Janus Henderson Global Life Sciences Fund Class A (JFNAX)

JFNAX Holdings List

As of Feb 28, 2025

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No.	Symbol	Name	% Weight	Shares
1	LLY	Eli Lilly and Company	10.12%	541,782
2	UNH	UnitedHealth Group Incorporated	5.99%	621,968
3	LON: AZN	AstraZeneca PLC	4.00%	1,301,616
4	CPH: NOVO.B	Novo Nordisk A/S	3.40%	1,849,298
5	JNJ	Johnson & Johnson	3.31%	988,275
6	ABT	Abbott Laboratories	3.18%	1,134,427
7	BSX	Boston Scientific Corporation	3.09%	1,465,859
8	EPA: SAN	Sanofi	2.89%	1,307,060
9	AMGN	Amgen Inc.	2.77%	443,481
10	ABBV	AbbVie Inc.	2.75%	647,802
11	VRTX	Vertex Pharmaceuticals Incorporated	2.68%	275,406
12	TMO	Thermo Fisher Scientific Inc.	2.36%	220,075
13	NVSN.MX	Novartis AG ADR	2.27%	1,024,252
14	ARGX	argenx SE	2.15%	169,763
15	ISRG	Intuitive Surgical, Inc.	2.08%	178,828
16	SYK	Stryker Corporation	1.78%	226,632
17	MRK	Merck & Co., Inc.	1.75%	933,062
18	DHR	Danaher Corporation	1.69%	401,307
19	AKRO	Akero Therapeutics, Inc.	1.55%	1,557,186
20	ASND	Ascendis Pharma A/S	1.43%	450,068
21	SWX: ROG	Roche Holding AG	1.41%	208,288
22	MDGL	Madrigal Pharmaceuticals, Inc.	1.29%	186,527
23	MCK	McKesson Corporation	1.22%	93,896
24	SRPT	Sarepta Therapeutics, Inc.	1.20%	554,266
25	PCVX	Vaxcyte, Inc.	1.15%	774,702
26	HCA	HCA Healthcare, Inc.	1.13%	182,337
27	MDT	Medtronic plc	1.13%	604,992
28	GMED	Globus Medical, Inc.	1.11%	682,553
29	RVMD	Revolution Medicines, Inc.	1.07%	1,296,317
30	RNA	Avidity Biosciences, Inc.	1.02%	1,644,190
31	COR	Cencora, Inc.	1.02%	197,411
32	LNTH	Lantheus Holdings, Inc.	0.98%	512,716
33	SLNO	Soleno Therapeutics, Inc.	0.92%	927,066
34	DXCM	DexCom, Inc.	0.88%	492,126
35	ELV	Elevance Health, Inc.	0.86%	107,038
36	PEN	Penumbra, Inc.	0.81%	140,662
37	ZTS	Zoetis Inc.	0.81%	238,894
38	TEVA	Teva Pharmaceutical Industries Limited	0.79%	2,354,360
39	CVS	CVS Health Corporation	0.76%	567,732
40	VRNA	Verona Pharma plc	0.75%	529,349
41	HUM	Humana Inc.	0.73%	132,999
42	BHVN	Biohaven Ltd.	0.72%	955,621
43	MIRM	Mirum Pharmaceuticals, Inc.	0.69%	715,033
44	INSP	Inspire Medical Systems, Inc.	0.61%	162,209
45	EW	Edwards Lifesciences Corporation	0.60%	415,506
46	BBIO	BridgeBio Pharma, Inc.	0.60%	845,214
47	ZLAB	Zai Lab Limited	0.58%	822,848
48	GILD	Gilead Sciences, Inc.	0.57%	247,316
49	COO	The Cooper Companies, Inc.	0.57%	309,293
50	ETNB	89bio, Inc.	0.56%	2,978,851
51	PTCT	PTC Therapeutics, Inc.	0.55%	490,253
52	DYN	Dyne Therapeutics, Inc.	0.49%	1,789,518
53	ARDX	Ardelyx, Inc.	0.45%	4,164,450
54	CNC	Centene Corporation	0.45%	382,580
55	ALGN	Align Technology, Inc.	0.44%	116,543
56	TFX	Teleflex Incorporated	0.42%	156,345
57	AVDL	Avadel Pharmaceuticals plc	0.40%	2,490,826
58	TVTX	Travere Therapeutics, Inc.	0.40%	916,188
59	STE	STERIS plc	0.39%	87,468
60	UTHR	United Therapeutics Corporation	0.38%	59,200
61	EWTX	Edgewise Therapeutics, Inc.	0.36%	687,090
62	ACLX	Arcellx, Inc.	0.36%	277,035
63	JANX	Janux Therapeutics, Inc.	0.36%	540,480
64	IDYA	IDEAYA Biosciences, Inc.	0.34%	805,752
65	ILMN	Illumina, Inc.	0.34%	186,546
66	LEGN	Legend Biotech Corporation	0.33%	461,214
67	ALNY	Alnylam Pharmaceuticals, Inc.	0.32%	64,601
68	INSM	Insmed Incorporated	0.31%	184,539
69	NBIX	Neurocrine Biosciences, Inc.	0.30%	125,928
70	SHC	Sotera Health Company	0.30%	1,190,266
71	GPCR	Structure Therapeutics Inc.	0.28%	588,513
72	RYTM	Rhythm Pharmaceuticals, Inc.	0.28%	250,970
73	ICLR	ICON Public Limited Company	0.27%	71,035
74	TYO: 7741	HOYA Corporation	0.26%	108,500
75	XENE	Xenon Pharmaceuticals Inc.	0.26%	343,756
76	FOLD	Amicus Therapeutics, Inc.	0.26%	1,335,459
77	CRNX	Crinetics Pharmaceuticals, Inc.	0.24%	335,229
78	CYTK	Cytokinetics, Incorporated	0.23%	247,188
79	IQV	IQVIA Holdings Inc.	0.18%	46,838
80	CGON	CG Oncology, Inc.	0.16%	309,788
81	NEO	NeoGenomics, Inc.	0.16%	799,184
82	APGE	Apogee Therapeutics, Inc.	0.16%	250,825
83	IMNM	Immunome, Inc.	0.16%	821,206
84	MTSR	Metsera, Inc.	0.15%	291,761
85	PRAX	Praxis Precision Medicines, Inc.	0.14%	179,474
86	RCKT	Rocket Pharmaceuticals, Inc.	0.13%	666,988
87	n/a	Heartflow Inc - Series F	0.12%	1,934,015
88	n/a	Bicara Therapeutics	0.12%	437,827
89	n/a	Curevo Inc	0.11%	2,031,087
90	GERN	Geron Corporation	0.10%	2,930,421
91	FDMT	4D Molecular Therapeutics, Inc.	0.08%	885,867
92	n/a	Attralus Inc Pp	0.08%	669,935
93	n/a	Element Biosciences Inc Pp	0.07%	425,023
94	n/a	Magnolia Medical Technologies Inc Pp - Series D	0.06%	1,821,717
95	n/a	Asher Biotherapeutics - Series C	0.06%	2,580,733
96	n/a	Shoreline Biosciences Inc Pp	0.06%	747,187
97	n/a	Curevo Inc Series B-1 Usd (Private Placement)	0.05%	886,774
98	n/a	Beauty Health Co/The	0.04%	2,000,000
99	n/a	Sonoma Biotherapeutics Inc - Series B	0.04%	1,255,200
100	LXEO	Lexeo Therapeutics, Inc.	0.04%	668,529
101	EFGBNK.0 03.28.19 0005	EFG International Finance Guernsey Ltd.	0.04%	342,803
102	n/a	Freenome Holdings Inc - Series C	0.04%	337,474
103	n/a	Asher Biotherapeutics Inc Pp	0.03%	1,214,301
104	n/a	Twinstrand Biosciences Inc Pp	0.03%	344,314
105	n/a	Sonoma Biotherapeutics Inc - Series B-1	0.02%	669,428
106	CRGX	CARGO Therapeutics, Inc.	0.02%	277,309
107	n/a	Janus Henderson Cash Liquidity Fund Llc	0.02%	781,711
108	BCAX	Bicara Therapeutics Inc.	0.01%	42,555
109	n/a	Magnolia Medical Technologies Series E1 Usd	0.01%	301,933
110	n/a	Magnolia Medical Technologies C/Wts Usd.001	0.00%	37,748
111	n/a	Clementia Pharmaceuticals Inc	0.00%	874,311

As of Feb 28, 2025

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Asset Allocation

Asset Class	% Weight
Stocks	99.17%
Other	0.55%
Not Classified	0.26%
Cash	0.02%

Sector Breakdown

Sector	% Weight
Health Care	92.64%
Other	7.36%

Country Breakdown

Sector	% Weight
United States	78.43%
United Kingdom	4.96%
Ireland	4.30%
Switzerland	2.75%
Denmark	2.72%
DU	2.30%
France	1.93%
Japan	1.44%
Other	0.67%
Germany	0.46%
China	0.04%