Sionna Therapeutics, Inc. (SION)

NASDAQ: SION · Real-Time Price · USD
38.73
-0.51 (-1.30%)
May 19, 2026, 12:04 PM EDT - Market open
Market Cap1.75B +191.8%
Revenue (ttm)n/a
Net Income-85.57M
EPS-1.92
Shares Out 45.15M
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume117,635
Open38.97
Previous Close39.24
Day's Range37.48 - 39.19
52-Week Range12.42 - 48.45
Betan/a
AnalystsStrong Buy
Price Target51.60 (+33.23%)
Earnings DateMay 12, 2026

About SION

Sionna Therapeutics, Inc., a clinical-stage biopharmaceutical company, researches and develops medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed cystic fibrosis transmembrane conductance regulator (CFTR) that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-directed CFTR corrector that has completed Phase 1... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date Feb 7, 2025
Employees 59
Stock Exchange NASDAQ
Ticker Symbol SION
Full Company Profile

Financial Performance

Financial Statements

Analyst Summary

According to 11 analysts, the average rating for SION stock is "Strong Buy." The 12-month stock price target is $51.6, which is an increase of 33.23% from the latest price.

Price Target
$51.6
(33.23% upside)
Analyst Consensus: Strong Buy
Stock Forecasts

News

Sionna Therapeutics price target raised to $55 from $44 at Stifel

Stifel analyst Paul Matteis raised the firm’s price target on Sionna Therapeutics (SION) to $55 from $44 and keeps a Buy rating on the shares. After a deep dive Into…

1 day ago - TheFly

Sionna Therapeutics to Participate in the 2026 RBC Capital Markets Global Healthcare Conference

WALTHAM, Mass., May 13, 2026 (GLOBE NEWSWIRE) -- Sionna Therapeutics, Inc. (Nasdaq: SION), a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for c...

6 days ago - GlobeNewsWire

Sionna Therapeutics reports Q1 EPS (60c), consensus (50c)

“We entered 2026 with strong execution across our programs, highlighted by the recent completion of enrollment in our proof-of-concept Phase 2a trial of SION-719, an important milestone for Sionna,” s...

7 days ago - TheFly

Sionna Therapeutics Reports First Quarter 2026 Financial Results

Enrollment completed in the PreciSION CF Phase 2a proof-of-concept trial evaluating NBD1 stabilizer SION-719 as an add-on to standard of care in participants with cystic fibrosis; topline data on trac...

7 days ago - GlobeNewsWire

Sionna Therapeutics Earnings release: Q1 2026

Sionna Therapeutics released its Q1 2026 earnings on May 12, 2026, summarizing the period's financial results.

7 days ago - Filings

Sionna Therapeutics Quarterly report: Q1 2026

Sionna Therapeutics has published its Q1 2026 quarterly earnings report on May 12, 2026.

7 days ago - Filings

Sionna Therapeutics Slides: Corporate presentation

Sionna Therapeutics has posted slides in relation to its latest quarterly earnings report, which was published on May 12, 2026.

7 days ago - Filings

Sionna Therapeutics initiated with an Outperform at Wedbush

Wedbush analyst Laura Chico initiated coverage of Sionna Therapeutics (SION) with an Outperform rating and $53 price target The company’s focus remains on developing next-generation CFTR modulators th...

14 days ago - TheFly

Sionna Therapeutics price target raised to $63 from $52 at JonesResearch

JonesResearch raised the firm’s price target on Sionna Therapeutics (SION) to $63 from $52 and keeps a Buy rating on the shares after the company completed enrollment in the Phase…

21 days ago - TheFly

Sionna Therapeutics Proxy statement: Proxy filing

Sionna Therapeutics filed a proxy statement on April 27, 2026, providing details for shareholder voting and corporate governance matters.

22 days ago - Filings

Sionna Therapeutics Proxy statement: Proxy filing

Sionna Therapeutics filed a proxy statement on April 27, 2026, providing details for shareholder voting and corporate governance matters.

22 days ago - Filings

Sionna Therapeutics Completes Enrollment in PreciSION CF Phase 2a Trial Evaluating NBD1 Stabilizer, SION-719, Added to Standard of Care in Participants with Cystic Fibrosis

Topline data is on track for anticipated readout in the summer of 2026 Topline data is on track for anticipated readout in the summer of 2026

22 days ago - GlobeNewsWire

Sionna Therapeutics to Participate in the Raymond James 2026 Biotech Innovation Symposium

WALTHAM, Mass., April 07, 2026 (GLOBE NEWSWIRE) -- Sionna Therapeutics, Inc. (Nasdaq: SION), a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for...

6 weeks ago - GlobeNewsWire

Three new option listings on March 17th

New option listings for March 17th include GBank Financial Holdings Inc (GBFH), Oculis Holding AG (OCS), and Sionna Therapeutics Inc (SION).

Other symbols: GBFHOCS
2 months ago - TheFly

Sionna Therapeutics Transcript: Leerink Global Healthcare Conference 2026

The company is advancing two NBD1 stabilizers for cystic fibrosis, targeting significant unmet need with both add-on and dual combination strategies. Key clinical data from ongoing studies are expected by mid-2026, supported by strong financial resources and a validated predictive assay.

2 months ago - Transcripts

Sionna Therapeutics price target raised to $50 from $45 at Guggenheim

Guggenheim raised the firm’s price target on Sionna Therapeutics (SION) to $50 from $45 and keeps a Buy rating on the shares after the company announced FY25 earnings. The firm…

2 months ago - TheFly

Sionna Therapeutics Transcript: TD Cowen 46th Annual Health Care Conference

The discussion highlighted the strategy to address unmet needs in CF by developing NBD1 stabilizers, with a focus on dual combinations aiming for clinically meaningful improvements in CFTR function. The phase II study is designed for robust mechanistic proof, and future plans include dose-ranging and co-formulation.

2 months ago - Transcripts

Sionna Therapeutics files automatic mixed securities shelf

08:21 EST Sionna Therapeutics (SION) files automatic mixed securities shelf

2 months ago - TheFly

Sionna Therapeutics files automatic mixed securities shelf

08:21 EST Sionna Therapeutics (SION) files automatic mixed securities shelf

2 months ago - TheFly

Sionna Therapeutics files automatic mixed securities shelf

08:21 EST Sionna Therapeutics (SION) files automatic mixed securities shelf

2 months ago - TheFly

Sionna Therapeutics reports Q4 EPS (46c), consensus (55c)

Cash, cash equivalents and marketable securities totaled$310.3 millionas of December 31, 2025. Sionna expects its current cash position to fund operations into 2028. “2025 was a remarkable and transfo...

2 months ago - TheFly

Sionna Therapeutics Reports Fourth Quarter and Full Year 2025 Financial Results

Ongoing PreciSION CF Phase 2a proof-of-concept trial evaluating NBD1 stabilizer SION-719 as an add-on to standard of care in participants with cystic fibrosis is on track with topline data anticipated...

2 months ago - GlobeNewsWire

Sionna Therapeutics Annual report: Q4 2025

Sionna Therapeutics has published its Q4 2025 annual report on March 2, 2026.

2 months ago - Filings

Sionna Therapeutics Earnings release: Q4 2025

Sionna Therapeutics released its Q4 2025 earnings on March 2, 2026, summarizing the period's financial results.

2 months ago - Filings

Sionna Therapeutics Slides: Corporate presentation

Sionna Therapeutics has posted slides in relation to its latest quarterly earnings report, which was published on March 2, 2026.

2 months ago - Filings