Fidelity Select Biotechnology Portfolio (FBIOX)

FBIOX Holdings List

As of Dec 31, 2024

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No.	Symbol	Name	% Weight	Shares
1	ABBV	AbbVie Inc.	13.66%	3,266,627
2	AMGN	Amgen Inc.	7.26%	1,183,439
3	KRYS	Krystal Biotech, Inc.	6.92%	1,877,722
4	VRTX	Vertex Pharmaceuticals Incorporated	4.49%	473,209
5	REGN	Regeneron Pharmaceuticals, Inc.	3.98%	237,590
6	GILD	Gilead Sciences, Inc.	3.60%	1,656,603
7	ALNY	Alnylam Pharmaceuticals, Inc.	3.60%	649,970
8	EBR: UCB	UCB SA	2.50%	532,974
9	ARGX	argenx SE	2.49%	172,004
10	ASND	Ascendis Pharma A/S	2.14%	659,409
11	ACLX	Arcellx, Inc.	1.84%	1,016,891
12	CPH: ZEAL	Zealand Pharma A/S	1.76%	752,230
13	SRRK	Scholar Rock Holding Corporation	1.66%	1,632,599
14	PCVX	Vaxcyte, Inc.	1.66%	860,280
15	INSM	Insmed Incorporated	1.57%	963,319
16	BHVN	Biohaven Ltd.	1.37%	1,559,312
17	NTRA	Natera, Inc.	1.30%	349,532
18	UTHR	United Therapeutics Corporation	1.26%	151,493
19	AVBP	ArriVent BioPharma, Inc.	1.23%	1,967,500
20	IRON	Disc Medicine, Inc.	1.21%	812,188
21	CNTA	Centessa Pharmaceuticals plc	1.17%	2,976,494
22	SMMT	Summit Therapeutics Inc.	1.17%	2,792,829
23	CRNX	Crinetics Pharmaceuticals, Inc.	1.11%	924,450
24	BPMC	Blueprint Medicines Corporation	1.01%	493,352
25	MRUS	Merus N.V.	0.94%	946,454
26	MDGL	Madrigal Pharmaceuticals, Inc.	0.89%	122,095
27	n/a	Bio Ab2 Holdings Llc Arc	0.88%	1,954,526
28	CADL	Candel Therapeutics, Inc.	0.80%	3,915,674
29	MRNA	Moderna, Inc.	0.75%	768,622
30	MNKD	MannKind Corporation	0.67%	4,406,401
31	TGTX	TG Therapeutics, Inc.	0.65%	919,220
32	MLTX	MoonLake Immunotherapeutics	0.65%	510,858
33	RCUS	Arcus Biosciences, Inc.	0.61%	1,742,262
34	ROIV	Roivant Sciences Ltd.	0.59%	2,113,319
35	CORT	Corcept Therapeutics Incorporated	0.57%	483,346
36	VERA	Vera Therapeutics, Inc.	0.56%	567,325
37	NRIX	Nurix Therapeutics, Inc.	0.51%	1,141,946
38	XENE	Xenon Pharmaceuticals Inc.	0.50%	539,634
39	NUVL	Nuvalent, Inc.	0.50%	268,899
40	RVMD	Revolution Medicines, Inc.	0.49%	479,698
41	n/a	National Resilience B Pc Pp	0.48%	732,064
42	RNA	Avidity Biosciences, Inc.	0.48%	694,717
43	n/a	Bridgebio Pharma Inc Pipe	0.47%	733,408
44	BNTX	BioNTech SE	0.47%	175,500
45	JANX	Janux Therapeutics, Inc.	0.47%	370,999
46	VRDN	Viridian Therapeutics, Inc.	0.45%	1,006,328
47	DYN	Dyne Therapeutics, Inc.	0.44%	794,491
48	IDYA	IDEAYA Biosciences, Inc.	0.43%	717,557
49	VKTX	Viking Therapeutics, Inc.	0.42%	445,557
50	APGE	Apogee Therapeutics, Inc.	0.42%	392,132
51	PTGX	Protagonist Therapeutics, Inc.	0.39%	423,913
52	IMVT	Immunovant, Inc.	0.38%	649,621
53	RARE	Ultragenyx Pharmaceutical Inc.	0.37%	374,439
54	PRAX	Praxis Precision Medicines, Inc.	0.36%	199,147
55	NUVB	Nuvation Bio Inc.	0.36%	5,728,471
56	PTCT	PTC Therapeutics, Inc.	0.35%	334,011
57	IONS	Ionis Pharmaceuticals, Inc.	0.33%	407,077
58	VRNA	Verona Pharma plc	0.32%	295,988
59	RNAC	Cartesian Therapeutics, Inc.	0.32%	766,754
60	n/a	Oruka Therapeutics Inc Pipe	0.32%	704,883
61	EPA: ALSEN	Sensorion SA	0.31%	20,279,025
62	DAWN	Day One Biopharmaceuticals, Inc.	0.27%	915,332
63	SPRY	ARS Pharmaceuticals, Inc.	0.27%	1,082,956
64	KROS	Keros Therapeutics, Inc.	0.26%	708,078
65	ELVN	Enliven Therapeutics, Inc.	0.25%	479,038
66	APLS	Apellis Pharmaceuticals, Inc.	0.24%	321,622
67	NTLA	Intellia Therapeutics, Inc.	0.24%	879,921
68	GERN	Geron Corporation	0.24%	2,896,812
69	PRTA	Prothena Corporation plc	0.24%	738,117
70	n/a	Bio Ab2 Holdings Llc Adi	0.24%	1,954,526
71	SWX: GALD	Galderma Group AG	0.24%	91,670
72	BBIO	BridgeBio Pharma, Inc.	0.24%	367,896
73	n/a	Tectonic Therapeutic Inc Pipe	0.23%	215,508
74	EXEL	Exelixis, Inc.	0.22%	278,054
75	ATYR	aTyr Pharma, Inc.	0.22%	2,524,394
76	n/a	Metsera Inc Ser B Pc Pp	0.20%	1,686,508
77	COGT	Cogent Biosciences, Inc.	0.20%	1,073,294
78	CYTK	Cytokinetics, Incorporated	0.20%	177,752
79	DNLI	Denali Therapeutics Inc.	0.19%	394,963
80	CRSP	CRISPR Therapeutics AG	0.19%	202,007
81	n/a	Summit Therapeutics Inc	0.19%	440,529
82	TWST	Twist Bioscience Corporation	0.18%	166,525
83	SWTX	SpringWorks Therapeutics, Inc.	0.18%	211,909
84	QURE	uniQure N.V.	0.18%	427,459
85	LEGN	Legend Biotech Corporation	0.18%	231,810
86	n/a	Scorpion Therapeutics B Pc Pp	0.18%	3,099,905
87	n/a	Triveni Bio Inc Series B Pc Pp	0.18%	7,167,431
88	TSHA	Taysha Gene Therapies, Inc.	0.17%	4,196,276
89	UPB	Upstream Bio, Inc.	0.17%	440,957
90	GOSS	Gossamer Bio, Inc.	0.17%	7,914,394
91	GPCR	Structure Therapeutics Inc.	0.17%	259,176
92	ARCT	Arcturus Therapeutics Holdings Inc.	0.16%	399,330
93	SDGR	Schrödinger, Inc.	0.16%	350,701
94	ALEC	Alector, Inc.	0.16%	3,535,753
95	PHAT	Phathom Pharmaceuticals, Inc.	0.16%	821,324
96	SYRE	Spyre Therapeutics, Inc.	0.16%	284,853
97	n/a	Fidelity Cash Central Fund	0.15%	6,387,284
98	AXSM	Axsome Therapeutics, Inc.	0.14%	71,003
99	IMCR	Immunocore Holdings plc	0.13%	191,705
100	TRDA	Entrada Therapeutics, Inc.	0.13%	309,169
101	ATXS	Astria Therapeutics, Inc.	0.13%	596,256
102	DSGN	Design Therapeutics, Inc.	0.12%	839,131
103	INZY	Inozyme Pharma, Inc.	0.12%	1,866,312
104	TYRA	Tyra Biosciences, Inc.	0.12%	363,102
105	ALLO	Allogene Therapeutics, Inc.	0.12%	2,359,877
106	n/a	Cardurion Pharmace Ser B Pc Pp	0.12%	1,020,908
107	n/a	Scorpion Therapeutics Inc Seri	0.12%	2,066,543
108	ARWR	Arrowhead Pharmaceuticals, Inc.	0.11%	257,115
109	BCRX	BioCryst Pharmaceuticals, Inc.	0.11%	622,451
110	NVO	Novo Nordisk A/S	0.10%	51,700
111	GLUE	Monte Rosa Therapeutics, Inc.	0.09%	540,520
112	NMRA	Neumora Therapeutics, Inc.	0.09%	352,915
113	ITCI	Intra-Cellular Therapies, Inc.	0.09%	44,099
114	EXAS	Exact Sciences Corporation	0.08%	64,200
115	DNTH	Dianthus Therapeutics, Inc.	0.08%	153,693
116	CGON	CG Oncology, Inc.	0.08%	112,200
117	SEPN	Septerna, Inc.	0.08%	140,200
118	RAPP	Rapport Therapeutics, Inc.	0.07%	171,463
119	RYTM	Rhythm Pharmaceuticals, Inc.	0.07%	54,003
120	BCAX	Bicara Therapeutics Inc.	0.07%	171,200
121	AMLX	Amylyx Pharmaceuticals, Inc.	0.07%	782,806
122	REPL	Replimune Group, Inc.	0.07%	243,922
123	GERNW	Geron Corporation	0.07%	2,100,000
124	IGMS	IGM Biosciences, Inc.	0.07%	455,823
125	CRGX	CARGO Therapeutics, Inc.	0.06%	183,200
126	IMNM	Immunome, Inc.	0.06%	244,582
127	n/a	Crescent Biopharma Inc Pipe	0.06%	12,099,897
128	VTVT	vTv Therapeutics Inc.	0.06%	178,200
129	KYMR	Kymera Therapeutics, Inc.	0.06%	59,941
130	CLDX	Celldex Therapeutics, Inc.	0.06%	94,364
131	n/a	Cartesian Therapeutics ([Wts/Rts])	0.05%	5,385,728
132	CATX	Perspective Therapeutics, Inc.	0.05%	713,700
133	EWTX	Edgewise Therapeutics, Inc.	0.05%	84,821
134	THRD	Third Harmonic Bio, Inc.	0.05%	219,600
135	AVIR	Atea Pharmaceuticals, Inc.	0.05%	667,100
136	HRMY	Harmony Biosciences Holdings, Inc.	0.05%	64,425
137	PHVS	Pharvaris N.V.	0.05%	112,407
138	SRPT	Sarepta Therapeutics, Inc.	0.05%	17,689
139	n/a	Jade Biosciences Inc Pipe	0.05%	345,917
140	WVE	Wave Life Sciences Ltd.	0.05%	154,911
141	n/a	Candid Therapeutic Ser B Pc Pp	0.04%	1,666,667
142	ZBIO	Zenas BioPharma, Inc.	0.04%	223,300
143	STOK	Stoke Therapeutics, Inc.	0.04%	159,570
144	ANNX	Annexon, Inc.	0.04%	339,687
145	ONC	BeiGene, Ltd.	0.04%	9,198
146	TXG	10x Genomics, Inc.	0.04%	112,400
147	BMEA	Biomea Fusion, Inc.	0.04%	392,129
148	CAMP	Camp4 Therapeutics Corporation	0.03%	262,886
149	RAPT	RAPT Therapeutics, Inc.	0.03%	802,700
150	n/a	Korro Bio Inc Pipe	0.03%	32,866
151	RCKT	Rocket Pharmaceuticals, Inc.	0.03%	93,892
152	RXRX	Recursion Pharmaceuticals, Inc.	0.02%	149,900
153	NGNE	Neurogene Inc.	0.02%	43,557
154	BEAM	Beam Therapeutics Inc.	0.02%	39,350
155	FHTX	Foghorn Therapeutics Inc.	0.02%	197,249
156	CTNM	Contineum Therapeutics, Inc.	0.02%	58,800
157	GKOS	Glaukos Corporation	0.02%	5,700
158	SLNO	Soleno Therapeutics, Inc.	0.02%	15,900
159	n/a	Scholar Rock Wt 12/31/25 Pp	0.02%	17,850
160	n/a	Elevatebio Llc Ser C Pc Pp	0.01%	216,600
161	LXRX	Lexicon Pharmaceuticals, Inc.	0.01%	642,604
162	n/a	Warrant on Astria Therapeutics Inc	0.01%	115,136
163	NVCR	NovoCure Limited	0.01%	11,113
164	SAGE	Sage Therapeutics, Inc.	0.01%	58,062
165	ADVM	Adverum Biotechnologies, Inc.	0.01%	63,055
166	SWX: IDIA	Idorsia Ltd	0.01%	289,343
167	AUTL	Autolus Therapeutics plc	0.01%	105,233
168	AURA	Aura Biosciences, Inc.	0.01%	29,073
169	n/a	Saliogen Therapeut Ser B Pc Pp	0.00%	94,461
170	ABSI	Absci Corporation	0.00%	39,900
171	BOLD	Boundless Bio, Inc.	0.00%	23,700
172	n/a	Cyclerion Therptcs Inc Pp Pipe	0.00%	4,740
173	ORKA	Oruka Therapeutics, Inc.	0.00%	100
174	n/a	Optinose ([Wts/Rts])	0.00%	91,712
175	n/a	Disc Medicine Inc Cvr Rt	0.00%	1,555,907
176	GRTSQ	Gritstone bio, Inc.	0.00%	1,333,333
177	n/a	Codiak BioSciences Inc Ordinary Shares	0.00%	448,539
178	n/a	Aradigm Corp	0.00%	148,009
179	n/a	Warrant on Chinook Energy Inc	0.00%	115,821
180	n/a	Allena Pharmaceuticals Inc	0.00%	93,683
181	n/a	Axcella Health Inc	0.00%	66,454
182	n/a	Codiak Biosciences Wt 9/15/27	0.00%	46,000
183	n/a	Medavail Holdings Inc Pipe	0.00%	55
184	n/a	Afferent Pharma Ser C Pc Pp	0.00%	8,274,568
185	n/a	Aradigm Corp	0.00%	11,945
186	n/a	Cash	-0.11%	0
187	n/a	Deferred Tax Liability	-0.17%	7,413,667

As of Dec 31, 2024

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Asset Allocation

Asset Class	% Weight
Stocks	97.23%
Other	2.62%
Cash	0.15%

Sector Breakdown

Sector	% Weight
Health Care	92.35%
Other	7.63%
Materials	0.02%

Country Breakdown

Sector	% Weight
United States	86.48%
Other	3.95%
Ireland	3.36%
Denmark	1.50%
Canada	1.50%
Switzerland	0.81%
United Kingdom	0.67%
Germany	0.55%
Netherlands	0.37%
Bermuda	0.29%
Belgium	0.21%
Singapore	0.14%
Sweden	0.09%
Israel	0.04%
France	0.02%
Jersey	0.02%