Hello, everyone. I'm Ankur Dhingra, Vice President of Investor Relations for Agilent. I welcome you all to Agilent's Investor Day, our third since launch of new Agilent in 2015. This has typically been an in-person event. Due to the pandemic, we have all found new ways of working, so we are all here virtually this time, and I thank you all for your participation in this new format. Today, we will provide a comprehensive update about our strategy and businesses. Joining today are Mike McMullen, Agilent's President and Chief Executive Officer, Bob McMahon, Agilent's Senior Vice President and Chief Financial Officer, Jacob Thaysen, President of Agilent's Life Sciences and Applied Markets Group, Sam Raha, President of Agilent's Diagnostics and Genomics Group, and Padraig McDonnell, President of Agilent CrossLab Group. Before we get into the event, let me cover our safe harbor.
Today's presentation and comments by our executive team will include forward-looking statements about growth, prospects, and financial performance of the company. These statements are subject to various risks and uncertainties and are only valid as of today. The company assumes no obligation to update them. Please look at the company's recent SEC filings for a more complete picture of our risks and other factors. Today's comments will refer to non-GAAP financial measures. For historical measurements, you will find the most directly comparable GAAP financial metrics and reconciliations on our website. Unless otherwise noted, all references to increases or decreases in financial metrics are year-over-year, and references to revenue growth are on a core basis. Core revenue growth excludes the impact of currency and the acquisition and divestitures completed within the past 12 months. With that, it's my pleasure to turn the event over to Mike. Mike?
Welcome to our first virtual Analyst Investor Day. Just delighted you can join us here today. We are very much looking forward to sharing with you the Agilent story. The plan for today, Bob and I will open with an Agilent overview, then you'll hear from our group presidents, Jacob, Padraig, and Sam, on their respective group strategies that align directly to our Agilent Enterprise Growth Strategy. We open it up for Q&A from our sell side coverage. I'm up first. I will cover three topics with you. First of all, our current shareholder value creation model. How we plan to continue an approach that is delivering. Our plan to continue to drive growth, how we plan to accelerate our momentum, and looking forward, what can you expect from the Agilent of the future? A reminder, who is Agilent?
We are a global leader in a $58 billion life science and diagnostics marketplace. We touch almost all the world's 275,000 laboratories. We have significant opportunities for shareholder value creation. We are greater than $5 billion revenue, highly profitable with a track record of double-digit EPS growth. It's not just about maintaining our slice of a big market. We are focused on growth and value creation. In a global pandemic, we've continued to increase our market share in key markets, improve year-over-year operating margin while delivering EPS growth. All of which drive value creation. We have a plan to continue on the path we are on. We are not complacent. We plan to continue doing what we promise. I want to remind you about our approach to creating shareholder value.
Our shareholder value creation model is all about delivering above-market growth, continued operating margin expansion, and a balanced capital deployment policy with prioritization on growth. This approach is delivering and remains intact and will remain unchanged. When I first talked about this in 2015 with many of you, I really believed in it. I still believe it's the best approach for Agilent. We are a growth company. This is the stuff that Chief Executive Officers dream of. Our team is on fire, and it shows in our performance. Growing market share, improving margins, we continue to create shareholder value. Let me remind you of the growth company we've built. In the past five years, we've added $1.3 billion in revenue. We are executing a buy and build strategy to win the high growth markets, building on a strong core franchise. Our strategic approach is relatively straightforward.
Our execution is what has made a difference. We are building on our analytical lab instrument franchise. Led by our CrossLab Group, we are now targeting the entire lab market ecosystem, not just the Agilent install base, and the results speak for themselves. We've also built and expanded our business in other high growth markets. For example, as expanding our biopharma tools offering, building the cell analysis and oligo CDMO business, these investments are paying off. The results to date, more than 80% of the $1.3 billion in increased revenue delivered by the Agilent team since 2015 are from high growth markets. There's more to come. Our buy and build growth strategy is working. We are outpacing our competition by growing faster in these high growth markets. Our shareholder value creation model is delivering. Delivering above-market growth, 6% CAGR since 2015.
Operating margins up 500 basis points. Double-digit EPS, 14% compound annual growth rate. We are creating shareholder value, and there's more to come. Enough about the past. Let's look to the future. How will we sustain our success, this delivery of excellent results, and accelerate our momentum? First of all, let's talk about where do we compete. Just a reminder of the markets we're in. We're in large, attractive markets, driven by investments to improve the human condition, the quality of life. Across these markets, we have leadership positions in key technologies and service offerings. We are operating from a position of strength. Collectively, for these markets we participate in, the overall growth rate is 3%-5%. Solid, but there are faster-growing segments within this overall large market. This is where we are pointing with our build and buy strategy on these high-growth segments.
The result, as you can expect, is continued above-market growth. Let's talk about how we're going to do that. Here's Agilent's build and buy growth strategy, which is comprised of our three core growth strategies. First, Transform the Analytical Lab. We are continuing to lead the transformation of the analytical lab. We believe customers need to have both world-class scientific outcomes and to manage a lab environment efficiently and effectively, what we call improving the economics of the lab. Second, Gain Share in Cancer Diagnostic and Genomics. We plan to more deeply penetrate this existing market and build scale in our chosen areas. Finally, Enter and Expand in High-Growth Markets. We will continue to add offerings in biopharma tools, grow our cell analysis business and our oligonucleotide businesses, and help in the fight against COVID-19.
Our growth strategy is enabled by our innovation prowess, our digital M&A capabilities, and our ability to expand globally as well, all built on the foundation of our unique One Agilent culture. Let's take a deeper look at each of these strategies. In the analytical lab market, our customers are in the midst of a major transformation. These customers are seeking both innovative scientific outcomes and efficient lab operations. Agilent is leading the transformation. At the core of our efforts is an integrated platform strategy, where in the lab we will offer intelligent instruments, new customer business models like subscription services, integrated workflows, all in an integrated digital ecosystem. You're going to hear more later today from Padraig and Jacob, a few additional comments. In this transformation, our integrated platform is intended to address critical customer needs, shown here in green on this slide.
Our customers have four big needs: leading scientific capabilities, efficient operations with knowledgeable and dependable support, all in a digitally connected environment. These needs are met with our integrated platform, as you can see in the center graphic. This is where our LSAG and ACG businesses join together, and where we apply our unique winning formula. We have an industry-leading portfolio, both the breadth and the size of the installed instrument base. This is coupled with services scale and an integrated software and solutions portfolio. The result, accelerated growth. We are improving both the science and the economics of the lab.
Our second growth strategy is focused on gaining share in cancer diagnostic genomics. We are taking a differentiated approach to these markets to leverage our strengths and competitive advantages, all focused on finding that sweet spot where our strengths match market opportunities for faster growth and building scale in our areas of interest. These are our key growth strategies. For cancer diagnostics, expand the menu on our leading automation platform. Leverage our leadership in IHC companion diagnostics with pharma. For genomics, provide best-in-class workflow components. Enable clinical research and diagnostic testing. You'll hear later some more exciting details from Sam. We are entering and expanding our presence in high-growth markets. Our focus areas are biopharma tools, cell analysis, and building a GMP-grade oligo business for RNA-based therapeutics, what we call our NASD business, and Agilent has a role to play in helping this global fight against COVID-19.
Let's take a deeper look. We have built a greater than $600 million biopharma business, growing double digit across the entire biopharma value chain. We are focused on executing three strategies. Developing leading analytical tools and workflows across the entire biopharma value chain. Building market leadership in oligo-based APIs for RNA-based therapeutics. Integrated cell analysis solutions for immunotherapy, biologics research, cell and gene therapy. A large, double-digit growth business for Agilent, with more to come. We are aggressively investing to increase our oligonucleotide capacity, building on our strengths to continue to grow share in this high-growth market. Our Frederick, Colorado state-of-the-art facility came fully online in 2020 with an initial production line, and we're expanding further to capture more growth, as we just announced plans for $150 million capacity expansion. We have a broad-based book of business with over a dozen customers with multiple programs per customer.
We have built this business to date on clinical trial demand and expect further growth as products come on market. We continue to take share in this rapidly growing market by capitalizing on our differentiated strengths and capability and our willingness to aggressively invest. More to come from Sam. As you know, cell analysis is a rapidly growing market. As we entered 2016, we had zero cell analysis business at Agilent. Today, we have a greater than $300 million business. It's scaling fast and growing double digit. Our broad portfolio has positioned us well to meet the needs of emerging therapeutic development. We are well positioned to support research and treatment areas like immunology, infectious disease, and other therapies. Jacob will cover this in more detail and share our go-forward plan to capture continued growth in this very exciting market.
Agilent continues to help in the fight against the COVID-19 pandemic. We put our broad portfolio to immediate use in three key areas, testing, research, therapeutic development. Our quick response to the pandemic delivered a 2% point bump in revenue growth. As we look forward, we see additional opportunities for Agilent in serology testing, direct viral detection, and wastewater viral detection. You'll hear more about this later from Jacob and Sam. While COVID-19 offerings are not part of our core strategy, we will continue to look for opportunistic ways to support the fight against the virus. You've heard about our growth strategies. A key question to ask now is, how do we consistently execute and outperform? I believe we have a few critical strategic enablers. Our focus on innovation. We'll have a video to show you later about innovation at Agilent.
Our ability to expand globally, a successful M&A track record, and our growing digital capability, all built on a unique One Agilent culture, where we emphasize collaboration, people, and results orientation. I can't emphasize this enough. The Agilent culture is our secret sauce. It makes high performance sustainable and possible over a long period of time. The pandemic has changed our customers' behavior. They are now increasingly engaging in our digital channels, and we think this is a change that will stick. Our digital investments are not just about improving how we serve customers. We also continue to invest in our internal systems to improve capability and drive efficiency. We are fortunate to have made investments prior to the pandemic, and we will continue to invest. The results are clear. We are able to extend what we can offer to customers. We are improving our customer experience.
We have greater efficiency in our operations. We are aggressively investing in digital to drive growth, increase loyalty, and improve operating margins. Five years ago, we focused on building a strong core business. In the intervening years, we built M&A capability so we could further expand into high-growth strategic markets. This growing focus on strategic deployment of capital occurs within a well-defined framework. We will continue to buy businesses where the market is high growth. It makes strategic sense and where the acquisition is accretive both to growth and to earnings. The result so far has been the addition of over $400 million of profitable revenue growing double-digit. Agilent grows when we focus on a particular geographic growth market. In particular, we are paying close attention to China, where market growth is expected to be above the overall global market average.
Our focus on China is built on three assumptions. First, because it's a high-growth market. Second, because we have not yet fully penetrated the market for some of our lines of business. Finally, we are established in China. For the past 30 years, we've built knowledge of the market and built organizational capability that provides us with competitive advantage. We believe we can win in this geographic market because we have compelling offerings, an excellent team, and we are well established and trusted. I believe you'll continue to see revenue growth from our focus on China. This is where I'm tempted to brag. When we are benchmarked externally, our employee engagement scores are well into the 90th percentile. You might say world-class. Our Glassdoor rating is over four, and you know that employee engagement is a critical predictor of future company performance.
As a result, we can attract the talent we need, and we get to keep our top talent. It also makes us a much more attractive acquirer in our M&A pursuits. Our talent advantage allows employees to work as one team focused on a relentless drive to satisfy customers, seamless collaboration to drive results. I often refer to our One Agilent culture as our secret sauce that drives our high performance. It is our culture that makes our high performance sustainable over time. We have a winning culture, and I couldn't be more proud of our Agilent team. In wrapping up my comments, I want to affirm that we have a plan to continue our high performance. We have no plans to take our foot off the gas. While the pandemic challenged us this year, the Agilent team is engaged, focused, and optimistic about our future.
Our approach is straightforward and remains the same. We have a single-minded focus on supporting our customers and driving shareholder value creation. You can expect more above-market growth, operating margin expansion, and a balanced deployment capital with prioritization and growth. In summary, you can expect sustained double-digit EPS growth. Now, I'll turn it over to Bob.
Thanks, Mike. Hello, everyone, and thank you for attending our Analyst and Investor Day. As Mike talked about, we are proud of what we've accomplished, and what's even more exciting are the opportunities ahead of us. I'm going to spend some time on what we've accomplished and how the company has changed, moving into faster-growing markets while still delivering strong returns for our shareholders, how this positions us for the future, and what you can expect from us. Mike touched on our value creation model. It starts with above-average market growth. How do we do that? Through driving and investing in innovation, creating a differentiated value proposition to our customers, and creating a leading product and service portfolio, one that few can match, helping drive market share gains, and by leveraging our global scale to drive growth where the opportunities are.
That above-market growth helps enable us to continue to expand our operating margins. We've delivered 500 basis points of improvement since 2015, ending 2020 at 23.5%. We believe we have more opportunities ahead of us. Leveraging our agile Agilent system that has helped drive gross margin productivity, but also the scale of our service offerings, creates increased productivity. We've invested in our digital capabilities, making it easier to do business with us and stay connected to our customers. This played out during the pandemic. When our customers needed us the most, we were there. Investing in the business internally, expanding capabilities, and focusing on higher growth M&A targets as well. Deploying capital in a balanced fashion and deploying capital back to our shareholders through dividends and share repurchases.
This has been and will continue to be a value driver for us, all together resulting in double-digit earnings per share. Our build and buy strategy is working. We have been investing internally and externally, driving a meaningful segment of business, now over $600 million, or 12% of the company, that has exceptional growth prospects. That top box, biopharma tools, cell analysis, and NASD, grew strong double digits in Q4, and that we expect will continue to have excellent growth prospects going forward, leading the business with high single digit to double-digit growth over the next several years. Our CrossLab business has had outstanding performance and we expect it to continue. Investing in making our instruments easier to use and smarter helps drive productivity in the labs. In addition, continuing to drive the attachment rates of consumables and services is a multi-year opportunity for us.
We believe we are strongly positioned in this market given our technology breadth and global scale and reach, all on top of a strong core franchise. Going forward, we expect growth in all segments with the faster-growing areas becoming an even more meaningful part of the business. With this increased growth, we have also built a more resilient business model during the same period, with 58% of our revenues recurring. This was no more apparent than how we performed in 2020. To illustrate just how different the company is today, we went back to compare how today's Agilent performed in 2009 during the global financial crisis. In 2009, our business, a higher instrument-oriented business with lower exposure to markets like pharma, performed slightly lower than the world gross domestic product, but we are no longer that company. Let's fast-forward to 2020.
We have demonstrated that our business is vastly different than what it was during the global financial crisis. The focus on higher growth, more resilient segments of the market, such as pharma, and a focus on service and recurring business streams, we've been able to show how much stronger our business is. Even our instrument business performed better in 2020 than 2009 given our technology platforms and technology leadership. We continue to invest aggressively. If the pandemic showed us anything, it told us we are investing in the right places and will continue to do so. We are spending almost $400 million a year in R&D and tens of millions more in digital-related investments to drive technology leadership. We are disproportionately spending on higher growth markets, which the group presidents will talk to you about. It's not just about R&D.
We invested $185 million to build new capacity for oligo manufacturing, which came online only a year ago and have already announced another $150 million expansion earlier this year, with more opportunities likely to come in 2021. I spoke earlier about the global scale helping drive above-market growth. That shows up in the broad distribution of our revenue around the globe, enabling us to capture opportunities as they come along. This, along with our footprint, gives us flexibility to meet the needs of our customers while driving growth. We are leading the way in working with our customers to adopt more ways of interacting with us and providing them with value in multiple ways. We talked often about the digital investments we have made and are making, driving increased customer satisfaction and stickiness. E-commerce is leading the way, with almost two-thirds of our consumables business ordered digitally.
We are also providing value in other ways, such as service contract renewals via online, and more recently, leveraging technology subscriptions, leasing, and software as a service as new ways of interacting with our customers. All told, over half a billion dollars of business goes through these channels, increasing at a rate much faster than the company. These investments have not come at the expense of margins. In fact, they have helped drive our productivity. We have driven 500 basis points of margin expansion driven by revenue growth, but also productivity gains, driving lower raw material costs, increasing capacity, and driving productivity. Going forward, you can expect more of the same, although likely more to come from OpEx leverage. This above-market growth and margin expansion has driven a 14% earnings per share compound annual growth rate, with 85% coming from income growth.
Earnings per share performance has been driven by high-quality earnings growth. Our balanced capital deployment has also served us well, as 15% of our earnings per share growth, or about two points of the EPS CAGR, has come as a result of share repurchases. You can see our balanced capital deployment in this chart. We have increased our capital deployment in the last six years, focused on growth investments both internally and externally while maintaining a healthy balance sheet, while increasing our leverage from years past. Going forward, you can expect more of the same, looking more similar to the past few years. We will remain disciplined in our M&A pursuits, but do not expect to reduce our leverage. We intend to maintain our investment-grade rating, but have flexibility within our framework to invest and provide returns to our shareholders.
Let's see how this capital deployment has played out. Since 2015, we have invested $2.5 billion in M&A. The businesses we purchased now represent 8% of our revenue in FY 2020, roughly $400 million, with a majority of that in our cell analysis business. That revenue has grown double digits and is a profitable source of income to the company. In addition, we continue to raise our dividends each year, providing a good source of additional returns to our shareholders. Our share repurchase program has been very successful. What can you expect from us going forward? Leveraging the faster-growing businesses, we expect to increase our expected core growth rates to 5%-7% over the next several years. This is an acceleration from the last Analyst Investor Day, given our increased exposure to faster-growing markets, our share gains, and compelling opportunities you'll hear more about.
We also expect to continue to drive operating margin expansion up to 100 basis points per year, also more aggressive. This is while we continue to invest in fast-growing areas and build capabilities. You can expect us to continue our build and buy strategy in deploying capital. You can also expect continued deployment for both M&A, but also returning capital to shareholders. You can expect at least 2% earnings per share growth coming from share repurchases, as well as continued growing dividend. The result is continued double-digit earnings per share growth. I'll turn it over to Jacob, who will share more about our Life Sciences and Applied Markets businesses. First, take a look at one of our key elements of our build and buy strategy, the cell analysis business.
Technology advances our future. Agilent Technologies is committed to delivering a future filled with innovation. This is particularly true for the cell analysis market. In the last few years, Agilent has established a unique position in this space. Characterizing cellular behavior and function is an increasingly critical step in understanding normal cell behavior versus diseased states. A wide range of diseases, from cancer and diabetes to neurodegenerative disorders, are characterized by altered or abnormal cell function and metabolism. Studying cellular ecosystems and the interactions between cells and in response to disease and therapeutics, cell function and metabolism is key to understanding these diseases and could lead to the development of future therapies. Traditional methods for measuring cellular function require researchers to kill cells, known as destructive endpoint assays, in order to understand how those cells were functioning when they were alive.
Agilent enables a more holistic approach to understanding the entire cellular ecosystem. Our cell analysis solutions allow researchers to gain deeper and more relevant insights to answer biological questions by studying live cells and their interactions and responses in real time. Agilent entered the cell analysis market with the purchase of Seahorse Bioscience in 2015. The subsequent acquisitions of Luxcel, ACEA Biosciences, and BioTek have expanded the portfolio of cell analysis solutions. The combination of these advanced technologies and analytical instruments are highly complementary to one another and form the foundation for Agilent's continued market growth in this area. Agilent is targeting three segments in cell analysis: immunology, immuno-oncology, and immunotherapy, infectious disease, virology, and vaccine research, and therapeutic development and production. Combined, these segments represent a $5 billion opportunity growing at 10% each year.
With Agilent's expanding range of cell analysis solutions, researchers can easily select the optimum combinations that best meet the needs for answering their biological questions and throughput needs. From investigating immuno-oncology and potential new immunotherapies or infectious disease and vaccine research, to the development and production of a new class of therapies, researchers rely on Agilent cell analysis tools to address their fundamental questions about cellular function and behavior. Agilent Cell Analysis Division is made up of a global team based in the U.S., Europe, and China, focused on long-term growth. This team works with key global customers in development of innovative workflows. Cell analysis tools provide a critical mechanism for better understanding biological function. It's also a key element driving Agilent's growth. As a company, we're committed to both innovation and growth. There's no better example of this than our thriving cell analysis business.
It is a great pleasure to spend time providing an overview of Agilent's Life Sciences and Applied Markets Group, known as LSAG. As you know, LSAG is a significant part of Agilent and the home of our analytical instrument portfolio, informatics solutions, and cell analysis businesses. We are the industry leader with the broadest portfolio in a connected ecosystem. This is key to our strategy on transforming the analytical lab together with ACG, which I will address in more details later in this presentation. The numbers speaks its own language. Even though FY 2020 was a challenging year, our low single-digit negative rate of growth was the best in the industry, and hence we built out our leadership position by taking market share across our portfolio and geographies.
Speaking about geographies, we have a well-balanced footprint, with our largest market being China, that constitute approximately 30% of our revenue. We continue to see China as a long-term growth driver. We are building out our market share position there. Our leadership position in our six end markets are fueled by an extensive customer reach to more than 260,000 customer labs. A fantastic and strong innovation engine with an industry-leading installed base of more than 600,000 instrument. This is significant aftermarket opportunities for ACG that Padraig will address later. We are not sitting still. Over the past 12 months, we have launched more than 15 new instrument solutions, which I consider quite impressive due to the COVID-19 challenges. Over the past 24 months, we have almost completely refreshed our portfolio.
I believe that's a position of strength that is key to drive the transformation of the analytical lab. However, before digging deeper into our strategy, I wanted to provide you with a few examples that not only illustrate how our solutions support our customers make impact on the quality of life, but also how our commercial team is making a sustainable impact on our customers. Let me start by cell analysis. Many of you know the story about how Dr. June at UPenn treated the first child ever with CAR T-cell for leukemia, Emily Whitehead, who has now been cancer-free for more than eight years. This was a milestone in the treatment of acute lymphoblastic leukemia and has now resulted in an FDA-approved treatment.
Dr. June used Agilent's Seahorse solutions to improve the design of the CAR T- cells, and in fact, we are now further expanding our collaboration with Dr. June through our thought leader program, with the aim of characterizing and monitoring cell therapy production using our broad range of cell analysis tool. I'm quite excited about the opportunity to work closer with Dr. June to advance the fight against cancer, where our cell analysis tools play a vital role. Another great example where our broad analytical instrument solutions are making an impact on human conditions is related to the investigation of long-term impact of climate changes, and this example is literally close to home for us here in California, in which researchers are studying the effect of chemicals released in the devastating wildfires that has burned through the U.S. West Coast over the past years.
Researchers from UC Davis are using highly sensitive and accurate Agilent solutions based on our GC/Q-TOF to identify the chemicals in the ashes. The composition of these ashes are quite different, as many of the fires have burned through industrial and residential areas with a significant amount of materials different from the traditional wildfires. At this point, we still don't understand the impact of these particles on the human condition. This has a real impact on mine and many of my colleagues' families. Finally, Agilent is also actively involved in supporting Professor Knappe from NC State and his research team to map out the consequences of PFAS in the environment. PFAS is a chemical that is widely used as a fire fighting foam, cookware, but also in food packaging.
These materials have been used for decades and are now posing a real threat to our health. It has been linked to various cancers and hypertension, and as the chemical is accumulating in the body, even small concentrations of PFAS can become a serious problem if consumed regularly over a long period of time. Based on Professor Knappe's research, it was found that for the past 35 years, the PFAS level in the Cape Fear River was nearly 1,000 x greater than the recommended levels. Since this is the river is the main water source for approximately 60,000 people, it's a serious concern. A significant effort has, since the conclusion of the research, successfully reduced the PFAS level in the Cape Fear River. The PFAS problem is a real environmental challenge across the world, and it's not simple to measure due to its composition and low concentration level.
Agilent's highly accurate GC and LC-MS solutions have proven to be best in class for such analysis, and we see a significant interest for these solutions around the world. These few examples illustrate well how our instrument solutions are key to address essential challenges for the human conditions. This gives me a great sense of pride to be a part of a team that has such an impact on the world we live in. To be honest, I'm just as proud of mentioning the impact our commercial team had on our customers during the past nine months fighting and dealing with the pandemic. When the COVID-19 pandemic hit, first in China and then rest of the world, we pivoted quickly to remote customer engagement and continued to serve and support our customers in the challenging times.
Many of our customers were struggling in the spring to close down labs in orderly fashion, and our team continued to serve and support them while dealing with their own COVID-19 impact on their own lives. Going through this has created lasting relationship with those customers, and we truly saw the impact of having a clear strategy, a strong culture driving innovation, teamwork, and empowerment of each team member. At all levels in this company, our colleagues used our best effort to reach out, engage, and support our customers and each other. This makes me really proud and truly impressed by the innovation and what the team came up with. We quickly moved to digital conferences and took advantage of significant investment we have made in the digital channel, which continued to fuel our sales funnel.
As an example, we had more than 2,000 customers signed up for an Agilent organized 100% virtual cell analysis conference to the fraction of the cost of a face-to-face event, but with a similar impact. Remote customer engagement, virtual conferences are areas that we truly believe have long-term sustainability way beyond COVID. Of course, we have also been in the direct fight against COVID with our cell analysis solution, supporting research, vaccine development, and oncology testing while our Bravo automation platform and consumables is central to the automated QPCR testing. Now, let's turn back to the strategy. Our customers' expectations are changing. From making purchase decision focused on each instrument category and scientific outcome to making purchase decision from vendors who can provide a differentiated solution with both scientific and lab productivity outcome. This goes way beyond providing a combination of an instrument, service, consumables, and informatics.
In fact, delivering on these custom expectations require complete transformation of the analytical lab with focus on the combination of several dimension, including the digital lab ecosystem, intelligent and smart instrument, end-to-end workflows, data analytics, Smart Alerts, and new business models. LSAG and ACG are executing on this strategy together, and you'll see me address the first three elements in my section. My partner will address the three others. It is beyond question that delivering on these customer expectations will require a broad instrument portfolio, significant investment in the digital lab, and strong clinical mass in our aftermarket to ensure uptime and lab productivity. Few industry players have this combination, but Agilent is certainly one of them.
Let me start by addressing the digital lab. We envision that the future lab will be a completely digital connected lab where all instrument solutions are operated from the same informatics platform with smart and intelligent instruments that will inform the user of the performance and the potential need for preventive maintenance. There'll be a full traceability of all samples and overview of the laboratory status and bottlenecks. All this information is stored in a cloud-based data lake that allow the user to combine informatics in across modalities to increase scientific accuracy and ensure complete insight into samples and lab performance. All the relevant data is available at the fingertips for all the stakeholders in the lab. This is powerful and plays to Agilent's strength. Now let's take a look at the digital lab.
As demand for analytical tests continues to increase, Agilent's customers need to improve the productivity of their labs while ensuring the highest levels of data quality and security. At Agilent, we recognize that meeting our customers' needs requires us to evolve and transform as a company. This evolution is being led through the Digital Lab Program, aligning product strategy and development across Agilent to deliver a unique user experience through a comprehensive portfolio of software-enabled solutions. This ecosystem will enable Agilent products to deliver significantly more value to customers. The capabilities we will deliver in this ecosystem are focused in three fundamental areas. First, we will revolutionize data access and analytics through common, secure data and communications infrastructures.
Improved data access and analytics will enable our users to use data in completely new ways, providing new insights along with the trusted answers they need. Second, we will improve time to value with intuitive products and intelligent services that require less training, mitigate errors, automate diagnostics, and allow remote assistance. Improved time to value means our customers can deploy their products faster and maintain them with less effort. Third, we will improve lab productivity by facilitating end-to-end sample tracking, providing comprehensive system utilization data, and eliminating manual data re-entry. Improved lab productivity enables our end users to deliver meaningful results to their customers more efficiently and at a lower cost than ever before.
By taking a comprehensive holistic view of our customers' business, from analytical request to delivery of results, from asset utilization to smart consumables management, our ecosystem will enable Agilent to stand out from its competitors in this dynamic market space. Our journey has already begun. OpenLab Shared Services and OpenLab ECM are providing a unified customer experience with respect to compliance support. Agilent SLIMS empowers end users to efficiently track samples as they move through the laboratory. CrossLab Asset Monitoring, the first service in the CrossLab Connect suite, and CrossLab Smart Alerts are accelerating our customers' productivity by providing new subscription software-based services to enable customers to monitor and manage their fleet of instruments as efficiently as possible.
The more lifetime value our customers get from their laboratories by using Agilent products and services, the more they will turn to Agilent as their trusted partner for those scientific products and services. Watch Agilent for future developments as we continue our digital journey.
As you can see, the digital lab will ensure that the user obtain real-time analytical insights, ensure rapid time to value through ease of use and access to data at any time, and all the information to ensure a highly efficient lab. This is not just a vision on how the future's going to look like. This is actually what we're already doing by transforming the analytical lab. We already providing the digital lab through our OpenLab platform, our SLIMS, best-in-class LIMS solution, Smart Alerts, CrossLab Connect, that allow customers today to get a deep insight in the lab performance and productivity. We also fully recognize that our customers are at different maturity levels with respect to the digital lab, we are therefore committed to an ecosystem architecture that allows our customers to move forward step by step. We call this land and expand.
We are leading the way for our customers by executing on the strategy with a clear roadmap for the future. Another key pillar in our strategy are smart instruments. Over the past years and throughout our portfolio, we have integrated sensors and intelligence in our instruments that allows for real-time monitoring of performance, ensuring that the instruments can signal if and what type of preventive maintenance is needed, helps configure for optimized performance, and a lot of other features. Let me share an example of our new 5800 ICP-OES. By capturing data from the entire wavelength range, the built-in algorithm provide a visual periodic table overview of the elements that are available in the sample and ensure that the correct measurement is performed the first time. In many labs, this reduces reruns by up to 30% and hence provides a real productivity improvement.
The failure mode predictor deliver proactive information about the health of the instrument, ensuring that no measurement have been started that can't be finished. I'm sharing this as one of the examples, but all our instruments provide similar smarts, and you will hear more from Ulrik about the power of Smart Alerts to get a full overview of the instruments in a lab in one view. The final dimension I will touch upon are end-to-end automation. As mentioned earlier, the user expectation and experience operating analytical instruments are changing, with more focus on rapid time to results and outcome. Here, the lab managers and technician in cannabis labs are good examples. This is a fast-moving segment that doesn't have the same experience as we see from many other segments.
Agilent is committed to enable those customers to ensure the highest quality of analysis, efficient lab performance with ease of use. We have therefore developed 10 ready-to-use eMethods that cover all the relevant cannabis analysis, these can be directly downloaded from agilent.com to the relevant instrument and off you go. This not only reduces time to value from weeks into hours, also ensure that the lab has the optimized eMethods available to ensure highest performance testing from day one. We have made all the relevant consumables, data analysis, and report templates available to make this a true end-to-end experience. Agilent is already the leader in the cannabis space, also with tailwind here in FY 2020, we expect that eMethods will further solidify that position. As mentioned earlier by Mike, we view biopharma as a real growth driver for Agilent and for LSAG.
This correspond to approximately $3 billion market opportunity with an expected 10% CAGR. This space fits us very well with our portfolio strength and our aim of transforming the analytical lab, and we are hence investing more than 7% of our R&D into this space. Over the past years, we have made significant investments to develop the workflow solution required to address the monoclonal antibody market opportunity, and we have seen great market adoptions. For example, in recent years, 2D-LC has been shown to be highly promising for detailed characterization of monoclonal antibodies. We have developed a highly automated 2D-LC and Q-TOF system for multi-attribute analysis directly from cell culture supernatants. This workflow enables assessment of five essential parameters, including monoclonal antibody titer, size variance, molecular weight, amino acid sequence, and post-translational modification in a completely automated way.
This takes several labor and time-intensive steps away and ensure the highest quality of results. However, we also make investments beyond monoclonal antibodies, and we are making real headway into the cell and gene therapy. Our market-leading LC/Q-TOF oligo workflow is a great example of us making an impact in a new opportunity space. Finally, I see a further extension of the analytical tool opportunity into at-line and online measurement at the manufacturing floor for both QA/QC and PAT. We already in deep partnership and developing workflows to address this space, both from a chromatography and from a spectroscopy perspective. In my final market opportunity example, I'm proud of Agilent's leadership position in live cell analysis. As you know, we're building this business up through a series of acquisitions, starting with Seahorse and followed on by Luxcel, ACEA and BioTek.
We now have a business above $300 million in a $5 billion market space with a significant growth opportunity. We entered this space based on our deep insight in cancer and immunotherapy from DGG, recognizing that the understanding of live cells would be central to advanced immunotherapy offerings. We also realized that tools for measuring live cells would be central to better understand our immune system for developing treatments for infectious diseases and biology in general. Needless to say, COVID-19 has emphasized that hypothesis, and as stated earlier, we see a significant interest from our cell analysis solution in those spaces. The real power of our live cell analysis offering is in the clear alignment with our analytical lab strategy by building differentiated multimodality workflows that are connected through a common informatics platform.
We have already seen this play out in the CAR T-cell space, where the power of our combined solutions truly come through, and the best thing, we're just getting started. I think you felt my passion for this business during the past 20 minutes, and I'm proud of leading the best in industry team with a strong company culture. We have an industry-leading portfolio of instrument solutions addressing real challenges for a safe and healthy future. Our strategy of transforming the analytical lab together with ACG is working and in full execution mode, and our customers do agree. We have the numbers to prove it. Thank you for your attention. Now I'll turn it over to Padraig, who'll share more about Agilent's CrossLab business. First, let's take a look at how innovation thrives here at Agilent.
Innovation is in Agilent's DNA. Agilent scientists, engineers, and technologists are driven to challenge the status quo, continually seeking to create additional capabilities for our 275,000 worldwide laboratory customers. This spirit of innovation helps us deliver industry-leading analytical and diagnostic solutions for our customers' critical questions and challenges. Our investment in research and development has been pivotal to innovation. Agilent has consistently invested in R&D each year. In addition, we have many programs that enable us to collaborate with leading researchers in universities, government, and industry throughout the world. However, our culture of innovation expands beyond R&D and is core to the company. From the development of products, services, or solutions offered to our customers to improvements in processes and internal operations, it's that culture of innovation that is key in allowing us to continue to deliver trusted answers for our customers.
Our vast range of expertise and unique perspectives result in a broad portfolio of products and services that push scientific boundaries and enable scientific breakthroughs and discoveries from infectious disease research, cancer research, diagnostics and companion diagnostics, new drug discovery, and ensuring the quality and safety of these next-generation therapeutics, food quality, and the safety of air, water, and soil for the sustainability of our planet.
At Agilent, we never use the word failure. If a project doesn't work out as anticipated, we don't call it a failure. Instead, we ask ourselves, "How can we learn from this, and what can we do better in the future?" In the Agilent culture, we work together to tackle the hard problems that, if solved, can really make a difference for our customers. That's really what drives us. We have the freedom to think creatively and to take the path that will lead us forward in innovation and contribution.
There will always be opportunities to challenge the status quo. Agilent selects markets where there are unmet needs, markets where we can make a difference. In meeting those needs, we can help improve the quality of life for everyone for many years to come.
Thank you for the opportunity to share our story today. I'm Padraig McDonnell, President of the Agilent CrossLab Group. CrossLab is an established, healthy, and growing business for Agilent. Our foundation set out at our establishment nearly six years ago is built on a strong customer-focused strategy, executional excellence, and a culture and value system that is second to none. We'll continue to execute on this solid strategy, building, investing in capabilities to move us forward, fully aligned to Agilent's corporate strategy. We are making asymmetric investments on a core set of strategic initiatives and enablers to help us grow the entire company. We're doubling down on areas that are fundamental to our future growth, such as digital, biopharma, customer enablement, portfolio expansion, and base business growth. Our secret sauce is our global scale and reach of our customer service organization.
I'm excited to share with you now our approach to growth and how we will help transform the analytical lab. First, a quick overview of our business. The Agilent CrossLab Group is a $1.9 billion business with a strong and growing operating margin of 27%, with 4% core growth in FY 2020 and an impressive 7% five-year CAGR growth. We've been quite resilient through the pandemic, regaining our momentum to generate 7% core growth in Q4 alone. Our sales are evenly distributed across the globe. They're ever so slightly by Asia, of which 19% of that 37% is China. Our footprint shows that a service portfolio that represents two-thirds of our revenue and consumables, which makes up the remaining third of our business. We achieve our exceptional performance by delivering customer lifetime value through digitally enabled, innovative, integrated solutions and exceptional service scale and reach.
Like our colleagues in LSAG, we serve six growth markets, delivering innovative, integrated solutions that improve the science and economics of the laboratory. Our products and services can be found in more than 260,000 global customer laboratories. We perform more than 1 million customer interactions from sales to service, and our impressive install base of more than 600,000 serviceable instruments is a foundation for our growth. Across our divisions, CrossLab provides the products, services, and expertise to get labs operational and optimized through the life cycle of the lab from start-up to shutdown. As I mentioned in the opening, CrossLab plays a significant role in Agilent's Build & Buy strategy. In transforming the analytical lab, we are generating customer lifetime value, taking advantage of our install base and delivering next generation lab optimized services.
Improving the customer experience with digital and innovating our business models to get Agilent's products and services into customer hands. We also help the company to enter and expand presence in high growth markets, specifically biopharma and China. Of the strategic enablers, we have innovation and digital woven through our approach, we choose to focus on specific geographies and M&A opportunities where it would help us grow. As Mike mentioned, our One Agilent culture cements the organization and is a critical component of how we operate. Above all, the COVID-19 pandemic accelerated our digital strategy. In addition to providing critical consumables to our customers, we saw quick and positive responses to our increased online and remote services. We also provided and continued to see solid growth in remote technical service and support offerings.
Online and on-site educational services to address the lab operational concerns, automated compliance and computer system validation, remote lab monitoring, and scheduling software. Our digitally enabled services portfolio will continue to mitigate the risk of COVID-19 related lab challenges and may even be transforming the way customers want their services delivered in the future. Customer lifetime value is a win-win proposition. First, Agilent's portfolio digitally enables innovative, integrated product software and services solutions that help customers achieve their scientific, operational, and economic outcomes over the lifetime of the instrument. Many of our lab-wide or enterprise services are vendor agnostic, such as asset utilization monitoring, and able to deliver these operational and economic benefits over a wider span of the lab, even to customers that don't own or operate Agilent instruments. Add in our global services scale and reach, and Agilent has created a trusted partnership with customers.
This partnership creates customer loyalty for our brand, which in turn generates a recurring and growing revenue stream for Agilent. A second win for us. The revenue doesn't stop at the instrument. It is evergreen of the life of the instrument, upwards of seven to 10 years. That is where we focus on growing this lifetime value for our customers who reward us with their consumables and service business and hopefully their loyalty when they need to replace or add an instrument. This is an incredibly powerful flywheel that once started, only grows faster and stronger in time. The first part of our flywheel is our install base. The opportunity for growth by leveraging our install base is huge. Approximately $30 million with every 1% increase in connect rate.
We are focusing on connecting even more of these instruments with integrated services offerings and platforms for ease of use. Investments in data analytics is helping us generate even more insight into our customer instruments, consumables, and services used. This will allow for greater and more targeted cross-sell/upsell opportunities. In the same way, we are making smart investments in our portfolio, expanding incrementally in areas that we see most growth potential, like biopharma and emerging areas like COVID-19 and cannabis and regions like China. Offering more complete solutions in the form of workflows is key to connecting with customers who want solutions in a box over traditional DIY method development. Here we are addressing the needs brought on by the personal turnover with plug-and-play solutions that a lower skilled replacement workforce can use while maintaining lab productivity and quality.
We will keep this wheel moving through our proven R&D engine and an open innovation model, which will enable us to take advantage of opportunities faster. Lastly, our global services scale is a competitive advantage for us, enabling us to reach more customer labs with more digitally enabled technical experts faster, delivering the trusted answers our customers have come to expect from Agilent. As I began on the previous slide, the unique global scale of our customer service organization really does make the difference for Agilent through superior customer service and brand loyalty. With 4,500 employees in 28 countries, we have the global scale and reach to deliver on our priorities quickly and expertly. Our global customer service organization has a deep understanding of lab operations. With 75% of the field engineers with a chemistry or biochemistry degrees, many with advanced degrees.
This expertise benefits Agilent too, as our service engineers are a superior source for sales lead generation across the company. In fact, our field service teams helped us to identify and win $265 million from leads that were generated, proving how valuable this team is to the business growth. In addition to the experts we send out to the field, we believe that our global contact center employees are a key differentiator for us as well. Even before COVID-19 struck, these professionals were troubleshooting lab issues remotely about 40% of the time. Many of our competitors don't have remote tech support in certain countries, clearly Agilent is an industry leader in this respect. In fact, our customer satisfaction service scores reached record levels across the customer journey, including onboarding, use, and support.
Our investments in digital prior to the pandemic paid off immediately as our remote technical infrastructure allowed our employees to seamlessly move from office to home office and stay connected with customers. With the acquisition of the ACEA Biosciences, we now have increased our install base for service opportunity with greater access to untapped or under-penetrated segments such as molecular biology and cell analysis laboratories. We see tremendous opportunity to capture share of the laboratory by addressing customer needs to improve their lab productivity and economics. Our next-generation lab optimization services deliver increased visibility and simplification, operational and economic optimization, and business transformation solutions to help customers make the most of their instrument investments. From Smart Alerts to our automated compliance engine, our digitally enabled offerings are helping customers monitor and maintain their systems with greater ease.
Our recently released asset utilization monitoring software is delivering unique insights to customers to optimize instrument use and performance. Recently, a large U.S. pharma company registered more than 4,000 assets with our utilization monitoring software, which provides insights to drive capital planning and instrument life cycles. Our education services saw a surge during COVID-19, including a 500% growth in registrations as we quickly pivoted to provide Agilent University and virtual instructor-led training online. We're transforming the way the laboratories work with new access models like instrument subscriptions, which provide whole workflow solutions with instruments, consumables, softwares, and services in one package. Rentals provide flexibility to quickly ramp lab productivity, as well as provide support between instruments order and installation. We'll also continue to deliver consultative services, including lab business intelligence, to help customers make smart economic and operational decisions.
In fact, a large European headquartered pharma customer tapped into CrossLab's enterprise planning expertise, purchasing $10 million of Agilent's relocation services to establish a new research and development campus, partnering with Agilent to plan for their future. Together, these next-generation service offerings will deliver the productivity and economic outcomes customers want while improving Agilent brand recognition and securing customer loyalty. Early investments in digital were affirmed during the pandemic, where customers used our digitally enabled channels for two-thirds of their consumables transactions with us. From our on-demand service request to ready-to-use carts, to on-site inventory options, customers are applauding and adopting our new and expanding shopping options, which is improving their speed and ease of experience. New digitally enabled buying models continue to attract new customers and deliver recurring revenue through e-renewals, subscriptions, and leasing and rentals.
Expanding our flexible spend programs into China and Korea markets opens up additional opportunities to capture more share and tap into changing budgeting behaviors. Our evolving service models and more self-service support through our award-winning online Agilent community and virtual assistant remote support shows that we can continue to deliver quality services in the way that customers want it, even in the hard-to-reach labs and locations. WeChat tech support and marketing, the preferred method for service interactions in China continues to be a strong connect point for our customers in this geography. Most of all, our customers have spoken with their words and their wallets, showing that we're on the right track for continued growth through the digitally enabled shop, buy, and support programs.
I just mentioned that our new digitally enabled buying models are attracting new customers to Agilent, but I want to also point out that new business models, subscriptions, rentals, and leasing are helping Agilent penetrate new and emerging markets, accessing customers at different price points and providing growth opportunities through global expansion. The current instrument acquisition process puts a lot of pressure on the customers to know exactly what they want and need over the next seven to 10 years, and have the budget to acquire those assets. Agilent has taken the pain out of the process, providing more flexible alternatives to buying an instrument outright. Instrument subscriptions are a great way to bring an entire workflow, including the instrument, consumables, software, and services into the lab at one price point for the length of the subscription plan.
Rentals, great alternatives for customers with short-term or highly dynamic analytical needs, like increasing throughput or testing new processes, or try before you buy rentals of new instrumentation. We consider rentals the Zipcar of the analytical instrument world. Leasing, by contrast, is a longer-term access model, or for those that may not be in the position to buy today, but know what they need and how will they use the instrument. Think of leasing as a minivan you reserve for the week-long road trip with your family, reliable and ready for the road. Instrument subscriptions is the fully loaded option here. The luxury car that comes with GPS, free gas, and roadside assistance all at one price, billed monthly. Our popular flexible spend plan offers customers another option for allocating funds, CapEx or OpEx, and that's to be used in Agilent consumables and services later.
This is the ultimate in ease of use and takes the worry out of the end-of-year spend plans or use-it-or-lose-it lab dollars. As Mike and Jacob have mentioned, biopharma is a key market for Agilent and CrossLab. Our consumable services and workflows support biotherapeutic research and development, helping customers reduce costs and time to market. Our column portfolio is expanding to adapt the growing range of biotherapeutic modalities. From the proteins, peptides, monoclonal antibodies, antibody-drug conjugates, and related recombinant proteins and cell and gene therapies, we are adapting and expanding. Our advanced bio columns have been designed for 6 different types of analysis and include complementary consumables and standards for sample prep and analysis. In the services space, our compliance services and asset monitoring are becoming increasingly desired by large pharma companies. We anticipate continued growth as the customers realize returns on this investment.
A big opportunity for us in biopharma is the expansion of our biomolecular service organization. The addition of BioTek and theACEA opening more doors to service in biopharma, and we're designing a customer service organization to address the needs of these labs specifically. We also see our flexible buying models as a game changer for these biopharma customers, as they quickly ramp up R&D or production while needing to keep on top of the latest technologies. Our workflows developed with our instrument partners in LSAG is another Agilent advantage. The complexity of biotherapeutic molecules makes general workflows a must for fast, efficient analysis and outcomes.
We focused on this customer need, creating off-the-shelf solutions with high-quality instruments, consumables, software, and services that customers can use to produce trusted answers to solve those tough questions in cell and gene therapy research, or in the production or development environment of new medicines. A recent example of partnering with biopharma customers comes from a recent work outfitting a build-out of a cGMP production facility in Europe. Here we developed a fit-for-purpose solution based on specific requirements to stand up a functional lab. The solution included 360 commissioned instruments, strategic sourcing of over 25 vendors, on-time delivery, which came in under budget at $1.4 million, and trained laboratory staff. This example shows another way we can partner with biopharma customers. This time delivering enterprise-wide solutions for laboratory construction based largely on our in-depth knowledge of the market and the needs of our customers.
China continues to be a strategic priority for Agilent and CrossLab, contributing significant revenue to our overall results through our large install base, digitally enabled service and brand loyalty. As you can see, ACG has delivered 15% CAGR in China for the past five years, with expectation for us to continue this trend. We believe we have real competitive advantage here with our install base opportunity we deliver China is the under-penetrated market for services with room to improve our connect rate in regions. Digital pioneer, first mover in WeChat for business, regional scale, close to 700 employees in Greater China, including contact center, sales, service, and service delivery employees. Brand awareness, strong CrossLab brand loyalty and high ACSI scores regionally. Local focus and investment. Conducting business in China for China. Consumables, parts, services, workflows specific to the China market. Historical presence.
Delivering products and services in China for years. China is and will continue to be a region we respect and invest for steady and substantial growth. We deliver results. We continue to grow above market rates with steady growth through the COVID-19 pandemic. Our execution is unmatched. Digital investments are paying off. Continued strength in China. Customer preferred service organization. We produce a growing recurring revenue stream. Strong accretive margins resulting from a focus on customer lifetime value, service delivery scale, and solution selling. Our future is bright. Opportunity for greater install base connect rate, new product and service introductions, biopharma market growth potential.
In closing, I hope that you're as excited and as optimistic for Agilent CrossLab's future as I am. I'm buoyed by the knowledge that we have the right team, the right strategy, and the right capabilities to move our plans forward and deliver value for you, our investors, as well as the customers and communities we serve. Thank you. Next, I will turn over to my colleague, Sam Raha, who will share about our Diagnostics and Genomics Group. First, please enjoy this short video highlighting one of our very exciting and fast-growing opportunities in Sam's business.
Agilent's strategic focus on growth can clearly be seen in its involvement in the fast-growing market for nucleic acid-based therapeutics. For Agilent, the development and manufacture of oligonucleotides or oligos, which pharmaceutical customers use to produce nucleic acid-based therapeutics, is a key element of the company's growth strategy. Oligos have the potential to treat cancer, rare and infectious diseases, cardiovascular indications, and other disorders. With the announcement of plans earlier this year to expand its state-of-the-art manufacturing facility in Frederick, Colorado, Agilent will more than double its capacity to develop and manufacture oligos at the site. Agilent expects demand for therapeutic oligos to grow at double-digit rates each year to over $750 million by 2025. Company's added manufacturing capacity will enable Agilent to meet this growing demand and to continue being a partner of choice to pharmaceutical and biotech companies.
As a leading oligo manufacturer for more than 20 years, Agilent is uniquely qualified to support this critical and growing industry. Our Frederick facility ensures we keep up with customer demand while continuing to deliver a premium service. Agilent also has an oligo manufacturing site in nearby Boulder. Both oligo manufacturing locations are Current Good Manufacturing Practices, cGMP facilities, as designated by the U.S. Food and Drug Administration. Both produce high-purity gram to multi-kilogram lots of active pharmaceutical ingredients for clinical stage and on-market commercial products. When customers partner with Agilent, they benefit from our industry-leading nucleic acid experience, our understanding of pharma and biotech customers' key requirements, and our commitment to this market. Our expertise allows customers and partners to efficiently advance their lead oligo candidates from clinic to market with a shared common goal of patient health and safety.
Agilent's focus on growth is not only a winning strategy for customers, researchers, and shareholders, but it's just one more example of the work we do helping to improve the quality of life.
I'm glad we were able to share that with you and give you a sense of the impressive things that our NASD team is accomplishing. We're very proud of them for what they've done and what they continue to do, and I'll have a chance to share more on NASD later in my presentation. Good morning, everyone. I'm Sam Raha, President of Agilent's Diagnostics and Genomics Group, DGG, and I look forward to sharing our story with you today. DGG provides products and services for research, translational research, and clinical testing around the world. Over the last five years, we've delivered revenue growth of a CAGR of 7%. In FY 2020, even amidst the pandemic, we delivered growth of 3% on the top line and operating margin of 18%, with a business over $1 billion.
Now, in terms of COVID-19 impact, for our cancer diagnostic clinical testing business, we saw the most significant dip in late Q2 and early Q3, and since then, we've seen a continuous improvement in this trajectory of our volume. Now, while employee safety remains our top priority, we are very proud that, through the pandemic, we've been able to continue focusing on our customers and provide them the products that they need to continue their testing. Along with that, we've been in person in their labs to ensure that they have the productivity to continue the level of testing that's required to serve their communities. To give you a frame of reference for DGG in terms of revenue, about a half a billion dollars comes from our cancer diagnostics businesses in pathology and companion diagnostics.
The other half a billion dollar comes from our DNA and RNA businesses in NASD and genomics. Looking at it geographically, about half of our revenue comes from the Americas when you include NASD. When you exclude NASD, the distribution of revenue is roughly equal between the Americas and EMEA. Either way, we're under-penetrated in Asia Pacific and see a particular opportunity for driving aggressive revenue growth in China. In DGG, we're focused on improving the human condition by providing our customers in pharma, diagnostics, and academia government segments with differentiated solutions that enable them to do four things more effectively. First is to better understand the underlying biology of living organisms, and our products in genomics enables them to do this, from elucidating.
The mechanisms of action on a molecular basis and key pathways, that's how we support this. Second, it's enabling customers to diagnose disease. We do this with our pathology products across all cancer indications, as well as our genomics products, both for cancer as well as inherited disease. Next, we enable our customers to more effectively select the right treatments. Our companion diagnostic tests really enable this by ensuring that the profile of individuals are used to match them with the most effective therapies. Finally, we play a role in enabling our customers to be more effective in developing and commercializing novel therapeutics. Our role here as a leading CDMO for oligo-based therapeutics enables us to really play a part here.
While more than 80% of our revenue comes from consumables and services, we're also excited to have a growing install base now of nearly 30,000 instruments that are serving customers in nearly 20,000 labs around the world. Further to what Mike shared earlier, DGG is also playing an important role in Agilent's build and buy strategy. I'll be sharing more details on this in the subsequent part of the presentation. Let me start with companion diagnostics. An important driver of our continued penetration of the cancer market continues to be the deep and productive relationships we have with biopharma partners to really develop, register, and commercialize companion diagnostic tests. Globally, we're working with nearly 20 biopharma companies on multiple programs, including over a dozen biomarkers across all types of cancer.
Our PD-L1 franchise continues to grow, now with seven indications that have been approved by the U.S. FDA, and registration in 85 other countries. We've now sold tens of thousands of PD-L1 kits. The course of treatment of over 1 million patients have been informed by our tests. Just imagine the thousands of years of life that have been extended by matching patients with the right treatment. Our pathology franchise is focused on cancer diagnostics and continues to grow above market. The way we've grown here and our continued focus is on expanding our menu of high-value assays. Examples of this include MMR and the recent approval in June of our second generation HercepTest. Providing these high-value assays on our flagship automated staining platform, the Dako Omnis, which has industry-leading ease of use, flexibility, and productivity for medium and high throughput labs.
We're also expanding our PD-L1 franchise, and recently approval for our seventh indication. Now, our pathology solutions are being used today in over 2,000 anatomical and molecular labs around the world, in over 85 countries. Finally, in partnership with Visiopharm, we're also excited about our expanding menu of digital pathology image analysis applications. For example, with our breast cancer panel, including ER, PR, and HER2. As I mentioned earlier, we're under-penetrated in China and see it as an opportunity for substantial growth. We're focusing and investing to see that growth. At the heart of our strategy is focusing on customer enablement. Just within the last few months, we opened a new center of excellence for genomics applications to work more closely with customers. Soon, in 2021, we'll be launching a pathologist PD-L1 training program by leveraging our Dako academies there in Shanghai and Guangzhou.
Another important part of getting closer to our customers and serving them better is investing in expanding our operational capabilities. Within the last few months, we established the capability to directly import diagnostic products into China. Coming in 2021, we're going to have the manufacturing capability to significantly reduce the turnaround time for customers that are ordering our SureSelect NGS consumables. As we continue to serve a growing number of customers in China, we continue to add to the talented team we have there. In this coming year, we're going to be making important improvements to our customers' digital experience, both in terms of finding the products that they're interested in online, as well as learning more about the applications and ultimately being able to purchase from us in a seamless way.
In terms of companion diagnostics, building on our legacy and having developed the first ever companion diagnostic in the world nearly 22 years ago, we received approval in China last year for the first ever companion diagnostic there, which is PD-L1 base for tied to Merck's Keytruda, and subsequently, we've also received approval for PD-L1 tied to Bristol Myers Squibb's Opdivo. We are excited about leveraging Agilent's long-standing capabilities and leadership in China for our analytical instruments, and our service businesses as we look to building a market-leading franchise in cancer diagnostics and genomics there. Let me turn now to our genomics business. Irrespective if a customer is using a workflow based on NGS microarrays or qPCR, what's really important is the quality of the starting samples and the confidence that they have in these samples.
That confidence most often comes from our gold standard platforms such as the Bioanalyzer and TapeStation that are found in thousands of labs around the world. We also offer customers the market-leading NGS target enrichment platform, SureSelect. Now, along with being cited in over 4,500 scientific publications, SureSelect chemistry is also being leveraged by over 1,000 customers every day, including some of the leading cancer diagnostic testing labs and inherited disease testing applications. We continue to innovate here with the recent launch of an RNA-seq application on SureSelect just this last quarter, and coming up in early 2021, the launch of a powerful new efficient exome. Our Bravo automation platform allows customers to process thousands of samples a week, and our Magnis system, uniquely designed for SureSelect, provides walkaway automation and provides a level of consistency and reduction in hands-on time that is unmatched.
Along with our leadership position in genomics quality control, as well as for target enrichment for NGS, we're also focusing on applications expansion. This includes a new offering for single-guide RNA for CRISPR-based gene editing, as well as a number of products that are being used for COVID-19, both in research and diagnostic testing. DGG products have been assisting customers in their tireless effort to understand and combat the global pandemic. While this is not exhaustive, our products are being utilized in a number of ways. In terms of therapy and vaccine development, our NASD business is working with pharma partners to develop oligo-based molecules that could be a therapy for COVID-19, and our Fragment Analyzer, automated quality control platform nucleic acids, is being used by a number of the companies that are developing mRNA-based vaccines for COVID-19.
In terms of diagnostics, our AriaMx qPCR instrument, along with a number of our bio reagents, are being used as core components of the diagnostic tests that are being used by our customers. In response to the demands for reliable and effective serological tests for COVID-19, we plan to submit an IVD serology test to the U.S. FDA in December for emergency use authorization. We also intend to register the test in Europe and other regions in the first half of 2021. We formed a specialist team with the experience and expertise in clinical diagnostic testing to really engage with these customers and advance this opportunity for us. Let me turn to NASD and nucleic acid-based therapeutics. This is a market that continues to grow at a rate of nearly 20%, we estimate to be about three-quarters of a billion dollars by 2025.
This growth is fueled by a number of things, including the rapid growth in the number of programs, in all different stages, growing from 2017, nearly 50%, to over 650 programs in 2020. The growth is also being fueled by an expansion in the number of therapeutic areas that are being treated by oligo molecules. This includes cancer, COVID-19, and a number of chronic diseases that much more broadly affect humanity. High cholesterol and heart disease is in my family. The lives of my grandfather and an uncle were cut short by it. My father suffered his first heart attack when he was 52, and I've been managing my cholesterol for over two decades now. The powerful possibility of an oligo-based therapeutic such as Novartis' inclisiran for heart disease, being able to impact population health at a global level is very exciting and could also affect millions of lives.
To meet this growing demand, we opened our second manufacturing facility in Frederick, Colorado in the summer of 2019. This is the most state-of-the-art GMP manufacturing facility and also one of the largest. Along with successfully ramping our first manufacturing line there, Train A, and thereby doubling our capacity, we announced this past August our plan to invest in an incremental $150 million to build an additional manufacturing line. Though it's early, we're making progress per our plan and intend to start product shipments from this line in the second half of 2022. NASD is primed for further capacity scaling to continue our explosive growth. As our products are key ingredients or active pharmaceutical ingredients, I'm also happy to share that we've passed FDA inspections at both our Boulder and Frederick, Colorado sites.
Along with the enormous capacity that we built and we continue to invest in, what really differentiates us is three things. First, it's the deep knowledge and expertise we have with oligos, for synthesis, for manipulation, stability, scale-up. As you know, oligos have been a key part of our business for over two decades, being fundamental to our NGS as well as our microarray product lines. Next, it's the consistent high quality of our GMP oligos, which meet the exacting requirements of our customers to be that dependable API that is at the core of their novel therapies. Finally, it's the way that we engage our pharma customers. It's based on a deep understanding of their requirements, their processes, and how they want to and need to work.
We provide customized program management for all phases of their work, from development through clinical trial support to on-market commercial product support. Looking ahead, our continued explosive growth will come from a number of things, including molecules moving into the commercial phase and the resulting increase in volume. It's new programs that we'll take on with existing and new customers, as well as us adding new molecule types, such as single guide RNA for CRISPR. To wrap up, the DGG business has shown the ability to grow profitably over the last several years and even through the pandemic, and we have the right competencies and capabilities to continue that growth. We also have the right leadership team of general managers and commercial leaders with the deep domain expertise in their areas, along with a track record of results.
We put that together with a compelling portfolio of products that are addressing growing markets. With this combination, I am confident that we will continue to make important contributions to our customers and will continue growing faster than the market. Thank you again for the opportunity to speak with you today. I'm going to turn it over now to Mike McMullen to share some closing thoughts. Mike?
Thanks, Sam. Just a few closing words. First, a huge thank you for participating in today's event. I trust you find our growth prospects compelling. I know I do. Since I stood in front of you at our last Investor Day over two and a half years ago, I'm even more convinced that we're executing the right strategy and are even better positioned for the future. We have higher growth prospects and more aggressive margin goals. I believe Agilent is on a roll, and we will continue to be on a roll. If you're a sports fan like me, you know when something special is happening with a team. We have a great team, firing on all cylinders. We are pursuing the right opportunities and winning. I couldn't be prouder of Agilent. As I often say to the team, the best is yet to come.
Before going to Q&A, we want to show you firsthand what we mean about the One Agilent culture, the secret sauce of the company, our sustainable competitive advantage.
Agilent Technologies is a global leader in life sciences, diagnostics, and applied chemical markets. We ignite innovation and provide trusted answers to the 275,000 worldwide labs using Agilent solutions. The key to our success? That's easy. It's our culture. The Agilent culture is a competitive advantage. It's the foundational support that underpins our business. We are laser-focused with a one-company mindset, delivering integrated products and services to our customers through disciplined team collaboration. Treating people with respect is core to who we are. We have a diverse, inclusive culture that is essential for bringing in new ideas and experiences that improve what we do. The strong bonds of our Agilent culture help us succeed during good times and overcome challenges during difficult times. Even in the midst of a global pandemic, the Agilent culture is one that is focused on serving customers.
Our customers continue to respond very favorably to our team's engagement and our enhanced digital capabilities. As a result, this year's customer satisfaction rankings are at all-time highs. We were there when our customers needed us, without risking the safety and health of our employees. In fact, the Agilent leadership team made protecting the health, safety, and welfare of our employees a top priority. Agilent also made a point of stating there would be no layoffs and no reductions in salary as a result of COVID-19. In compliance with local regulations, we also quickly moved to support many employees working remotely. We assisted our team with things like necessary equipment for working from home and approving flexible working hours for parents. We are providing ongoing regular communications to employees about our response to the pandemic so they're engaged and involved in understanding our approach.
We've even done things like granting an additional paid holiday this year as a thank you to all employees for their sacrifices during the pandemic. Agilent's award-winning workplace culture has been recognized around the world by organizations such as The Great Place to Work Institute and media like Forbes and The Wall Street Journal. We have the people, processes, products, and services that enable and execute our strategy of delivering value to our customers. It's the Agilent culture that is the foundation for all we do. From being a great place to work and valuing teamwork, to putting customers first and delivering shareholder value. It's the Agilent culture, coupled with the strength of the Agilent team, that truly sets us apart.
Ladies and gentlemen, thanks again for participating in today's event. At this time, we will transition to a live Q&A session. Joining in the Q&A will be Mike McMullen, Agilent's President and Chief Executive Officer. Bob McMahon, Agilent's Vice President and Chief Financial Officer. Jacob Thaysen, President of Agilent's Life Sciences and Applied Markets Group. Sam Raha, President of Agilent's Diagnostics and Genomics Group, and Padraig McDonnell, President of Agilent CrossLab Group. Please stand by as we bring the panelists into the meeting. That the speakers are in position, Agilent's management team will take questions from the analyst community. Attendees have been placed in a waiting room and will be brought into the speaker panel to ask their question. Our first question comes from Tycho Peterson with J.P. Morgan. Tycho, please enable your video and audio at this time. Please go ahead, sir.
Hey, guys. Good morning.
Morning, Tycho.
Mike, I'm wondering if you could talk about the evolution of the cell analysis portfolio. I know in the past you talked about downstream applications and bioprocess, so I'm curious how you're thinking about leveraging that technology downstream. Similarly, it seems like there'd be a number of interesting clinical applications for the cell analysis portfolio. How are you thinking about, even though it's just in LC-MS, maybe leveraging that in the DGG channel as well?
Yeah. Great questions. You're on two themes that we agree completely with. Tycho, I'll make a few opening comments, then pass it on to Jacob. In fact, we've built up this cell analysis business through a series of acquisitions that we highlighted today. We see the ability to expand into a broader section of the biopharma value chain, if you will, as part of that story. This is where the combination of the diagnostics capabilities we have because of the Dako acquisition, we're very comfortable now taking those platforms and technologies into the diagnostics area as well.
Again, I think this is why we emphasize such the importance of this One Agilent culture, because you hit on the real key theme, which was the technology may sit in one part of the company, but other parts of the company need to enable that in terms of go-to-market plan on the diagnostics front. Jacob, why don't you add a few comments to or course-correcting comments if you will, on Tycho's question?
Yeah, thank you. This is a good way to start out. It's an area that I'm very excited about. First of all, Tycho, I think we are very proud of what we have already with the cell analysis business we have built over the past years. We can definitely do more, but we definitely have the portfolios today to make a big difference. As you mentioned, today our focus is on cell analysis, particularly to support immune oncology, understand the immune system and of course, biology and infectious diseases. There's clearly opportunities to use that also in the online space for connecting that up to bioreactors, and getting online measurement and real-time measurement. This is something we're working with partners on. We don't have a product on the market today, but it's clearly something that we see interest in industry.
From a diagnostic perspective, we are already using a lot of the instruments for diagnostic applications where customers are buying our plate readers, particularly ELISA and other things that is out there. It's a part of that solution that Sam mentioned about going into serology tests where we also offer the BioTek automation there. We're definitely looking for other opportunities. We are connecting also for the flow analysis business. We're connecting that with the best-in-class flow antibodies that sits in great partnership under Sam. A lot of opportunities there. We're just getting started.
Okay. If I can ask one follow-up on the HCP business. I'm curious on the subscription model. You talked about that being a game changer for pharma. Can you talk to the take rate there? We've seen other industries go through a sales to operating lease transition, most notoriously in clinical chemistry and assay. That was pretty disruptive for that sector. I don't think it'll be as bad as for you guys, but how do you think about shifting from a capital sale model to a subscription model for some of your customers? Why would pharma be most interested per your comments? Because they obviously have pretty strong budgets.
Yes, Tycho, great question, and I'm going to have Padraig jump in on this question as well. We think we're early days, but we think that it really offers a lot of advantages, particularly on the ability to stay fresh on a technology cycle and not have to go through the kind of traditional capital replenishment program. Padraig, how would you respond to or what would you add to my response to Tycho's question?
Yeah, thanks, Mike, and thanks, Tycho. I think we are in the early stages with subscriptions in the industry. We see, for example, in cannabis workflows and small biopharmas, a big uptake, and there is a strong demand in these sections for customers using access CapEx without using their budgets. What we see is that they're able to plan over time. We're seeing it in certain smaller segments, but we do believe it's going to scale over time as customers require.
Yeah. Tycho, just to build on Padraig's response. I talked to a CEO of a smaller biopharma company just getting started, and he was all in on the subscription concept because basically it was a cash conservation view from him. Others see it as advantage from maintaining the most recent technology. What we see from an Agilent perspective, it's really a whole different sales process and you get a much different attachment rate. Of service and consumables with the overall instrument for products. Fundamentally, 100% attach rate.
Yeah, if I can add to that also, I fully agree with your analysis there over to the clinical space that we have seen that. We've seen it start about 10 years ago, 10, 15 years ago, that moved and was a disruption or at least a change in that space. I'm not sure we're seeing that in our space yet. There's a lot of different drivers. There's a different kind of reimbursement logic in our space, if any at all. What we are focused on is to ensure we have the business models, tools to support our customers wherever they're going. I think that's the key focus right now.
That's exactly right, Jacob. I think about it in a title as a portfolio of suite of options to provide customers as opposed to a transformation of the overall business. I think we're still going to have capital sales, but this gives us another arrow in the quiver, so to speak, to be able to support customers that may have a different profile or different stage in their partnership or in their evolution.
Okay, thanks. Thanks for doing the analyst day.
You're welcome.
Our next question comes from Vijay Kumar with Evercore ISI. Vijay, please enable your video and audio at this time. Please go ahead, sir.
Hey, Vijay.
You guys are looking better now. I think the one item that's pretty clear is the consistency of the background. It's pretty remarkable. Thanks for hosting the Analyst Day. One big picture on the LRP, Mike, you look at the core revenues, you guys did 6% the last five years.
Right. The core outlook is five to seven. Do you have NASD coming in, which is all incremental cell analysis, which is coming in incremental. When you think about the five to seven , should we be perhaps thinking at the upper end of the range? I'm curious to think that Sam, in his presentation, had the addressable market for NASD at $750. Is that your revenue opportunity by 2025, or is that just the market? Maybe some commentary around that would be helpful.
Yes, sure. Vijay, thanks for joining us, and thanks for the commentary on how we're showing up as One Agilent team, I think even in this virtual world. Because I hope that message really came through about how important that is for overall the future company success. The first thing I'd say is, the message we're trying to communicate is we think that the growth prospects are improved for Agilent from our prior messaging. I was talking to Bob this morning, and I said, "This really is an Agilent first to have a core revenue range out there with a seven in it." I would lean towards that end of the spectrum. There's always going to be some variability up and down in a certain market cycle.
We're really trying to communicate a message here that the growth prospects for Agilent going forward are actually better than they have been over the last five years. You also see us taking a similar position relative to margin expansion. We think the stories are only going to get better for our investors. Sam, could you add some clarity around Vijay's question about is it a market size or the Agilent business volume?
Yeah, happy to, Mike. Then Vijay, thank you very much for the question. There's a lot to be excited about in the NASD business. You've already heard me talk about the growing number of programs, the number of therapeutic areas that are coming online. I would say beyond what I already shared there, that we think that this is going to be a billion-dollar market over the next seven years. When you look at how we continue to take share, we continue to really gain new customers with meaningful molecules that we can't fully predict it, but likely to have commercial demand for it. You could see this business over the next five years becoming a half a billion-dollar business.
That was a five-year kind of look on the total market. We think we can be, what, half a billion in five years. The other point I want to try to communicate, I think, Sam, to hit on that point, is the broad-based nature of our customers. We have over 20 different pharma partners. A few of those allow us to talk publicly about our business with them. It's a broad-based book of business, which gives us a lot of confidence moving forward. As you can see, we're trying to very aggressively build out future capacity. Sam dropped a few hints that there will be something perhaps beyond the next train as well.
Fantastic. One maybe for Bob on the EPS algorithm here, Bob. I think if I heard the numbers correctly, you get maybe the upper singles on the revenues, maybe a few 100 basis points from margin expansion. Share repurchase, couple of 100 basis points gets us to double digits. I look at the net leverage of stock returns right now. Your share repurchase is supported just by your free cash that you're generating. Is M&A all of an upside in the model, and how should we be thinking about that?
That's a great question, Vijay. Because it is. The model that we were just talking about is core. The opportunity to continue to invest in fast-growing markets in places like cell analysis and other areas that we've demonstrated the ability to do that. If you think about the last four years, there's $400 million of revenue that wasn't there before. It's hard to forecast going forward, but if you added that 400 would be on top of the core business. We feel very good about the cash flow generation as well as our ability to continue to drive M&A growth opportunities in that balance fashion that we've seen, returning cash to shareholders but also driving growth.
You touched on a pipeline, Mike, on the M&A pipeline.
Yeah. It's a fairly active market right now. I think it's picked up, I'd say, in the last few months, Vijay. I think the first few months of the pandemic, I think everyone was trying to figure out how do you keep the deal flow going, and how do you keep those relationships going, and even how do you start a new one without doing your traditional face-to-face? We've really seen a, if you could almost say, a resurgence of the strength of our firm over the last few months. Nothing to announce, but we're actively working on a number of opportunities. I would say, as you probably know, the valuations are still fairly rich. If anybody has the word COVID somewhere in a marketing brochure, they now think the company's worth twice what it should be worth. We remain interested in adding to our core business.
As you correctly pointed out, this is all upside. We don't have to do M&A to make our model work. We can get that double-digit EPS growth without it. If we do the right M&A, which we will, it's the additive to that. We remain very interested and active in the market, but also want to remain disciplined and make sure that we're using the shareholders' money wisely in terms of how we invest.
Fantastic. Thanks for taking the question, guys.
You're quite welcome.
Our next question comes from Doug Schenkel with Cowen. Doug, please enable your video and audio at this time.
Hey, everyone, thanks for your efforts pulling together all this today, and thank you for taking my questions.
Doug, thanks for joining us via video. I know you're thrilled.
I'm thrilled to be here. maybe just going back to Oh.
Yeah. There you go.
Nope, I'm back.
There you go.
Just going back to some of your prepared remarks early on, Mike.
Yeah, sure.
on cancer diagnostics and genomics. You talked about these as some of your key growth drivers and key areas of focus for the company. In many ways, this makes sense given your leadership position in pathology and genomics sample prep. That said, there are many adjacencies within this category where you are under indexed or really lack a presence. With that in mind, one, should we expect meaningful catalysts in the form of internal developments related to cancer diagnostics and genomics in calendar 2021? Two, is this category the highest priority as you think about strategic endeavors?
Three, building off of that, would you be willing to add assets that are more focused on research and translational tools, in the near term with the idea of evolving them over time into clinical tools that could be sold into the pathology channel?
Great questions and happy to make a few comments here. I'm going to actually answer them in reverse order and then we'll have Sam jump in. To answer the last question, that's exactly how we see it, which is we would very much like to add additional research tools because we have this concept that we've evolved from this life science research to diagnostics continuing through translational research. We've seen that in aspect. We've seen that in some aspects of genomics already, and we think that'll continue with all of the portfolios. You heard a number of examples today on cell analysis. We didn't talk a lot about it relative to mass spec, but there's a number of our technologies that we see going in this continuum inclusive of other parts of the genomics offerings which we don't currently have.
That's very much in our area of interest. I wouldn't say it's like a father and mother when you ask them which is their favorite child, right? What I would tell you is this is one of our key growth initiatives for the company. At the same point in time, we have multiple shots on goal. We have multiple vectors for it. This is clearly very important in an area that we plan on incrementing both our internal investment, as well as a key priority on the M&A front. I would put it up there with a lot of the other things you heard about some of our growth initiatives all push towards this higher growth segments of the market.
When it's a $58 billion market, what you want to do is you want to pick the segments that are growing the fastest, that's where we're really focused on. Sam, maybe you can provide your perspective on the first comments around the strength of the portfolio. Clearly, we want to add scale in certain areas of the marketplace where we see it as well, we're under indexed. Sam, your thoughts there?
Thanks, Mike, and Doug, thank you very much for the question. You already acknowledged even in the question that we've got leadership in advanced staining in our pathology portfolio. Yeah, that gives us access to thousands of labs around the world. On the NGS-based diagnostics side, I want to make sure you're also aware, we're already serving, through our SureSelect chemistry, hundreds of labs, including some of the leading NGS-based cancer diagnostic companies and diagnostic testing labs. Our Magnis automation system, particularly for SureSelect, is something that's starting to have good traction in China, in the U.S., in Europe. That's another way we are deepening how we're serving the diagnostic market. Beyond that, I will tell you that it's more than just cancer. It's about other application expansion.
I think you heard me talk a little bit about our excitement now to start reading single-guide RNA for gene editing, CRISPR-based gene editing. That's something that we're starting and seeing good interest from our differentiated chemistry there. We also, you heard it in Mike's comments, we are looking to apply our qPCR capabilities, infrastructure, and our reach into environmental testing, which comes from our traditional Jacobs business and Padraig's business to look at wastewater monitoring, for example, for COVID-19. That would be an expansion there. We also have on-record investments through our early-stage partnership program, for example, Inivata. That gives us insight and closer access into determining how and when we play in single-cell genomics, for example.
Beyond the leadership we absolutely have in genomics-based quality control and target enrichment for NGS, there's a number of expansion applications we're looking at, and we're going to continue to focus on that organically and hopefully look to complement that because we've got great access to the market.
Great. Thank you for all that. Maybe just a couple of quick cleanup questions. First for Bob on the 50 to 100 basis points of operating margin expansion per year, that target. I'm just wondering, is there a path for ACG margins to get up around 30% and DGG to get past 25%, keeping in mind that your analytical instrumentation margins are already pretty high at this point? That's the first one. The second one is really, I think, for Padraig. You talked about 1% of incremental service attachment translating into $30 million in revenue. Can you just remind us where your service attachment rate is today and where you think that can go over the next five years? Thanks again, guys.
Great. Doug, Bob wants to take the first one and Padraig can take number two.
Yeah. The short answer, Doug, is yes, I think we absolutely believe that. I think what you can see, particularly in the ACG business, is just this tremendous advantage that we have with scale in our service organization that really helps drive very nice profitability across multiple years. I think we still have a lot of runway in front of us on two vectors. One is that scale that I talked about. The other thing is our consumables business within ACG is already the most profitable business on a operating margin business that we have, or one of the most profitable. As we get that attach rate up, which Padraig will talk about, that helps drive that mix as well.
We've got not only the ability to leverage the infrastructure or the people in the field, the service engineers in that service organization, which we've been able to do even this year, to drive margin expansion. I also see the ability to actually increase that attach rate on the consumable side, which will help drive that as well. I think on DGG as well, we have the opportunity in those areas that Sam was talking about, certainly driving very good profitable growth in our genomics business. Don't forget NASD. As we scale that business up over time, that's going to be very accretive to the overall operating, not only dollars, but margin. Sam talked about it having a potential to be over a half a billion dollars in the next several years. That's a great opportunity to actually drive both of those.
Bottom line, we're super excited about both the opportunities to drive margin there. We're not going to let Jacob off the hook either.
Padraig, maybe you can talk about the connect rates and so forth.
Yeah. I think we're really in the early innings with this. We're in the mid-20s in terms of attach rate. We see it over the years, it expanded by one or two points per year. Over the long term, we can see the opportunity to double it. In terms of how we're going to do this, it's by adding new digital and services capabilities on that side. Also the customer lifetime value, new products and services to keep the instrument running over the lifetime of the product. Also, continuing to drive the portfolio, invest in class chemistries, and including for the biopharma market, all go towards increasing the attach rate over time, which we're very bullish about.
Thanks, Padraig.
Our next question comes from Brandon Couillard with Jefferies. Brandon, please enable your video and audio at this time. Please go ahead, sir.
Hey, everybody. Thanks, Mike and the team, for putting on a great event this morning.
Thank you. Really slick production. Appreciate it.
Maybe question for Bob or Mike. In terms of the new growth algorithm and the new long-term outlook, your new core growth and margin expansion targets imply about a 37.5% incremental as opposed to the prior 35 at the midpoint. Can you tease out how we should view how you will really manage within that new range? Meaning, in the prior model, incrementals went up as the top line moved up to the top end of the range. Are you going to manage things any differently now? Meaning managing more toward an EPS growth bogey to meet that minimum 10% hurdle. If you grow 7%, does that mean you expand the margin to 100 basis points? How do you manage that relative to the higher reinvestment level?
Yeah, I'll take an initial swipe at that, Bob, and then you can jump in and check the finding on the math. I think, the way we manage the company, which is when we get to those higher ends of upward areas of growth, when you get the 6%, 7%, then you're going to be able to really expand the margin. We're not going to artificially constrain it and say, "Well, we've got to hit 10% so we can actually don't have to worry about increase in the margins because we've got this great top line going." This business, more volume would pump through our facilities, we get the margins. We heard Bob talk about the scalability relative to NASD. I would expect us to see those higher margin flow throughs as we push the higher ends of that growth range as well.
Generally, we've never had a growth range out there with a seven in it, so we really wanted to communicate the fact that we think our growth prospects are even better than what they've been in our last five years. Bob, why don't you provide some additional color on Brandon's question?
Well, I think you're absolutely right. I think the beauty of this business is as the faster the business grows, the stronger the fall through in terms of the profitability, and I would see that continuing. The areas that we're focused on in terms of faster-growing businesses throw off a very healthy incremental margin. Places like cell analysis that we talked about as well. NASD on the incremental side throw off. We're making investments there in terms of building capacity. If you look at it on an incremental basis, it's quite healthy and so forth. We think that that model has worked in the past, and we're looking to accelerate that model going forward and continue to see that margin expansion. I think we have margin opportunities across all three businesses.
I think what you've seen over the last year and a half or so is a significant improvement in the OpEx leverage. That's through the investments that we've been making in digital and our ability to leverage our footprint as we brought in new businesses and driving out efficiencies there. The fact that we've got that, and then once that top line, we're not having to add number of HR people, number of IS people, and the digital capabilities are actually helping drive better connectivity and customer satisfaction, but also driving internal productivity as well.
Yeah. Brandon, I hope one of the things that came through today, to Bob's point, is really the scalable platforms we've built, whether it be the digital platform that Bob's talked about right now, whether it be our shared services model, or, as you heard from Padraig, the scale we have in our services business. You've seen, and I know you're a very close study of Agilent's performance, the scale advantage we have on services has been a big part of the story on the margin expansion there. We think we're building these scalable platforms that allow us to be more aggressive in our outlook on margin expansion.
Maybe a follow-up for Jacob. You mentioned you've really refreshed the instrumentation portfolio entirely over the last 18-24 months. What are the biggest opportunities for an installed base refresh? To what extent do you see a pent-up demand situation in front of you after a couple of years of kind of flat to declining growth?
Yeah, you're right. There's been certainly some years there where we have seen some more challenging market conditions. We use those tough times to really refresh our portfolio, and I see opportunities in many different spaces. I think the first that comes to mind is in the GC space, our GC portfolio, which we have really refreshed, put in a lot of smart instruments so they really create value for the customer in terms of increased productivity and insights on the performance of the laboratories. There's a really good business case for them to upgrade onto the 88 series on each tool. The HPI market has been a little challenging here over the last few years, so it remains to be seen when exactly that is coming through. I'm very confident that when the investment goes back, a large part of that will go to Agilent.
I also see the investment we have done in the, particularly in the mass spec over the last few years, is paying off. We've seen that over, actually, the last few quarters, that our LC-MS business is thriving a lot. We are certainly taking share there, and I think we will see a lot more in that going forward.
Yeah, I think maybe, Jacob, just to build on what you're saying, we are certainly seeing some very encouraging signs. It's early days, but certainly Q4 in terms of the performance of the instrumentation business, and that's continuing. I think we're very well positioned, as Jacob was saying, to be able to do it, because we've been taking share in a depressed market. Q4 started to see a turnaround. That's continuing here into our fiscal Q1. We're very optimistic about not only the portfolio, but our competitive position going forward.
Yeah. That combined with how we work with our customers in the tough times in spring, where they were in big challenges, and we were there to help them. I think we're seeing that paying off right now. The combination of a refreshed portfolio, the customers starting to see money, and us really have been supporting our customers in tough times is clearly something that pays off.
Our next question will come from Dan Leonard with Wells Fargo. Dan, please enable your video and audio at this time.
Oh.
Hey, Dan.
First question maybe is just more on communication strategy. Can you elaborate on your thought process behind offering and operating a high-level operating framework as opposed to something that's more specific and dialed into a three-year window like you've done in the past? Is that just reflective of COVID uncertainty or something different?
No, not at all. I think we were just trying to be very helpful and communicate a message of increased confidence about our growth and margin expansion prospects. We thought that these ranges around revenue growth, core revenue growth, our assumptions around share repurchases and dividend growth, along with the operating margin expense, it would really be helpful to think about the longer-term growth prospects of Agilent from an earnings growth standpoint. As Bob mentioned, the M&A would be icing on the top of that cake, so to speak. Bob, anything else you'd add?
Dan, I think it's fair to say you can take this algorithm, as you said, and look at it and apply it to the next three years. If we think about the business opportunities that we have in those three buckets, the groups or even the high growth, that's going to get us to that 5% - 7% growth rate. That's an increase versus what we've seen. Certainly, we've got a number of catalysts, over the next several years that are going to help drive it. Certainly, I think just an expansion of the macro improvement here, on the core business, which we just talked about. Things like NASD, the cell analysis business and the biopharma, which we talked about across a number of the groups here, we think that those are going to be leading the growth rate for the company.
The beauty of Padraig's business, which is not just the biopharma, but the services and so forth, that's going to get back to that high single-digit growth rate because we are significantly under-penetrated there in terms of some of the markets and the dynamics there. The underlying health of that market is still very strong. I think Padraig talked about even in the space of this last year, which was challenging for sure, our contracted services business grew high single digits. When you think about that moving forward, there's no reason to think that should continue and accelerate. You get more activity in the lab, which will be on demand and higher attach rates. That's a beautiful flywheel for us. We'll certainly think about that, the framework as a guide for the next 3+ years.
Okay. Appreciate that. My one follow-up for Jacob. Jacob, you talked a lot about the digital lab strategy. Can you elaborate a bit further on how that's organized internally and how you monetize it? Is there a standalone unit inside Agilent focused on this? If so, how big is it? At what rate is it growing? Does rather the monetization just show up in greater instrument revenue? Anything you could further add?
Let me just start by saying all of that, meaning that we have a division that is our informatics division, that is responsible for our CDS tools. That's the nucleus of our digital lab strategy, but there's also parts of that, as said with Padraig, in our business. We have a business unit that is focused on going out there in place and make money based on our CDS, and thereby also our digital ecosystem. Over time, we see that grow beyond the CDS, connecting all instruments with the Smart Alerts that Padraig talked about. We have a LIMS business now with our SLIMS portfolio, and then connect it all together. Clearly, we believe that we can take market share in the informatics business itself. That would be a growth driver on its own.
The big opportunity is the leverage towards the instrument placement, consumables, and services on top of that based on that customer lifetime value that Padraig also talked about. It's really all of those above, but it's not just something floppy, it's a real business that drives real growth and real money today.
Just to add to this, Jacob, I'd just say that within our envelope of our R&D investments, this is an area of very strong increases year-over-year. This is a priority for the company. Yeah.
Our next question comes from Derik De Bruin with Bank of America Merrill Lynch. Derik, please enable your video and audio at this time.
Hi, good morning.
Hey, Derik. Looking good.
Thanks. A couple of questions. Obviously, China is a major push for you, and it's a huge market for the overall life sciences industry. Can you talk a little bit about local competition, number one? There's big investments locally in that market. Number two, the markets there are not as well established, and certainly there's a lot more switching going on and opportunities there. I'm just wondering, what has been the competitive response to this market from some of the other larger life sciences tools companies in the U.S.? What are your competitors doing? Number three, can you talk about pricing and talent? How are the margins in China holding up relative to some of the other end markets? Are you helping to offset those?
Just a big question on sort of that outlook and the competitive dynamic in APAC, but in particular in the Chinese market.
Yeah, Derik, as you know, that's a very important market for Agilent, over 20% of our revenues. The story I told today in my prepared remarks was still, we believe, an area of opportunity for the company, not only the overall market growth rate, but we have certain elements of our business such as ACG, and DGG, which we think are under-penetrated relative to the opportunity. Now to your specific questions, we're seeing it's a very high margin business for us, which makes China attractive. We've seen relatively stable pricing over the last year or so, albeit just like the global situation went down at the start of the pandemic, but it's been fairly stable. I would say that, the other thing I would point out too in terms of organizational capability and strength and being established, our attrition rates are half of the market.
We have the teams, people who've joined the company stay with Agilent, perform well. I think that gives it an edge up because we are actually very well established there, both in terms of the stability of our organizational structure, but also the stability of our customer relationships. I think you see how this has been paying off, which is really, we've been doing outsize performance relative to our peers over the last several quarters. On the local competition front, competition continues to get better. That pushes us to make sure we stay ahead of them on the innovation front. I think that's sort of a big statement. Some areas are more advanced than others.
I think in the core analytical instrumentation business, mass spec and cell analysis and other aspects of that portfolio, the Chinese companies struggle to really keep up and have that same customer experience that you see coming from Agilent. Other places like genomics, they're right on the edge with us. We got to keep pushing the innovation. That's why you heard Sam talk about doing more in China relative to his business. Bob, your close study of this as well. Anything to add to that?
No, I think you hit it spot on.
Yeah, Mike, maybe I will come with a comment. I think both Padraig, Sam, and I were sitting in China kickoff meeting here-
Yeah. That's a good one. Yeah.
The beginning of the week where we spoke to all the leaders in the Chinese companies. First of all, as Mike's saying, the team is highly energized in China and is doing very well right now. As Mike also saying, that it's still a game that's played out between the multinational companies in China. We have a very close eye to what is happening in the Chinese market. Just a reminder, ACEA is very much a Chinese entity also. Even though the headquarter was in the U.S., they had a big operation and a lot of R&D expertise sitting in China. We definitely expanded our footprint and our presence in China with the ACEA acquisition.
We are continuing to keep a close eye to this, and we'll be ready to move deals on innovation front, but also, of course, from an M&A perspective, something is popping up.
Great. I just have two quick follow-ups. One is, you mentioned that you're number two in the NASD market. Who's number one, what are the competitive differences between the two companies? What's the difference between the two? Why would one go with somebody else versus the other?
Sam, why don't you talk about your NASD business, all right? Want to answer Derik's question?
Yeah, sure. I'd be happy to. Mike, I'm not sure we talk about other companies here, but there is another.
You can tell who the leader is, leader for a while, but in terms of market share. Yeah, go ahead.
The leader in the space with the most market share is a company called Nitto Denko. We have been, Derik, I don't know if I'd say knock on wood because we feel very good for all the reasons where we're able to gain share. We have been continuing to gain significant share. The dynamics here are what leads us to win in this market is the combination of not only the technology we have, it's also about pharma really care about can they continue to expand with us, right? They are all planning on and having successful on-market drugs. Our commitment, as evidenced by both the opening of the new site last year, the further investment this year, those things help.
I think another part that I haven't necessarily talked about is, much like in our companion diagnostic business, it's very important here for pharma to have confidence in our ability to also engage with U.S. FDA and other regulatory authorities around the world. We've been able to do that very successfully to add that. It is also about knowing exactly how to work with them along the programs. Not everyone will succeed their internal programs through the clinical trial phases. I think we built a reputation, we built a capability set, and like Mike mentioned earlier, and though we talk publicly about two customers, our book of business is very strong as we enter 2021. We are working on dozens of programs with nearly 20 pharmaceutical companies, including some of the leading pharma in the world that I won't name.
We feel like we're going to continue to gain share and really grow this business.
Our next question comes from Dan Brennan with UBS.
Great. Thanks for doing this, guys. Hey, do I look good, Mike?
You sure do. I didn't think I was going to mention that. Always.
My kids don't think so. I guess the first question is on M&A. Mike, a lot of those have been a few questions towards this already, but the balance sheet's great. You could argue that this is the most exciting time we've seen in many years across your end markets, particularly in cancer diagnostics.
Absolutely.
The biotech was the largest you've done, why not, or is it possible that you might consider being a lot more aggressive over the next five years on M&A? Obviously, you have to wait for the right deal, the right price. Nonetheless, given the leverage, given the balance sheet, given interest rates, given the science, given your channel and this opportunity today, I just wonder if we look back over the next three to five years, if it's the right move for Agilent to really take a step up on the acquisitions.
Yeah. Thanks for that question. That's actually our intent. As part of my story today, I talk about how we build up organizational capability over the last several years, and that was culminated in the BioTek deal. You shouldn't assume that's the ceiling of the size of the deal. We think we can do multiples of that for the right opportunity. We'd want to keep with that overall framework. We're looking for things that are accretive to our growth rates and would add profit to the corporation. May not be initially at the corporate average. It could be dilutive from our standpoint, but accretive to earnings. As Bob mentioned, we'd want to maintain investment grade. We want to use that balance sheet to drive growth. You shouldn't assume that the BioTek is the ceiling.
For the right opportunities, we will go to multiples of that.
Just related to that, before I go to my second question, is there like an actual cap on the leverage that you would go to for the right deal?
Yeah. Hey, Bob, how about I let you handle that one?
As Mike said, our intention, and I mentioned it, is to maintain investment grade. That would imply roughly two turns from where we are right now and still be comfortably there, and that gets to the multiples here. We're not going to, because we don't need to, I would say, bet the farm, so to speak, to drive growth, because we think we have excellent growth prospects in the core business. 5%-7% with the investments that we've been making. This would be additive, and I think about it as kind of bolt-on or recent opportunities across our markets as opposed to kind of a fourth leg of the stool, so to speak.
We think we can create shareholder value without it, but we want to get it, and it'll just be additive to our story.
Great. Then maybe as a follow-up, just on Chemical & Energy, since it hasn't really been explicitly addressed during the presentation. I'm just wondering, first off, I know the exciting product innovation that you've had maybe has gotten drowned out with the macro environment that we've seen. Maybe can you speak to a little bit about what has been happening with the Intuvo, 600 and the 800, and what kind of feedback has been, and how you think about that opportunity implicit within your guidance range in the FY. I'm just wondering, is there anything that you can do maybe to mitigate more of the economic sensitivity of this business? Obviously, it's a good business. You're a leader, nonetheless, it does swing a lot more significantly than your other businesses. Anything within your strategy to kind of discuss that?
Okay, sure, Dan. Sorry, I was ready to jump in on that one. I'll make a few opening comments here, then I'll have Jacob give you the specifics about how customers are responding to our offerings. Relative to the guide assumptions and what we're seeing, we started seeing some signs of life again in the fourth quarter. We didn't feel one quarter yet was a reason to call a turn, but the book of business, as Bob mentioned, through November, since we last spoke at our earnings call, we've now closed off the month of November. The momentum for that orders and the year-end activity is happening relative to customer spending has occurred all through November. We think that relative to the guide assumption, that if this strength continues in C&E, this will be upside to our guide.
As you mentioned, there can be a cyclical nature to this aspect on the CapEx side. We're a little bit cautious in terms of calling that too soon because I learned my lesson my first year as CEO. We want to be very clear that this momentum continues in C&E and the PMIs continue to move in the direction they are, you could expect us to outperform relative to the current guide assumptions. To mute that volatility, it really comes back down to the ACG story, which is continue to build that aftermarket presence in service and consumables with our Chemical & Energy customers. What we're seeing is that the C&E customer is now moving from more of an in-source model where they have it delivering themselves to now looking to vendors like Agilent to start taking over some of the service operations.
I think that's really ultimately the answer for us from a volatility standpoint, is to continue to build out that ACG franchise. We're the clear leader in this space, and I think we just reinforced it with customers with some of these introductions. Jacob, don't you have some comments there?
Yeah, actually, now it's almost, I think it was February 2019, we introduced the 8890 and 8860. At that point in time, the market was still relatively good, though 2019 was also a very tough year. We saw a very strong pickup of the
88 series, actually moved faster rev volume than we had in our own plans. We saw very strong interest from our customers, and they could see the 8890 being, of course, the new best-in-class instrument. We also saw the 8860 really picking up, where this was more focusing on the mid-range, but also the combination with Mass Spec, which really we are taking clear market share in. Now, as you said, the market has been muted here over the past years, but we have also invested more directly into our informatics platform to even better serve that space when it's coming back. We have spent actually quite a lot of time here with customers over the past 12 months to really understand and really be ready when the markets come back, that we can really be a part of that upswing.
As Mike is saying, we see some early indications, but it's too early to call at this point of time.
Our next question comes from Steve Beuchaw with Wolfe Research. Steve, please enable your video and audio at this time.
Hi, thanks for having me on here. How's everybody doing?
We're doing just fine, Steve. Thanks for joining us today.
Happy to be here. We've covered a lot of ground already, but there are a couple areas that we haven't really spoken about that I thought we might try to round out the story on.
Absolutely.
One would be the food market. A lot has happened there in the last few years. To some extent, there's been manufacturing consolidation, and this is independent of COVID, right?
Yeah.
Independent of anything going on in China. There are certainly some changes in China. Then on top of all that, we've had a big change in terms of how people go about eating, right? Where you actually consume your meals, which has a lot of upstream implications for the supply chain. Can you put all that together? Sorry, I think I asked you five questions there. Talk about how you imagine the food business growing within the bounds of your three-to-five-year plan.
Yeah. We think it's a mid to high single-digit grower for all the reasons you outlined. There's been a major transformation of the industry structure relative to China, as you know, but also on a global basis. If anything, COVID, and the way that people want to eat these days, has only increased the interest from the public to have safe food. We think this is really good drivers for the food safety business overall, but also authentication of, is what you're eating really what it's supposed to be? There's also that element of food fraud prevention, for example, as well. We think the prospects are really quite good. Bob, I think we put up a pretty strong number this past quarter.
Yeah. It was in the 20s in terms of percent of year-over-year growth, certainly, starting off very strong here in this year as well. To build on what Mike's saying, I think we've made a lot of investments, certainly, in China as that market had kind of decentralized and so forth. I think we've, over the last several quarters, really seen the fruits of that paying off in terms of a nice recovery there. I think it's not just a China story, though. I think it's really around the world.
Yep
testing and focus on changes in where food is being produced and how it's being produced. I think we have the opportunity to benefit from that. The portfolio that Jacob just talked about in terms of being the strongest that we've ever had, I think really sets us up nicely for capturing opportunity where we're already a leader in the food market.
Yeah. To add on that, I think both of you mentioned well the China square. We've now seen a change over to contract labs, but also still the government labs have started to purchase again, and we have definitely continue to have a strong market share in the government labs, but now have seen the contract labs also increase significantly. On the global basis, what we also see of great opportunities and great growth drivers are cannabis market, which sits in our food segment, where we are the absolute leader. Even in a tough market here in 2020, we have seen growth in that market, and continue momentum in that business. There's also a lot of upcoming in the plant-based food market, artificial meat and all that we see a lot of interest in, particularly here in U.S., of companies coming up with new areas.
That's where our instruments, again, and our solutions are really taking share. A lot of interest and a lot of dynamic going on in the market, but to our benefit.
I appreciate that. The second thing I wanted to ask about that just hadn't been touched on very directly so far in Q&A is, setting aside NASD, setting aside some of the COVID-specific therapeutic dynamics that are going on, how do you think on your three-to-five-year plan about the structure of manufacturing across broader biopharma? There are some who might call it localized manufacturing, some who might call it onshoring. Is that an important variable for you? How does Agilent sort of play into any changes to, not even necessarily the amount of capacity that's out there, but the structure of that capacity?
Yeah, I think we see a structure changing over the marketplace to more onshoring. I think it's not just with the pharmaceutical industry, but also with the chemical space as well for certain key fine chemicals. We're already seeing those discussions happen with our customers. Some are driven by their own strategic endeavors or focus, ability to really have a more tighter control of the supply chain locally. Also, you're seeing it relative to governments pushing the same concept as well. We think that trend is early days, but we think it's going to be there. We're already having discussions with certain customers about it. It's probably more of a 2022 event, really, to be honest with you, relative to revenues. This is where having this global scale is really important too, because you can help them maybe even move something from one country to another.
I think it's more going to be about when they introduce new molecules to marketplace. Let's do it onshore. Bob, I know you studied this one closely.
Yeah.
Anything I missed there?
I was going to jump in here because I think, Steve, one of the things to think about there is all the investments that Jacob was just talking about in terms of the infrastructure and the investment around informatics. When we have a greenfield opportunity, our win rate is significantly higher than our install base because of the ability for us to invest in the informatics platforms and so forth. We've seen that in China. You certainly have an incumbent's bias in an existing facility. These things, we think that we're going to take our disproportionate share going forward. It's not just in the pharmaceutical space, as Mike said, it's also in some of the chemical spaces where you're looking for regionalization, and maybe smaller footprint in terms of size of a factory.
That factory, they're not going to take product and instruments from another factory and put them in. They're going to have a new opportunity from a QA/QC lab, I think we've demonstrated in new spaces, we take greater share than what we have. We're very excited about that opportunity.
Yeah, I think on top of that, Bob, thanks for mentioning the informatics, but it plays very well into products, and I started here on when you have companies that start to go into different market and have a global footprint instead or regional footprint, you also dilute the specialization you have, maybe from if you have everything in one place. That really speaks to that the customers are looking for ease of use, have a global overview on the productivity in the laboratory. It really fits well into where we're going, both the smart instruments, modelers, and that informatics ecosystem that gives you the data anywhere you sit in the world.
Our next question comes from Puneet Souda with SVB Leerink.
Hi, Mike and Bob and team.
Hi, Puneet.
All right, great. Can you hear me well?
We sure can.
All right, great. Thanks. First a bigger question for Mike. Mike, if I could sum it up, the leading growth drivers here, NASD oligos therapeutics, multi-year tailwind for you, especially when you think about the spectrum nature of these products, the cell analysis and cell therapeutics, that's a rapidly growing segment. Obviously, inorganic growth has helped you in past there. You're growing deeper and deeper into pharma and LC-MS and GC-MS and Cross Lab is also helping you there. China position is really doing well. When you think about that going ahead in the next three to five years, I don't think we could have appreciated that NASD ramp and the cell analysis is going to play out like this five years ago.
What are some of the things that are potentially underappreciated here that become more and more meaningful over the next five-year timeframe, if you could elaborate on that? Then I have a follow-up for other folks on the call.
Yeah. You've got the story, Puneet. That's exactly it. We've got a number of really positive growth drivers, I can remember getting similar questions a few years ago, I'd say people don't appreciate the fact that we've got this NASD business that could really be material to the company, I think that's played out. I would say that we often look through our position in cancer diagnostics and genomics. While they've been a part of the portfolio, there's a lot of exciting things happening in that space today. There's a lot of new things happening there. I think that's an underappreciated aspect of Agilent's growth story. It was a question we got earlier about, its investment priority, both organically and from an M&A perspective.
We think we still have untapped synergies with the presence we have with the former Dako franchise, but also the fact that we can really capitalize on this research technologies to diagnostics continuum. I think this idea, that whole area that we can have a bigger play in end markets and diagnostics and overall in the research side of genomics, I think that's part of the story that's underappreciated. I also always get questions about, hey, when's this high single digit gain going to be over for ACG? When's it going to stop? We say, why would it? I think that's also an underappreciated part of Agilent story is the sustainability of growth in a market that continues to expand as customers' needs change. There'd be a few other things that I point out.
The third thing would be whatever we do relative to M&A, that we haven't yet announced.
Okay, great. Sam, if I could ask you, quite a bit of discussion about NASD. When we think about the research oligos market, and the expansion there beyond SureSelect, you have NGS liquid biopsy, NGS and liquid biopsy TAM emerging here, quite a large TAM there with other markets, including synthetic biology and others. Wondering, if pricing gets a little bit more competitive in the marketplace, obviously, you guys have shown that you can deliver scale here with therapeutic oligos, for example. Wondering, how should we think about your position on the research oligos and longer term? I have just a quick follow-up for Jacob and Padraig.
Puneet, great question. First affirming that on the oligo side, we have over two decades of expertise, deep expertise, manipulation, manufacturing, all the different things we can do. That plays well, and we continue, by the way, to improve our efficiency and our own cost basis for that, because it's going to continue being an essential part for many things in the company. There are application expansion, which I think allows us to continue further leveraging our position related to oligos, right? You heard me speak a little bit about single-guide RNA, which is really still based on nucleic acids and our manufacturing capability there. I think that there's a number of application expansion. One other thing I will say, and I haven't spoken too much about this yet, is we're focused increasingly now on something called our interoperability strategy.
We're already in hundreds of genomics labs, and actually thousands of genomics labs, and we think, particularly around certain applications like cancer diagnostics, certain inherited diseases, we can provide this combination of easy-to-use powerful answers. What I mean by that is, setting up a workflow, for example, which would include our TapeStation for quality control, together with our Magnis system, together with our SLIMS informatics for interpretation and reporting. You put that together in such a way that you provide something that's truly differentiating. The way the market's going, and it's similar to the trends that you've heard Jacob and Padraig talk about, there's an increasing number of technicians that are getting involved. The testing is happening in a more diversified way.
By providing that, we think we have value, and we think that allows us to protect our customer base and also get more value, if you will, from our offerings.
Hey, Sam, just one other thing to build on that then, and Puneet. You mentioned liquid biopsy and so forth, and while we don't have a specific offering, we play in that market today already.
Right? Many of the customer, the companies that are in that space, are supported by Sam's business. We have the opportunity to kind of play the field here in terms of working with companies as opposed to It's an area of exploration that we continue to look at. We play in that space today, so I don't want people thinking that, hey, we don't. We just play in it at a different than the liquid biopsy test.
Great point. By the way, Puneet, just to fill, I don't know how I forgot to answer that key question that you had in there. Absolutely, what Bob said and beyond that, both through our R&D focus in genomics as well as with Darlene Solomon, our Chief Technology Officer, and our labs group, liquid biopsy is an area of extreme interest for us.
Got it. Okay, that's very helpful. A quick one for Jacob and Padraig on LC-MS and OpenLab informatics. Mass spec is becoming increasingly important here as we go to larger molecules, as complex mAb, bispecifics and other complex ADCs, and also cell and gene therapy merging into that. As you think about that, your mix of large molecules versus small molecules, maybe can you speculate as to sort of what that could be over the next five years, where that can land and how you're getting levered there, and what sort of the path that you see for getting more mass spec being more and more important there? Obviously you have a strong position here with LC-MS. Does that mean higher utilization for these tools, higher revenue growth for you in those segments?
On the OpenLab, obviously you've gone to gain market share there versus a strong competitor in the marketplace. Going ahead, obviously you can win in the greenfield opportunities, but just walk us through, how do you continue to enhance that position and gain further market share in the CDS market specifically? Appreciate it.
Okay. Padraig, do you want me to start and then you can-
No.
You can start and I'll reply.
I think first of all, you're actually right on the LC-MS space. We already have a very strong market share in the small molecules. While been kind of a separation between large and small molecules, the biotech versus incumbent pharma, this is all blending together. Each large pharma today have both small and large molecule. There's still a separation in many of the laboratories. That is, that difference of what we focused on is to developing those ease-of-use workflows. Our LC-MS business is using for the large molecule the BioConfirm software that makes it really the walk-up logic. You can go and walk up to the instrument, you can get the analysis done, and we give you the results back. You don't have to be the actual specialist anymore.
We have really used also, and Padraig can speak to that, the design then to really make sure that it's not only the instrument, but the consumables and of course, the services go hand-in-hand on the automation. That's a key focus. We are also on that, integrating that into our OpenLab CDS, so it becomes a unified experience for the customer. Anything on that part before I talk about this?
Yeah. I think on the large molecule side, you see, and as it was on the small molecule, a lot of really key workflows becoming the key topic about how it works end-to-end. The ProZyme acquisition has really helped with that in a lot of the spaces. Over time, we have a big attach rate opportunity. Of course, people that use mass spec in analytical labs, they want to make sure it's used efficiently and operating really well. That's where our services scale comes in, our consumables range really helps, too.
Yeah. The question is, how do we compete against competition in an already entrenched space from a CDS perspective? I actually think it goes beyond CDS. It's the ecosystem. I truly believe that the next-generation informatics ecosystem is all about how you enable more than one or two instrument solutions being attached, but really have the full laboratory fully digitalized, and how to ensure you can share data even between the different techniques in the laboratory, but also between the sample and understanding the operational ability of the lab. Many are being competitive right now. Maybe the data systems are 10, 15 years old and need a refresh. When that is happening, the customers are looking for what's the new best in class. Here we definitely are seeing that we are able to take share.
Great. Thanks, guys.
Our next question comes from Jack Meehan with Nephron Research.
Hello. Can you guys hear me?
We sure can.
Yeah, it's good to see you guys, too. Thanks for all of the detail today. Wanted to follow up on cell analysis.
Sure.
It's a $300 million business. Are there any goalposts you can give us as to how big you think this is going to be in five years, like you did for NASD? It's obviously a pretty hot market. Deals would be very strategic, but do you think they'd also be accretive?
I'll take the second one, then I'll point to you, Jacob, on the first question. Ultimately accretive, yes. There's a lot going on in this space, very attractive. It's a hot space. We're really pleased with the fact that we invested early in this space. We think there's targets out there that fit our M&A framework, to answer your question. Jacob, how big could this business actually be?
Yeah.
You have a paper fence up right now.
I'd definitely like to take that competition up with Sam and see who gets to that $500 million goalpost first. What I really believe is that the understanding of the immune system, clearly been accelerated by COVID, but even before that, the immune oncology and so on, is key and it's going to be a big investment area over the next years. We are well-positioned from a life science perspective. There is great opportunities with the current portfolio we already have in place. I can definitely envision that we can invest even further in it from an M&A perspective and add other techniques or content into our current business. Now, I want to remind you that all the acquisitions we have done in this space has been accretive. These have not been dilutive investments. I think you will see us continue on that trajectory.
Yep. I think that if you want to do the math on the growth rate, we would expect this business to be growing faster than the overall company.
Yeah. I think that's certainly something we should aim for.
Certainly double digits. There's no reason not to.
Yep.
Right.
We'll see who gets to $500 million first.
Yeah. Let's take that bet.
Wanted to also follow up on liquid chromatography. This is an area you've been competing well, too. What is the medium-term forecast considered for share dynamics? It'd be great just to get your thoughts on what's going on competitively in the market, both share and pricing.
Jacob, why don't you take that one? That's a core part of your business.
Yeah. We are one of the ones, if not the one leader in the liquid chromatography, and are doing quite well. Our strategy is really to go in, we have some core platforms, upsell afterwards. We see that strategy work well, that customers might want to get with an entry-level configuration, afterwards are willing to step into a more dedicated or specialized workflow, we have those offerings. That's a very powerful strategy, we are successful with that today. We have certainly seen while the other markets here over the last few years have been challenging, both into China with small molecules and the food market and so on. Clearly, our liquid chromatography business has been suffering, so has the industry. When we look into the numbers, we have over the past year taken share.
I'm pretty confident that we will take share. The question is, how's the market's going to act? I'm optimistic about 2021, also from a growth perspective.
Our next question comes from Patrick Donnelly with Citi.
Great. Thanks, guys.
Glad to.
Good to see you.
Hey, Mike. How are you?
Maybe just one on the wastewater opportunity. We've heard a few companies call that out. Can you just talk through what that could look like for you in terms of sizing and then timing as well? Then just on the competitive landscape, again, it's been a bit buzzy here. Can you talk about where you guys fit in on the competitive landscape and how things look there?
As it relates to that particular opportunity.
Yes.
Okay. Sam, how about I start you can kind of jump in there. We really like this opportunity for Agilent, because we are a leader in environmental analysis, this is where this wastewater monitoring is going to occur. We're already established in these labs, customers trust us. We're also in a position to teach them some of the newer techniques on the genomic side. As Sam, I think, will elaborate here, we have the enabling genomics portfolio that make this happen, along with the customer relationship, along with the science. Not sure we're ready to size the opportunity yet. What I would say is, I'll pass it to Sam, is whatever happens there would be incremental to what we have included in our FY 2021 outlook.
None of these new opportunities that I talked about in my slide deck relative to COVID are in our guide assumptions. Sam?
Patrick, thanks for the question, Mike already provided, I think, the core elements of it. First, in terms of the opportunity, as you know, it's still to be seen exactly how big even that market opportunity is, but a unique way, right, for public health officials to really broadly look at the level of infection and also the change as it goes up and goes down, and then being able to drill more deeply into it. Another interesting element of this is that it would allow epidemiologists and others to potentially access individuals who don't have access to healthcare, because they're part of the overall wastewater equation. What we bring to it, combination, building on what Mike said, we have, we believe, a relatively unique access into the environmental testing labs. We have leadership there, particularly through Padraig's business. We have presence. These are long-standing relationships.
I think that's a very meaningful part of what Agilent brings and what we differentiate. What we have that others have also. It's going to be based fundamentally on quantitative PCR, qPCR. We have that. Something else that we have that's differentiating. This will be mass volume testing, in these defined hubs. Our Bravo platform, as you've probably heard Jacob and others talk about, is one of the leading high throughput automation systems being used with COVID-19. What we really bring is access to these customers with a great degree of trust. qPCR, which really, at the end of the day, let's be honest, that's not too differentiated between us and all the other major players that you know, that are leading in that space. We have that too. We could put that together with the automation.
We think that that gives us, together with some of the things that Jacob's also talked about. The LIMS systems and the analytics that we can bring together to give a very trustable, dependable, easy answer. That's what we see as our opportunity.
No, that's helpful. Thanks, Sam. Mike, maybe one for you.
Sure.
I know you touched on China throughout the presentation, during the Q&A a little bit. Know it's one of your favorite topics, you guys are obviously under-penetrated in DGG, ACG, over 20% of the total revs. Can you just talk through, I guess, that opportunity in the next few years, what we should expect in terms of the growth rate? Maybe just the most exciting upside drivers in China overall. Thank you.
Yeah. Patrick, as you know, I love to talk about China. I've always been very bullish on the opportunities there. We expect geographically, this country to be one of the leaders in growth, and perhaps the fastest growing geographic market for us, because we think the market fundamentals are there. They're building their own indigenous pharmaceutical industry. They're going to be investing very heavily in pharma R&D, and we've seen that already. They're also investing very heavily in quality of life concerns, whether it be environmental cleanup, air quality, food safety. We like the market macro picture there, and we like the fact that some of our lines of business aren't yet fully penetrated. Think about ACG. I think, for maybe about 15%, 18% of your total business is now in China.
We have this huge, large installed base already established. We're seeing the enterprise service. Before it was all about placing new instruments, and driving the science, they're also interested very much in the productivity economics of the lab story we have as well. We think there's tremendous upside on the ACG business in China, as well as the DGG business, which is an area that historically we had not focused a lot on. We now have built up ability to directly interact with customers. We changed our commercialization structure. As Sam alluded to in his presentation, we stepped up our in-country investments in China. Listen, Jacob's on the hook here. He thinks he's got pockets of growth here as well. He's really well established. There's upside in some of his platforms as well.
We think we're going to continue to be talking to the investment community about revenue strength coming from China for Agilent.
Yeah. I think the only thing I would add, Mike, is the beauty of what I think we're going to be able to do, particularly in ACG and DGG. These aren't new products. We have a blueprint. We know how to do this. We've demonstrated it in other markets. We're just going to do it there.
Yeah. You hopefully heard, I happened to think of one other point, Bob, which was this whole theme today about the digital capabilities we've been developing, in particular the WeChat platform, is very important to our ability to service our customers, and we've got a leading position on that platform as well, and as we mentioned earlier, a long heritage of being in this country for decades.
We've seen also, Mike, a big move from on-demand services to contracts in China.
Yeah.
I think we're going to see a lot of opportunity increase attach rates due to that.
Thanks, Mike.
Our final question today comes from Steve Willoughby with Cleveland Research.
Hi, everyone. Hey, Mike.
Hey, Steve.
Hey, guys.
How you doing?
Two questions for you.
Sure.
I was wondering your thoughts. Because of COVID and the race to develop vaccines and therapeutics and all the related investments by not only pharma, but also academic and government entities, assuming that non-COVID related programs do start to return to normal levels, what are your thoughts on underlying market growth rates increasing over the next few years as both COVID and non-COVID programs continue? I'm not holding anything against all the different initiatives that you've talked about today, which I think are very interesting. I was just wondering if you thought that there is any potential for sort of underlying market growth rates to improve over the next several years.
Yeah. We're not calling that yet, but there's indications that could happen if it plays out that way. Even in this digital world, we've had a lot of customer engagement. What I hear from the academic research community as well as pharma, right now the investments have been prioritized around COVID. They're telling a story that it could actually be complementary. Then you're seeing governments globally much more willing to perhaps fund directly and support investments in life sciences. We think that could lead to a more robust overall R&D environment for a few years. Again, a lot of things still need to be worked out, but I think that's a reasonable scenario that you've put out, Steve. We've got to assume that in the numbers we shared today. I think that's a possibility that could develop.
Okay. My follow-up question, maybe for Sam. I don't believe it's been touched on yet today, your COVID serology test. You provided some color on when you're expecting that to be submitted. Any perspective you can provide on what you expect your differentiation to be within the market? It sounds like any revenue that it might generate would be incremental to the guidance that's provided for 2021. Is there any way to frame up what you think that serology test could look like in terms of opportunity?
Well, Steve, just confirming the first thing that you said, it would be incremental. It's not really in our numbers, as you've heard Mike and Bob say. What I would say about this, there are a number of serology antibody-based tests that are on the market. What there's still an opportunity for and a dearth of in the market is tests that are reliable, that have continuity of supply, particularly tests that, and this is what the FDA is looking for, continue to increase the accessibility and in a distributed manner, and also ones that are amenable to high throughput testing and automation. What we're bringing to market in partnership with Jacob's organization, biotech capabilities and systems that we have, would allow the last part of what I talked about.
Once again, our access, and this has been part of the theme today, into thousands of not only clinical diagnostic testing labs, but also into environmental and all these other places that are a little bit unusual, but where testing is happening, I think also gives us a unique opportunity to serve the antibody-based testing need, which will be interesting to see. Now that the vaccines were encouraged, the vaccines that have become available and are becoming available, we think managing COVID-19 is going to be around for a while, a long time in our lives. Antibody tests, as you know, are a complement to qPCR and really allows monitoring, potentially, if even an individual has gained the immunity that they need. That's how we see it.
Yeah. Sam, maybe I should add on that because I think it's important, talked about what's the revenue opportunity. We, of course, made plans and we have some expectations, but I think what we've also learned over the last nine months is that trying to predict how the world's going to look like in a COVID world the next three months is very difficult. This could change very quickly and suddenly that's required for immunity testing. What happens now if the vaccines only have efficacy for six months or 12 months or something? Suddenly you're looking at a completely different landscape of requirement. That's, of course, the game we want to be a part of, and we will see how that plays out.
Thanks, Jacob and Sam. Steve, while we haven't put anything in our guide for assumption for 2021, you shouldn't take away from our excitement we have here. We actually think we can come to market with something, and Agilent has a place to take a piece of this market, given our quality, our brand, our ability to supply, and the fact that people trust us, offerings that come from Agilent and they trust our team. I must say, unfortunately, we're coming up to the end of our time together. I do hope that you're walking away from our first virtual Analyst Investor Day with a deeper understanding and excitement about the Agilent of the future. We're very excited about the future for Agilent or what I'm calling the Agilent of future.
The message we're really trying to deliver is we've had a great run, but it's going to be even better in the outer years. My apologies to everyone on the call that we didn't get to all of your questions. We look forward to engaging with you in the days and weeks to come. I would say again, thank you for joining us, and stay safe and healthy.