Spruce Biosciences, Inc. (SPRB)

NASDAQ: SPRB · Real-Time Price · USD
85.74
+1.74 (2.07%)
At close: Dec 26, 2025, 4:00 PM EST
83.83
-1.91 (-2.23%)
After-hours: Dec 26, 2025, 6:32 PM EST
2.07%
Market Cap91.77M
Revenue (ttm)697,000
Net Income (ttm)-47.88M
Shares Out 1.07M
EPS (ttm)-82.48
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume36,870
Open83.40
Previous Close84.00
Day's Range82.88 - 86.28
52-Week Range4.28 - 240.00
Beta3.51
AnalystsBuy
Price Target191.90 (+123.82%)
Earnings DateNov 10, 2025

About SPRB

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sle... [Read more]

Industry Biotechnology
Sector Healthcare
Founded 2014
Employees 21
Stock Exchange NASDAQ
Ticker Symbol SPRB
Full Company Profile

Financial Performance

In 2024, Spruce Biosciences's revenue was $4.91 million, a decrease of -51.32% compared to the previous year's $10.09 million. Losses were -$53.04 million, 10.7% more than in 2023.

Financial Statements

Analyst Summary

According to 5 analysts, the average rating for SPRB stock is "Buy." The 12-month stock price target is $191.9, which is an increase of 123.82% from the latest price.

Price Target
$191.9
(123.82% upside)
Analyst Consensus: Buy
Stock Forecasts

News

Spruce Biosciences Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directors

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological...

13 days ago - Business Wire

Spruce Biosciences Reports Third Quarter 2025 Financial Results and Provides Corporate Updates

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological...

6 weeks ago - Business Wire

Spruce: BTD For TA-ERT For MPS IIIB Could Ignite BLA Submission With Added Bonuses (Rating Upgrade)

Spruce Biosciences received FDA Breakthrough Therapy Designation for TA-ERT in treating San Filippo Syndrome Type B [MPS IIIB]. BTD enables potential rolling BLA submission, Priority Review, and Accel...

2 months ago - Seeking Alpha

This Biotech Stock Soared 1,400%. Investors Are Optimistic About Its Rare-Disease Drug.

The microcap biotech stock had its best day ever after the FDA granted its rare-disease drug a breakthrough designation.

2 months ago - Barrons

Spruce Biosciences Receives U.S. FDA Breakthrough Therapy Designation for Tralesinidase Alfa Enzyme Replacement Therapy (TA-ERT) in Sanfilippo Syndrome Type B (MPS IIIB)

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological...

2 months ago - Business Wire

Spruce Biosciences Resumes Trading on the Nasdaq Capital Market

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological...

3 months ago - Business Wire