Janus Henderson Global Life Sciences Fund Class I (JFNIX)

JFNIX Holdings List

As of Apr 30, 2025

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No.	Symbol	Name	% Weight	Shares
1	LLY	Eli Lilly and Company	9.78%	504,586
2	UNH	UnitedHealth Group Incorporated	5.36%	604,474
3	LON: AZN	AstraZeneca PLC	4.07%	1,317,890
4	BSX	Boston Scientific Corporation	3.20%	1,442,715
5	EPA: SAN	Sanofi	3.18%	1,343,921
6	ABT	Abbott Laboratories	3.06%	1,084,647
7	VRTX	Vertex Pharmaceuticals Incorporated	2.93%	267,023
8	ABBV	AbbVie Inc.	2.57%	610,948
9	AMGN	Amgen Inc.	2.51%	400,714
10	NVSN.MX	Novartis AG ADR	2.44%	995,846
11	ARGX	argenx SE	2.43%	174,725
12	JNJ	Johnson & Johnson	2.33%	690,591
13	CPH: NOVO.B	Novo Nordisk A/S	2.17%	1,507,022
14	TMO	Thermo Fisher Scientific Inc.	2.13%	229,749
15	ISRG	Intuitive Surgical, Inc.	1.96%	176,523
16	DHR	Danaher Corporation	1.75%	407,506
17	MDT	Medtronic plc	1.74%	954,025
18	SYK	Stryker Corporation	1.70%	211,410
19	HCA	HCA Healthcare, Inc.	1.63%	219,174
20	SWX: ROG	Roche Holding AG	1.59%	225,412
21	AKRO	Akero Therapeutics, Inc.	1.52%	1,548,578
22	SLNO	Soleno Therapeutics, Inc.	1.49%	925,043
23	ASND	Ascendis Pharma A/S	1.49%	404,440
24	VRNA	Verona Pharma plc	1.48%	952,488
25	MRK	Merck & Co., Inc.	1.43%	779,751
26	MCK	McKesson Corporation	1.38%	89,891
27	MDGL	Madrigal Pharmaceuticals, Inc.	1.35%	186,791
28	RNA	Avidity Biosciences, Inc.	1.17%	1,659,473
29	COR	Cencora, Inc.	1.10%	174,073
30	LNTH	Lantheus Holdings, Inc.	1.09%	486,319
31	GMED	Globus Medical, Inc.	1.05%	675,875
32	CVS	CVS Health Corporation	1.02%	707,959
33	RVMD	Revolution Medicines, Inc.	0.99%	1,131,005
34	ELV	Elevance Health, Inc.	0.96%	106,300
35	DXCM	DexCom, Inc.	0.91%	590,812
36	BBIO	BridgeBio Pharma, Inc.	0.89%	1,071,457
37	PCVX	Vaxcyte, Inc.	0.81%	1,044,311
38	TEVA	Teva Pharmaceutical Industries Limited	0.76%	2,273,665
39	MIRM	Mirum Pharmaceuticals, Inc.	0.73%	782,553
40	PEN	Penumbra, Inc.	0.72%	114,196
41	GILD	Gilead Sciences, Inc.	0.72%	311,702
42	TVTX	Travere Therapeutics, Inc.	0.69%	1,538,768
43	EW	Edwards Lifesciences Corporation	0.66%	406,634
44	n/a	Janus Henderson Cash Liquidity Fund Llc	0.65%	30,151,659
45	PTCT	PTC Therapeutics, Inc.	0.61%	565,159
46	ZTS	Zoetis Inc.	0.59%	175,891
47	SRPT	Sarepta Therapeutics, Inc.	0.56%	417,624
48	INSP	Inspire Medical Systems, Inc.	0.55%	160,623
49	COO	The Cooper Companies, Inc.	0.54%	306,267
50	ZLAB	Zai Lab Limited	0.53%	774,958
51	NUVL	Nuvalent, Inc.	0.51%	310,685
52	ETNB	89bio, Inc.	0.51%	2,954,697
53	CNC	Centene Corporation	0.49%	379,640
54	ARDX	Ardelyx, Inc.	0.49%	4,126,910
55	HUM	Humana Inc.	0.47%	83,811
56	AVDL	Avadel Pharmaceuticals plc	0.47%	2,466,448
57	DYN	Dyne Therapeutics, Inc.	0.46%	1,812,283
58	INSM	Insmed Incorporated	0.42%	271,900
59	STE	STERIS plc	0.42%	86,615
60	BHVN	Biohaven Ltd.	0.41%	860,269
61	ALGN	Align Technology, Inc.	0.40%	107,095
62	TFX	Teleflex Incorporated	0.38%	130,135
63	ACLX	Arcellx, Inc.	0.38%	274,324
64	JANX	Janux Therapeutics, Inc.	0.38%	534,838
65	RYTM	Rhythm Pharmaceuticals, Inc.	0.36%	255,211
66	ALNY	Alnylam Pharmaceuticals, Inc.	0.35%	62,109
67	IDYA	IDEAYA Biosciences, Inc.	0.35%	797,867
68	LEGN	Legend Biotech Corporation	0.34%	456,616
69	GPCR	Structure Therapeutics Inc.	0.33%	567,809
70	EWTX	Edgewise Therapeutics, Inc.	0.30%	851,171
71	NBIX	Neurocrine Biosciences, Inc.	0.30%	129,592
72	SHC	Sotera Health Company	0.29%	1,157,051
73	UTHR	United Therapeutics Corporation	0.29%	43,776
74	XENE	Xenon Pharmaceuticals Inc.	0.28%	340,922
75	SRRK	Scholar Rock Holding Corporation	0.28%	391,758
76	MTSR	Metsera, Inc.	0.25%	477,694
77	TARS	Tarsus Pharmaceuticals, Inc.	0.25%	219,184
78	CRNX	Crinetics Pharmaceuticals, Inc.	0.24%	331,949
79	ICLR	ICON Public Limited Company	0.23%	70,341
80	APGE	Apogee Therapeutics, Inc.	0.21%	248,120
81	TYO: 7741	HOYA Corporation	0.21%	81,500
82	PRAX	Praxis Precision Medicines, Inc.	0.20%	249,921
83	FOLD	Amicus Therapeutics, Inc.	0.20%	1,210,839
84	ILMN	Illumina, Inc.	0.18%	108,141
85	IQV	IQVIA Holdings Inc.	0.16%	46,382
86	BCAX	Bicara Therapeutics Inc.	0.15%	479,328
87	n/a	Heartflow Inc - Series F	0.13%	1,934,015
88	IMNM	Immunome, Inc.	0.12%	649,262
89	n/a	Curevo Inc	0.11%	2,031,087
90	n/a	Magnolia Medical Technologies Inc Pp - Series D	0.07%	1,821,717
91	FDMT	4D Molecular Therapeutics, Inc.	0.06%	842,949
92	n/a	Shoreline Biosciences Inc Pp	0.06%	747,187
93	LXEO	Lexeo Therapeutics, Inc.	0.06%	664,629
94	n/a	Element Biosciences Inc Pp	0.05%	425,023
95	n/a	Curevo Inc Series B-1 Usd (Private Placement)	0.05%	886,774
96	n/a	Beauty Health Co/The	0.04%	2,000,000
97	n/a	Sonoma Biotherapeutics Inc - Series B	0.04%	1,255,200
98	n/a	EFG International Finance Guernsey Ltd.	0.04%	342,803
99	n/a	Freenome Holdings Inc - Series C	0.04%	337,474
100	n/a	Curevo Inc Series B Usd (Private Placement)	0.04%	674,104
101	n/a	Asher Biotherapeutics - Series C	0.03%	2,580,733
102	n/a	Twinstrand Biosciences Inc Pp	0.03%	344,314
103	n/a	Attralus Inc Pp	0.02%	669,935
104	n/a	Sonoma Biotherapeutics Inc - Series B-1	0.02%	669,428
105	n/a	Asher Biotherapeutics Inc Pp	0.02%	1,214,301
106	n/a	Magnolia Medical Technologies Series E1 Usd	0.01%	301,933
107	n/a	Magnolia Medical Technologies C/Wts Usd.001	0.00%	37,748
108	n/a	Clementia Pharmaceuticals Inc	0.00%	874,311

As of Apr 30, 2025

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Asset Allocation

Asset Class	% Weight
Stocks	98.84%
Other	0.61%
Not Classified	0.28%
Cash	0.27%

Sector Breakdown

Sector	% Weight
Health Care	92.64%
Other	7.36%

Country Breakdown

Sector	% Weight
United States	78.43%
United Kingdom	4.96%
Ireland	4.30%
Switzerland	2.75%
Denmark	2.72%
DU	2.30%
France	1.93%
Japan	1.44%
Other	0.67%
Germany	0.46%
China	0.04%