Ionis Pharmaceuticals, Inc. (LON:0JDI)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions GBP. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Sep 12, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020
Market Capitalization	7,161	4,409	5,698	4,453	3,173	5,790
Market Cap Growth	-16.62%	-22.62%	27.97%	40.32%	-45.20%	-9.75%
Enterprise Value	6,934	4,013	5,489	3,843	2,663	4,845
Last Close Price	44.93	27.91	39.27	30.50	23.58	41.81
PS Ratio	10.39	7.83	9.22	9.13	5.30	10.84
PB Ratio	15.53	9.38	18.77	9.37	5.57	10.64
P/TBV Ratio	15.53	9.38	18.77	9.37	5.57	11.05
P/FCF Ratio	-	-	-	-	228.03	10240.42
P/OCF Ratio	-	-	-	-	139.52	220.26
EV/Sales Ratio	9.99	7.13	8.88	7.88	4.45	9.07
EV/FCF Ratio	-32.76	-	-	-	191.38	8569.00
Debt / Equity Ratio	3.14	3.33	5.09	2.39	1.62	1.26
Debt / FCF Ratio	-	-	-	-	66.39	1217.15
Asset Turnover	0.33	0.24	0.28	0.23	0.32	0.26
Inventory Turnover	48.06	91.49	61.67	36.18	27.98	0.60
Quick Ratio	2.61	7.74	5.44	6.49	9.13	3.30
Current Ratio	2.87	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-59.91%	-93.10%	-76.34%	-40.12%	-3.77%	-39.52%
Return on Assets (ROA)	-5.87%	-9.91%	-7.55%	-9.96%	-0.75%	-3.82%
Return on Capital (ROIC)	-6.85%	-12.12%	-9.71%	-12.93%	-1.02%	-5.18%
Earnings Yield	-2.73%	-8.22%	-5.05%	-5.03%	-0.67%	-5.62%
FCF Yield	-2.96%	-9.89%	-4.57%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-7.95%	-4.42%	-0.95%	-0.59%	-1.01%	8.85%

Updated Jun 30, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.