Good morning. My name is George Grofik, and I head Investor Relations and Communications at Royalty Pharma. It's my privilege to extend a warm welcome to our inaugural Investor Day. Thank you all for attending. It's great to see everyone in person, it's been after quite some time. We have a full agenda, which I'll discuss in just a minute. However, before I do that, I'd like to mention a few housekeeping details. First, just a comment on COVID safety. While masks are not required, we have placed some at the entrance for anyone who would like to wear them, along with hand sanitizer for your convenience. Second, for those who are viewing our live webcast, a copy of our presentation can be found on the investors page of our website at royaltypharma.com. You'll also find a copy of the press release for this event on our website.
Third, there will be two question and answer sessions during the event. If you do ask a question, please identify yourself and use a microphone. Lastly, after the final Q&A session, there will be an opportunity to join Royalty Pharma's management team for lunch and to ask questions in a more informal setting. I'd like to remind you that information presented at today's event contains forward-looking statements that involve known and unknown risks, uncertainties, and other factors that may cause actual results to differ materially from these statements. I refer you to our 10-K on file with the SEC for a description of these risks, and all forward-looking statements are based on information currently available at Royalty Pharma, and we assume no obligation to update any such forward-looking statements. Non-GAAP financial measures will be used to help you understand our financial performance.
GAAP to non-GAAP reconciliations are provided in each of the quarterly earnings press releases available on our website. With that, our speakers today are Pablo Legorreta, Founder and Chief Executive Officer, Chris Hite, EVP and Vice Chairman, Marshall Urist, EVP, Head of Research and Investments, Terry Coyne, EVP, Chief Financial Officer, and Brienne Kugler, VP, Research Investments, and Sara Klymkowsky , VP, Research Investments. Pablo will start off by discussing our unique business model, strategy, and track record. After which, Chris will detail the enormous opportunity for the biopharma royalty market. Marshall will then outline the unique capabilities of our research and investments team, and we will then move to the first Q&A session, followed by a short break. In the second session, Brienne and Sara will discuss case studies of how we support biotech companies on their growth journeys to provide win-win solutions.
As part of this discussion, we'll feature a video from Vlad Coric, CEO of Biohaven, in which Vlad underscores how Royalty Pharma has been an important partner to his company. Terry will then discuss our outlook for compounding growth over this decade, and after some brief final remarks from Pablo, we will close the formal part of the event with a second Q&A session. As I mentioned earlier, there will be a lunch with management afterwards, and we would be delighted if you could join us. Now, for those less familiar with Royalty Pharma, this slide provides a brief overview of our business. Since Pablo founded the business in 1996, Royalty Pharma has become the largest buyer of biopharma royalties and a leading funder of innovation across the industry.
We have a portfolio of royalties on about 45 approved and development stage products, which includes 12 blockbusters and some of the most transformative therapies in the industry. The right-hand side shows a selection of some of these important medicines. Based on this broad portfolio, we reported top line Adjusted Cash Receipts of over $2 billion in 2021, and our efficient business model converted the vast majority to Adjusted EBITDA. We would now like to play a short video which provides more insight into the culture and people of Royalty Pharma.
At Royalty Pharma, we have many significant strengths that put us way ahead of the competition and can be the partner of choice of academic institutions, hospitals, foundations, biotech, and big pharma. An amazing board, a brand name that is now recognized in the industry as the innovator in royalty funding and life sciences.
I think what's unique and a privilege about what we do at Royalty Pharma is the combination of science, medicine, and investing. What's extraordinary is that in what we do, good medicine makes for good business and good investments.
Royalty Pharma's investment process is very iterative. We work closely with our counterparties to ensure that the deal and the structure fits everyone's objectives.
We really become partners with the company we do business with, and we have a presence right across since day one.
Royalty Pharma is differentiated from other life science investors because of our history and our track record. We're able to leverage our expertise to be able to provide value to our partners and make it a win-win situation for both.
I think one of the things that differentiates Royalty Pharma is the collaborative culture and the ability to collaborate internally, but also the external collaboration they can have with various partners in the life sciences ecosystem.
Royalty Pharma have assembled a fantastic team of people with a combination of creativity, brilliance, obviously very hardworking, but people who are very, very diligent in what they do.
One of the most unique things I think about my experience at Royalty Pharma is the diversity of backgrounds and opinions and experiences that I get exposed to. I work with lawyers, accountants, molecular biologists, MDs, PhDs, finance professionals.
What is special at Royalty Pharma is our ability to invest across the entire spectrum of the biopharma ecosystem, from research and academic organizations to small and mid-sized biotech companies, to among the largest and most global pharmaceutical companies.
Taking a long-term view in investing in drug development really gives us a unique perspective, but it has also kept us innovating in funding life sciences over time. Having the confidence, having the belief, is really what's absolutely critical to seeing a medicine achieve its full value.
Royalty Pharma's efficient business model has allowed us to compound growth since our founding 25 years ago. We have a track record of compounding growth year in and year out. Looking ahead through 2025, we expect to continue this level of growth.
The future of Royalty Pharma is very bright and very exciting. We're in the middle of this ecosystem, and our greatest strength is our team, and it's also what I'm most proud of at Royalty Pharma.
With that, I'd like to turn the podium over to Pablo.
Thank you, George. I'm super super excited to be here today with all of you and to address our existing shareholders and the potentially new shareholders. As a result, I'd like to extend a warm welcome to Royalty Pharma's inaugural Investor Day. I'm delighted that so many of you have been able to join us in person and online. For those of you newer to our story, I'm Pablo Legorreta, founder and CEO of Royalty Pharma. I started my business career in 1987 as an M&A banker before founding Royalty Pharma in 1996. I've always been very intrigued by biotechnology and its potential to transform drug discovery and development and its potential to cure disease. Royalty Pharma started making royalty investments in 1996 by acquiring Neupogen royalties that came out of an R&D partnership.
From this initial $20 million investment, we have grown to a publicly listed company with a top line in excess of $2 billion. Enormous potential to fund important medical breakthroughs and improve human health. I'm immensely proud of Royalty Pharma and the progress we have made since our IPO in June of 2020. We are the pioneers and leaders in the biopharma royalty market. We have a unique and powerful business model and have tremendous prospects for compounding growth in the coming years. Most importantly, by funding and accelerating the golden age of life sciences innovation, we're helping to transform patients' lives.
Today, my team and I are excited to provide a deeper understanding of the fundamental elements of our business and outlook, and ultimately, why we believe we represent a uniquely attractive and straightforward investment proposition to both healthcare-dedicated investors as well as generalist investors seeking consistent growth. Let me begin today with our vision and our mission, which guides us. Our vision is straightforward. We aspire to be the leading partner funding innovation in life sciences. Our mission is to accelerate innovation in life sciences and transform patients' lives globally. By successfully living our vision and mission, we're confident we can deliver against our organizational goals. We have a clear strategic plan to drive robust and value-enhancing growth. This is based on five pillars. First, we will continue to seek to capture a leading share of third-party royalty acquisitions for approved products and select late-stage development opportunities.
When we look at development stage opportunities, we more than doubled the number of therapies in our portfolio in 2021 and added some really interesting medicines like gantenerumab for Alzheimer's, otilimab for rheumatoid arthritis, seltorexant for depression, and aficamten for hypertrophic cardiomyopathy. You will hear later from Marshall how we have generated above-industry success rates in our development stage investments. Our second pillar is to acquire newly created royalties, what we term synthetic royalties, on both approved and development stage products, typically to help biotech partners fund R&D and commercial launches. This is an innovative funding mechanism that we developed in recent years, and you will hear more about this from Chris, including why we believe this approach provides a huge opportunity for us going forward. Our third pillar is to provide additional funding in the form of launch and development capital.
This is a smaller part of our strategy, but it's nevertheless important as it allows us to tailor individualized solutions for partners in return for long-term payment streams. Cutting across each of these pillars is our fourth pillar, M&A. We have a multifaceted strategy which enables us to acquire royalties through facilitating M&A transactions. We can partner with buyers when non-strategic royalties are disposed of after the close of the deal. We can also help fund the acquisitions of companies that have significant royalties and further create synthetic royalties. A great example of this last approach is the MorphoSys transaction, which we announced in June of 2021, under which we agreed to provide up to $2 billion of funding for their acquisition of Constellation.
In this acquisition, we utilized our full suite of funding tools to enable mid-cap M&A, which has historically been an area of limited M&A activity given funding challenges. Lastly, since our IPO, we have added a fifth pillar to our strategy, which is to identify opportunities in synthetic adjacencies, which leverages our team's capabilities. An early example is our strategic alliance with MSCI to develop thematic life sciences indices. Having set out our vision and mission and strategy, I want to dive a little deeper now into our business prospects. Today, I want to leave you with a few key messages which we will expand on during the course of our presentation. First, we have a tremendous track record of growth.
From 2010 to 2020, our pioneering of the biopharma royalty market has enabled Royalty Pharma to deliver a 13% compounded annual growth rate in adjusted cash receipts, our top line. Second, our unique and flexible business model allows investors to gain access to the best of biopharma industry without exposure to many of the common industry challenges and risks. Third, we have a large economic moat. We have maintained around a 60% share of the royalty funding market and an even greater share for larger transactions. Our model, scale, and platform provide durable competitive advantages, which we're confident will sustain our clear industry leadership going forward. Fourth, while we have been at this for over 25 years, we see enormous opportunity and feel we're just getting started. There are strong fundamental tailwinds supporting growth of royalty, of the royalty funding market.
The wave of life sciences innovation that is underway will create huge demand for capital from the biopharma industry, which we estimate at over $1 trillion. We're uniquely positioned to play a leading role in providing funding solutions to accelerate this wave of innovation, and in doing so, we will help transform patients' lives. Lastly, by capturing the clear opportunities we see ahead, we expect to deliver attractive compounding growth. We expect to deliver double-digit top-line growth through 2025 and achieve at least a 10% top-line CAGR through 2030. This would position us as one of the fastest-growing biopharma companies over the decade. This is a bold claim, and we will describe in detail how we expect to achieve this growth over the course of today's event.
Let's drill down into these five factors that have and will continue to drive our success. By successfully pursuing our strategy, Royalty Pharma has become the partner of choice and the leading provider for delivering royalty-based solutions across the biopharma ecosystem, from global pharmaceutical companies to small mid-cap biotechs to academic institutions and nonprofit organizations. We have built a deep network and unique relationships through our consistent innovation of tailored funding mechanisms to meet the specific and often very different needs of our partners. Our approach is always to achieve win-win solutions. We have built a track record of exceptional financial performance that my team and I are very proud of.
Since 2012, we have doubled our top line, and in the past five years, we have deployed an average of $2.1 billion of capital in royalty acquisitions, representing around a 40% increase over the average of the prior five years. This reflects the growing demand for royalty funding, our market leadership position and consistent innovation in funding solutions, our best-in-class platform and research process, and the ongoing wave of life sciences innovation, further supported by our public company status as we become even more well-known to the global industry. As Terry will discuss later, we have continued to achieve attractive returns on this capital deployment, which have remained consistent over time. It's important to understand where we've been, to appreciate where we are, and more importantly, where we're going. We have consistently innovated new funding solutions as we have evolved and scaled our business.
In the 1990s, we operated as a closed and serial fund focused on third-party royalties and achieved proof of concept in our business model. In that period, we deployed around $40 million in capital. In the 2000s, we converted into an ongoing business with an indefinite life and lowered our cost of capital with leverage. Over this period, we deployed around $4 billion in capital, and we expanded into M&A-related royalties. Since 2010, we have substantially expanded the investment scope of our business, grown our team, and evolved our model further. The types of funding solutions we provide has expanded to include development stage funding, synthetic royalties, and supplemental funding. In total, we have invested around $20 billion in capital over the period since 2010.
As I will discuss shortly, we took a major step forward with our IPO in June of 2020, which gave us deeper access to the capital markets, increased our transaction capacity, and broadened our shareholder base. With our significantly larger balance sheet, we were able to announce $5.9 billion of royalty transactions in the past two years, well ahead of the run rate we indicated at the time of our IPO. Looking forward, I am as excited as ever about the prospects for our business. We have maintained our market leadership position and built a strong track record through consistent innovation and a deep understanding of the needs of our partners. With an addressable market of well over $1 trillion, we plan to significantly scale our business to meet the enormous opportunities we see ahead.
Lastly, we plan to continue to innovate with new funding solutions as we believe there is no shortage of opportunities to deploy capital towards attractive value-enhancing transactions. With that, I want to expand on my point earlier about how our business model offers a unique way to invest in biopharma by maximizing exposure to many of the industry strengths, while minimizing exposure to many of its co-common challenges. In terms of biopharma industry strengths, our portfolio provides broad exposure to some of the most transformative therapies in the industry, including 12 therapies with more than $1 billion in end market sales and many well-known best-in-class brands. We have a level of diversification of the top line, and especially the bottom line, which is unique given the breadth of our portfolio.
This also brings us a high level of therapeutic area diversification, which is not common in the industry. Our portfolio benefits from long product life cycles, and our average expected duration is around 13 years, exceeding that of many big pharmas and large biotechs. Our broad portfolio, which is characterized by waves of growth, also means we're less exposed to losses of exclusivity or so-called patent cliffs, and this in turn supports our expectation of delivering more consistent and sustainable growth than the biopharma industry. We have an exceptional level of management continuity and owner-operated mindset and are aligned with shareholders, with employees and the board owning 34% of Royalty Pharma shares. Lastly, we're not constrained in our investment choices. Effectively, the entire life sciences R&D ecosystem is our pipeline.
When we turn to industry challenges, we do not take on early-stage development risk, which clearly differentiates us from biopharma. Our pre-approval investments are focused on late-stage products with compelling proof of concept, which combined with deep due diligence, increases our chances for success. We do not bear the high R&D and SG&A cost basis of big pharma or biotech, and we're able to scale our business at marginal additional cost. We're not constrained in terms of therapy area in which we choose to invest and in the different modalities within any given therapeutic area. We focus solely on the strength of the science and the level of unmet patient need. Finally, our proprietary sourcing provides a competitive advantage. Around half of our deals are negotiated on a bilateral basis and are not option-driven, as Chris will highlight later. Moving on to our competitive advantages.
Over our more than two decades pioneering this industry, we have developed significant strengths and built deep capabilities, ultimately creating a strong competitive moat. Today, our business is stronger than ever. As a result, we remain the leader in the royalty funding market with around a 60% share of transactions by value. Our business model differs from other royalty buyers. We're a publicly traded company with a long duration portfolio, a mid-single digit cost of capital, and a low cost of debt. Our competitors, by contrast, are typically based around serial structures, as we were when we first started 25 years ago. With shorter portfolio duration, higher cost of capital, and asset specific debt or equity investments. Our scale also sets us apart. Our royalty portfolio of around 45 approved and development stage products is uniquely broad, and we have a proven ability to execute large and complex deals.
We have deep capital markets access, both equity and debt bonds, and the ability to leverage our portfolio. By contrast, our competitors typically have smaller, more concentrated portfolios and are limited to more costly private debt and equity. Lastly, our platform has a strong, competitive, and durable advantage. We pioneered the market for life sciences funding, and we have a long-tenured experienced team which we continue to grow. We have a singular focus on biopharma, and we have a long history of success of successful collaboration and deep industry relationships, which continue to make us the partner of choice. Our competitors typically have a multi-strategy approach without a sole focus on biopharma, and they lack the history, track record, and network that we have painstakingly built over the past 25 years or so. Importantly, our competitive position has strengthened further since our IPO.
Across multiple metrics, our business model, scale, and platform have each benefited from our becoming a public company. As well as improved access to capital, we have more than doubled the weighted average maturity on our debt to over 12 years, and we have nearly doubled our capital deployment and cash flow streams compared with pre-IPO levels. We have also increased the number of in-depth reviews we conduct of investment opportunities as well as the size of our team by a factor of nearly two times. Over the last decade, we have been the market leader in royalty transactions with an overall share of around 60%. What is especially striking is our share of the larger, more complex transactions.
For deals valued at between $250 million and $500 million, our share is 53%, while for those valued at more than $500 million, our share is 83%. In short, we're the go-to partner of choice for larger transactions. This reflects our deep access to capital and diversified portfolio as well as our proven ability and long track record in innovating and executing funding solutions for our biopharma partners. Royalty Pharma has a diversified collection of growth drivers across our portfolio. First, we have a base royalty portfolio of around 25 approved products, including 12 blockbusters. As we will explain later, this portfolio is performing well and has contributed to increase in our top-line guidance. Second, we expect significant growth in the coming years from the nine recent product launches across our portfolio.
Based on consensus models, six of these products are expected to become blockbusters by 2025. The list includes truly transformative medicines that many of you will be familiar with, such as Erleada for prostate cancer, Evrysdi for spinal muscular atrophy, and Nurtec ODT for migraine. Third, we have a pipeline of 10 development stage candidates. Here, we have a highly competitive track record of picking winners with great success rates. Lastly, future royalty acquisitions. Terry will detail our new capital deployment target of around $10 billion-$12 billion over the next five years, which we expect to drive further growth and value creation for our shareholders. An important differentiator of our business, especially when looking at other biopharma companies, is our long duration portfolio and ability to consistently replenish and add to our growth.
Currently, our portfolio has a weighted average duration of around 13 years, which compares very favorably to many large biopharmas. Of course, we will seek to deploy capital in value and growth-enhancing transactions so that our runway is consistently extended. Since our IPO, we have increased the duration of our portfolio that extends beyond 2030 to 80% from 70% through new royalty acquisitions. This process of consistent portfolio replenishment and diversification allows us to absorb losses of exclusivity in a way that other biopharma companies cannot. As an example, last year, we faced the expiration of royalties on our HIV franchise. This was our fourth-largest source of royalties in 2020, accounting for 13% of total royalty receipts.
Despite the resulting 900 basis points drag from losses of exclusivity on our top line, we still delivered high teens growth in 2021. Royalty Pharma offers access to a broad range of market-leading therapies. Around a quarter of our royalty streams currently come from blockbuster products. In fact, 12 products in our royalty portfolio have end-user sales of more than $1 billion. Of these, four have global sales greater than $3 billion. This degree of exposure to the growth of premier therapies is rarely available in the biopharma industry. This is also important because these products marketers will continue to aggressively invest in given their importance to the company.
Another important advantage of Royalty Pharma, which sets us apart from Big Pharma and biotech, is that we're not constrained in terms of therapy area in which we choose to invest and in the different modalities or drug classes within any given therapy area. We're generally agnostic in this regard and are led purely by the strength of the science and the unmet patient need. Over our history, we have been able to invest in multiple core products in the same class, which is unique and which also builds deep capabilities in certain areas. For example, in the anti-TNF category, we receive royalties from Humira, Remicade, and Cimzia. In prostate cancer, we receive royalties on Erleada and Xtandi. For us, the primary advantage is our ability to expand investments in the most practice-changing and innovative therapeutic categories in the industry, with minimal to no regulatory complications.
A secondary benefit is that this provides us with a partial hedge against competitive shifts in these therapeutic areas. We intend to capture the leading share of this very large opportunity by accelerating our deployment of capital. Most recently, you will have seen that the rapid expansion in the royalty funding market and our strengthened competitive position as a public company have resulted in us investing in royalty transactions at a rate that exceeded our initial target. At the time of our IPO, we provided a five-year forward capital deployment target of greater than $7 billion, which implied an average annual cash spend on royalty acquisitions of around $1.5 billion. To reflect our most up-to-date assessment, today, we're increasing our five-year forward capital deployment target to around $10 billion-$12 billion. This implies an average annual investment of $2 billion-$2.5 billion.
When we look further out, we see the potential that this annual spend could increase to around $4 billion-$5 billion per year, given the very significant opportunity we see for funding life sciences innovation. Based on the strong secular trends, the business momentum we're experiencing, and the increase in our capital deployment plans, we are today raising our long-term top-line growth guidance. At the time of our IPO, we forecasted a compounded annual growth rate in Adjusted Cash Receipts, our top line, of 6%-9% for the period 2020-2025. In February 2021, we lifted this by 100 basis points to 7%-10%. Today, we're significantly raising this outlook by around 50% to 11%-14% annually.
On a relative basis, our new long-term growth target compares very favorably to the S&P 500, the S&P healthcare sector, and our biopharma peer group, and is a healthy 1.5x-2x these benchmarks. Furthermore, as Terry will detail later, we now expect to achieve at least 10% top-line CAGR through 2030, which would likely position us as one of the fastest-growing biopharma companies over the decade. This is a bold statement, but reflects our confidence in our competitive position and capabilities together with a very, very large opportunity set I just described. Importantly, we're committed to delivering premier growth while operating as a responsible business. We consider ESG to be an important driver of value for all our stakeholders.
We're a relatively small company in terms of headcount and footprint, but we're putting in place an environmental program centered on carbon neutrality and waste reduction, supported by employee engagement and training. Our social commitments to our people, our stakeholders, and our community are already well embedded in our policies and behaviors. We have a strong focus on diversity and inclusion and on employee development and satisfaction, which has resulted in a very low employee turnover. We also issued a $600 million social bond last year, which aligns with the United Nations sustainable development goals. We committed to use the funds from this bond to invest in innovation for underserved diseases such as rare diseases and for top diseases or leading causes of death, as defined by the World Health Organization or United Nations. Lastly, we're very committed to philanthropy.
On governance, risk management, compliance, and the highest ethical standards are foundational to our culture. We maintain a diverse, independent board, many of whom are with us today here. With robust ESG policies, practices, and oversight. We're increasingly using ESG to inform our investment process. Expanding on my comments on philanthropic support, this slide shows select examples of the important donations that Royalty Pharma and its management have made since 2020. In total, we have contributed $62 million to nonprofits. Most recently, we signed a collaboration with Mount Sinai Hospital, under which we will provide $20 million to help understand and combat health disparities. Our donations have also helped to advance a world-class national cancer institute at Brown University, and we have provided support for the COVID-19 response, as well as improving access to blood cancer care.
This slide summarizes our recently announced alliance with Mount Sinai to improve health equity. Many of you will be aware that there are disparities in health outcomes in some communities as a result of racial, ethnic, gender, and other factors. Through this alliance, we will provide financial support over the next five years, together with our data and analytics capabilities, to advance the care of these underserved communities. Fundamental to our success is a team-oriented culture and owner-operated mindset. We have 66 highly engaged employees with an equal gender balance and significant diversity, including by ethnicity and national origin. Our executive team has an average tenure of around 12 years, and around one-quarter of our people have advanced degrees. As I mentioned earlier, we pay close attention to employee satisfaction and, as a result, have experienced very low turnover at around 7%.
Lastly, around 34% of our capital is owned by employees and the board, which means that we're fully aligned with the best interest of our shareholders because we too are shareholders. At Royalty Pharma, we have built a powerful engine which we are confident will sustain value creation and compounding growth for many years to come. At its heart is our flexible business model, our platform, and our scale. By leveraging these core attributes, we build on our role as a leading partner in life sciences innovation, providing sophisticated, tailored funding solutions. This, in turn, allows us to accelerate innovation and improve human health. With our low cost of capital, we generate returns on investment, which we reinvest in our virtuous cycle. The output from this engine is compounding top-line growth, which, coupled with our efficiency and high cash conversion, enables us to deliver sustained, attractive shareholder returns.
In closing, Royalty Pharma offers a simple investment thesis. Successful investing in the biopharma industry requires a very particular skill set. It requires deep understanding of the science, of competitive and technological risks, of regulatory and clinical trial risks, of trends in drug pricing and reimbursement, and of litigation and IP risks. It also requires strong financial know-how, including the ability to accurately model the impact of losses of exclusivity. A successful investment in biopharma often requires an investor to tie all of these inputs into a financial model. The key here is that we need to get most of this, if not all of them, right. You get a few wrong, and things go not well. Through our business model, we bring access to many of the most transformative products in the industry.
We have a long history of picking winners, blockbusters supported by a rigorous and institutional diligence process. We offer a broad and highly diversified portfolio with very limited binary risk. Our business model allows Royalty Pharma to consistently replenish and extend the duration of our portfolio, supporting the longevity and sustainability of our compounding growth outlook. We think this is a compelling proposition. Finally, we bring the depth of experience, a proven track record, and a real passion for what we do. With that, I'd like to thank you for your time, and I will now hand it over to Chris to expand on the enormous business opportunity we see ahead of us. Thank you.
Okay. Can you hear me? I'm gonna come over here, switch it up a little bit on everybody. I'm Chris Hite. I'm an executive vice president at Royalty Pharma. I've been at RP now just over two years. Prior to joining RP, I was an investment banker for 25 years. Don't hold that against me. Primarily focused on pharma and biotech and the M&A and capital formation activities. Today, I'm gonna talk about our market opportunity, and I wanna leave you with five key messages. One, we have an expanding opportunity in the existing royalty space. This is really driven by the industry fragmentation of R&D and of marketing drugs, all of which leads to royalty creation. Two, the sector has significant capital needs.
We estimate that unprofitable biotechs over the next 10 years will need between SG&A and R&D over $1 trillion. It's a lot of capital. Three, we've come up with innovative funding solutions to meet that capital needs, which dramatically expands the market opportunity beyond existing royalties. Four, we can use all of our structures and investment techniques to facilitate M&A. Five, we believe that we have a differentiated sourcing and engagement with our partners that gives us a competitive advantage. Those are the key messages. Let's jump into it. You're gonna hear this a lot today from people at RP and also from our partners, which is we create win-win solutions. You heard Pablo talk about the structures and how we invest. They're on the left-hand side, part of the slide.
On the right, you can see in the bubble, the partners and where we use the structures, to invest. Let's start with existing royalties. You can see that we've done a lot of deals with foundations, hospitals, pharma. There's biotechs that we've done with PTC and Dicerna most recently, where an existing royalty exists. We acquire the royalty. We take the long-term risk of the drug. Why is that good for our partners? Well, it diversifies their assets. For biotech companies that sell us the royalties, it's a non-dilutive financing mechanism, and it allows them to get upfront capital today as opposed to elongated payments. Win-win solution. Next, synthetic royalties. This is a dramatic increase in the total addressable market for Royalty Pharma. We came up with this innovative solution.
You can see the folks that we've done this with, both large pharma as well as biotech. Why is it a win for our partners? One, if you're a biotech company and you do this, it's much lower cost of capital than selling equity. Two, it allows the biotech and the pharma, who sometimes partner with other pharmas, to retain operational control of the programs and of the marketing of the drug. Three, it's just a significant lower cost of equity. Let's move down to launch and development capital as the next structure. You can see some of the companies we've partnered with in this, Biohaven, Cytokinetics, MorphoSys. We provide this funding mechanism in addition to the synthetic royalties to get companies more capital, especially around the launch of their drugs. Why is this a win for them?
Once again, lower cost of capital than issuing equity and far less restrictive than debt. We provide this capital, and we're willing to be very flexible and patient as opposed to the debt providers. Finally, we can use all of these structures to help facilitate M&A, and you're gonna hear a lot about the MorphoSys transaction, and we'll talk a little bit later on how we help large pharma when they acquire biotechs. Let's dig into the existing royalty marketplace. This is a complicated slide because the industry is complicated. The industry is highly fragmented. When you think about it, there are more than 5,000 labs out there, academia, not-for-profit labs, that get funding from governments, raise their own capital, do basic research.
They out-license that research and form companies both on the biotech side, and they out-license it to pharma in exchange for royalties. Large pharma and biotechs also cross-license programs in exchange for royalties. You can see that Royalty Pharma has, for the last 25 years, played in between every one of these bubbles, where they've acquired these existing royalties from either academia, from large pharma, or from biotechs. That's the existing royalty marketplace, once again driven by the highly complex and very fragmented sector. The left side of the slide and the right side of the slide, where you see the synthetic royalties, that's how we've grown the marketplace dramatically beyond the existing royalty structure. I'll get into that in a few slides.
Let's spend a little bit of time on academia and not-for-profit existing royalties. The NIH alone funds $45 billion a year and gives grants to these labs in academia, not-for-profits. Globally, we estimate there's $100 billion per year spent by governments, academia, and research institutions for basic research that they then can out-license. This has been a very large piece of our business over the last 10 years. If you go back over 10 years and our committed capital represents roughly 25% of our committed capital to these not-for-profits in academia, of which you can see many examples of who we partner with on the right-hand side of the page. Foundations like the Cystic Fibrosis Foundation, universities like UCLA, Emory, and Duke, as an example. That's in the not-for-profit academia existing royalty marketplace, which we expect to grow in the future.
Now let's spend a little bit of time on existing royalties that are at large pharma and biotech. If you go back 10 years, in 2010, the average licensor partner for each approved drugs, there was 1.5 licensor partnership for each approved drug. That has more than doubled over the last 10 years to now 3.1 partnerships or license per each approved drug. Dramatic increase, and it shows the fragmentation of the sector. On the right-hand side of the slide, you can see a recent deal that we did where we acquired a royalty on Cabometyx from GSK last year. Okay, that was a deal done in 2021, a 3% royalty on Cabo. Think about how that was created. You have to go back basically 20 years where GSK and Exelixis formed a collaboration to discover compounds.
That collaboration was terminated in 2008. In exchange, GSK got a royalty that we acquired basically 13 years later. Along the way, Exelixis launched the drug in the US but partnered with other parties ex-US in exchange for double-digit royalties. That's just a snippet of what happens in the pharmaceutical and biotech sector every day. Collaborations, partnerships, where they're partnering on both R&D and marketing, which creates royalties, which has been a huge opportunity for us historically and will continue to be in the future. Now I'm gonna move over to the expanding market of synthetic royalties. When you think about this, it's a significant opportunity for us, and it's really just been developing over the last few years. Think about the amount of capital spent by the sector. It's enormous.
If you think about academia not-for-profits over the next 10 years, we're expecting those institutions to spend over $1 trillion on R&D. As I mentioned, they out-license that, creates existing royalties. Unprofitable biotechs are expected to spend $1.1 trillion on SG&A and R&D over the next 10 years. Pharma, profitable pharma, will spend approximately $1.6 trillion in R&D over the next 10 years. Royalty Pharma created the synthetic royalty opportunity where we actually can now partner with any pharma or biotech company on any program. There doesn't need to be an existing royalty there. We can create one, contractually through a true sale of a revenue participation right. We can create a synthetic royalty. It dramatically increases our market opportunity beyond the preexisting royalty streams that I just talked about. How do we actually generate top line?
Think about the end users, the end user sales from that investment by these institutions. The end user pharmaceutical market is estimated to be $2.3 trillion by 2030, of which $1.3 trillion hasn't even been approved yet. That is where we actually get a piece of those end user sales through existing royalties and synthetic royalties. A question many ask that aren't necessarily close to the biopharma or pharma sector, "Is this market growing? What's happening?" Well, the answer is yes, it's growing. If you look at the left panel, the venture capital investments over the last five years have increased threefold from $12 billion in 2016 to $36 billion in 2021.
Those investments lead to company formation, which turns out to be IPOs, which have also increased more than threefold over the last five years from 21 IPOs in 2016 to 74 IPOs in 2021. Those companies need a lot of capital. The public biotechs that are greater than $0.5 billion market cap has also increased threefold from 97 in 2016 to 308 in 2021. All of which, as we just learned, need a lot of capital. We can provide that capital through synthetic royalties and through launch and development capital. Now just digging down a little bit on the synthetic royalty opportunity and how it's really under-penetrated. If you look on the right side of the slide, this pie chart.
From 2017 to 2021, biotech basically raised $260 billion in funding through a combination of IPOs, follow-on equity offerings, pharma licensing deals, convertible debt, and just a tiny sliver of synthetic royalties. Just 2% of the marketplace. I was a former banker. I can tell you that five years ago, the synthetic royalty opportunity was not being discussed at the board level or the C-suite. It just wasn't. If companies needed to raise capital, they would go do a 10% equity dilution deal with their bankers or convertible bond offering with their bankers, not even think twice about it. That's what they did to raise their money. I think going forward, we're starting to see this really develop over the last couple of years.
The synthetic royalty opportunity is now really at the forefront of their thinking at the board level and the C-suite level. Why? Well, once again, it's a win-win opportunity for these companies because it allows those companies to retain operational control. Ask Immunomedics, ask Biohaven. Had they partnered those drugs at that early stage, and lost operational control, would they have been as attractive to a strategic acquirer? As I mentioned, synthetic royalties are much lower cost of capital than selling equity across the entire company when we're really just funding specific assets in the synthetic royalty opportunity. It's a. There's lots of wins, and we're really seeing this as emerging growth opportunity in the sector.
Once again, as I mentioned, $260 billion raised by the companies over the last five years with synthetic royalties really just being 2% of that $260 billion or $4 billion. We estimate that the biotech sector will need to raise $450 billion in total capital over the next five years. Just hypothetically, if the synthetic royalty opportunity just expanded from 2% of that pie to 4%, that's an $18 billion market opportunity in synthetic royalties alone. If it expanded to 8%, that's a $36 billion opportunity for synthetic royalties going forward. Massive opportunity. The question is. Do our partners like these structures? The answer is yes. We have repeat business with our partners. Biohaven, four transactions. BioCryst, two transactions. Cytokinetics, two transactions. They understand the benefit of doing synthetic royalty deals with us.
They understand the advantages of launch and development capital. They understand it's a cheaper form of capital for them, allows them to retain operational control. People are really starting to understand this. I don't need to spend a whole lot more time because Marshall , Brienne, and Sara will really go through a lot of these case studies. Repeat customers is evidence that they like what we're doing. I'm gonna switch gears now to M&A and how we can facilitate M&A. On the left-hand side of the slide here, where it lists mid-cap M&A. Okay. I was an M&A banker for 25 years. There was really not much mid-cap to mid-cap M&A at all in the sector, and there's a really simple reason for that. The reason is the target companies want cash as consideration.
If you're a mid-cap biopharma company just launching a drug, you know, one, you're not creditworthy 'cause you're likely not making money, and two, you don't have the capital to deliver to the target shareholders. How are you gonna get the capital? Well, banks aren't gonna lend it to you. Guess what? Royalty Pharma can extend you the capital through buying existing royalties, creating synthetic royalties, providing launch and development capital, and we did that with MorphoSys buying Constellation for $2 billion. Once again, Sara will go through this case study in great detail. How else can we facilitate M&A? When a large pharma company buys a small biotech company, oftentimes they're buying it for their lead compound, lead drug. As we know, there's a lot of fragmentation.
The biotech company may have an existing royalty on something they outlicensed years before that. This was the case with Astellas and OSI. I actually happened to be the banker on this deal representing Astellas back in the day. It was a hostile transaction where they were trying to buy OSI for one of their oncology drugs. OSI had a royalty estate on the DPP-4 patents. Astellas had zero interest in that, no interest in that. They were buying it for the oncology drug. I told Astellas at the time, and I'd worked with Pablo and the team for many years, so I knew that they would be very interested in this.
I said to Astellas, "After you buy the deal, after you buy the company, we can approach Royalty Pharma and you can sell that." That's exactly what we did. We closed the transaction with OSI. I picked up the phone. I called Pablo. I said, "Would you be interested?" Right after the transaction, we sold that DPP-4 royalty estate for $609 million, which helped defray the upfront cost to Astellas. Once again, a win-win transaction that Royalty Pharma created. I'm gonna switch gears now to sourcing. We think sourcing provides us a competitive advantage. Sourcing, we track, we engage, we do diligence, we execute transactions. I'm gonna spend a little bit of time on sourcing, tracking, and engagement. You might imagine we have a comprehensive database of royalties and licenses out there.
We map those, we closely follow the clinical and commercial progress of those using our strategy and analytics team, as well as the broader team. We engage with parties early, so they understand how we can work with them, how we can provide capital. They understand how we work. We understand how they work. We drive earlier engagement. Years before maybe we're ready to invest or they're ready to take our capital, we're meeting the companies, we're understanding their programs, and they're understanding what we do. What are the results of that? If you look at the right side panel, companies that are in phase three or later that have a market cap of greater than $1 billion, we effectively, over the last handful of years, have met with 80% of those companies. That's a lot of companies.
If you're a company phase two or later that has a market cap of greater than $0.5 billion, we've met with 66% of those companies over the last handful of years. A lot of companies. We're engaging with companies when it would be probably one or two or three years before we'd ever want to invest in that company, but they understand how we work. We're building relationships, and that really, I think, leads to the following slide. Pablo mentioned this, and I think it's really a remarkable slide. We went back to 2016 to current, and looked at the 14-D-9s of every M&A deal in the pharma sector. We read the background on the mergers, and we determined how many were broad auctions, limited auctions.
The limited auctions is three or less parties or how many were bilateral negotiations. Basically, 87% of every pharmaceutical M&A deal is an auction. 87%, with 59% being broad auctions. Only 13% deals done in pharma are bilateral negotiations. Compare that with Royalty Pharma's transactions over the last five years. 52% of our transactions are bilateral negotiations, with only 30% being broad auctions. Why? Early engagement, relationships, trust. Those are really meaningful words, and we really deliver on that. They know that we deliver win-win solutions. We're really proud of that. I'm gonna leave you with my five key messages again today. One, the existing royalty opportunity is growing and expanding given the industry fragmentation of R&D and how drugs are marketed. Two, the sector needs a lot of capital.
Remember, unprofitable biotechs are expected to burn over $1 trillion over the next 10 years. Three, we've come up with innovative funding solutions to address that need. We don't have to rely on an existing royalty to be out there. We can create a royalty on virtually any product under development or ready for launch in pharma or biotech. Four, we can use all of our funding solutions to facilitate M&A. Five, we believe our relationships and early engagement provides us a competitive advantage on sourcing transactions. With that, I'd like to thank everybody for attending here in person and those on the webcast, and I'd like to hand it over to my partner, Marshall.
Thanks. Good morning, everybody. I'm Marshall Urist, and I head up the Research and Investments team here at Royalty Pharma. By way of quick background, I've been at Royalty Pharma for nine years or so, and before coming, I had a career as a sell-side analyst in biotech. For anyone who's new to our story, the Research and Investments team is the group of Royalty Pharma that is really central to our investment process. From the earliest stages that Chris talked about in terms of identification and sourcing through our diligence process, which he'll tell you a lot about today, then through structuring and negotiation and ultimately execution, of course, collaborating with many other parts of our team along the way.
I'm gonna talk about the Research and Investments effort at a high level and some of the things that we're doing now and why we're really excited about the future. Then you're gonna hear from a couple of our key team members. Brienne Kugler, a VP in our team, is gonna talk about our partnership with Biohaven, one of our most important and successful partnerships. Then Sara Klymkowsky , another VP in our team, is gonna talk about one of our most complex and interesting deals over the last year, and that's our deal with MorphoSys. The three key messages I wanna leave you with today. The first is that everything we do starts with our team. It is foundational. Attracting, developing, retaining the very best talent is absolutely critical for our success and makes everything else possible.
Second, we have a really differentiated investment process that we've institutionalized and honed over 2.5 decades, and I'll talk a lot about that. Then finally, we really think about Research and Investments as a platform that has scaled and will continue to scale into the future to leverage our very unique position in the biopharma ecosystem that you heard about from Pablo and Chris earlier. What makes it unique? First is tenure. Like I just mentioned, we've been at this for twenty-five plus years, and that gives us a really unique perspective. We have a one Royalty Pharma team philosophy that I'll talk about that's really critical to how we work and our track record to date. We have an open business model, meaning there's no cookie-cutter definition of what a Royalty Pharma deal looks like.
We really start with trying to find a win-win solution for our partners. As I just mentioned, we think of what we do as a real platform that is really built to scale with all the growth we see ahead of us. We have a really deep due diligence process. Finally, an important part of our process is a continuous focus on process improvement, with a great example of that recently being the establishment of the strategy and analytics team and our data effort that I'll talk about later. Before we get into the details, I wanna come back to our team. This incredible team that you see here is the foundation of everything that we do. We can have the best processes and the best platform, but without incredible people to execute it really wouldn't work.
I couldn't be prouder of the team we have today. Our team has grown a lot over the last 10 years or so. In 2012, just before I joined in 2013, research and investments was about six people. At the end of 2021, that had grown over threefold to 21 people, and as we look ahead to 2025 and beyond, we fully expect to continue to scale the team to meet the opportunity that we see in front of us. Another way to look at how we've scaled and evolved over time is thinking about Royalty Pharma in terms of functions and capabilities. In the mid-nineties, as Pablo talked about when he founded Royalty Pharma, it really was more or less just research and investments. Then over time, we've purposefully added key internal capabilities, finance, accounting, legal.
More recently, as I mentioned, we've added a data effort in strategy and analytics. We've added Chris and his team in investments and capital strategies. Even in accounting, we've deepened our expertise there with an advisory and strategic part to that as well. In parallel with that, the investment capabilities and what we do evolved, has evolved very significantly, as you heard about from Pablo and Chris. When Pablo started, it was just preexisting royalties on approved products and has grown dramatically in the ensuing decades to include development stage or unapproved therapies, R&D funding, equity investment, synthetic royalties. More recently, the develop and launch capital structures that you've seen us start to work with, and we fully expect to continue to innovate into the future with new structures to fund biopharma.
Let's get into our process, and we really think of it as three key drivers. The first is our approach and how our teams work, and I'll talk more about that in a second. Second is the depth and breadth of our diligence process. Then finally, and I think most importantly, is a deep culture of accountability, where there's one team that owns the whole process. The executive leadership team that you're hearing from today is really involved in every step. That owner/operator mindset that Pablo talked about really drives us even down to the individual team and project level. I mentioned this whole concept of one Royalty Pharma team, and I think to understand it best, I think we need to contrast how we work to how traditional business development is often done in biopharma.
As Royalty Pharma evolved, we really developed our process and how we work to avoid some of the key drawbacks that we see in the traditional model. The first one is the idea of siloed due diligence. As you can see here on the left, that often, as due diligence goes through, progresses through the various stages, lots of different stakeholders in the organization will contribute views. The R&D organization might have perspectives on the science or the clinical diligence. Commercial, the commercial people provide key model inputs. I t's all very siloed with different people providing different inputs, and you don't have one central team that's driving the process.
All of that due diligence is packaged and then passed on to a committee or a series of committees or some other body that's really there to make the decision. I think that concept of layered decision-making is the second thing that we're really set up to avoid. Finally, of course, all of that leads to a transaction decision, and I think our view on that is that it also tends to lead to reduced accountability. Now to contrast that, on the other side is how Royalty Pharma works, and we bring this one Royalty Pharma team philosophy. I can't overestimate how important this is. Our one Royalty Pharma deal team is involved from the very, very beginning of identifying and developing opportunities through doing diligence, structuring, and negotiation all the way through to execution.
As I mentioned, without question, we work with different parts of our team, like legal and finance along the way, but it's that deep product knowledge, the feel for the product, the clinical trial, the company that really informs every stage of what we do. As that progresses through the various stages, as I mentioned, our executive leadership team is there along the way as we build and refine our thesis. What that means is true unified decision-making when we get to the end. There aren't various steps. Everyone is brought along together to result in a final decision.
I think that continuity, that unified decision-making, is really key to our track record and the power of what we do, and I think it leads to that ownership and accountability, and, importantly, the high levels of conviction that we need to make our investments. There's a ton of detail on this slide about our investment process, but it's up here for a purpose, to make some key points. The first is our process is deep and wide. We often say internally, "If it's knowable and we need to know it, we will go and find the answer." There is no resource that we won't go after to try and answer a question. Knowing what questions to ask is not enough.
I think the platform aspect of what has been built at Royalty Pharma over the 25 years is having the ability to go out and know where to find the best, most informed answers to all of these questions. E ven knowing what questions to ask and knowing who to ask isn't enough. I think the other really powerful part of our platform is having the ability to integrate all of this various forms of information into one coherent investment process and make a coherent investment decision. Now, we're always adding and refining this list, but I think taking a step back here really shows you how deep we will go and every question we will try and answer in trying to get to the right conclusion on a given product. What does this look like in practice?
Well, I think one of the founding insights that Pablo had when we were first working on our process is that the biopharma world is just too varied, too complex, too dynamic to ever have all of the domain-specific expertise that you need in-house for a given project. We developed this idea of having a small internal team that then you go out and you build this very large external team that's sometimes not obvious when you see the deals we do from the outside. It might look like a small team at Royalty Pharma, but in all actuality, you have a very big external team that's staffed by world-class expertise on a project-by-project basis. To show you what that actually looks like in person, in the real world, we have four recent prominent investments.
You can see here for each of these, we had a relatively small internal team, and then we had over 15 times that many people that were working externally on each project. You can see that's how we create a lot of scale, and that's how we create a lot of leverage from our relatively small, focused internal team. Now, an important point, and this is something that is not always hard to see from the outside, is that we will really run hard and fast and go far, even sometimes when projects don't work out.
I think that culture of saying no and being able to walk away when a project isn't right or isn't going the direction we want it to is also a critically important part of our culture and our process, and I'll return to that in a second. Here's a real example. This is a paused project. Of course, I can't tell you what it was, but you can see here we had our regular small internal team, and then we made a huge investment of time and effort to try and get this project over the line, as you can see here. Unfortunately, we got to the end. Some information came to light at the sort of end of our diligence that meant we couldn't go forward.
There was no hesitation on our part in terms of saying, "If it's not right, it's not right, and we'll walk away." No sunk cost decision-making, no inertia of a project might have on its own. We've built a platform and a process over two decades. I think key to that has been a real focus on continuous process improvement. Are we leveraging the best sources of information? Are we doing everything that we can do to be the best at what we do? A great example of that process improvement is the strategy and analytics team that's headed by Sandy Balkin that's been built over the last few years. Strategy and analytics is an in-house data team that manages a very large resource of in-house data that is really helping us in a number of ways.
I think at a high level, there are two big benefits that we're seeing. The first is probably clear, and that's internal. Having these data resources and the people to help us interpret all that data is really key and it's becoming more important every day to our investment process and giving us the very best, deepest insights for the projects that we work on. As we've done more and more with strategy and analytics, it's been clear that the second aspect of how this is gonna be really powerful for us is external. That's what we've seen, that all of these deep, really interesting insights that we're generating, we can also share with our partners to help them in terms of commercial strategy or clinical trial design or understanding the competitive landscape.
I think as we share these kind of insights with our partner, it evolves Royalty Pharma's position to not just be a provider of funding, but to be much more of a strategic partner. I think there's definitely a virtuous circle dynamic there as we provide not just capital, but greater strategic insight that we more and more become the partner of choice. What's the vision for strategy and analytics? There's two big efforts inside of that team. The first is called strategic search and evaluation. It's led by Bill Grau. That is a science-driven effort that really focuses on development landscape, things like development landscape scanning, therapeutic area mapping, really being on top of all of the incredible basic science that's coming out all the time.
The real core mission of this team is horizon scanning for Royalty Pharma, positioning us for the future. You know, our deal teams internally are so intensely focused on trying to get the next deal right or focused on the next two deals that sometimes it can be hard to take a step back and really think long-term about how we should be positioning ourselves. I think that's the core mission for this team.
You know, part of this effort is gonna be earlier partner engagement, like Chris referenced as well, to start to identify exciting opportunities early on and engage with them and we get to know them, they get to know Royalty Pharma better, so that when the time comes for potentially working together, they know us better, and we've helped them think through how we and royalties could be a part of their part of their capital plans. Now the other big effort here is also really exciting, and that's a data analytics effort that's led by Sandy, who I mentioned, and then also Oodaye Shukla.
This is a deep data analytics effort that focuses on things like medical claims, real-world evidence, thinking about sales and marketing benchmarking, so does the forecast match the spending level that a company might be thinking about or thinking about payer and formularies in a really deep way. Really what we're trying to achieve here is a proprietary integration of many different data sources so that we have an absolutely best-in-class platform for market evaluation and forecasting. I think the kinds of insights we're getting from this are really exciting and are becoming absolutely core to nearly every project that we work on at this point. It's great to talk about all this at a high level, but I wanna show everyone exactly how we use this in a real way and how it's so powerful for our process.
I wanna use an example of a recent transaction, which was our deal that we announced in January with Cytokinetics. Now, for anyone who doesn't know, Cytokinetics is a biotechnology company that's based in San Francisco that focuses on muscle biology in areas like cardiology and neuromuscular disease. We were talking to them about funding a key phase three program of theirs called a drug called aficamten, which you heard Pablo mention earlier, for a disease called hypertrophic cardiomyopathy, which is a bit of a mouthful, or HCM. This is a great example to talk about how we use strategy and analytics because it poses some common challenges that we would often work through in a different way in the past. Specifically, that's that HCM is a novel disease area.
There are no FDA-approved therapies, so there's no precedence to help you think through the commercial opportunity. Often that means that there's more limited external sources of data. Also importantly, Cytokinetics and with aficamten were gonna be second to market behind Bristol Myers Squibb, who recently had the first in class drug called Camzyos approved in the last few weeks. How did we approach this? Well, we partnered with Strategy and Analytics, as we're increasingly doing on every project, to really deeply interrogate the in-house data resource.
I wanna put some numbers on the kind of resources that we're bringing to bear here, which is that we have an internal medical claims and an electronic health record database that encompasses 150 government and commercial payers, 90 million patient lives, and over 20,000 physician practices, which gives us a huge data set to really drive interesting insights about disease. Here's the kinds of insights that we're starting to get. The first one is relatively simple, and it might surprise some people that these kind of questions can be hard to answer. For a novel disease area, simply asking the question, how many addressable symptomatic patients are diagnosed in the U.S., can be hard sometimes.
You're often stuck with triangulating from different sources of information from the academic literature or from, or from epidemiology. Like in this case, the companies who are involved in this space are putting out, will put out numbers as well. Often, I think part of our challenge at Royalty Pharma is being able to independently verify that information in a really high conviction way can be challenging. We look deeply into that database I just described, and we're able to confidently say that we, that as we work through it, we think there are about 88,000 symptomatic addressable patients, in the United States with HCM. Now interestingly, that falls more or less right in the middle of the range that Bristol Myers had put out there.
I can't overemphasize how important it is for us and our process and driving conviction to be able to have these kind of insights. Now, knowing the number of patients is just the beginning. I wanna talk next about some of the deeper, higher level insights that we're able to get that I think are even more interesting and what has us so excited about this for the future. That's the panel in the middle. This focuses on the patient journey, the idea to what happens to patients after they're diagnosed. I think one of the key features of our database is that we can take longitudinal insight over time, so follow a patient over many years.
Here we looked at all patients who were first diagnosed with HCM in 2018, and then we're able to follow them over the subsequent years. When we looked at this data, we saw something really interesting, which is that when you look even a year later, that less than half of those patients had actually even come back to their physician for additional HCM care, and then it falls off in the subsequent years. Now, some of that is probably because maybe they're not sufficiently symptomatic to need a high frequency physician relationship. C ertainly a lot of it is because when there's no approved drugs for that condition, when they're only non-specific therapies, when they're not companies investing in physician, patient, and disease education, that you have a market that hasn't really come together yet.
What we saw here was an incredibly clear opportunity for market development and market expansion. Remember I referenced that one of the key questions was Cytokinetics and aficamten were gonna be second to market. When we saw this, we also realized that having Bristol there first, having them develop, invest in market expansion and market development, was only going to be helpful to Cytokinetics. I hope this gives you a flavor for why we're so excited about these kind of efforts and how these kind of insights are becoming so critical to driving our conviction, and this resulted in part in our $450 million deal that we announced with Cytokinetics back in January.
I wanna switch gears a little bit and talk about something I referenced before, which is our culture of saying no. Now, many of you might have seen this graphic before of our investment funnel, but I wanna use it to make a different point than maybe we've talked about in the past. That's that you can see that in 2021, we saw 300 things in total at the very top of our funnel. You can see we only signed CDAs or confidentiality agreements to take another step forward in 85. Then we only really did an in-depth review, and by that we mean we really started to go deep and put resources in 61 of those.
I wanna take a step back and have everyone realize that we are so deliberate about how we invest the team's time, which is probably one of the most important decisions we make. You can see from this funnel is that we have such discipline about saying no. If it's not something that we really see a potential in, there is no hesitation about walking away if it's not right. I think that discipline to walk away from things is an underappreciated part of our process. Now, let's look at the funnel in a different way to give everyone a different sense of kind of how our pipeline and how it is evolving and how our business is evolving.
Here, we can look at both the initial review level, that's the top of the funnel, and then the in-depth review, that's the third layer, across several characteristics of different kind of projects. In the first, let's compare pre-approval and approved opportunities. When you look at the top funnel, it probably will surprise no one that 80% of the opportunities that we see are approved. Now, when you go to the in-depth review level, you can see there's a very significant shift, which pre-approval opportunities go down to a little bit more than half. There's two big conclusions here. The first one is that there's a very high bar for us to move pre-approval opportunities out of the top of the funnel.
At the same time, pre-approval opportunities are a very significant part of how we spend our time, and I'll come to that in a moment. Second, let's think about synthetic and pre-existing royalties that you heard about from Pablo and Chris. At the top of the funnel, synthetics account for 75% of those opportunities. When we work down to the in-depth review level, it goes down. Synthetic royalty opportunities are 60%, but it's still a very significant portion of what we're seeing and what we spend our time on. This should give you a sense of why we're so excited about this as a potential as an important part of our business today and an increasingly important part of our business in the future. Finally, think about it in terms of inbound versus outbound opportunities.
Again, not surprisingly, inbound opportunities are about 80% of what we see at the top of the funnel. If you go down to the in-depth review level, you can see that flips entirely where outbound opportunities are 70%. What that tells you is that things that we pre-identify as interesting, that thematically we like or that are important products, is really where we spend most of our time. I think that's another important part of understanding our process and our track record and our internal discipline. Let's spend a little bit more time on development stage therapies. Like you heard about this morning, we've done a lot of this over the last 10 years, $8 billion in development stage investments.
We have a very high bar here, and we're currently really excited about the 10 development stage therapies we have in our portfolio. Now, the middle panel here, this pie chart, is something that our team, that I am extremely proud of, which is if you break down all of our development stage opportunities by disease area, you can see there's been a huge variety of areas that we've invested in. I think there's no better example here of the power of our platform and our approach than what we've been able to do with a good success rate and a lot of discipline in terms of our development stage investments.
All of that has rolled up into a really great track record of converting these development stage therapies into approved medicines, and that's 80% by the number of investments and 95% by investment value. Another way to look at our pipeline and our funnel and how we've scaled and grown recently is shown here. You can see even over the past two years, we've seen over 50% growth in initial reviews, and that's been mirrored by an over 50% increase in our in-depth review rate, which is part of what gives us confidence and what should give everyone else confidence that we have been scaling significantly as our markets have grown.
We feel really confident we'll be able to continue to scale to meet the opportunity that you heard about from Pablo and Chris. I've talked a lot about how we do what we do and the types of questions that we ask, but I haven't actually touched a lot on the content. What do we actually look for? You can see here at a high level a lot of the things that we look for. Actually, one of the most important things of what we look for is actually not even up here. That's that we don't start from asking the question, is there an attractive economic or financial return opportunity in this project? We actually start by asking questions about the product. Is this an important medicine? Is it important to patients in this system?
Does it deserve a place alongside all the other incredible medicines in the Royalty Pharma portfolio? If the answer to that is yes, we will work really hard and bring all of our creativity and long-term perspective to try and find a win-win solution that's economically attractive for us and our partner. I think that product-first approach is another absolutely core part of our process and a core part of our success. Now, our investment philosophy and approach has been and will continue to be the same, which is that we follow the most exciting products that we're seeing at any given time in a therapeutic agnostic manner. Full stop, that won't change.
Now, that doesn't mean as we work through things that we don't have investment theses and themes that we think are interesting in our work with strategy and analytics or as we think big picture about all the projects that we're working on. We thought it'd be fun to share a few of those with you today. The first one is this idea of under-innovated large markets. I think the shift towards specialty markets over the last few years, which we've seen get so much more attention, smaller patient populations, higher price points, has meant that all of this incredible innovation and science that we've seen has not, to the same extent, been applied in some of the larger markets that are out there that are higher volume, lower price point.
That's a really exciting opportunity because we think we're gonna see cycling back to bringing a lot of this exciting innovation to bear in some of these other markets. I think thematically, our investments in migraine are a good example of that. More recently, the successful trial with AstraZeneca for PT027 in mild-to-moderate asthma is another. The second one is the idea of new modalities for new diseases. Now we've been asked many times about our level of interest in cell and gene therapy and things like that. I'll tell you the way that we think about it, which is that there's been such incredible technological innovation in terms of technology platforms.
What we're really excited about is now the next stage of that, which is seeing all of that incredible investment in technology platforms start to produce some really exciting new products to tackle disease in a new way. I think we're just at the very beginning of that process, and that's the thing that we're really excited about and we think is gonna be a big opportunity for us in the future. Next is brain disease, neurodegenerative disease, psychiatric conditions. Here's another area where there's been a tremendous amount of science to really, truly, for the first time, understand what drives these diseases, and also investments in drug design and delivery to actually tackle them.
This is another area where we see a convergence of this science to actually start to produce some really exciting new products that are gonna be meaningful because we know there's profound unmet need in this space. Finally, another thing we're excited about is the idea of targeted therapy beyond oncology. We all have seen how powerful it's been in terms of patient benefit to match a drug's mechanism with the driver of their cancer. That powerful concept has really seen much less application outside of oncology. I think another theme that we're excited about is seeing sort of mechanistic insight in areas like immunology or neurology and others start to be brought to bear to really match drugs to the drivers of a patient's disease in new areas.
In fact, the example that I talked about with Cytokinetics in HCM is a perfect example, which is that you had a genetically-driven cardiac condition and a drug that was designed to attack the underlying driver of that, of that condition, and we've seen it drives very significant symptomatic benefit. I think we're real excited about that theme into the future. I'll wrap up here with a couple slides to bring a lot of the themes that I've talked about together, which is that I think there is that just simply looking at what we've done over the last two years gives us confidence and is such clear evidence of our ability to execute on the process and the platform that I've laid out for you today.
Our team has added 21 new products in 25 different diseases to our portfolio over just two years, really showing you our ability to do high quality work, high conviction conclusions across a huge range of diseases, both with products that are approved and pre-approved. I think this should give you a feel for why we're so confident in our ability to capture an increasing share of all of the incredible innovation and opportunity that's out there. Put this in a different way of how we've scaled even significantly over the last 10 years. If you take the last ten-year period and you divide it in half into five years. If you look at the number of transactions into the first five years of the last decade, we did 12 transactions.
In the last five years, we more than doubled that to 28. Same thing with royalties acquired. In the first five years of the last decade, we acquired 15 royalties. In the last five, we've over doubled that to 35. You can see, we've scaled our business and our team and our platform very significantly over the last 10 years, and this is again why we're so excited and so confident in about our ability to continue to drive growth that you heard about from Pablo and Chris earlier. It was great to talk to you guys about everything that we have going on in research and investments, and you'll hear from a couple of our team members after our Q&A session. Thanks a lot.
We will now kick off the first of two Q&A sessions. If you do ask a question, please use a microphone, identify yourself, and we would also request that you limit your questions to the content covered in the first three presentations. We'll take the first question from Steve.
Thank you. Steve Scala from Cowen and Company. Wonderful presentation this morning. I have two questions. I'd just like to understand the profile of your top-line growth. You noted that the company grew 13% 2010 to 2020. You're guiding to 11%-14% in 2020 to 2025. You said that you could grow 10% or more in 2020 to 2030. Just doing the math, it implies that growth could be as low as about 6% in 2025 through 2030. I'm just wondering, with a presentation just filled with promise this morning, why would there be a decline, especially of that magnitude? Second question is, I'd like to ask a question about cystic fibrosis. You've noted that it may or may not be an issue.
You've quantified the impact, which is modest, but that's not the question. The question is, have you had discussions with Vertex year to date on this topic of their new triple? And if so, what has been the tenor of those conversations? Thank you.
Thank you. I guess, I'll ask Terry to take both questions.
Great.
Which are very appropriate for him.
The question on growth, I'm gonna get into that in a minute. I think, you know, high level, we're really proud of 10% or more growth over this decade and confidence in our ability to deliver on that. If you look at the guidance that we've given today of growth from 2020 to 2025, it's 11%-14%. You know, longer term, 2020 to 2030, it's 10% or more. I wouldn't really characterize that as a major step down. I'll also touch on this later, but this assumes, and I think that, you know, we would all probably say after Chris's presentation and Marshall's presentation, that this is conservative. This assumes for this target, you need to make a capital deployment assumption.
We're assuming that it stays flat at $2 billion-$2.5 billion per year on average. I think Pablo would tell you that that's probably gonna end up being very conservative. I wouldn't call it a step down. I think it's really good growth, and it's something that, you know, we think will stand out versus biopharma and really all industries. Then the CF question.
I just was gonna add that, what's been shocking to me over more than two decades of investing in life sciences is that, the innovation taking place when I started was amazing, but not at the level we're seeing today. Today is just incredible what's happening in this industry. What has always shocked me is I remember always saying to myself, "We're growing now, and I can see how the business is gonna grow over the next three to five years, but where's the growth gonna come from five years from now, seven years from now?" It has always been a surprise to me that when we get there are things for us to invest in that are incredibly exciting and that, you know, end up delivering that growth. I do agree with Terry that I think we're conservative in the way we're addressing it.
Yeah. On the CF question, I mean, just at a very high level, we've been very clear about this. We're really excited about the CF franchise and its ability to be a long-term contributor to Royalty Pharma's business. We think Trikafta sets a really high bar in this space. I think that was evidenced by a clinical setback that we saw from another competitor just a few weeks ago. Just shows you how high the bar is and how transformative this product has been for CF patients. We're really confident in the long term with Trikafta. Our guidance that we've given through 2030 reflects a range of scenarios, some sort of more negative scenarios. You know, at this point, it would be inappropriate for us to comment at all about any discussions with Vertex at this point.
Great. Thank you very much. Take the next question from Terrence.
Thanks. Terrence Flynn, Morgan Stanley. A two-part question on guidance and then a question for Marshall. Terry, on the guidance, can you just talk if there's any change to assumptions on your IRR, just given kinda where rates are going? And then how are you thinking about that mix of traditional versus synthetic? It sounds, based on Chris's presentation, that you guys are extremely excited about the synthetic opportunity. How are you thinking about that as a driver of the future growth? Then for Marshall, just wondering if you can give us any color on kinda how that funnel is tracking for 2022. We're about halfway through the year now. Obviously, you guys had a big step up as you, as you've shown before, but how are things going this year, especially given the dislocation in the biotech market? Thanks.
In terms of return assumptions, we're sort of sticking with the same guidance that we've given previously. Just a reminder, what we've said is that for approved products, we're targeting returns in the high single digits to low double digits. For development stage products, we're targeting teens returns. Now, you could see, you know, I think we would expect sort of a natural, you know, there could be some variation in a rising rate environment. I think, you know, our goal is to continue to deliver, you know, very attractive, uncorrelated returns over the long term, consistent with how we've sort of been able to deliver it in the past. I'll touch on that again in my section in a second.
Yeah, thanks, Terrence. On the pipeline for 2022 and how the funnel, I think, you know, we feel really good about where things are. I think from a growth and intensity perspective, I think our team would tell you know, it's been a pretty intense year so far in terms of projects. I think in terms of mix, again, you know, we've seen a really good mix of things across all the, you know, approved, unapproved, you know, synthetics, et cetera. You know, the important thing to keep in mind is that our approach doesn't change, right? That focus on product and the importance of the product, you know, the bar doesn't change. You know, that will continually guide us.
I think what's happened in the public equity markets, we're certainly seeing, you know, an increase in inbounds and because of that. If anything, you know, I think it's maybe an acceleration of a trend that we've talked about before, which is, you know, royalties and royalty-based funding are just becoming a fundamental piece of the pie, and you'll see, Brienne will talk about that as well, an important piece of the pie for companies today. If anything, you know, what's happening out there is just accelerating that.
Great. Thank you. We'll take the next question. Next question, Geoff.
Great, thanks. Geoff Meacham from Bank of America. I just had a couple. By the way, really helpful event, so thanks for putting it on. The wave of recent IPOs obviously will lead to a ton of innovative products in the next couple of years. Obviously, the vast majority are pretty early stage, and Marshall, you're gonna be pretty busy. The question is, are there creative ways for Royalty to get involved earlier than the approval process, and still participate in value creation? You know, I don't know, like, thinking manufacturing or in clinical development. The second question is, you know, you guys have a lot of legacy non-controlling interests that predate the IPO.
I'm just curious on the math of maybe paying off some of that for the benefit of public shareholders. I wasn't sure if there was a you know criteria for doing that, whether there's a discount or things like that. Thank you.
Yeah. Geoff, on your question on how we're thinking about, you know, the fact that a lot of the crop of IPOs and new companies that we've seen have been on the earlier side. I don't think, you know, you're not gonna see from us any kind of significant shift in the stage at which we really get involved in new products or development programs. Now, that being said, I think as I highlighted and Pablo highlighted, you know, we are always looking to be as creative as possible to achieve that. I think in the main, you're not gonna see any very significant shift from us.
That being said, I think given all of that incredible science, I think we did wanna highlight, you know, between what I talked about and what Chris mentioned about how, you know, earlier engagement, I think, in trying to develop those relationships is an important part of our strategy going forward to address some of what you're talking about.
Yeah, a couple of things. Jim Reddoch, that has been involved with us for more than a decade, is gonna. Now that Marshall is leading the research and investments team, he's gonna spend quite a bit of time out actually trying to cultivate relationships earlier stage with biotech companies that can become potential partners for us down the road. A lso with universities and foundations and research hospitals where we have exceptional relationships, but you just have to be on top of them. Jim is gonna lead an effort, you know, to try to make sure that we're all present at that earlier stage with all of these companies. That I think is really critical.
The second thing I would say, in terms of changing the pre-approval investments, I think another thing that for me is very exciting is what's happening with our strategy and analytics team. I've been talking about this in the earnings calls because it's not only what Marshall showed us about how, you know, the insights that we gain are very powerful. He gave the example of Bristol Myers with a range and how we come up with 88,000. What has happened in other projects is that we come up with bigger differences, you know, where we think that the market is smaller or maybe even bigger than what people think. Those insights are valuable.
Also, I think to the extent that we can actually be much more knowledgeable about the industry, clinical trials, what different companies are doing in clinical development, we can have more intelligent conversations with the potential partners about their clinical programs. If we can add value in those conversations to them, then it's a partnership. You know, we will be able, I think, to negotiate better terms for us because we're delivering more value to these companies. That, I think, is something that we're gonna start to see more and more of over the next few years, and it's very exciting.
Geoff, your question on the non-controlling interest. You're correct. We do have a non-controlling interest where a portion of our pre-IPO investments get paid out to pre-IPO shareholders. Our assumption is that will continue to be, you know, an outflow that feeds into our adjusted cash receipts, which is our top line. T hat will, as a percentage of our top line, decline over time because those pre-IPO investors don't participate in post-IPO investments. You've seen that that's been coming down steadily as we add new products where there is no non-controlling interest component.
Thanks, guys.
Thank you. We'll take the next question. Chris?
Thank you. Is this on? Thank you. Chris Shibutani from Goldman Sachs. Two questions, one on the capital allocation, the $2 billion-$2.5 billion that you've provided, and then you also talk longer term about going to $4 billion. Can you talk about what you believe might be the constraints to bridging that gap? It is the volume or the nature of the opportunity set that you need to achieve? Is it internal constraints or capacity constraints? And then a second question about the synthetic royalty approach. I think you certainly outlined how that's going to be a growing component of your overall portfolio. When you talked about advantages, you really sort of reiterated the capacity of the partner to retain control.
Are there particular types of companies or therapeutic areas or any other criteria where you think that the synthetic approach would be particularly advantageous? Thank you.
I think, Chris, regarding your first question, the deployment of $2 billion-$2.5 billion per year, it's obviously an increase from what we guided just a couple of years ago. I think it's a reflection of two things. One is the size of the opportunity, and you saw a lot of statistics that Chris talked about regarding the capital needs of the industry, which are really enormous, and the opportunity in synthetics, which we're very excited about. There's also M&A. You saw the Constellation MorphoSys deal last year. Those are more difficult to predict because the stars have to be aligned, but those could be very significant. I think today we have the confidence to guide investors, analysts to the $2 billion-$2.5 billion per year.
It could be larger in one year, you know, smaller in another. I think you have to think about this as a rolling average, probably, or some, you know, how much we deploy over two, three years. I think the $4 billion-$4.5 billion figure is what we see could happen over time. The opportunities are there. There's no question that the opportunities are there. The question is, are the assets gonna meet our very strict investment requirement? That's the key. Are we gonna be excited about those products? If the answer is yes, and the science is really interesting, then I think we will slowly move towards a higher capital deployment. I guess it's a question of being conservative and, you know, guiding with confidence.
The other is more what we see down the road. Terry, do you wanna add something or Chris, about the size of the opportunity?
On the synthetic royalty question, you know, are there a particular set of companies that they may be relevant for? You know, I'll just reiterate that five years ago, there really wasn't much discussion at all. You know, as a banker, when I was out meeting clients, presenting to the C-suite or the boards, it was, you know, the capital formation was always, "Should we do an equity deal or a convertible bond?" You know? There was never a discussion, "What about a synthetic royalty?" That has really begun to shift. As I mentioned, you know, if you're now the CFO of any publicly traded biotechnology company, I think absolutely, you've gotta consider, as part of your overall capital raising criteria, a synthetic royalty should be on the table at least to look at.
You know, we may not be willing to do it at that point in time of when they need to raise the capital, but it's absolutely, for all the reasons I stated, it's really a win-win solution for them. It's much cheaper when you look at, you know, Immunomedics when we did a synthetic or Biohaven when we did a synthetic. If they had raised capital from the equity market at that point in time compared to the synthetic, the cost differential to the existing shareholders is dramatic. Once again, I just think it's gonna be much more part of the conversation, going forward, and it really should be. Every single company should really consider it in my view.
Thank you, Chris. We'll take the next question, please. Question in the back of the room.
Thank you. Greg Fraser from Truist Securities. In terms of deal size, we've seen how high you're willing to go for the right deal. What about on the lower end? Do you have sort of a minimum that you're trying to stay above? A question on the recent alliance with Mount Sinai, pretty intriguing for the reasons that you mentioned. I'm curious if you have access or if you will have access to their population data, and how that alliance might help inform your investment decisions.
Sorry, can you just repeat that last bit? What exactly did you ask?
If you would have access to their large database of population information?
It is a very exciting collaboration for us. I think coming from abroad, I did not grow up in this country, but obviously I've been here for 30 years. One of the things that has shocked me is the disparities in health. This is the country that has the highest level of innovation in life sciences, more than any other country in the world. The best hospitals. There is disparities in health equity and in access to health and also outcomes. I think when we started to look at that, and we have at Royalty Pharma this commitment of investing a quarter of a percentage point of our top line in philanthropy per year.
When we looked at the different alternatives that we could get involved with, we felt that Mount Sinai and the effort they have in this Institute for Health Equity Research would fit so well with our brand, and really have us doing something which is really great in terms of giving back to our community and society. What's gonna happen through this collaboration is that we're gonna fund a lot of the work that is taking place there, to the tune of about $20 million over the next four years. You know, we're gonna help them through the research.
Not so much the research and investments team, but the strategy and analytics team with all of the data we have, the hundreds of millions of patient data that we have access to better inform the research that they're gonna be doing. In fact, the you know, contribution is gonna go from us to them to a certain degree because we have access to much bigger data sources. This is relatively new at Royalty Pharma. We have two, three years working on this, and it's really incredible what you can get in terms of information, longitudinal information about patients, how they progress, claims data.
You know, I think that's gonna help all of the work being done at Mount Sinai to not only be focused on this community, you know, the area where Mount Sinai operates, but that research have impact nationally and potentially globally. To try to better understand what's going on and then provide solutions. Now, we might also get benefit from Mount Sinai because of the work they're doing and things that they're doing in their research that will benefit us. It'll be mutual, but it's very, very exciting, and we'll see how it develops. It's something that's brand new to us.
I would tell you that the entire team at Royalty Pharma, when we had interactions with Mount Sinai, met with them, and a lot of my colleagues got very excited because we've all been looking for things to do on a philanthropic side as a company, where we can give back to our community and society. It's always difficult to find something that makes so much sense. What we all felt is that this really made sense for us. Some of my colleagues are very excited to maybe in, you know, their free time, spare time, dedicate a little bit of their time to getting involved. I'll stop there.
Deal size?
Yeah.
You know, I think, you know, ballpark, and every deal is obviously different a little bit, but maybe $100 million from an investment perspective, you know, would probably be a cut-off. You know, there's gonna be some exceptions perhaps, but obviously, Marshall went through and showed all the work we're gonna do and whether you're gonna do all that work, whether it's a smaller transaction or a larger transaction. You know, we'd like, obviously, to invest bigger dollars if we're gonna put all that work in.
Great. Thank you very much. Next question, please. We do have one question from the online audience. Can you talk a little bit about competitive dynamics? How have you been able to maintain your market share with a seemingly increasing number of market participants?
I think I touched a bit on the advantages we have at Royalty Pharma. I honestly think I would start by saying that there are other players out there, you know, that are trying to work with companies to provide capital and fund them. The reality is that when you look at Royalty Pharma, a lot of the things that we've discussed today, the structure we have, public company, scale, the team, which is exceptional, I honestly think we're in a totally different, you know, level than many of the other market participants. I think they're even in a different business that we're in. It's really a different business, different approach, different that we're in. There's some overlap in some cases, but it's very different.
What I would say about competition is that the market is so big, and the capital needs are so significant that there's room for many participants. I think what's happening as time goes by is that the creativity, the approach we have that Marshall highlighted very well, which starts with, you know, relationships that start very early with a company and which we follow and where we really get to know the management teams, understand their needs, understand their challenges, and then trying to find solutions to them. All of that approach really results in us having these transactions which are not competitive. You know, and Marshall highlighted really well how maybe 2/3 of the transactions are sort of proprietary, seventy percent are proprietary. I think, you know, great to have competition.
It creates a more dynamic market. Companies seeing different alternatives is obviously a very good thing. At the end, what happens in many cases is that we're just in a totally different, you know, well, discussion with many of these companies. It's just different. You know, it's something that we embrace, but we're very confident with the position we have, the strengths we have, which are just growing. We're getting stronger, and I think that's putting us, you know, five years, ten years ahead of other potential competitors.
Great, thank you. We have time for one or two more questions before the break.
Good morning. Michael Bunyaner, TLF Capital. If we were to step back and think about the success that you've built and this incredible opportunity that you're looking at. The core skills and experience of a lot of the participants was in the transaction business. You clearly now are in the ownership and holding business. Can you step back and share how all of the shareholders benefit, yourself and public shareholders, from this? Because clearly you have very, very attractive annuity that you're building.
I think my view has been that we've always been in a business that is not transaction-driven. It's not a business where, you know, we have capital, there's a company that needs funding, and we transact. It's much more a business of relationships, long-term relationships. It's a business where we've actually made investments and hold our investments. We don't sell them. We create this incredible business with very unique attributes and a portfolio with very long duration. I think that's an important aspect of our business. Others that are getting into the market do see it as a transaction business and have even sold assets, which, you know, we could acquire. It's, again, very different approaches. I think you touched on the fact that all of us here are shareholders of Royalty Pharma.
You know, that is something very unique because it's this mindset of owner-operated business, where what really matters to us is make sure that we're gonna do well five, 10 years from now. That make the right investments with the right performance, the right returns, because we own so much of this business that we want that to happen. Another thing that we have mentioned in the past is that very unique to Royalty Pharma. When we went public, I had discussions with the rest of my team and said, "I want us to commit to hold 80% of what we own for five years, contractually not sell for five years." I don't know of many companies, if there's any that do that, but we've all done it. That really shows this commitment to the long term and to the business that we all have.
Thank you. Do we have any other questions? We have one last question from the online audience. How do you expect the business mix to trend between your five strategic pillars, and do adjacencies include earlier stage investing?
I think we need to maintain an open mind. That's been part of the success of Royalty Pharma, that we've innovated in so many different ways over the last two decades. Recently, what I've seen is that there are opportunities that come to Royalty Pharma that are not product specific, that are broad technology platforms that could be applied across the industry. Could be things like mRNA or other things. You know, delivery technologies like, you know, Halozyme's technology. What I realized is that these technologies, if they meet the investment criteria that we have, which is high, are ones that we could get behind and then help these companies adopt these technologies more broadly.
There's an example that we haven't talked a lot about recently of an investment we did in a company called ApiJect. It's small, but could have broad industry potential. It's not a product, it's a technology. W e have decided as a team to actually be more open-minded and look at these things and be very selective. It's gonna start, like many things, small, and eventually, if we have success, it will grow. Y ou know, that's an example of an adjacency. Obviously, the MSCI collaboration where we're helping MSCI to create life sciences indexes and launch them is something that I'm also very excited about.
It's gonna start small, but over the years, it could become big as, you know, the industry becomes more sophisticated and many indexes are adopted to give investors things they need to make better investments. It will be a royalty for us that we will collect for a very long period of time. I think the point is we have an infrastructure, relationships, an incredible team, and why not take advantage of a lot of the knowledge we have to very selectively make these investments in things that we think could be additive to our business, but could also, over time, have potential to deliver good revenue and returns for us. That's what I would say about adjacencies. It's something we're doing now, it's small, and we will see where it goes.
Great. We'll take the next question from Steve.
Thank you. Steve Scala from Cowen. Pablo Legorreta, you've been in the industry for a long time. I'm just wondering, based on your experience, how you look at China as an opportunity or a risk going forward. Investors are very apprehensive about the opportunity. When you're looking at a product that may have a large potential market in China, is that something that you would go after with more vigor because you view it as a phenomenal opportunity? Or would you shy away from it because you're concerned about long-term risk?
I think China is interesting for sure, and the team and myself have been to China multiple times over the years to try to get a feel for what's going on there. Actually, as part of this MSCI effort, you know, we started to realize that it is incredible. There's something like 700 companies or maybe the market, the biotech market cap was $700 billion or something to that extent, and it was $50 billion or less, you know, like five years ago. T here's incredible science now taking place in China. The market is huge. We were just recently talking to AstraZeneca CEO, Pascal, and how he was talking about China. He's become the biggest pharma company in China with, I think, $6 billion-$7 billion of revenue.
There's clearly a lot of potential there. I think a lot of the products that we invest in will have a China component. There's no question that we're benefiting from that. At the end of the day, when we model the investments, the focus is U.S., Europe, and then we do look at other markets, but obviously, the focus is U.S. and Europe. If there's a China benefit, great. I think we will keep an open mind to see what happens over the years. Obviously, this relationship with MSCI will be helpful also because we're gonna start to see how the whole biotech market is developing in China with all of these indices. We'll keep an open mind and see if at some point we wanna have a more specific effort in China.
I think it's not only China, but it's Asia, Japan also. I think we have some colleagues that are gonna look at that, you know, more closely. You know, we'll go and visit and see if it's gonna be an opportune time for us to get involved. In Japan, we have actually done transactions with Japanese companies. You know, Chris talked about one of them. We have had discussions with some really interesting biotech companies, Chinese biotech companies that have really interesting drugs that are being, you know, co-developed with big pharmas, and they might have royalties. I guess we just have to be open about this and just see what happens.
Great. Thank you, Pablo. This will conclude the first of our two Q&A sessions. We'll take a short break. Thank you for all the questions, and we'll reconvene at around 11 A.M.
We're now ready to begin the second part of our investor day, and we'll kick it off with case studies from Brienne Kugler, VP on the Research and Investments T eam, and Sara Klymkowsky , VP on the Research and Investments Team.
Thank you, George. It's a pleasure to be speaking with everyone in the audience and to all those who've dialed in today. I'm Brienne Kugler, a Vice President on the Research and Investments team here at Royalty Pharma. I've been here for the past eight years, and prior to that, I was on the sell side. As Marshall and Chris had talked about earlier, we view ourselves as true partners to biotech companies. Over the next few slides, I'll be walking you through one of our long-term partnerships with Biohaven. You'll also have the opportunity to hear later from Biohaven CEO, Vlad Coric. I wanna start by first talking about how our long-term partnership with Biohaven first began. I'm gonna take you back to the spring of 2018. Biohaven was a relatively young company then.
They had just IPO the prior year and were advancing their lead drug, Nurtec, an oral CGRP inhibitor for migraine through phase III developments. What did we do when we first heard about the opportunity to work with Biohaven? Well, we started our typical due diligence process that Marshall talked about earlier. What did that mean here? Well, first, we knew that the phase III efficacy trials for Nurtec had already read out positively. Second, on the safety side, we are still waiting for the long-term safety trial to read out. In order to get comfortable there, we engaged with external expert consultants, poured through thousands of pages of clinical study reports, and looked at patient level data. At the same time, we also started getting up to speed on the migraine market.
What we saw there were several hallmarks of a large underserved population that had treatment options that either provided inadequate treatment relief or were contraindicated in many patients. After extensive physician diligence, we began to believe that Nurtec could be an attractive option for many of these migraine sufferers. Our entire deal team grew very excited that Biohaven could have a potential blockbuster on their hands. We were able to negotiate a transaction with Biohaven and start our partnership by acquiring a synthetic royalty on both Nurtec and zavegepant, as well as purchase equity in Biohaven. Over the next several years, we did three additional transactions with Biohaven. I wanna first talk about our March 2019 deal.
At that time, Biohaven was getting ready to file their NDA with the FDI, and they were looking to acquire a priority review voucher in order to accelerate the timeframe that the FDA would review Nurtec. We knew that this would be a win-win for both us and Biohaven, as it would enable Biohaven to launch Nurtec earlier. Since we already did our diligence recently, we were able to, within a matter of days, get this capital to Biohaven. This is just another benefit of working with Royalty Pharma on repeat transactions. I also wanna talk about our August 2020 deal. At that time, Biohaven was launching their drug Nurtec, and was looking for additional commercial launch funding for that, as well as they wanted to accelerate the R&D development of their second CGRP inhibitor, zavegepant.
We were able to come up with a unique, customized, up to $450 million deal that showed our flexibility in engaging with our biotech partners to meet their needs. In total, we've provided Biohaven with up to over $800 million of capital over these four transactions. We've been very proud to help Biohaven build such an amazing brand in Nurtec. We've really seen that Nurtec's product profile has resonated in the migraine community with both migraine patients and physicians. We've seen encouraging trends from the oral CGRP class on prescriptions, and Nurtec has had an absolutely stellar launch. Consensus sales have significantly increased since the time of our initial transaction and are now above $2 billion by 2025.
We're also delighted to see that Pfizer last week is talking about a significant peak sales potential for the CGRP franchise of over $6 billion. Now, I wanna spend a little bit of time discussing the announcement last week that Pfizer will acquire Biohaven for almost $12 billion. We are thrilled that Nurtec and zavegepant will be in Pfizer's hands, marketed by the leading primary care sales force. We've been partners with Biohaven for a long time. What does this mean for us at Royalty Pharma? Well, from an economic perspective, this means that a portion of the capital that we've given to Biohaven over time will now be accelerated. At the time of the acquisition close, we will receive our returns back on our common and preferred equity.
Once zavegepant is approved, we have an option to accelerate a $475 million milestone. Putting this together, by the first half of 2023, we expect to receive about a 1.8 times cash on cash return on the investment. Importantly, we will still continue to be receiving Nurtec and zavegepant royalties for many years to come. This is a very similar playbook to what happened with our Immunomedics transaction, where we acquired a synthetic royalty and equity. Upon Gilead's acquisition of Immunomedics, our equity portion was accelerated, and we are continuing to receive Trodelvy royalty payments. It's great to see in the last two years, two very exciting biotechs that we partnered with and were able to remain unencumbered by working with Royalty Pharma as a strategic partner.
We were able to eventually recognize substantial value from their shareholders via M&A transactions. We're now gonna play a short video with the Biohaven CEO, Vlad Coric, where he talks about our partnership.
Biohaven is a biopharmaceutical company focused on really the most severe disorders that face our society, neurologic and neuropsychiatric disorders. What we really wanna do is meaningfully change the treatment paradigm. When you look at what we're trying to accomplish as a company, to bring a paradigm shift in the migraine space and also create a blockbuster drug, you really needed a partner like Royalty Pharma who could understand all aspects of our business and grow with us. Royalty Pharma is an impressive company.
When you look at their team, they're experts, not just on the financial end of the spectrum, but also on the science, and that's what really differentiates them 'cause they can really get into an in-depth understanding of your company and develop that long-term view of how can their scientists and their financial experts help you meet your needs as a company and growth over time. When you look at their portfolio of blockbuster drugs, they're really the leader in the royalty monetization space, and so when they do a deal with you, it's also an endorsement of your science and also where you're headed as a company. The first thing they got to do is really assess us as a company, understand our needs in a customized way, come up with a financing plan that was a win for us and a win for Royalty Pharma.
There was always this innate sense of wanting to understand our business, where we're going, and how can they help us become successful. It was really that customized approach with Royalty Pharma that's now led to several deals with them. Because as we've grown with the business, they've come up with really unique ways to finance our drug development, and that's been a win for patients and our investors and Royalty Pharma's investors as well. It's a very capital-intensive process to bring a drug from discovery to clinical trials to approval and launch, and you really needed a company like Royalty Pharma who could work with us and grow with us over time and help us fund this company.
What was unique about the second deal with Royalty Pharma around zavegepant was Royalty Pharma had a keen understanding of our business and that we had to keep our resources on our marketed asset, Nurtec ODT and its launch, but yet we needed to grow the pipeline in zavegepant and other assets. When you look at the company's performance, we've had increase in valuation over 50% every single year since our IPO, and that's really thanks to Royalty Pharma helping to fund the company. How do we feel about our decision to work with Royalty Pharma? I have to say, I think it was the most important decision we've made as a company.
When you look back at the role they played in our first financing all the way through our launch and now, financing our pipeline, I don't think there's any other company that would have been as innovative, as Royalty Pharma and creative with us all along the way. It's really thanks to Royalty Pharma, that we've had the success that we have today.
Now, you just heard Vlad say that partnering with Royalty Pharma was the most important decision that Biohaven has made as a company. Biohaven is just one example here of biotechs we've partnered with. We've also partnered with BioCryst and Cytokinetics. In total, we funded around a quarter of their total capital that they've raised over the past several years. This really highlights a point that Chris talked about earlier, that we see royalties as an increasingly important mix of the total capital that biotechs are looking to raise. As we look forward, we see a future where biotechs more widely recognize the benefit of working with a partner like Royalty Pharma that can play an impactful and strategic role in the biotech company's growth journey. With that, I will turn it over to Sara Klymkowsky to walk through another recent transaction. Thank you.
Thank you. Hi, everyone. Really excited to be here today. My name is Sara Klymkowsky , and I'm a VP on the Research and Investments team at Royalty Pharma, and I've been at Royalty Pharma for more than 10 years. Really, effectively, I grew up at Royalty Pharma, and it's been a really fun and exciting journey. As we just heard from Brienne about our exciting investment and relationship with Biohaven, at Royalty Pharma, we view ourselves as a true partner to biopharma, and we've been fortunate to work with companies along every stage of their growth journey. Today, I wanted to highlight three things that I think we do better than anyone else. We partner with companies and help them do big and bold things with our full suite of funding solutions.
We seamlessly handle an incredible degree of transactional complexity, and we create win-win outcomes for our partners and our shareholders by focusing on high-quality companies and therapies that benefit patients. I have a perfect example to walk you through today to showcase what we can accomplish when we put these strengths into practice. Okay, let's get started. We partner with companies to help them do big and bold things with our full suite of funding solutions. I really think about this slide as summarizing the problem and our opportunity. Last summer, MorphoSys, a mid-cap biotech, approached us with one of these bold ideas. MorphoSys is a company with a well-known expertise in antibody development, and importantly, a marketed blood cancer therapy called Monjuvi. They wanted to acquire Constellation, a company specializing in epigenetics with a small molecule discovery platform and two attractive candidates in hematology.
This bold vision was driven by the confidence that the acquisition would do a number of important things for MorphoSys, accelerate their growth strategy with these pipeline into product candidates, bolster their position in hematology, and provide them an entry into solid tumor development and expand their capabilities, strengthening their research and technology platforms. As Pablo and Chris mentioned earlier today, midcap M&A in biopharma has been difficult, and the traditional funding sources and partners just didn't make sense for MorphoSys. Here's where Royalty Pharma stepped up. We provided up to $2 billion to fund the acquisition of Constellation and help MorphoSys become a more fully integrated commercial and development stage company. Okay, here's the part of the story where Royalty Pharma created a customized and complete funding solution for MorphoSys.
We provided more than $1.4 billion in upfront cash, up to $150 million in milestone payments. We worked with MorphoSys to craft development and launch funding of up to $350 million customized to fit their needs. Finally, we purchased $100 million of equity in MorphoSys at the close of the transaction. Up to $2 billion in funding to help MorphoSys realize their strategic vision. How did we do it? This slide should look familiar from Pablo's comments earlier today. We used every strategic pillar to help MorphoSys raise enough capital to support their vision. The first pillar, we purchased existing royalties from MorphoSys. MorphoSys had existing passive non-strategic royalties on Tremfya from J&J, otilimab from GSK, and gantenerumab from Roche.
The second pillar, we worked with MorphoSys to create new synthetic royalties on the therapies at the heart of the Constellation transaction. That's Pelabresib in myelofibrosis and CPI-0209. Our third pillar, we created customized launch and development capital funding to support MorphoSys in the medium and longer term. All of this was possible because of the fourth pillar, our ability at Royalty Pharma to create funding solutions that help companies and facilitate M&A. This next slide walks through our second strength, our ability to seamlessly handle an incredible amount of transactional complexity without slowing our partners down. It really comes down to our comprehensive approach and process. Chris touched on this earlier today, but sourcing is a key competitive advantage at Royalty Pharma.
We've been in this industry for decades and have quality, long-standing relationships. As you can see, we had multiple prior in-depth conversations and discussions with Constellation, and our relationship with MorphoSys was built over more than 10 years. When I think about the groundwork of this transaction, I think it really started more than a decade ago. The next is tracking. We were already following the therapeutic areas and key therapies at the heart of this transaction when we got the call from MorphoSys. We were up to speed and knowledgeable, ready to engage. The next is engagement. I think about this as we were ready to engage with MorphoSys to fully and truly understand their capital needs, and that allowed us to quickly move on to focusing on crafting a win-win solution.
I'm on the research and investments team, and you heard Marshall walk through our diligence process earlier today. I can't emphasize enough that diligence is truly at the heart of what we do at Royalty Pharma. This is a perfect example. We had multiple therapeutic area-focused teams working in a coordinated, parallel way, getting to an answer on all of these products. Our entire process culminates in execution. We developed our deep understanding of MorphoSys' capital needs. We deployed our full suite of funding solutions, and we completed the process in under 60 days. Okay, our last strength, our ability to create win-win outcomes for our partners and our shareholders.
As part of this more than $2 billion deal, we acquired a portfolio of royalty streams anchored by Tremfya, an incredibly attractive established therapy with upside potential, and importantly, a key driver of a solid base return. The development and launch capital serves a similar role here. Long duration, predictable, stable cash flows, creating a solid base return. The anchors of this transaction provide a solid foundation to add exciting development stage therapies to our portfolio. Otilimab, with strong proof of concept in rheumatoid arthritis from GSK, Pelabresib and CPI-0209 in myelofibrosis and hematology, and solid tumor with great upside potential, and Gantenerumab in Alzheimer's disease, which is higher risk, but with multi-blockbuster potential in the hands of a premier company with Roche.
I wanted to thank you so much for the opportunity to walk you through one of our most exciting and complex transactions of the last year. Truly only something that Royalty Pharma, with her multi-decade history in the industry, could do. With that, I'll hand it over to Marshall.
It's been just really exciting to talk to everyone today about what we do in research and investments. You heard from me about our process and a little bit about where we see going in the future. You heard from two of our key team members and one of our most important partners. Just wanna remind you of the three points that we wanted to leave you with today. The first, and you got a flavor for this, is our team, and maintaining and growing our team in a high-quality way is the foundation for everything that we do. Second, our differentiated deep process with a real focus on always trying to stay at the forefront in process improvement.
Then finally, that what we really are is a scalable platform that has scaled and will continue to scale to capture the market opportunity in front of us. With that, I'll pass it over to Terry.
Great. Thanks, Marshall. Thanks everyone for hearing about Royalty Pharma. My name is Terry Coyne, I'm the CFO. Been at the company for 12 years. The last three years I've been the CFO, and for the first nine years, I worked in the research and investments team, and I had the privilege over that period of leading many of our largest transactions. I've seen incredible growth in this business over the past 12 years, but I truly feel our best days are ahead of us. My goal during the presentation is to help you understand how our unique business model can compound growth over time and drive significant long-term stakeholder value. Let me begin with a few important points about Royalty Pharma's compelling financial characteristics. One, we're experiencing continued momentum in our business.
We're increasing our top-line growth outlook by nearly 50% through 2025 to 11%-14% CAGR over that period. We're also increasing our capital deployment outlook over the next five years by over 50% from $7 billion previously to $10 billion-$12 billion now. Two, we have a long track record of successful capital deployment. We've built a highly fruitful, diversified portfolio that provides low risk access to 35 commercial products, including 12 blockbusters. Many of the products in our portfolio are in the early years of their launches with substantial growth ahead of them. Three, we're leveraging a highly efficient, diversified business model with among the lowest cost of capital in the industry to drive future growth. This is key, value creation.
We've built a cash flow compounding engine. Fourth, and finally, we're so confident in the opportunity today ahead of us that we can say with confidence that we expect to generate top-line growth of 10% or more over this decade. With that, let me walk you through the simplicity of our financial model. We collect royalties on market-leading products across the biopharma industry, which drives Adjusted Cash Receipts or our top line. Royalties represent a percent of top-line sales of the underlying pharmaceutical products. These products are well-covered by the street, and we're transparent about our royalty rates. It makes modeling our top line pretty easy. We have very low G&A expenses, around 9% of our top line in 2021, and we pay interest on our investment-grade debt.
The vast majority of our remaining cash flow gets redeployed into new, long-duration royalties at attractive rates of return. We use conservative leverage to broaden our capital base and enhance our equity returns. The process of identifying new royalties, conducting due diligence, and structuring deals is extremely complex. That's our expertise. What investors get is a very simple financial model. This has been our key to value creation since inception 25 years ago, and we're seeing more opportunities now and investing at greater levels to fuel this virtuous cycle. Royalty Pharma has a proven track record of compounding growth. We're a fairly new public company, but the growth profile we're describing today is not new. We have a 25 year history of compounding growth and value creation.
On this slide, you can see from 2010 to 2020, we grew at a CAGR, a top line CAGR of 13%. Today, we can say with confidence that this level of growth will continue. From 2020 to 2025, we expect to grow our top line at a CAGR of 11%-14%. That means we now expect our Adjusted Cash Receipts, our top line, to grow from $1.8 billion in 2020, our IPO year, and $2.1 billion last year, to $3 billion-$3.5 billion in 2025. This is a really important point I'm gonna make here. We expect Royalty Pharma to grow over the long term, irrespective of individual royalty expiries. Expiries are a fact of life for this industry.
Royalty Pharma has a strong track record of continuously refreshing our portfolio with market-leading therapies. Our growth outlook has evolved nicely over time and well ahead of our initial guidance at IPO. Now, at IPO, we guided to a CAGR from 2020 to 2025 of 6%-9%. Last year in February, we updated this growth outlook to 7%-10%. Today, we're now targeting 11%-14% through 2025, which is nearly a 50% increase at the midpoint of our guidance. It's driven by two key factors. First, our existing portfolio has performed well. We've added great new royalties. Many of them are outperforming. This accounts for the vast majority of our growth outlook. Second, our powerful model is working. Over this period, we expect to deploy significant capital in new value-enhancing royalties.
As I just covered, we use cash flow and conservative leverage to buy value-enhancing royalties, and this leads to attractive, compounding long-term growth. Since 2020, our IPO year, we announced $5.9 billion of transactions. We added 21 unique therapies across six therapeutic areas, nine development stage therapies, and ten of the products that we added are now or are expected to be blockbusters in the future. What this all is expected to add up to on consensus estimates is a contribution to our top line of over $750 million by 2025, with significant upside potential from our pipeline. We're really proud of the scale of capital deployment. It's better than we expected. We had guided to over $7 billion over five years, and we've delivered $5.9 billion in two years.
Most important is the quality. Products like Tremfya and Evrysdi and Cabometyx, these are top products across the industry with their best years ahead of them. We've always believed our growth stands out for three reasons. The first is the diversity of growth. You can see at the pie on the right that our growth is diversified across different products and franchises. Second is the magnitude of growth. At 11%-14%, we think our growth compares really well across biopharma, but really all industries. Third is the duration of growth. Around 90% of our deals over the last two years have durations beyond 2030, many into the mid to late 2030s. I think this is very differentiated when you compare us with other biopharma companies. Capital deployment is a key metric for our business.
At IPO, we guided to at least $7 billion over five years. We're now guiding to $10 billion-$12 billion over the next five years. That takes us from around $1.5 billion per year to $2 billion-$2.5 billion per year. Now, this will be uneven. There could be years where we invest $1 billion, and there could be years where we invest many multiples of that. We're very disciplined. Patience is key to value creation in our business. Chris described in detail how large the opportunity is.
Marshall explained how our model allows us to scale, to capitalize on the opportunity while maintaining that high bar to ensure value-enhancing growth. Our guidance implies around a 50% increase, but over the long term, we see an opportunity to double this capital deployment to $4 billion-$5 billion per year. Let me now describe the components of our 11%-14% growth outlook. An important benefit of our portfolio is that we're diversified across products, therapeutic areas, and marketers. We break the portfolio into four components. The first is our established growth portfolio. These were products approved prior to 2018. It includes 25 commercial therapies, 12 of them were blockbusters last year. We expect this segment of the portfolio to have a CAGR of 3% from 2020 to 2025. Next is the recently launched products.
There's nine products in this segment of the portfolio. These products are launched in 2018 or later. They have significant growth ahead of them. We expect this segment of the portfolio to take our growth from 3% to 7% over the period. We layer in the development stage pipeline, and this excludes gantenerumab, which I'll touch on in a second. When you layer in our development stage pipeline, there's ten different potential pipeline candidates here. It takes our growth from 7% to around 8% through the period. Finally, we layer in future acquisitions, which could take us to 11%-14% through the period. Another way to look at our growth over the period is that around 25%-30% come from our established growth portfolio.
Around 25%-30% will come from recently launched products, and around 10% will come from our development stage pipeline. Then around 30% we expect to come from future deals. Now let's drill into each of these buckets. We'll start with the established growth portfolio. This segment of the portfolio delivered $1.8 billion in top-line contribution in 2020, and we expect it to grow to $2 billion-$2.2 billion in 2025. The key drivers here are the cystic fibrosis franchise, Tremfya, Cabometyx, and Tysabri. It's also partially offset by some expiries. Our royalty on Gilead's HIV franchise expired in 2021, and our royalty on Merck's Januvia is expiring this year.
These were great investments that generated lots of cash that we've redeployed into many of the new products that are in our portfolio today. On the right side, you can see the market position and scale of these products. I'll just highlight a few. The cystic fibrosis franchise is expected to reach sales of $10 billion in 2025. These products have completely transformed the treatment of cystic fibrosis. We're very proud to have them in our portfolio. Tremfya for psoriasis and IBD has had an excellent launch with significant growth ahead of it. Then there's Tysabri. It's a more mature product, but it generates meaningful cash flow. Now, this is a deal that I led when I was on the research and investment team and worked very closely with Sara Klymkowsky on this.
This is a product that's consistently outperformed expectations, our expectations when we made the investment and also consensus expectations pretty much every year since then. The key thing is that these are extremely important products to their marketers, and we expect them to deliver predictable growth for Royalty Pharma. They really provide a very strong base for our business to grow. Next, we have our recently launched products. We expect this segment of the portfolio to grow at a CAGR of around 70% over the period, from very little in 2020 to $350 million-$450 million by 2025. It's driven by some of the stronger launches across the industry, like Erleada for prostate cancer, Evrysdi for spinal muscular atrophy, Nurtec for migraine, and Orladeyo for hereditary angioedema.
In a period where many products and launches have performed below expectations, our team has been successful in identifying and investing in a number of upside launches. On the right side, you can see the market position and scale of these products, or the expected market position and scale. These aren't just important drivers for us. The top marketers in the industry are gonna be focused on driving their growth. Now let's turn to our pipeline of late-stage development products. We're pleased with how our pipeline has grown. We had four products in the pipeline at IPO, and now we have 10. Now some will not succeed, but we think our track record is really strong. Since 2012, we've invested $8 billion in development stage products.
If you look at the success rate based on the number of trials that have read out, nearly 80% of our deals have been approved based on the number of deals and nearly 95% based on the value of deals. A couple that I would highlight that are under the radar. The first is seltorexant. It's a product in development by J&J for depression with insomnia symptoms. We're hoping to see some phase III data later this year. This is a big unmet need, and it also kinda touches on a couple of the themes that Marshall highlighted earlier.
The first is a market that's been underinvested in, and it's also, you know, it falls under the brain category. We think it could be a very important therapy for those patients. The second is aficamten. We think that this product has the potential to be differentiated in the hypertrophic cardiomyopathy market. We're excited to see that Camzyos was approved recently, and as Marshall highlighted, it's great that Bristol's gonna be laying the groundwork for that new market. We think that aficamten could be an important driver for our business over the long term. One potential upside driver is gantenerumab for Alzheimer's disease. It's not in our guidance, given that it is higher risk.
If it works with consistent phase III data, subcutaneous delivery, and Roche as the global marketer, we see multi-blockbuster potential. One thing I'd also highlight is that we're also entitled to the same royalties on the Brainshuttle delivery of gantenerumab, which could be further differentiating. Now, most of the products in our development stage pipeline won't launch until late in our guidance period, so the contribution's fairly modest at around $50 million-$100 million using consensus estimates. We actually see nice upside potential to these consensus figures. Looking longer term, our development stage pipeline could be a really important driver for our business. If you look at royalties on risk-adjusted consensus sales of the products in our development stage pipeline, in 2030 could be $200 million-$400 million.
Royalties on non-risk-adjusted consensus sales could be between $400 million and $800 million. Again, this excludes gantenerumab, which could provide some nice upside optionality there. I'll now walk through our non-GAAP P&L, which will help you understand the components of our long-term guidance. We collect royalties and pay out a portion to non-controlling interests. This leads to adjusted cash receipts, our top line. In 2021, we had G&A of $185 million, which equated to 9% of our adjusted cash receipts. That leads to Adjusted EBITDA of $1.94 billion. If we then subtract interest and other expenses of $170 million, it brings us to nearly $1.8 billion. This is the cash that the business generated that we could redeploy in new royalties.
Now, certain of these royalties, royalty investments will show up on our non-GAAP P&L. The biggest relates to upfront and milestone payments on development stage deals. Last year, this amounted to $193 million. These expenses were previously excluded consistent with industry practice, but we've updated our non-GAAP P&L to include these expenses following similar updates that were made across the industry beginning in the first quarter of 2022. I think what this P&L shows you, it's very clear that our business is efficient in generating cash flow to reinvest in new value-enhancing royalties. Let me summarize our expectations for the key components of our non-GAAP P&L through 2025. We expect adjusted cash receipts to grow at 11%-14% CAGR to $3 billion-$3.5 billion in 2025.
We expect operating and professional costs to be between 8%-10% of our top line, reflecting the efficiency of our business. This implies adjusted EBITDA of $2.7 billion-$3.2 billion in 2025. We expect interest expense to be between $200 million-$300 million. This assumes that interest expense increases a touch related to some of our near-term refinancings, but it's not significant. I think, again, what you can see here is that this business can generate significant cash for us to redeploy in new royalties. Now I'm gonna show you how Royalty Pharma's unique ability to generate cash over time can power our capital deployment. This is the virtuous cycle of our business.
On the left, if you first start with balance sheet cash, now, at the end of the first quarter, we had cash of a little over $2 billion. Then we layer in cash that the business can generate from existing royalties and also new royalties. That could take our capacity over the next five years to over $15 billion. We're able to enhance this capacity with conservative leverage. This analysis shows how our capacity can grow if we take our leverage to 4x. This could lead to over $20 billion of cumulative capacity. Now, if you put that in the context of the guidance we just gave of capital deployment of $10 billion-$12 billion over the next five years, you can see that this business can be really self-funding. Our primary focus is buying royalties.
This is how we can create the most value. We also expect to return a portion of the cash generated by the business to shareholders through dividends and potentially share buybacks over time. Let's spend some time talking about returns. We get asked all the time about our returns. This is the first time we've discussed it with investors. On the left-hand side of this slide, what you can see is that over time, our returns have been very consistent and predictable, averaging in the low teens on an unlevered basis. Now, our estimated cost of capital is between 5% and 7%. You can see that there's a big spread between our cost of capital and our unlevered returns.
One thing I'll point out that's not on this slide is that nearly 90% of the deals over this period are expected to deliver returns above our cost of capital, which we're really proud of. The beauty of this business, and something that we think is very underappreciated, is our ability to enhance returns with leverage. On the right-hand side, you can see if you start with low teens unlevered returns, then layer in the benefit of conservative leverage. Historically, we've funded about 1/3 of our deals with low-cost debt. That takes our levered returns to the high teens or low twenties. This is really the return on the equity investment in our royalty deals. One of the great things about this, like the left-hand side, is that this can be very consistent as well.
Now, the emerging economic environment is certainly creating uncertainty for many companies and industries. We think the defensive nature of large, diversified biopharma is clear. Within biopharma, we think Royalty Pharma's model stands out. I'll break this into four buckets. The first is the risk of stagflation. We think the scale, duration, and diversity of non-cyclical growth of our portfolio should be very attractive in this environment. Our business outperformed in 2008 and 2009 during the financial crisis, and we outperformed in 2020 during COVID. This business is resilient. Our unique margin structure, where the vast majority of our G&A is fixed as a percent of our top line, is very protected to the bottom line and very unique. The second is the impact on our cost of funding.
We were fortunate to have fixed long-duration debt, with 60% maturing in 2030 and beyond. We're committed to our investment-grade credit rating, which provides deep access to debt when we need it. Third, it's no secret that many smaller biotechs have faced significant pressure. We think this should expand the universe of opportunities, that we will continue to be selective. Royalties should become more attractive in this environment. It could also increase M&A, where we see a role for Royalty Pharma to play. Fourth, and this is critical, we're confident that we can continue to deliver attractive returns given the flexible nature of our business model. This is a slide that I'm really proud of, and I think it often gets overlooked. Royalty Pharma has a track record of consistently identifying exciting waves of biopharma innovation and finding ways to participate.
From Rituxan, the first monoclonal antibody for cancer, to Gilead's HIV franchise, to Humira, where we invested in 2006 and it later became the biggest-selling product, to more recent life-changing therapies like Trikafta for cystic fibrosis. The list goes on and on. I remember first joining Royalty Pharma in 2010 and staring down these near-term expiries for Neupogen and Neulasta and Rituxan. We talked a lot about this at the time. These were huge royalties for us. Those expiries came and went, and our growth didn't miss a beat. We think we're even better positioned now with a diversified portfolio of long-duration therapies to form a base to add wave after wave of exciting new therapies in the future. This constant portfolio replenishment with top therapies in the industry is in our DNA, and we're really confident that it can continue.
We appreciate that investors wanna understand the profile of cash flows from new royalties that aren't yet in the portfolio. Standing here today, we don't know exactly what we will invest in. We view that as a strength and core to the model. We're gonna continue to focus on the best therapies that have the biggest impact on patients. We think looking at historical curves can be helpful as you think about your models. What you have here is a representative curve showing cash inflows over time for every $1 billion invested using actual acquisitions that we made over the past five years and consensus estimates. What you can see in this curve is that in the first five years of most royalties, you see a period of significant growth.
Many products will continue to see nice growth through 10 years or longer, while others could moderate, and some will have a shorter overall duration. You can often see a significant tail beyond 10 or 12 years. Many of our recent investments have durations of 15 years or longer. Now, there's clearly a range depending on what we buy, and the shading here reflects this. Now I'll show you why we think this is important. Using that curve, let me show you how royalties can compound over time. For the purpose of this analysis, we assume that we invest between $2 billion and $2.5 billion per year through the entire decade. Again, we think this could prove conservative based on the expanding opportunity set that we're seeing. First, we'll start with investments from 2022 to 2024.
Investing that amount, by 2030, we could if we invest $2 billion-$2.5 billion per year, it could lead to $1.2 billion in top-line contribution by 2030. If we then layer in investments from 2025 to 2027, it could add another $1 billion by 2030. Finally, layer on investments from 2028 to 2030, it could add another $400 million. Cumulatively, all of these investments could lead to an additional $2.5 billion in top-line contribution by 2030. I think what Pablo would say, if you ask him, he actually just said it a little while ago during the Q&A, is that this guidance or this capital deployment is very conservative. Either way, I think it highlights the compounding nature of this business.
Now let's bring this all together. We described how the growth can compound over time, you know, over the last decade, we grew by a CAGR of 13%. If you look from 2020 through 2025, we expect to grow at a CAGR of 11%-14%. From 2020 through 2030, we expect to grow at a CAGR of 10% or more over that period. Now, kind of dissecting the components of the growth over that period, we expect to see growth from our existing portfolio. That reflects a range of scenarios for our key franchises, including the cystic fibrosis franchise, and again, does not include any contribution from gantenerumab.
When you layer in new investments and assuming that it stays flat at $2 billion-$2.5 billion per year, could lead to 10% growth or more over the period, which we think could position us at the top grower among all large biopharma companies. Let me recap. The business is seeing strong momentum. We've increased our guidance on capital deployment, and we've increased our guidance for Adjusted Cash Receipts. It's driven by a diversified portfolio of market-leading therapies. We have a great portfolio of newly launching therapies and an exciting pipeline of development stage therapies that offer nice long-term upside potential. We developed this efficient cash flow compounding engine to drive future growth, and we're confident that we can continue to deliver very predictable returns over the long term.
What all that should add up to, we think, could add up to is the top growing biopharma company from 2020 through 2030. With that, I'm gonna hand it back to Pablo for his closing remarks.
Thank you, Terry. Excellent presentation. Very clear slides and message. Before we start the final Q&A session, I want to thank everyone in the audience for your continuing interest in Royalty Pharma, and I hope to meet many of you over lunch. I also want to leave you with a brief reminder of the key messages I began today's event with. Royalty Pharma is a unique investment proposition, really an N of one. With an excellent track record of double-digit growth, we maximize the best of the biopharma industry without many of the potential pitfalls. We have built a large and durable economic moat, and we have an enormous opportunity at the heart of funding the golden age of life sciences innovation.
By successfully executing our strategy, we expect to deliver double-digit top-line growth through 2030, which would make us one of the fastest-growing biopharma companies over the decade. I personally have never felt more optimistic and upbeat about the prospects for this special company, and I hope many of you will join us in our exciting journey. Thank you. George, I think we can start the questions. Before we do that, and as my colleagues join us up here in the podium, I actually want just to recognize something that is really important here. One is the incredible team that exists at Royalty Pharma. You've obviously had the experience to hear from many of them today, but there's many more people that are so critical to the success of this company that you haven't met.
There's a couple that I actually like to recognize here. One is George Lloyd. If you can stand up, George. Who is our General Counsel and joined us about 12, 14 years ago, George. He was our lead counsel when we were doing deals, working for Goodwin Procter and eventually joined us. I think George is a very special person because he's not only an incredibly sophisticated and experienced lawyer, but he's incredibly commercial, practical, which is critical when we're getting into these very complex transactions. Someone also that through very meticulous work has been able to actually create significant value beyond the value that some of the investments that we've made have produced.
In the case of our HIV AIDS franchise with reinstitution of patents, I think there was probably close to $1 billion of additional value that was created through a very smart. Actually, it was DPP-4. I misspoke. H e was able to create very significant value for the business through very smart IP strategies, and it's happened in other investments, and he's now built an incredible team under him with Jason Mehar, Sean and Yoon really experienced lawyers that are, you know, really taking us to the next level. Then the other person here that you haven't heard from is Jim Reddoch, who's been obviously my partner, joined, you know, very early days of Royalty Pharma.
I think there's many, many things that Jim has done for Royalty Pharma, but you know one of the things that became so obvious to them and apparent is that he has really had an incredible influence building the team you see here today, helping me you know hire Marshall, Terry, Molly that is no longer with us, and obviously Sara and Brienne, but many other people. He's done it in a very thoughtful way. I think you know Chris is obviously a new addition to the team, and you heard from him, and I think it's incredible the breadth of experience that he's brought to Royalty Pharma.
What I would say about the team is that the performance that you see today, in terms of, and you know over the past and now, as we see into the future, is really the result of this team. When I look at it, I just cannot just marvel myself by, you know, really reflecting on how talented this group of individuals, men and women are, and you know talented in many different ways. It's really. When you think about it, what is critical for this business to be successful is a very unique combination of skills. It's understanding the industry, you know, research and the fundamental research that is done every day, but also then turning that into actionable things that become an investment.
I think one of the things that has been so interesting to see is when all of these individuals join us, many of them from within, you know, medical backgrounds, science backgrounds, but having had experience on Wall Street as analysts at different banks, and, you know, how their whole mentality and approach changes over time to become investors, which is very different. It's not only being a good analyst, but really understanding risk, measuring risk. It's something that's in the gut. I think what's happened with a lot of my colleagues is that that has happened, and that's a critical part of this business. Anyway, I'll just finish by saying that they're incredibly talented, and I think it's probably the highest performing research and investments team in life sciences.
Thank you for the incredible job you guys do. There is many more people that are not here today, but, which is critical for us to acknowledge.
Thank you, Pablo. We'll now start the second and final Q&A session. If you ask a question, please identify yourself and use the microphone. Take a question from Chris.
Thank you very much. Two quick questions. First, on capital allocation. If we think projecting through the balance of the decade and spending that $2 billion-$2.5 billion upside potential there, you could have some extra cash on the balance sheet. Comment on your willingness to do things such as share repurchases or, increase the dividend. Secondly, for Marshall, leader of this high-performing life sciences research effort. With migraine, Pfizer recently provided us an update with their view that that portfolio can generate $6 billion in sales, which is above the level where I think most of the sell side consensus has been at. Can you share with us your views on this market, where you think it can go, and what are the key factors that can get towards that $6 billion Pfizer number, if that's an opinion that you share, which you referenced on your slide? Thanks.
I'll start on the capital allocation. You're right, the business can generate a lot of cash over time. As I mentioned, as I think, you know, hopefully you saw today, we're most excited about redeploying that capital in royalties. We see a huge opportunity to do that. We think the business can continue to scale. We pay a dividend. We grew the dividend by double digits last year. We're committed to continuing to pay the dividend. We also mentioned that, you know, over time, we can look to do share repurchases as an additional tool to return cash to shareholders. When the business generates the cash that it does, you know, I think that returning some of that to shareholders is very important.
We've actually paid a dividend, you know, for 25 years. That will be an element, but the mix is definitely gonna be focused on buying new royalties.
Great. Thanks, Chris, for the question on Biohaven and the migraine market. I'll start, and Brienne should comment too, since she was critical to all of those investments that you heard about. Before getting into the specifics there, I wanna take a step back and just, you know, make sure it's clear that what's happened with Biohaven is exactly the kinds of situations that we're trying to create and be involved with. You know, we help companies get started with development, with the launch, and then ultimately it ends up in the hands of a company who can bring resources to it that we never imagined when it started. And, you know, the Pfizer transaction is a great example. Brienne referenced Immunomedics too.
When you look at the investment that Gilead is making in Trodelvy, it's really staggering and amazing, and I think it's a way of sort of creating scale and gearing in our investments that we get really excited about. I'll pass it to Brienne in a second. I think what is interesting about the Pfizer transaction and their forecast at a high level is that I think it often gets overlooked the global opportunity, right, as well. There's not a huge list of companies that can maximize the value of that. I think the potential of them really speaks to thematically one of the things I touched on, which is that these markets are massive in terms of volume.
There's even probably some sort of off-market volume of people who aren't reflected in the numbers that we all see because of the deep dissatisfaction. You know, it's incredible to have Pfizer sort of take the baton from here and for our royalty, like Brienne spoke to. Brienne, why don't you talk about the potential?
Hi. Thanks for the question. We've been really excited to see what Biohaven has been able to do with Nurtec. It's just really a tremendous market, and the product profile has really just resonated with a lot of migraine sufferers that now have the ability to have a new oral option to treat their migraines. We're very excited for the potential for Pfizer to continue marketing the product. They're the leading primary care sales force. They're going to be increasing the number of sales reps that are going to be marketing Nurtec. We're just looking forward to this drug being in the hands of more patients going forward.
Great. Thank you very much. We'll take the next question, please. Steve?
Thank you. Steve Scala from Cowen. A few questions, and I'll follow up on migraine. I'm curious if you think Emgality growth will be hurt by Nurtec, and if yes, why was Emgality a good investment back in 2019? Secondly, Terry, on slide 90, Imbruvica is a product that's on the slide, but I don't think you mentioned it. AbbVie is now saying that Imbruvica will not grow again. That's quite different than consensus. I'm wondering what's in your models, and do you agree that contraction is likely in the future? Then lastly, if I can ask a big picture question to Pablo. Over the last 25 years, and obviously in retrospect, was there a common theme or a thread in your successful investments and a common theme or a thread in your unsuccessful investments? Thank you.
Yeah, I'll start just quickly on Emgality. You know, if again, if you take a step back, I think the receptivity in the marketplace that you've seen across the injectables, across the orals has been amazing when you think about it at a high level. I mean, the uptake has been pretty incredible, sort of speaking to the unmet need that Brienne talked about. You know, I think there is a future and a role for the injectable class. I think the way we think about it, though, between Emgality, Nurtec, and zavegepant, which is obviously in development as an oral in the preventative space as well, I think we're really well positioned to benefit as that market develops, whether, you know, Emgality, and I think Lilly is doing a great job with that product despite, you know, some oral pressure.
You know, I think it's exactly the kind of product that we like to be involved with, and it's a good example of how over time, we can build a portfolio in an area and really benefit from an overall thesis in a class or a target. Maybe I'll, Terry, you want to?
Yeah. On Imbruvica, our guidance reflects a range of scenarios, as you can imagine. I think consensus might have a little bit of growth, but remember, it's a global product, and they have been able to continue to show some growth outside of the U.S., while I think consensus has it sort of contracting a little bit in the U.S. We obviously look at these things under a range of scenarios and are very comfortable that we can deliver that, the guidance that we just gave under a range of scenarios.
Regarding your question about common themes in successful investments and also themes on unsuccessful investments. If I reflect back at the time when I started the business, we had a lot less experience. Also the industry was very different at the time. It was much more based on small molecules. It was sort of the you know beginning of biologics. You know the companies were different, a lot more the predominant companies were big pharmas. Biotech was starting. We made a lot of mistakes initially. Lost money. Very painful to lose money, but you try to learn and then reflect on what didn't work. What started to happen over the years is that we developed investment criteria of what constitutes an attractive product.
Some of those themes came across in the presentation, particularly when Marshall, Brienne, and Sara spoke. What we realized is that there's attributes that are common to successful products. What we've done over the years is that we have really become disciplined and really tried to stick to looking at a product and understanding if that product, you know, scores high in many of these attributes. If it does, we get very excited, but it has to be in many of them, because also in one of the slides that I actually think it was my last slide, where I talked about all of the things that you need to get right, investing in life sciences. It's many, and many have to be right, because if one or two is not right, it can be a disaster.
I think that's one of the attractive things that is not appreciated by investors about Royalty Pharma. I'm thinking here not so much about the specialist investors, but more, you know, generalists that I think we offer a very unique way of investing in life sciences with a lot less risk because of our diversification that's very unique, the duration of the portfolio, and the very high growth. It's a way for investors to potentially invest in the space, which is very exciting because of the innovation, but with a very interesting risk-reward balance that I think few other companies offer. Going back to my question, or your question, I'm sorry, about common themes, what we've realized is that we get excited when we see products scoring high in many of these attributes.
If the product doesn't score high in many of them, then we have now understood that it's better for us to pass, not invest. As Marshall said, we're disciplined. We don't care. We don't invest in a quarter or two any capital. We just, you know, we'd rather not make an investment that's not gonna succeed and also diminish the quality of the portfolio, which is very high. I n terms of themes, another thing that's become clear is that blockbusters have tended to outperform not only our expectations when we made the investment but also the analyst expectations that were following the companies that were launching them. They outperform for many reasons, you know.
When a drug is a blockbuster, you know, it's sort of the lowest risk investment in pharma to invest more in making a blockbuster even bigger, right? You're gonna run more clinical trials to see if there's more uses for the product. You're gonna invest in sales and marketing more. These products have tended to outperform. What's been great for us at Royalty Pharma, as Terry pointed out in one of the very last slides, is that we have been able, over the years, to actually invest in every wave of innovation that this industry has had in the most attractive products in each one of those waves of innovation. I mean, looking at things like TNF inhibitors, for example, we took time. You know, we tried in 1998 with NYU's Remicade. We didn't succeed.
We were patient. We ended up investing in Humira, eventually in Remicade and Cimzia. I can go through many therapeutic areas, and you can see how, you know, we've been able to invest in the most exciting drugs in all of these different waves of innovation. I think it's gonna continue because of the model that we have that is very open, very collaborative. Actually, there was a question asked before about competition. You know, the more I think about it is, you know, we're gaining strength as time goes by because of all of the things that we're doing. You know, even the thing that we're doing with Strategy and Analytics is putting us in a position where, you know, we will have something the others won't.
It's gonna put us in a very strong position with the different biotech companies. Blockbusters have been incredibly powerful. I think, you know, we've actually made mistakes. We learn from them. There are common themes, you know. One of the things that, for example, has to be there is huge alignment between the market and the drug that it has to matter for it. We've made investments in small drugs that we thought were great because of many reasons. You know, clinical data, but they were not important for the market. They haven't performed well. You know, there are obviously themes that I can point to. Thank you for the question.
Thank you. We'll take the next question. Phill?
Marshall, it strikes me listening to you and Brienne that you do research differently than we do 'cause you guys can get information that we can't get to. You know, that's material non-public information that we couldn't trade on. Which I'd love you to give us some examples of that and how it creates an advantage, and more credibility on the products that you invest in. If I remember right on the Nurtec, you guys were looking at patient-level data from the first study when people were betting on, I believe it was the maintenance treatment dose or vice versa. Just give us some examples of where that creates an advantage relative to the kind of research that we're doing here.
Thanks for that question, Phill. I think I can start, and maybe Brienne or Sara also could comment. I think it plays out on a number of different levels. Like you mentioned, when we partner directly with companies, right, as I referenced, we're under confidentiality with them. You know, if we do a synthetic royalty with a company, any, you can assume that we've gone very deep with them into the data. You know, as Brienne talked about, you know, Biohaven, we were, you know, deep into the details. You're right, there were actually two phase III trials, and we were waiting for a third as well as the long-term safety data as well.
We went deep to understand the safety profile because for anyone who remembers the history, the first generation in that class had some liver safety problems. I mean, there are other examples. With Immunomedics, when we did that deal as one example, you know, we were going through every patient's data before they were filing. I think you can assume that and for all of our synthetic royalties, we're getting really close and into the data. I think it goes kind of beyond just that. It's that, you know, we have, I think, the luxury of time and a long-term perspective and the support of being able to put the resources in to really.
This is what I was hoping, you know, to bring out during my prepared remarks, was that we have the opportunity to put all the resources we can into getting to an answer. I think having the institution that's built that way, and we're not trying to sort of optimize for, like, a margin on a deal, we're trying to get to the right answer, is also a big competitive advantage. I don't know. Sara, do you wanna?
Just listening to your answer, Marshall, which is great, and you're so right. There's other things that happen. You know, we're under confidentiality, so in addition to having access to patient-level data, we have access to things like FDA minutes, so we know what the FDA is thinking about the product, you know, what is the focus, the concerns the FDA might have. A lso, you know, through the interactions that we have with the management teams, we really get an incredible sense of how they're positioning the product, the marketing. There's a lot of things that we gain. What happens, Phill, is that we're able to get that information because we're financing the company. We're financing the product. You know, they share that information under confidentiality. We're making an investment in the product, funding the trial.
What's interesting, which is very unique about the Royalty Pharma model, is that we also then make an equity investment in addition to the royalty investment with incredible information that often public investors don't have access to. That is totally possible, doable, you know, legal, no issue, because it's a level playing field. We're actually, you know, working with a company who has the same information. Internally, they have that information they're sharing with us. We're not depriving the public investors from a potential gain. We're buying the equity directly from the company. It puts us in a very, very unique position where we're coming in and making an investment with deep knowledge, both on the royalty and equity side.
My vision for that has been that if we can, in those hybrid deals, end up, you know, doing deals where maybe 2/3 is a royalty, you know, of the capital we deploy, 1/3 is equity or could be, you know, three-quarters, one quarter. It's great. As we've seen with Immunomedics, we saw it with Nurtec recently. You know, we end up making a very significant profit on the equity, which ends up resulting in many cases with us, you know, recovering our entire investment with the equity investment and then really keeping the royalty almost for free. It's a very unique aspect of our model, but others.
Thank you. We'll take the next question, please. Taking the back row.
Hi. Drew Guff from Siguler Guff. Pablo and team, thanks for a great investor day, especially your preface comments about how the team looks at everything they do from an investor's point of view. You mentioned the FDA earlier. Can you talk a little bit about what it's like at this point to interact with the FDA, what some of the priorities are, for which types of drugs and drug approvals and the general, legislative and, regulatory environment?
Yeah, sure. Thanks for that question. You know, I think Pablo highlighted one of the, you know, key advantages we have is that, you know, we do have insight, very granular insight into the back and forth with the FDA. A key part of our process is having conviction that, you know, our partner has the right strategy, that we feel like their strategy is aligned with what the FDA is asking for. I think we've all had a lot of learnings that, you know, sometimes there's a little bit of gray area there between what the sponsor might hear and what the FDA says. I think that's, you know, one of our kind of advantages of being able to look at so many things is being able to see those kinds of patterns.
Getting conviction on the regulatory side is, you know, absolutely key. It's not just the FDA. You know, we look at interactions with the EMA, with the PMDA in Japan. Increasingly, there's a question about China. See some of that as well. You know, we really take it on a sort of product-by-product basis and look at sort of where, you know, where that specific product sits from a regulatory perspective. Certainly we bring, you know, part of what your question is referencing, you know, bring a frame where we look at what's going on, how things might be changing. I think our advantage is we wanna have really high confidence and high conviction that, you know, that the regulators are comfortable with what the partner is doing.
Great. Thank you. We have one question from Terence Flynn at Morgan Stanley. Has the bilateral deal mix of 50% over five years been generally stable? And what are the top reasons why you elect not to move forward with a potential transaction?
Can you repeat that question?
Has the bilateral deal mix of around 50% over the past five years been generally stable?
Are you asking if it hasn't changed? I couldn't hear you. I'm sorry, George.
Has the bilateral deal mix around 50% over the past five years been generally stable, and how has that evolved over time?
Well, that's the results over the last five years. We didn't look at the analysis, I don't think, prior to that. You know, I think the fundamental point really on the bilateral is the early engagement, relationship building, win-win solutions. I think Vlad said it best at Biohaven. You know, partnering with us, we were flexible and innovative in ways that we could provide capital, and that's not lost upon other participants in the sector. We're not really like a one-and-done company. We look to provide capital to help our partners finance their company. Typically, biotechnology companies n eed a lot of capital, even at launch and beyond launch, to fund the launch, to fund the next program. We really look for ways to be their partner over the long haul. I think that what is what really attracts people that allows us to have those bilateral engagements.
Is there a second question?
Second part of the question from Terrence Flynn is: What are the top reasons you elect not to move forward with a potential transaction?
Sure. We've been asked that before. When we look at it, there's really no one theme that drives why we don't move forward. You know, I talked to you about our process. At every stage along the way, there might be things that don't work out. I mean, obvious ones are, you know, we can't get comfortable with the clinical trial risk, or we might not love the design. A lot of times, you know, it may be a difference on commercial views or on commercial strategy.
You know, we really have to get comfortable and been doing more work recently to try to match, is the company's planned investment in their commercial infrastructure and their strategy aligned with the forecast that they're putting out there? You'd be surprised, a lot of times those two things aren't necessarily built to gel. The list goes on and on and on about about why that may happen. You know, I'll tell you as a part of that, as a part of the answer to that, you know, the reasons why things don't work out, you know, that don't happen much is, you know, really Pablo talked about competition. I think the competitive dynamic is typically not a big reason why things don't work out.
The biggest reasons are because on our side, for whatever reason, we're not comfortable with moving forward.
Great. Thank you very much. We'll take the next question from Mike.
Thanks so much for taking my question and for putting on such a spectacular event. Two from me. I think this is the first time, correct me if I'm wrong, that you've disclosed that Brainshuttle gantenerumab would confer the same royalty as regular gantenerumab. My question is, why disclose this now? And might this imply reduced confidence in the current subq version of gantenerumab? My second question is, regarding the SEC-mandated accounting changes that have been implemented industry-wide. Have these changes in any way changed the way in how Royalty Pharma intends to structure future deals? Thank you.
Oh, sure. Like the first part of your question on gantenerumab. No. We actually have talked about that before on conference calls. I think the question has come up, maybe Steve asked the question or someone else has asked the question and before on conference calls. You know, that's not new today, but I think Terry just wanted to be clear, 'cause part of the theme that he was talking about there was, right, all of the optionality within our development stage portfolio, and even within gantenerumab, there's both the initial program, which we're very excited about and looking forward to the answer later this year. Then also the Brainshuttle behind it, which is pretty cool technology as well.
The question on the SEC accounting changes that have led to some updates across the industry beginning in the first quarter. We don't expect that this to, in any way, change what we're doing at Royalty Pharma. We've always sort of been focused on, you know, the cash that the business generates that we're then able to redeploy in new royalties. That's, you know, how we think we can create the most value. Whether that, you know, whether there's a segment of that that shows up in the P&L, you know, at the end of the day, it's cash that, you know, the way I described it today is EBITDA less interest expense.
It's really the cash that the business generates on a consistent basis and growing basis that we're then able to redeploy in new value-enhancing royalties. The accounting will in no way drive where our investment focus is.
I think we have one of the simplest P&Ls to understand in the industry. When you look at the bars and, you know, how we start with the top line, cash expenses, EBITDA, I mean, it's so simple and transparent. As Terry said, the cash conversion is very strong, so.
Take the next question, please. Steve.
Thank you. Early on, there was a slide that showed products on the way, you know, in the future. On that slide, in fact, it was the first two you mentioned, were gantenerumab and otilimab, two products that I think investors have very low expectations for. I'm thinking about that, and then I'm thinking of the answer to Phill's question just a moment ago about how you have access to data that we don't have. I think there was an interim look at gantenerumab. I'm not asking what it is you know about these compounds that might be prompting your enthusiasm, but what's the nature of what you might have that we don't have? That's the question. Thank you.
Sure, Steve. We've touched on this topic before, and I think to be clear, you know, our excitement about both products is really driven by the characteristics that we've talked about many times, right? About the potential of this market, the marketer. The fact that you have two, like, clean up or down phase III trials that are really well designed. That you have differentiated delivery, like Terry talked about. It's also the idea of how we can build within a deal like Sara talked about, right?
You know, a really basis of attractive returns based on Tremfya and the development funding bonds, and then add a tremendous amount of optionality with things like gantenerumab and otilimab. I think that's the right way to think about it to your question. Certainly, there is a variability from deal to deal, depending on who the royalty holder might be in terms of the depth of information that we get. Sometimes we honestly don't know much more than you all do, and sometimes as we talked about, we have deep information. It's really highly varied.
Great. Thank you. We'll take the next question, please. Great. Well, if there are no further questions, this will conclude the Q&A session in today's event. As a reminder, we do have a management luncheon, which will begin shortly, and we thank you all for joining us today and for your continuing interest in the Royalty Pharma story.
One final thing. I think all of us here, the team would like to thank you, George, for the extraordinary job you did in putting together this analyst day, and the incredible work that has gone into it. A lso, the other thing that we all have to recognize is how you have guided us since we have become public. You know, in this process of learning how to be a public company and how to report to investors. I think the incredible experience that you had before you joined us has been of tremendous benefit to us. And so thank you, and you and your team have done exceptionally well for us. Thank you.
Great. Thank you very much, Pablo.
Thank you.
Thank you.