Denali Therapeutics Inc. (DNLI)
| Market Cap | 3.00B +29.2% |
| Revenue (ttm) | n/a |
| Net Income | -508.02M |
| EPS | -2.88 |
| Shares Out | 158.71M |
| PE Ratio | n/a |
| Forward PE | n/a |
| Dividend | n/a |
| Ex-Dividend Date | n/a |
| Volume | 487,540 |
| Open | 18.21 |
| Previous Close | 18.11 |
| Day's Range | 18.11 - 19.18 |
| 52-Week Range | 12.58 - 23.77 |
| Beta | 0.99 |
| Analysts | Strong Buy |
| Price Target | 35.43 (+87.46%) |
| Earnings Date | May 7, 2026 |
About DNLI
Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzym... [Read more]
Financial Performance
Financial StatementsAnalyst Summary
According to 19 analysts, the average rating for DNLI stock is "Strong Buy." The 12-month stock price target is $35.43, which is an increase of 87.46% from the latest price.
News
Denali Therapeutics Says AVLAYAH Launch Ahead of Expectations After Hunter Syndrome Approval
Denali Therapeutics NASDAQ: DNLI is seeing early commercial interest for its first approved drug, AVLAYAH, following its March 24 accelerated approval for Hunter syndrome, Chief Operating Officer and ...
Denali Therapeutics price target lowered to $40 from $42 at Morgan Stanley
Morgan Stanley analyst Sean Laaman lowered the firm’s price target on Denali Therapeutics (DNLI) to $40 from $42 and keeps an Overweight rating on the shares.
Denali Therapeutics Transcript: Bank of America Global Healthcare Conference 2026
AVLAYAH’s launch for Hunter syndrome is progressing well, with strong early engagement and a clear path to expand the label to adults pending COMPASS study results. The pipeline includes promising programs for Sanfilippo, Pompe, Parkinson’s, and frontotemporal dementia, leveraging a robust platform and global partnerships.
Denali Therapeutics Slides: Corporate presentation
Denali Therapeutics has posted slides in relation to its latest quarterly earnings report, which was published on May 12, 2026.
Denali Therapeutics price target lowered to $23 from $25 at Wedbush
Wedbush analyst Laura Chico lowered the firm’s price target on Denali Therapeutics (DNLI) to $23 from $25 and keeps an Outperform rating on the shares. The firm notes the Avlayah…
Denali Therapeutics Reports First Quarter 2026 Financial Results and Business Highlights
SOUTH SAN FRANCISCO, Calif., May 07, 2026 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today reported financial results for the first quarter ended March 31, 2026, and provided business...
Denali Therapeutics Quarterly report: Q1 2026
Denali Therapeutics has published its Q1 2026 quarterly earnings report on May 7, 2026.
Denali Therapeutics Earnings release: Q1 2026
Denali Therapeutics released its Q1 2026 earnings on May 7, 2026, summarizing the period's financial results.
Denali Therapeutics Proxy statement: Proxy filing
Denali Therapeutics filed a proxy statement on April 21, 2026, providing details for shareholder voting and corporate governance matters.
Denali Therapeutics Proxy statement: Proxy filing
Denali Therapeutics filed a proxy statement on April 21, 2026, providing details for shareholder voting and corporate governance matters.
Denali Therapeutics price target raised to $34 from $32 at Baird
Baird raised the firm’s price target on Denali Therapeutics (DNLI) to $34 from $32 and keeps an Outperform rating on the shares. The firm updated its model following the return…
Denali Therapeutics price target raised to $39 from $38 at BTIG
BTIG raised the firm’s price target on Denali Therapeutics (DNLI) to $39 from $38 and keeps a Buy rating on the shares as the company regains full rights to investigational…
Denali Therapeutics regains full rights to DNL593
Denali Therapeutics (DNLI) announced that it has received notification from Takeda (TAK) of its decision to terminate the collaboration agreement between the two companies to co-develop and co-commerc...
Denali Therapeutics Regains Full Rights to Investigational Therapy DNL593 (PTV:PGRN) for GRN-related Frontotemporal Dementia (FTD-GRN)
SOUTH SAN FRANCISCO, Calif., April 03, 2026 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today announced that it has received notification from Takeda of its decision to terminate the c...
Denali Therapeutics price target raised to $35 from $26 at Deutsche Bank
Deutsche Bank raised the firm’s price target on Denali Therapeutics (DNLI) to $35 from $26 and keeps a Buy rating on the shares. The firm says the approval of Avlayah…
Denali Therapeutics price target raised to $42 from $32 at H.C. Wainwright
H.C. Wainwright raised the firm’s price target on Denali Therapeutics (DNLI) to $42 from $32 and keeps a Buy rating on the shares after the FDA granted accelerated approval for…
Denali Therapeutics price target raised to $42 from $40 at Morgan Stanley
Morgan Stanley raised the firm’s price target on Denali Therapeutics (DNLI) to $42 from $40 and keeps an Overweight rating on the shares after the company received FDA accelerated approval…
Denali Therapeutics price target raised to $31 from $29 at BofA
BofA raised the firm’s price target on Denali Therapeutics (DNLI) to $31 from $29 and keeps a Buy rating on the shares after the company announced the accelerated approval of…
Denali Therapeutics price target raised to $41 from $34 at Stifel
Stifel analyst Paul Matteis raised the firm’s price target on Denali Therapeutics (DNLI) to $41 from $34 and keeps a Buy rating on the shares following Avlayah’s approval for the…
Denali Therapeutics price target raised to $32 from $29 at Baird
Baird raised the firm’s price target on Denali Therapeutics (DNLI) to $32 from $29 and keeps an Outperform rating on the shares. The firm updated its model as the Avlayah…
Denali Therapeutics Transcript: Study update
AVLAYAH received accelerated FDA approval as the first enzyme replacement therapy to cross the blood-brain barrier for Hunter syndrome, showing robust biomarker normalization and clinical improvements in both CNS and peripheral disease. The launch targets 75% of the U.S. treated population, with global expansion planned and a strong foundation for future pipeline growth.
Denali Therapeutics Press release: Study update
Denali Therapeutics issued a press release on March 25, 2026, disclosing material business information to investors.
Denali Therapeutics Slides: Study update
Denali Therapeutics has posted slides in relation to its latest quarterly earnings report, which was published on March 25, 2026.
Denali Therapeutics granted FDA approval of AVLAYAH for treatment of MPS II
Denali Therapeutics (DNLI) announced the U.S. FDA has granted accelerated approval for AVLAYAH, the first FDA-approved biologic specifically designed to cross the blood-brain barrier and reach the who...
Denali Therapeutics Announces U.S. FDA Approval of AVLAYAH™ (tividenofusp alfa-eknm) for Treatment of Hunter Syndrome (MPS II)
SOUTH SAN FRANCISCO, Calif., March 25, 2026 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today announced the U.S. Food and Drug Administration (FDA) has granted accelerated approval for...