Denali Therapeutics Inc. (DNLI)
| Market Cap | 3.22B +47.5% |
| Revenue (ttm) | 21.38M |
| Net Income | -314.42M |
| EPS | -1.70 |
| Shares Out | 160.29M |
| PE Ratio | n/a |
| Forward PE | n/a |
| Dividend | n/a |
| Ex-Dividend Date | n/a |
| Volume | 1,586,648 |
| Open | 19.97 |
| Previous Close | 19.72 |
| Day's Range | 19.78 - 20.36 |
| 52-Week Range | 13.75 - 27.30 |
| Beta | 1.08 |
| Analysts | Strong Buy |
| Price Target | 36.00 (+79.37%) |
| Earnings Date | Nov 3, 2026 |
About DNLI
Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzym... [Read more]
Financial Performance
Financial StatementsAnalyst Summary
According to 20 analysts, the average rating for DNLI stock is "Strong Buy." The 12-month stock price target is $36.0, which is an increase of 79.37% from the latest price.
News
Denali Therapeutics price target raised to $42 from $40 at Morgan Stanley
Morgan Stanley raised the firm’s price target on Denali Therapeutics (DNLI) to $42 from $40 and keeps an Overweight rating on the shares.
Denali Therapeutics price target raised to $24 from $23 at Wedbush
Wedbush analyst Laura Chico raised the firm’s price target on Denali Therapeutics (DNLI) to $24 from $23 and keeps an Outperform rating on the shares. The Avlayah launch remains on…
Denali Therapeutics Earnings Call Transcript: Q3 2026
AVLAYAH’s Q3 revenue reached $17.8M, driven by expanding coverage and faster patient transitions; Q4 guidance is $30M–$32M. A broad 2027 pipeline readout slate is ahead, supported by approximately $1.01B in cash and securities.
Denali Therapeutics Earnings release: Q3 2026
Denali Therapeutics released its Q3 2026 earnings on November 3, 2026, summarizing the period's financial results.
Denali Therapeutics Quarterly report: Q3 2026
Denali Therapeutics has published its Q3 2026 quarterly earnings report on November 3, 2026.
Denali Therapeutics reports Q3 EPS 37c, consensus (37c)
Reports Q3 revenue $17.78M, consensus $22.9M. Q3 net income of $70.1M included a one-time $194M net gain on the sale of a Priority Review Voucher, bringing cash, cash equivalents and…
Denali Therapeutics Reports Third Quarter 2026 Financial Results and Business Highlights
AVLAYAH® (tividenofusp alfa-eknm) net product revenue accelerated to $17.8 million in its second full commercial quarter Continued growth expectations drive Q4 2026 net product revenue guidance of $30...
Denali Therapeutics Receives 2026 Prix Galien USA Award for AVLAYAH® (tividenofusp alfa-eknm) as Best Biotechnology Product
SOUTH SAN FRANCISCO, Calif., Oct. 30, 2026 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today announced that AVLAYAH® (tividenofusp alfa-eknm) has been recognized as the “Best Biotechno...
Denali Therapeutics to Report Third Quarter 2026 Financial Results and Business Highlights on November 3, 2026
SOUTH SAN FRANCISCO, Calif., Oct. 22, 2026 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today announced that it will report financial results and business highlights for the third quart...
Large biopharma companies looking at China assets right now, says Goldman Sachs Salveen Richter
Salveen Richter, Goldman Sachs lead U.S. biotech analyst, joins 'Closing Bell Overtime' to talk biotech innovations in China.
Denali Therapeutics Transcript: Morgan Stanley 24th Annual Global Healthcare Conference
Competition in blood-brain barrier therapies is intensifying, driving innovation and benefiting patients. AVLAYAH's launch validates the TransportVehicle platform, enabling expansion into new indications and global markets. AI and U.S.-based manufacturing enhance efficiency and adaptability.
Denali Therapeutics Transcript: 12th Annual Cantor Fitzgerald Global Healthcare Conference
The company is leveraging its validated platform and strong capital base to advance a broad pipeline, highlighted by the successful AVYLAH launch for Hunter syndrome and multiple enzyme replacement therapies. Key clinical and biomarker data readouts are expected in 2027–2028, supporting global expansion and profitability goals.
Denali Therapeutics Slides: Corporate presentation
Denali Therapeutics has posted slides in relation to its latest quarterly earnings report, which was published on September 1, 2026.
Denali Therapeutics price target raised to $35 from $30 at B. Riley
B. Riley analyst Mayank Mamtani raised the firm’s price target on Denali Therapeutics (DNLI) to $35 from $30 and keeps a Buy rating on the shares. The AVLAYAH launch is…
Denali Therapeutics price target raised to $40 from $36 at Morgan Stanley
Morgan Stanley analyst Sean Laaman raised the firm’s price target on Denali Therapeutics (DNLI) to $40 from $36 and keeps an Overweight rating on the shares.
Denali Therapeutics price target raised to $34 from $25 at UBS
UBS raised the firm’s price target on Denali Therapeutics (DNLI) to $34 from $25 and keeps a Buy rating on the shares.
Denali Therapeutics price target raised to $34 from $31 at Baird
Baird raised the firm’s price target on Denali Therapeutics (DNLI) to $34 from $31 and keeps an Outperform rating on the shares. The firm updated its model following Q2 results…
Denali Therapeutics Earnings Call Transcript: Q2 2026
AVLAYAH's first full commercial quarter generated $3.6M in revenue, with strong physician and patient engagement and over 50% payer coverage. Cash reserves exceed $1.1B, supporting a robust pipeline and guidance for Q3 revenue of $10–12M.
Denali Therapeutics Quarterly report: Q2 2026
Denali Therapeutics has published its Q2 2026 quarterly earnings report on August 6, 2026.
Denali Therapeutics Earnings release: Q2 2026
Denali Therapeutics released its Q2 2026 earnings on August 6, 2026, summarizing the period's financial results.
Denali Therapeutics reports Q2 EPS (68c), consensus (47c)
Reports Q2 revenue $3.6M, consensus $2.19M. “We are excited by the positive response to our AVLAYAH launch from the Hunter syndrome community and the physicians caring for these patients. It…
Denali Therapeutics Reports Second Quarter 2026 Financial Results and Business Highlights
Strong first full quarter of AVLAYAH™ (tividenofusp alfa-eknm) launch generated $3.6 million in net product revenue Advanced TransportVehicle™ portfolio with two Alzheimer's disease programs now in cl...
Denali Therapeutics treatment of frontotemporal dementia granted orphan status
Denali Therapeutics (DNLI)’ progranulin replacement therapy was granted FDA orphan designation as a treatment of frontotemporal dementia, according to a post to the agency’s website.
Denali Therapeutics to Report Second Quarter 2026 Financial Results and Business Highlights on August 6, 2026
SOUTH SAN FRANCISCO, Calif., July 27, 2026 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today announced that it will report financial results and business highlights for the second quar...
Denali Therapeutics price target raised to $36 from $35 at Morgan Stanley
Morgan Stanley raised the firm’s price target on Denali Therapeutics (DNLI) to $36 from $35 and keeps an Overweight rating on the shares. Q2 earnings should reinforce a shift from…