Company Description
Silence Therapeutics plc, a biotechnology company, engages in the discovery and development of novel molecules incorporating short interfering ribonucleic acid (siRNA) to inhibit the expression of specific target genes in hematology, cardiovascular, and rare diseases.
The company develops Zerlasiran (SLN360), which is in Phase II clinical trial for cardiovascular disease associated with elevated lipoprotein(a); Divesiran (SLN124), an siRNA molecule that is in Phase I clinical trial for the treatment of genetic hematological conditions, including polycythemia vera; and SLN548 for complement-mediated disease.
Silence Therapeutics plc has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize siRNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Hansoh Pharmaceutical Group Company Limited to develop siRNAs.
The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007.
Silence Therapeutics plc was incorporated in 1994 and is headquartered in London, the United Kingdom.
| Country | United Kingdom |
| Founded | 1994 |
| Industry | Biotechnology |
| Sector | Healthcare |
| Employees | 116 |
| CEO | Craig Tooman |
Contact Details
Address: 72 Hammersmith Road London, W14 8TH United Kingdom | |
| Phone | 44 20 3457 6900 |
| Website | silence-therapeutics.com |
Stock Details
| Ticker Symbol | SLN |
| Exchange | NASDAQ |
| Fiscal Year | January - December |
| Reporting Currency | USD |
| CIK Code | 0001479615 |
| CUSIP Number | 82686Q101 |
| ISIN Number | US82686Q1013 |
| SIC Code | 2834 |
Key Executives
| Name | Position |
|---|---|
| Craig A. Tooman M.B.A. | President, Chief Executive Officer and Executive Director |
| Rhonda L. Hellums | Executive Vice President, Chief Financial Officer and Secretary |
| Dr. Steven J. Romano M.D. | Executive Vice President and Chief Research and Development Officer |
| Dr. Marie Wikstrom Lindholm Ph.D. | Chief Scientific Officer |
| Gem Gokmen Hopkins | Head of IR and Corporate Communications |
| Gianine Esposito | Chief Human Resources Officer |
| Dr. Barbara A. Ruskin J.D., Ph.D. | Senior Vice President and Chief Intellectual Property and Innovation Officer |
| J.P. Gabriel | Chief Technical Operations Officer |
| Curtis Rambaran M.D. | Chief Medical Officer |
Latest SEC Filings
| Date | Type | Title |
|---|---|---|
| Aug 14, 2025 | 8-K | Current Report |
| Aug 7, 2025 | 10-Q | Quarterly Report |
| Aug 7, 2025 | 8-K | Current Report |
| Jun 27, 2025 | 8-K | Current Report |
| Jun 25, 2025 | SCHEDULE 13D/A | Filing |
| May 16, 2025 | ARS | Filing |
| May 16, 2025 | DEF 14A | Other definitive proxy statements |
| May 15, 2025 | SCHEDULE 13G/A | Filing |
| May 8, 2025 | SCHEDULE 13D/A | Filing |
| May 8, 2025 | 10-Q | Quarterly Report |