Pacific Biosciences of California, Inc. (PACB)
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AGM 2022

May 25, 2022

Operator

Hello, and welcome to the Annual Meeting of Stockholders of Pacific Biosciences of California, Inc. Please note that today's meeting is being recorded. During the meeting, we will have a question and answer session. You can submit questions or comments at any time by clicking on the Q&A icon. It is now my pleasure to turn today's meeting over to Christian Henry, the Chief Executive Officer and President of PacBio. Christian, the floor is yours.

Christian Henry
President and CEO, Pacific Biosciences of California

Good morning, ladies and gentlemen, and welcome to PacBio's 2022 virtual annual meeting of stockholders. I am Christian Henry, Chief Executive Officer and President of PacBio, and a member of the board of directors. Today's meeting will consist of the formal annual meeting to address the proposal set forth in our proxy statement. Questions about the company's business may be directed after the meeting to the company's investor relations team following the formal portion of the meeting. As provided in the company's bylaws, I will act as chairman of this meeting. I have asked Brett Atkins, our General Counsel and Corporate Secretary, to act as secretary of the meeting and to record the minutes. Before proceeding any further, let me introduce the other directors who are in attendance virtually.

John Milligan, our Chairman of the Board, David Botstein, William Ericson, Randy Livingston, Marshall Mohr, Kathy Ordoñez, Lucy Shapiro, and Hannah Valantine. Also in attendance today are Susan Kim, our Chief Financial Officer, Michele Farmer, our Chief Accounting Officer, Todd Friedman, our Head of Investor Relations, Zach Myers of Wilson Sonsini Goodrich & Rosati, Surita Jolly of Ernst & Young, our independent registered public accounting firm, and Will Morrison, VP of Global Legal, and finally, Michael Dromgoole, representing our transfer agent, Computershare. I will now turn the meeting over to Brett Atkins, who will conduct the formal part of this meeting. Brett.

Brett Atkins
General Counsel and Corporate Secretary, Pacific Biosciences of California

Good morning, and again, welcome to PacBio's 2022 annual meeting. The meeting is being held virtually in accordance with the company's bylaws and Delaware law. During the formal meeting, we will address the matters described in the proxy statement, which was first made available to all stockholders on or about April 14, 2022, and is available on the company's website and the SEC's website. I have proof by affidavit that notice of this meeting has been duly given and that the notice of annual meeting of stockholders, proxy statement, and proxy were mailed on or about April 14, 2022 to stockholders of record as of 5:00 P.M. Pacific Time on March 31, 2022, the record date for the meeting. A complete list of these stockholders of record is available on the virtual meeting website until the end of this meeting.

The affidavit will be filed with the minutes of the meeting. Michael Dromgoole, a representative of Computershare, is acting as our Inspector of Election for this meeting. The Inspector of Election has signed an oath of office, which will be filed with the minutes of this meeting. Based on information provided by the Inspector of Election, I can confirm we have present virtually or by proxy a sufficient number of shares to constitute a quorum. Therefore, the meeting is duly constituted, and we may proceed with business. If you have previously submitted your proxy, it is not necessary that you complete another proxy or vote. Those stockholders who have not submitted proxies and who wish to vote remotely, or if you wish to change your vote, please follow the instructions provided online.

After voting is completed on all matters on the agenda, we will close the polls, and we will announce the preliminary results of the voting at the end of the meeting. It is now 9:12 A.M. on May 25th, 2022, and the polls for each matter to be voted on at this meeting are now open. The 1st item of business is the election of Class III directors. As indicated in the company's proxy statement, Dr. David Botstein, William Ericson, and Kathy Ordoñez have been nominated by the board of directors to serve as the company's Class III directors with terms expiring in 2025. The board of directors recommends voting for the three nominees.

The 2nd item of business is the ratification of the appointment of Ernst & Young LLP to serve as the company's independent registered public accounting firm for the fiscal year ending December 31, 2022. The board of directors recommends voting for the ratification of the appointment of Ernst & Young. The 3rd item of business is the approval of an amendment to the company's 2020 equity incentive plan to increase the number of shares of the company's common stock reserved for issuance under the plan by 18 million shares. Our board determined that it was in the best interest of the company and its stockholders to adopt this amendment to the 2020 equity incentive plan, subject to approval from our stockholders at this annual meeting. The board of directors recommends voting for the approval of the amendment to the company's 2020 equity incentive plan.

We will now proceed to the question and comment period. You will have an opportunity to vote after discussion has taken place. I remind you that the meeting has been called for the purpose of considering the three items of business previously described. Accordingly, all questions and comments should be confined to those matters at this time. The virtual meeting webcast is now open for stockholder comments, questions or comments concerning the business before the meeting. Any stockholder who has questions or comments should submit your questions or comments following the instructions in the online meeting. If you are voting today, you must submit your votes online at this time in order for them to be counted by the Inspector of Election.

The Inspector of Election will not accept votes or any change or revocation submitted after the closing of the polls. We will now briefly pause to enable those who are voting virtually to finish voting. It is now 9:14 A.M. on May 25, 2022, and the polls for each matter to be voted on at this meeting are now closed. The proxies and votes will be tabulated by the inspector of election. With regard to proposal one, the election of directors, Dr. David Botstein, William Ericson, and Kathy Ordoñez have been elected to the board of directors to serve as class three directors. With regard to proposal two, the ratification of Ernst & Young LLP to serve as the company's independent registered public accounting firm has been approved.

With regard to proposal three, the amendment to the company's 2020 Equity Incentive Plan to increase the number of shares of the company's common stock reserved for issuance under the plan by 18 million shares has been approved. These are the preliminary results of voting. The final vote count may vary following the final examination of the proxies and ballots. The final results of voting will be set forth in the report of the inspector of election, and will also be reflected in the current report on a Form 8-K to be filed with the SEC. I will now turn the meeting back to Christian.

Christian Henry
President and CEO, Pacific Biosciences of California

This concludes the formal business of the annual meeting of stockholders. The meeting is now adjourned. At this time, we would like to entertain questions or comments from stockholders. If you would like to submit a question, please do so by clicking on the Q&A icon. We will now pause for a moment to review any questions that are submitted. We do not have any questions in the queue. I would thank all of you for your attendance at today's meeting and for the interest you have shown in PacBio. We very much appreciate your support and attendance, and as always, thank you.

Operator

This concludes the meeting. You may now disconnect.

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