Janus Henderson Global Life Sciences Fund Class T (JAGLX)

JAGLX Holdings List

As of Mar 31, 2025

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No.	Symbol	Name	% Weight	Shares
1	LLY	Eli Lilly and Company	9.42%	535,792
2	UNH	UnitedHealth Group Incorporated	6.89%	617,818
3	LON: AZN	AstraZeneca PLC	4.02%	1,292,377
4	JNJ	Johnson & Johnson	3.60%	1,018,875
5	BSX	Boston Scientific Corporation	3.14%	1,460,610
6	ABT	Abbott Laboratories	3.10%	1,096,926
7	EPA: SAN	Sanofi	3.06%	1,298,138
8	AMGN	Amgen Inc.	2.90%	437,086
9	ABBV	AbbVie Inc.	2.83%	635,230
10	VRTX	Vertex Pharmaceuticals Incorporated	2.82%	273,639
11	CPH: NOVO.B	Novo Nordisk A/S	2.40%	1,626,374
12	TMO	Thermo Fisher Scientific Inc.	2.36%	222,700
13	NVSN.MX	Novartis AG ADR	2.34%	986,698
14	ARGX	argenx SE	2.13%	169,140
15	ISRG	Intuitive Surgical, Inc.	1.88%	178,170
16	SYK	Stryker Corporation	1.79%	225,798
17	DHR	Danaher Corporation	1.79%	410,016
18	MRK	Merck & Co., Inc.	1.75%	916,279
19	MDT	Medtronic plc	1.53%	798,165
20	SWX: ROG	Roche Holding AG	1.50%	214,651
21	ASND	Ascendis Pharma A/S	1.44%	433,326
22	SLNO	Soleno Therapeutics, Inc.	1.40%	923,651
23	MCK	McKesson Corporation	1.34%	93,552
24	AKRO	Akero Therapeutics, Inc.	1.34%	1,553,410
25	HCA	HCA Healthcare, Inc.	1.34%	181,895
26	MDGL	Madrigal Pharmaceuticals, Inc.	1.31%	185,841
27	COR	Cencora, Inc.	1.16%	196,685
28	GMED	Globus Medical, Inc.	1.06%	680,040
29	RNA	Avidity Biosciences, Inc.	1.05%	1,666,169
30	LNTH	Lantheus Holdings, Inc.	1.04%	502,368
31	VRNA	Verona Pharma plc	1.03%	761,585
32	ELV	Elevance Health, Inc.	0.99%	106,645
33	RVMD	Revolution Medicines, Inc.	0.93%	1,236,518
34	CVS	CVS Health Corporation	0.84%	583,908
35	DXCM	DexCom, Inc.	0.81%	558,098
36	TEVA	Teva Pharmaceutical Industries Limited	0.77%	2,345,688
37	BBIO	BridgeBio Pharma, Inc.	0.77%	1,042,874
38	ZTS	Zoetis Inc.	0.71%	203,923
39	PCVX	Vaxcyte, Inc.	0.70%	872,907
40	MIRM	Mirum Pharmaceuticals, Inc.	0.68%	712,399
41	PEN	Penumbra, Inc.	0.68%	119,524
42	EW	Edwards Lifesciences Corporation	0.63%	409,141
43	ZLAB	Zai Lab Limited	0.62%	799,798
44	GILD	Gilead Sciences, Inc.	0.59%	248,222
45	SRPT	Sarepta Therapeutics, Inc.	0.58%	425,047
46	COO	The Cooper Companies, Inc.	0.55%	308,155
47	INSP	Inspire Medical Systems, Inc.	0.55%	161,612
48	PTCT	PTC Therapeutics, Inc.	0.53%	488,447
49	CNC	Centene Corporation	0.49%	381,171
50	BHVN	Biohaven Ltd.	0.48%	943,603
51	TVTX	Travere Therapeutics, Inc.	0.48%	1,251,778
52	HUM	Humana Inc.	0.48%	84,489
53	ETNB	89bio, Inc.	0.46%	2,967,878
54	ARDX	Ardelyx, Inc.	0.43%	4,149,110
55	ALGN	Align Technology, Inc.	0.43%	126,344
56	STE	STERIS plc	0.42%	87,146
57	AVDL	Avadel Pharmaceuticals plc	0.41%	2,481,651
58	DYN	Dyne Therapeutics, Inc.	0.39%	1,762,688
59	TFX	Teleflex Incorporated	0.39%	133,033
60	ACLX	Arcellx, Inc.	0.39%	276,015
61	ALNY	Alnylam Pharmaceuticals, Inc.	0.37%	64,364
62	INSM	Insmed Incorporated	0.34%	211,475
63	LEGN	Legend Biotech Corporation	0.33%	459,515
64	EWTX	Edgewise Therapeutics, Inc.	0.32%	684,559
65	UTHR	United Therapeutics Corporation	0.30%	46,432
66	JANX	Janux Therapeutics, Inc.	0.30%	527,158
67	NBIX	Neurocrine Biosciences, Inc.	0.30%	125,465
68	SHC	Sotera Health Company	0.29%	1,185,882
69	NUVL	Nuvalent, Inc.	0.29%	192,147
70	RYTM	Rhythm Pharmaceuticals, Inc.	0.28%	250,045
71	IDYA	IDEAYA Biosciences, Inc.	0.28%	802,784
72	n/a	Janus Henderson Cash Liquidity Fund Llc	0.27%	12,543,863
73	ICLR	ICON Public Limited Company	0.26%	70,774
74	XENE	Xenon Pharmaceuticals Inc.	0.24%	342,490
75	CRNX	Crinetics Pharmaceuticals, Inc.	0.24%	333,994
76	FOLD	Amicus Therapeutics, Inc.	0.23%	1,330,540
77	APGE	Apogee Therapeutics, Inc.	0.22%	276,440
78	GPCR	Structure Therapeutics Inc.	0.22%	586,345
79	CYTK	Cytokinetics, Incorporated	0.21%	246,277
80	TYO: 7741	HOYA Corporation	0.20%	82,000
81	ILMN	Illumina, Inc.	0.19%	112,085
82	IQV	IQVIA Holdings Inc.	0.18%	46,667
83	MTSR	Metsera, Inc.	0.17%	300,343
84	NEO	NeoGenomics, Inc.	0.16%	796,242
85	CGON	CG Oncology, Inc.	0.15%	278,721
86	PRAX	Praxis Precision Medicines, Inc.	0.14%	178,813
87	BEAM	Beam Therapeutics Inc.	0.13%	317,304
88	n/a	Heartflow Inc - Series F	0.13%	1,934,015
89	n/a	Bicara Therapeutics	0.12%	437,827
90	IMNM	Immunome, Inc.	0.12%	818,181
91	n/a	Curevo Inc	0.11%	2,031,087
92	GERN	Geron Corporation	0.09%	2,531,635
93	n/a	Attralus Inc Pp	0.08%	669,935
94	RCKT	Rocket Pharmaceuticals, Inc.	0.08%	531,746
95	n/a	Element Biosciences Inc Pp	0.07%	425,023
96	n/a	Magnolia Medical Technologies Inc Pp - Series D	0.07%	1,821,717
97	FDMT	4D Molecular Therapeutics, Inc.	0.07%	952,085
98	n/a	Asher Biotherapeutics - Series C	0.06%	2,580,733
99	n/a	Shoreline Biosciences Inc Pp	0.06%	747,187
100	n/a	Curevo Inc Series B-1 Usd (Private Placement)	0.05%	886,774
101	LXEO	Lexeo Therapeutics, Inc.	0.05%	667,686
102	n/a	Beauty Health Co/The	0.04%	2,000,000
103	n/a	Sonoma Biotherapeutics Inc - Series B	0.04%	1,255,200
104	EFGBNK.0 03.28.19 0005	EFG International Finance Guernsey Ltd.	0.04%	342,803
105	n/a	Freenome Holdings Inc - Series C	0.04%	337,474
106	n/a	Curevo Inc Series B Usd (Private Placement)	0.04%	674,104
107	n/a	Asher Biotherapeutics Inc Pp	0.03%	1,214,301
108	n/a	Twinstrand Biosciences Inc Pp	0.03%	344,314
109	n/a	Sonoma Biotherapeutics Inc - Series B-1	0.02%	669,428
110	BCAX	Bicara Therapeutics Inc.	0.01%	42,502
111	n/a	Magnolia Medical Technologies Series E1 Usd	0.01%	301,933
112	n/a	Magnolia Medical Technologies C/Wts Usd.001	0.00%	37,748
113	n/a	Clementia Pharmaceuticals Inc	0.00%	874,311

As of Mar 31, 2025

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Asset Allocation

Asset Class	% Weight
Stocks	98.84%
Other	0.61%
Not Classified	0.28%
Cash	0.27%

Sector Breakdown

Sector	% Weight
Health Care	92.64%
Other	7.36%

Country Breakdown

Sector	% Weight
United States	78.43%
United Kingdom	4.96%
Ireland	4.30%
Switzerland	2.75%
Denmark	2.72%
DU	2.30%
France	1.93%
Japan	1.44%
Other	0.67%
Germany	0.46%
China	0.04%