Silence Therapeutics plc (SLN)

NASDAQ: SLN · Real-Time Price · USD
5.77
-0.46 (-7.38%)
At close: May 19, 2026, 4:00 PM EDT
5.68
-0.09 (-1.52%)
After-hours: May 19, 2026, 7:28 PM EDT
Market Cap272.54M +46.9%
Revenue (ttm)839,000 -97.0%
Net Income-75.04M
EPS-1.61
Shares Out 47.23M
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume269,600
Open6.04
Previous Close6.23
Day's Range5.74 - 6.27
52-Week Range4.19 - 8.40
Beta1.52
AnalystsBuy
Price Target31.20 (+440.73%)
Earnings DateMay 7, 2026

About SLN

Silence Therapeutics plc, a biotechnology company, engages in the discovery and development of novel molecules incorporating short interfering ribonucleic acid (siRNA) to inhibit the expression of specific target genes in hematology, cardiovascular, and rare diseases. The company develops Divesiran (SLN124), which is in Phase 2 development for polycythemia vera, and SLN548 for complement-mediated renal diseases. It also develops Zerlasiran (SLN360) for cardiovascular disease associated with elevated lipoprotein(a); SLN312 for dyslipidemia; SLN3... [Read more]

Industry Biotechnology
Sector Healthcare
Founded 1994
Employees 88
Stock Exchange NASDAQ
Ticker Symbol SLN
Full Company Profile

Financial Performance

In 2025, Silence Therapeutics's revenue was $559,000, a decrease of -98.71% compared to the previous year's $43.26 million. Losses were -$88.61 million, 95.6% more than in 2024.

Financial Statements

Analyst Summary

According to 6 analysts, the average rating for SLN stock is "Buy." The 12-month stock price target is $31.2, which is an increase of 440.73% from the latest price.

Price Target
$31.2
(440.73% upside)
Analyst Consensus: Buy
Stock Forecasts

News

Silence Therapeutics files $300M ordinary shares offering

16:11 EDT Silence Therapeutics (SLN) files $300M ordinary shares offering

1 day ago - TheFly

Silence Therapeutics to Participate in H.C. Wainwright BioConnect Investor Conference

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today announced that...

7 days ago - Business Wire

Silence Therapeutics price target lowered to $27 from $35 at Chardan

Chardan analyst Keay Nakae lowered the firm’s price target on Silence Therapeutics (SLN) to $27 from $35 and keeps a Buy rating on the shares. The firm updated the company’s…

11 days ago - TheFly

Silence Therapeutics reports Q1 EPS (11c) vs. (20c) last year

Reports revenue $422,000 vs. $142,000 last year, “The Silence team continues to advance research supporting the broad potential of our mRNAi GOLD platform, and we remain well positioned as we…

12 days ago - TheFly

Silence Therapeutics Highlights Recent Business Achievements and Reports First Quarter 2026 Financial Results

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

12 days ago - Business Wire

Silence Therapeutics Highlights Recent Business Achievements and Reports Fourth Quarter and Full Year 2025 Financial Results

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN, a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today reported financ...

2 months ago - Business Wire

Silence Therapeutics CEO Craig Tooman to end employment

Silence Therapeutics (SLN) announced that Craig Tooman, who has served as the company’s president, CEO and board member since 2022, agreed by mutual consent to end his employment with the…

5 months ago - TheFly

Silence Therapeutics Announces Leadership Changes

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

5 months ago - Business Wire

Silence Therapeutics to Participate in Fireside Chat at Jefferies Global Healthcare Conference

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today announced that...

6 months ago - Business Wire

Silence Therapeutics reports Q3 EPS (15c), consensus (21c)

Reports Q3 revenue $159,000, consensus $3.28M. “Silence continues to focus on operational execution, highlighted by the rapid achievement of full enrollment in our ongoing SANRECO Phase 2 study of div...

6 months ago - TheFly

Silence Therapeutics Reports Third Quarter 2025 Financial Results and Recent Business Highlights

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

6 months ago - Business Wire

Silence Therapeutics completes patient enrollment in SANRECO

Silence Therapeutics (SLN) announced it has completed patient enrollment in the SANRECO Phase 2 study of divesiran, a first-in-class siRNA targeting TMPRSS6, for the treatment of polycythemia vera. In...

7 months ago - TheFly

Silence Therapeutics Completes Enrollment in SANRECO Phase 2 Study of Divesiran for Polycythemia Vera (PV)

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today announced it h...

7 months ago - Business Wire

Silence Therapeutics to Participate in September Investor Conferences

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or the “Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

9 months ago - Business Wire

Silence Therapeutics reports Q2 EPS (19c), consensus (21c)

Reports Q2 revenue $224,000, consensus $3.38M. “The updated data we presented at EHA this past quarter were highly encouraging and supportive of the therapeutic potential of divesiran as a first-in-cl...

10 months ago - TheFly

Silence Therapeutics Reports Second Quarter 2025 Financial Results and Recent Business Highlights

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

10 months ago - Business Wire

Silence Therapeutics presents additional Phase 1 data highlighting Divesiran

Silence Therapeutics (SLN) “presented additional data showcasing the SANRECO Phase 1 study of divesiran in patients with polycythemia vera at the European Hematology Association 2025 Annual Meeting in...

1 year ago - TheFly

Silence Therapeutics Presents Additional Phase 1 Data Highlighting Promise of Divesiran as the Potential First-in-Class siRNA Treatment for Polycythemia Vera

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc (“Silence” or the “Company”) (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) th...

1 year ago - Business Wire

Silence Therapeutics reports Q1 EPS (20c), consensus (41c)

Reports Q1 revenue $142,000, consensus $3.58M. “Silence delivered another strong quarter focused on clinical and operational execution,” said Craig Tooman, President and Chief Executive Officer at Sil...

1 year ago - TheFly

Silence Therapeutics Reports First Quarter 2025 Financial Results and Recent Business Highlights

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

1 year ago - Business Wire

Silence Therapeutics Welcomes Tim McInerney to Board of Directors

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or “the Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

1 year ago - Business Wire

Silence Therapeutics to Webcast Presentation at the Leerink Partners Global Healthcare Conference

LONDON--(BUSINESS WIRE)---- $SLN #SenseofSilence--Silence Therapeutics plc, Nasdaq: SLN (“Silence” or the “Company”), a global clinical-stage company developing novel siRNA (short interfering RNA) the...

1 year ago - Business Wire

Silence Therapeutics price target lowered to $30 from $31 at Jefferies

Jefferies analyst Kelly Shi lowered the firm’s price target on Silence Therapeutics (SLN) to $30 from $31 and keeps a Buy rating on the shares following Q4 earnings. The analyst…

1 year ago - TheFly

Silence Therapeutics reports FY25 net loss 33c vs. 49c loss last year

DJ Silence Therapeutics (SLN) 2024 Loss/Shr 33c “2024 was marked by strong clinical execution and pipeline advancement, highlighting the broad potential of our mRNAi GOLD platform to silence disease c...

1 year ago - TheFly

Silence Therapeutics extends projected cash runway into 2027

Silence announced today that it will only initiate the zerlasiran Phase 3 CVOT study once a partner is secured. Following this announcement, Silence is extending its projected cash runway into…

1 year ago - TheFly