Ionis Pharmaceuticals, Inc. (LON:0JDI)

Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions GBP. Fiscal year is January - December.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Dec 18, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021	Dec 31, 2020
Market Capitalization	9,322	4,409	5,698	4,453	3,173	5,790
Market Cap Growth	106.80%	-22.62%	27.97%	40.32%	-45.20%	-9.75%
Enterprise Value	9,185	4,013	5,489	3,843	2,663	4,845
Last Close Price	57.65	27.91	39.27	30.50	23.58	41.81
PS Ratio	12.96	7.83	9.22	9.13	5.30	10.84
PB Ratio	20.28	9.38	18.77	9.37	5.57	10.64
P/TBV Ratio	20.28	9.38	18.77	9.37	5.57	11.05
P/FCF Ratio	-	-	-	-	228.03	10240.42
P/OCF Ratio	-	-	-	-	139.52	220.26
EV/Sales Ratio	12.72	7.13	8.88	7.88	4.45	9.07
EV/FCF Ratio	-40.79	-	-	-	191.38	8569.00
Debt / Equity Ratio	3.33	3.33	5.09	2.39	1.62	1.26
Debt / FCF Ratio	-	-	-	-	66.39	1217.15
Asset Turnover	0.32	0.24	0.28	0.23	0.32	0.26
Inventory Turnover	45.90	91.49	61.67	36.18	27.98	0.60
Quick Ratio	2.51	7.74	5.44	6.49	9.13	3.30
Current Ratio	2.79	8.47	5.90	7.07	9.75	3.56
Return on Equity (ROE)	-40.04%	-93.10%	-76.34%	-40.12%	-3.77%	-39.52%
Return on Assets (ROA)	-5.68%	-9.91%	-7.55%	-9.96%	-0.75%	-3.82%
Return on Capital (ROIC)	-6.51%	-12.12%	-9.71%	-12.93%	-1.02%	-5.18%
Return on Capital Employed (ROCE)	-13.10%	-17.60%	-13.10%	-18.50%	-1.30%	-9.60%
Earnings Yield	-2.05%	-8.22%	-5.05%	-5.03%	-0.67%	-5.62%
FCF Yield	-2.42%	-9.89%	-4.57%	-5.41%	0.44%	0.01%
Buyback Yield / Dilution	-8.89%	-4.42%	-0.95%	-0.59%	-1.01%	8.85%

Updated Sep 30, 2025. Source: S&P Global Market Intelligence. Standard template. Financial Sources.