the midst of doing it began in the Q1 of 2023, and I think by all of 2024, it will be rolled out, in which we've changed the cell line of the drug substance product that makes up Dupixent, in which we are now getting kind of three times the active protein yield per batch than we were getting before, right? You know, my batch costs and the Sanofi batch costs are not changing, but the amount of protein we're able to get out of that is a multiplier of three, which means we can obviously do three times as many doses off of the same batch cost, right?
Some of that benefit flew through, came through in the Q1 of 2023, and again, it will continue to come through, and we expect by, you know, by 2024, it will be, kind of throughout the world with regards to everybody selling Dupixent with the, with the CHO cell line within the drug substance of the product being sold. Again, big advantage. Kudos to the team back in Tarrytown with regards to the research that they were able to do to get this yield improvement. It's quite a substantial improvement to COGS.
Bob, with regard to capital allocation, you've been, you know, pretty consistent with the fact that so far, no interest in instituting a dividend or doing, you know, very large M&A. Is that still the case? When you think about your cash and, you know, the balance sheet here, should we assume a greater magnitude of share buybacks on the forward?
Salveen is alluding to, as of the end of the Q1 , we had $12.3 billion on a net cash position. Again, you know, our capital allocation priorities have not changed. You know, first and foremost, we continue to invest in ourselves. We think our R&D, particularly on the discovery side, we think we're the most prolific that are out there in terms of what we're able to develop, whether it be through RGC or a VelocImmune technology, and we're gonna continue to play that hard on that front. Certainly, we are doing M&A.
I mean, we do it for things that are kind of targets that we identify where we need new modalities, you know, gene editing, gene slicing, gene silencing, things of that nature, which we have in place with, whether it be Decibel, Intellia, and Alnylam. We continue to look for things like that. We love franchises, we like platforms. We do not like as much kind of maybe one-off assets in which we can add value to it. You know, we'll continue to stick to our druthers on B&D. We have been very active in the share repurchase market. Roughly, we bought back $700 million in Q1. I think we did $2.1 billion in all of 2022. Again, you know, we're pretty scientific in that approach.
We look at our intrinsic valuation, and we look at where the market price is, and if we think that there is a difference between the market, and the market is lower than the intrinsic, then we are going to take advantage of that, and we've been doing that. You know, I think, Salveen, we've been super successful in that. I think since we've launched our share buybacks in November of 2019, we've spent roughly $10 billion, and I think we've got it at an average price of $545. Our methodology is working. With regards to dividends, we are getting more questions now than we've ever had with regards to, you know, whether or not Regeneron will pay a dividend down the road.
I think the eight mg high dose data, which we showed in September of 2022, you know, showed the world the stickiness to the EYLEA franchise, with regards to the extension that we're gonna do, assuming we get, you know, approval at the PDUFA date. Again, we are taking a hard look at that. We certainly have the capacity to do it. Like anything, we, you know, we'll do an intellectual interrogation on it and, you know, come up to the right answer in terms of whether it's appropriate and whether the timing is right. You know, personally, I don't think the timing is right exactly now. Again, we'll push intellectual rigor into this exercise on determining.
Great. A last question here, just given we know Regeneron is a very much a research-focused organization. Was there anything through your partner portfolio or internal portfolio in terms of assets or, you know, upcoming data sets that you want to highlight?
Yes, Salveen, I think we were very excited, maybe even more excited than the market was with regards to the Alnylam ALN-APP, with regards to what that opens up. You know, the fact that, you know, maybe a new vertical for Regeneron will be neurodegenerative diseases, and to the extent that you can kind of inject an intrathecal injection and have it go all the way up to the brain and silence the genes that are, you know, making the amyloid, that's pretty fantastic stuff. It's kind of what we envisioned when we entered into our arrangement with Alnylam, but to see it come to fruition, granted, it's very early stages, but very exciting.
Great. With that, thank you so much. Really appreciate your time.
Thank you. Thanks, Salveen.
Thank you, everyone.