Castle Biosciences, Inc. (CSTL)

NASDAQ: CSTL · Real-Time Price · USD
38.63
+0.66 (1.74%)
Dec 12, 2025, 4:00 PM EST - Market closed
1.74%
Market Cap1.13B
Revenue (ttm)343.53M
Net Income (ttm)-12.24M
Shares Out 29.19M
EPS (ttm)-0.43
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume377,162
Open38.93
Previous Close37.97
Day's Range38.06 - 39.19
52-Week Range14.59 - 40.61
Beta1.14
AnalystsStrong Buy
Price Target40.67 (+5.28%)
Earnings DateNov 3, 2025

About CSTL

Castle Biosciences, Inc., a molecular diagnostics company, provides test solutions for the diagnosis and treatment of dermatologic cancers, Barrett’s esophagus (BE), uveal melanoma, and mental health conditions. The company offers DecisionDx-Melanoma, a risk stratification gene expression profile (GEP) test that predicts the risk of metastasis for patients with uveal melanoma; DecisionDx-SCC, a risk stratification test for cutaneous squamous cell carcinoma; MyPath Melanoma, a diagnostic GEP test for use in patients with difficult-to-diagnose me... [Read more]

Sector Healthcare
IPO Date Jul 25, 2019
Employees 761
Stock Exchange NASDAQ
Ticker Symbol CSTL
Full Company Profile

Financial Performance

Financial Statements

Analyst Summary

According to 6 analysts, the average rating for CSTL stock is "Strong Buy." The 12-month stock price target is $40.67, which is an increase of 5.28% from the latest price.

Price Target
$40.67
(5.28% upside)
Analyst Consensus: Strong Buy
Stock Forecasts

News

Systematic Review and Meta-Analysis Confirms TissueCypher® Outperforms Traditional Pathology or Clinical Factors Alone to Identify Patients at Increased Risk of Developing Esophageal Cancer

FRIENDSWOOD, Texas, Dec. 12, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publicat...

2 days ago - GlobeNewsWire

Expert Melanoma Panel Recommends Castle Biosciences' DecisionDx®-Melanoma as a Best-Practice Tool for Managing Patients with Melanoma

FRIENDSWOOD, Texas, Dec. 09, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publicat...

5 days ago - GlobeNewsWire

Castle Biosciences Earns a Houston Chronicle Top Workplaces Award for the Fifth Consecutive Year

FRIENDSWOOD, Texas, Nov. 17, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that it has ...

27 days ago - GlobeNewsWire

New Data Confirms Performance of DecisionDx®-Melanoma to Identify Patients with Less Than Five Percent Risk of Sentinel Lymph Node Positivity

Castle will present new data showing the clinical value of DecisionDx-Melanoma in improving sentinel lymph node biopsy decision making at Dermato-Onco2025.

4 weeks ago - GlobeNewsWire

Castle Biosciences to Present at the Piper Sandler 37th Annual Healthcare Conference

Castle Biosciences' executive management will present a company overview at the Piper Sandler 37th Annual Healthcare Conference on 12/2/25 at 1:10pm ET

4 weeks ago - GlobeNewsWire

Why Castle Biosciences' Rally Might Just Be Getting Started

Castle Biosciences (NASDAQ:CSTL) rallied more than 20% after delivering a strong Q3 performance. When analyzed through the lens of the Adhishthana Principles, the stock shows clear signs of momentum b...

5 weeks ago - Benzinga

Castle Biosciences, Inc. (CSTL) Q3 2025 Earnings Call Transcript

Castle Biosciences, Inc. ( CSTL) Q3 2025 Earnings Call November 3, 2025 4:30 PM EST Company Participants Camilla Zuckero - Vice President of Investor Relations & Corporate Affairs Derek Maetzold - Fo...

5 weeks ago - Seeking Alpha

Castle Biosciences Reports Third Quarter 2025 Results

Delivered Q3 2025 revenue of $83 million Q 3 2025 non-dermatologic revenue increased by 67% over Q 3 2024 Q 3 2025 total test reports for our core revenue drivers (DecisionDx ® -Melanoma, TissueCypher...

5 weeks ago - GlobeNewsWire

Castle Biosciences Launches AdvanceAD-Tx™ to Help Guide Systemic Treatment Decision Making in Patients with Moderate-to-Severe Atopic Dermatitis

FRIENDSWOOD, Texas, Nov. 03, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the launch o...

5 weeks ago - GlobeNewsWire

Castle Biosciences to Participate in Upcoming Investor Conferences

FRIENDSWOOD, Texas, Oct. 28, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that its exe...

6 weeks ago - GlobeNewsWire

New Data at American College of Gastroenterology Annual Meeting Show TissueCypher® Provides Actionable Risk Insights that Influence Clinical Management and Prompt Risk-Aligned Intervention in Barrett's Esophagus

FRIENDSWOOD, Texas, Oct. 26, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced new data dem...

7 weeks ago - GlobeNewsWire

New Analysis of 13,560 Patients Demonstrates DecisionDx®-Melanoma Stratifies Risk Across Histological Subtypes; Findings to be Presented at Fall Clinical Dermatology Conference

Castle is presenting data on DecisionDx®-Melanoma and its pipeline atopic dermatitis (AD) test at the 25th Annual Fall Clinical Dermatology Conference.

7 weeks ago - GlobeNewsWire

Castle Biosciences to Release Third Quarter 2025 Financial Results and Host Conference Call on Monday, Nov. 3, 2025

FRIENDSWOOD, Texas, Oct. 13, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that it will...

2 months ago - GlobeNewsWire

Castle Biosciences' Founder, President and CEO Derek Maetzold Honored with the CEO of the Year Award by The CEO Magazine

FRIENDSWOOD, Texas, Oct. 01, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that its fou...

2 months ago - GlobeNewsWire

Castle Biosciences Honored with a Greater Pittsburgh Top Workplaces 2025 Award

FRIENDSWOOD, Texas, Sept. 23, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that it has...

2 months ago - GlobeNewsWire

Castle Biosciences Named One of Newsweek's America's Greatest Companies 2025

FRIENDSWOOD, Texas, Sept. 17, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, has been included in the in...

3 months ago - GlobeNewsWire

New Data at American Foregut Society's 2025 Annual Meeting Demonstrates TissueCypher® Can Detect High-Risk Barrett's Esophagus Patients Not Identified by Pathology to Support Improved Care Decisions

FRIENDSWOOD, Texas, Sept. 09, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that new da...

3 months ago - GlobeNewsWire

Castle Biosciences: Strong Margins, Solid Balance Sheet, And Big Upside Potential

Castle Biosciences effectively translates complex diagnostics into a scalable, high-margin business, with strong clinical demand and a robust balance sheet supporting long-term growth. The investment ...

3 months ago - Seeking Alpha

New Evidence Published Supporting Use of DecisionDx®-SCC Test in Guiding and Improving Treatment Pathway Decisions in NCCN High-Risk Cutaneous Squamous Cell Carcinoma

New validation study shows DecisionDx-SCC significantly outperforms current staging systems in predicting risk of local recurrence and metastasis for NCCN high-risk patients Clinician survey confirms ...

3 months ago - GlobeNewsWire

Castle Biosciences, Inc. (CSTL) Q2 2025 Earnings Call Transcript

Castle Biosciences, Inc. (NASDAQ:CSTL) Q2 2025 Earnings Conference Call August 4, 2025 4:30 PM ET Company Participants Camilla Zuckero - Vice President of Investor Relations & Corporate Affairs Derek...

4 months ago - Seeking Alpha

Castle (CSTL) Q2 Revenue Tops Estimates

Castle (CSTL) Q2 Revenue Tops Estimates

4 months ago - The Motley Fool

Castle Biosciences Reports Second Quarter 2025 Results

Delivered Q2 2025 revenue of $86 million Q 2 2025 total test reports for our core revenue drivers (DecisionDx ® -Melanoma, TissueCypher ®) increased 33% over Q 2 2024 Raising full-year 2025 revenue g...

4 months ago - GlobeNewsWire

Castle Biosciences to Present at the Canaccord Genuity 45th Annual Growth Conference

Castle Biosciences' executive management will present a company overview at the Canaccord Genuity 45th Annual Growth Conference Aug. 12, 2025 at 12:30pm ET

4 months ago - GlobeNewsWire

Castle Biosciences' Founder, President and CEO Derek Maetzold Named a Most Admired CEO by the Houston Business Journal

FRIENDSWOOD, Texas, July 25, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that its fou...

5 months ago - GlobeNewsWire

FDA Grants Breakthrough Device Designation to Castle Biosciences' DecisionDx®-Melanoma Test

Castle announced that its DecisionDx®-Melanoma test has been granted Breakthrough Device designation from the U.S. Food and Drug Administration (FDA).

5 months ago - GlobeNewsWire