Good afternoon, ladies and gentlemen, and welcome to Veracyte's first quarter 2020 financial results conference call. As a reminder, today's conference call is being recorded. I'd now like to turn the conference over to Tracy Morris, Veracyte's Vice President of Corporate Communications and Investor Relations. You may begin.
Thank you, Sydney. Good afternoon, everyone, thanks for joining us today for a discussion of our first quarter 2020 financial results. With me today are Bonnie Anderson, Veracyte's Chairman and Chief Executive Officer, Keith Kennedy, our Chief Operating Officer and Chief Financial Officer, and John Hanna, our Chief Commercial Officer. Before we begin, I'd like to remind you that various statements that we make during this call will include forward-looking statements as defined under applicable securities laws. Forward-looking statements include those regarding our future plans, prospects and strategy, financial goals and guidance, product attributes and pipeline, drivers of growth, expectations regarding reimbursement and other statements that are not historical fact. It also includes statements regarding the potential impacts to our business resulting from the COVID-19 pandemic and the potential timing for a recovery of our business.
Management's assumptions, expectations and opinions reflected in these forward-looking statements are subject to risks and uncertainties that may cause actual results and/or performance to differ materially from any future results, performance or achievements discussed in or implied by such forward-looking statements. The company can give no assurance that they will prove to be correct and will not provide any further guidance or updates on our performance during the quarter unless we do so in a public forum. Please refer to the company's May 6, 2020 press release and the risk factors included in the company's filings with the Securities and Exchange Commission for a discussion of important factors that may cause actual events or results to differ materially from those contained in our forward-looking statements.
Prior to this call, we announced our first quarter 2020 results, which are available on our website at veracyte.com under Press Releases in the Investor Relations section. We also published a business and financial presentation, which we will reference during our remarks. This presentation is also available on our website under Events and Presentations in the Investor Relations section. I will now turn the call over to Bonnie Anderson, Veracyte's Chairman and CEO.
Thanks, Tracy, and thanks , everyone, for joining us today as we discuss our first quarter 2020 results and provide you with an update on our business during this challenging time. I'd like to take a moment to welcome Tracy Morris to the Veracyte team as she joins us for her first financial results call as Veracyte's Vice President of Corporate Communications and Investor Relations. Our call will be structured a bit differently from our typical quarterly financial results calls. I will start with a brief overview of the quarter and the impact of the COVID-19 pandemic on our business, along with our response. Keith will follow with detailed financials for the quarter. I will discuss why we believe we are well-positioned to emerge strong over the long term.
We will both be referring to our first quarter business and financial presentation, which, as Tracy mentioned, is available under Events and Presentations in the Investors section of our website. We delivered solid results for the quarter despite the rapid onset of the COVID-19 pandemic and shelter-in-place orders, which began to negatively impact our business in mid-March. We grew our genomic testing and product revenue to $30.4 million in the quarter, a 20% increase compared to the first quarter of 2019. Including biopharmaceutical collaboration revenue, our total revenue for the quarter was $31.5 million. We increased genomic testing volume for Afirma Percepta and Envisia during the quarter by 15% to 10,559 tests. Despite the pandemic headwinds, we have continued to make significant advances in our core diagnostics business, as well as progress with our pipeline and strategic growth opportunities.
This includes forging new biopharmaceutical collaborations that provide us with strategic leverage and enable us to extract additional value from our current clinical indications where we are helping to inform diagnostic and treatment decisions. In April, we launched our expanded Afirma Xpression Atlas, which detects significantly more genomic variants to inform treatment decisions for patients with suspected thyroid cancer. Data accepted for an oral presentation at ENDO, the annual conference for the Endocrine Society, demonstrated the test's ability to identify novel or rare gene fusions that may potentially be targeted with specific kinase inhibitor drugs that are currently available or in development to treat thyroid cancer patients. The Afirma XA utilizes RNA sequencing on the same fine needle aspiration sample used for testing with the Afirma Genomic Sequencing Classifier.
Underscoring physicians' interest in the Afirma Xpression Atlas, we have learned that a paper describing the test's clinical utility in identifying therapy targets for metastatic cancer was among the top 10% of downloads in the past year in Cancer Cytopathology, a leading journal of the American Cancer Society. Additionally, we launched More About You, a web-based campaign designed to educate patients about thyroid nodules and empower them to ask for Afirma testing by name. We believe both of these initiatives will help drive further Afirma growth when physician ordering practices begin to ramp back up. Further, two important articles related to our Prosigna breast cancer test were published in leading medical journals.
These include new data published in npj Breast Cancer that suggest that the Prosigna test may be able to offer new levels of individualized treatment for women with early-stage breast cancer, potentially enabling many to avoid more aggressive chemotherapy regimens based on their breast cancer subtype. The findings suggest potential growth opportunities for the Prosigna test in global markets, where the test reports intrinsic breast cancer subtypes. We also advanced integration of the NanoString diagnostic business to prepare for global expansion of our tests. This included instituting our order-to-cash process for our new Prosigna kit and instrument business and securing key distributor relationships in important international markets. We are also enhancing our regulatory function to execute upon our plans to secure ISO 13485 certification and regulatory approvals to sell our products in global markets. It is remarkable that all of this has been established in just a few months.
We progressed our pipeline and important strategic relationships that will help bring long-term value to the business. We recently signed a licensing agreement with Yale University, giving us exclusive access to the first genomic test that predicts fibrotic disease progression in patients with interstitial lung disease, including idiopathic pulmonary fibrosis, or IPF. This non-invasive blood-based test was developed in the lab of leading IPF researcher Dr. Naftali Kaminski and answers one of the key questions in fibrotic lung disease: which patients with pulmonary fibrosis will progress rapidly and which will have slower progressing disease so that they can be treated accordingly? The test will be an excellent complement to our Envisia classifier, which is available today in the U.S. and remains on track to launch on the nCounter system in international markets in 2021.
Further, we signed an exclusive licensing agreement with Boston University for additional intellectual property that will help advance our development of the first-ever non-invasive nasal swab test for lung cancer early detection. This novel test is slated to launch in the United States in 2021 and then internationally on the nCounter system in 2022. We also extracted additional value from our collaboration with the J&J Lung Cancer Initiative related to cohort expansion for the nasal swab program during the first quarter of 2020. These agreements follow our announcement in January of a multi-year collaboration with Acerta Pharma, the hematology research and development arm of AstraZeneca, to provide genomic information that will support their development of oncology therapeutics in lymphoma. We are pleased with the early progress of this important program.
Despite these advances, the pandemic has understandably impacted our business, with most states having issued shelter-in-place orders, hospitals and institutions severely restricting non-emergency procedures, and many smaller practices temporarily closing their doors to patients altogether. We began to see reported genomic test volume decline in the second half of March, and this has continued through April, where we experienced an over 50% decline during the month compared to the prior year. As some states have begun to loosen restrictions in the last week or so, we have seen a slight near-term rebound in Afirma samples in the physician office market segment. Although volumes remain dramatically suppressed among hospital customers for Afirma and for our other products.
Our guiding principle as the pandemic took hold was to protect the health and safety of our employees and the broader community while ensuring our ability to continue to deliver genomic test results to physicians and their patients. We accomplished both. We quickly halted all non-essential business travel for our employees, enabled most employees to work from home, and established social distancing protocols, such as relocating workstations and staggering work schedules in our CLIA lab to protect employees whose work requires them to be on-site. We have prohibited outside visitors to our facilities and have provided all on-site employees with face masks and other personal protection equipment. Our lab is running smoothly, and we continue to report test results. With access to customers restricted, we have digitally enabled our sales team to maintain engagement and service our customers virtually.
While clinical practice is limited, we are experiencing strong attendance in digital peer-to-peer educational programs across our product portfolio. We have also doubled down on training for our field team when they have not been engaged with customers. Given the uncertainties of the pandemic impact on the broader economy and its duration, we cannot predict when our business will return to normal levels. We have excellent momentum going into the pandemic. Realistically, we believe that business recovery will take some time. It remains to be seen, for example, whether pent-up demand for testing will result in immediate physician orders or whether physician practices will stagger appointments and procedures consistent with social distancing protocols. We also do not know when patients will resume non-emergency medical appointments where, for example, a thyroid nodule may initially be detected.
To guide our strategic priorities and plan as a result of this uncertainty, we have laid out a recovery framework on slide four in our business and financial presentation in which we are currently assuming a U-shaped recovery. This means we currently expect our business will return to normal operations in Q1 or Q2 of 2021. Of course, we'll be ready to pivot to alternative approaches if recovery happens sooner or takes longer, as we have also shown in our framework slide. Assuming a U-shaped recovery, we are prioritizing cash preservation and business flexibility. To that end, we recently took immediate actions to reduce costs. These included reducing my own pay and target bonus by 25% until the company can resume normal operations.
Veracyte's board of directors, executive leaders, and certain other employees are taking a reduction in pay, putting approximately 60 employees on temporary furlough with a current goal of bringing them back once our business rebounds; terminating a small number of employees; instituting a temporary hiring freeze; and lastly, securing vendor discounts and halting all non-essential outside spend. By taking these temporary but necessary cost-saving steps now, we believe we will be better positioned to emerge strong from the current situation. We are closely tracking shelter-in-place orders at the state and local levels, as well as policies from institutions and practices, and are positioned to redeploy to customers as they come back online. I will now turn the call over to Keith for a more detailed review of our first quarter 2020 financials.
Thank you, Bonnie. I'll also refer to our business and financial presentation as I discuss our first quarter 2020 results. Turning to page five, the table and footnote shown here, along with the details in our SEC filings, further explain how we recognize and report revenue under US GAAP. For discussion purposes, we may combine testing and product revenue to describe our diagnostic testing business and biopharma and collaboration revenue to describe our strategic arrangements. As a reminder, net sales of data or other services to our customers are classified under biopharmaceutical revenue, and all other non-customer revenue, such as milestones, are classified under collaboration revenue in our consolidated statements of operations and comprehensive loss. Turning to page six of the presentation, our performance against six key performance indicators, or KPIs, for the first quarter of 2020 compared to the prior year quarter is as follows.
As Bonnie mentioned, we grew our genomic testing and product revenue to $30.4 million, a $5 million, or 20%, increase compared to the prior year quarter. Total revenue of $31.1 million increased $1.6 million or 5%. Biopharmaceutical and collaboration revenue of $0.7 million declined $3.4 million, principally from the sale in the prior year quarter of data to Johnson & Johnson for $3.8 million, which contributed 4% to our gross margin in that quarter. Gross margins were 61%. In the first quarter of 2020, due to the expected impact of the COVID-19 global pandemic on our expected test volumes, we recognized a $1.1 million write-down of supplies that we recorded in cost of revenue. This write-down resulted in an approximate 350 basis points reduction in our gross margin.
As I just mentioned, the $3.8 million sale of data to Johnson & Johnson in the first quarter of 2019 contributed approximately 4% to gross margin in that quarter. Operating expenses, excluding cost of revenue, increased $8 million. Pre-pandemic, we ramped up our multi-product sales team, increasing sales and marketing headcount by approximately 60% in the first quarter of 2020 compared to the prior year quarter. Associated with the NanoString acquisition in the fourth quarter of 2019, we recorded an incremental $1 million in intangible asset amortization in the first quarter of 2020 compared to the prior year quarter, which is included in our operating expenses.
In response to the impact of the COVID-19 global pandemic on our business, in April this year, we announced a series of cost savings initiatives that Bonnie recapped in her prepared remarks. In 2020, we hope to mitigate approximately $20 million-$25 million in planned spend from taking these actions. Net loss of $11.7 million increased by $9.8 million, and net cash used in operating activities was $5.3 million compared to $1 million in the prior year quarter. We received $3 million in incremental cash from Biopharma partners in the prior -year quarter relative to the current -year quarter, principally from the sale of data to Johnson & Johnson. Genomic volume increased 15%, and cash at March 31st, 2020, was $153 million. Page seven provides a further breakdown of revenue into testing and product revenue, Biopharma and collaboration revenue, and total revenue.
As previously mentioned, genomic testing volume grew 15% over the prior year quarter. Our newly acquired product business was on pace on an annualized basis prior to the pandemic to outperform our previously announced expectations for this business, and we announced a multi-year collaboration with Acerta Pharma, the hematology research and development arm of AstraZeneca, which resulted in a small amount of revenue in the first quarter of 2020. For the three months ended March 31st, 2020, we accrued on average between $2,800 and $2,900 for the Afirma genomic classifier test, including variants that met our revenue recognition standard, which was between 90% and 95% of the reported Afirma classifier test volume. Though the range has remained consistent, we recognize that every percentage point may result in us not being paid for approximately 1% of test volume or approximately $250,000.
We have taken steps to improve field training and other process changes to try to improve upon this metric. The next six pages outline the sequential and year-over-year results underlying each of our KPIs. A few observations. First, turning to page eight, the stacked and clustered column charts graphically depict revenue and year-over-year growth in our core genomic testing and product services, as well as revenue from sales to biopharmaceutical customers or recognition of collaboration revenue, typically recognized upon satisfaction of performance obligations that are event- or milestone -driven. Turning to page 11, operating expenses increased $3.3 million sequentially and $8 million year-over-year. As we ramped up our multi-product sales team, we increased average sales and marketing headcount approximately 25% sequentially and 60% year-over-year, accounting for the majority of the increase in operating expenses.
As I stated earlier, through the actions we took in April in response to the impact of the COVID-19 global pandemic on our business, we hope to mitigate approximately $20 million-$25 million in planned spend from taking such actions. I will now turn the call back over to Bonnie.
Thanks, Keith. Looking ahead, we are confident in the fundamental strength of our business and our strategic positioning. Let me explain why, leaving you with these 5 points. First, our core genomic diagnostic business is strong. We have high-performing commercialized genomic tests that inform diagnosis and treatment decisions in four clinical indications, major cancers, and serious lung diseases, helping patients avoid risky, costly procedures and quickening time to appropriate treatment. We believe these qualities are more essential than ever to the needs of our healthcare system. All of our commercial tests are reimbursed by Medicare and private payers and adopted by physicians. Second, we believe we are poised for robust global expansion.
With our exclusive global access to the nCounter, a best-in-class diagnostic instrument platform that we obtained from NanoString in December 2019, we believe we are well-positioned to deliver a growing menu of advanced genomic tests to patients worldwide through laboratories and hospitals that can perform them locally. We estimate the global market opportunity for our tests to be over $40 billion. Third, we have a significant pipeline. We currently remain on track to launch three novel products in 2021. These comprise the first non-invasive nasal swab test for early lung cancer detection, which we believe will help patients with a high risk of cancer to get diagnosed and treated sooner while enabling low-risk patients to avoid invasive diagnostic procedures. Following the test launch in the U.S. in our CLIA lab in 2021, we plan to launch it internationally on our nCounter platform in 2022.
Our Percepta Atlas, which will provide physicians with important genomic alteration data at the time of lung cancer diagnosis to inform treatment decisions, remains on track for a 2021 launch. With the enthusiasm we have seen with the novel, extensive whole transcriptome variant data in our Xpression Atlas in thyroid cancer, a disease with minimal targeted treatment paradigms for patients today. We are very excited to begin the same journey in lung cancer, where physicians and patients rely on this data for timely treatment decisions. Our Envisia classifier adapted to the nCounter system, enabling us to offer it to physicians for their patients with suspected IPF or other interstitial lung diseases in global markets before the end of 2021. Fourth, our growing biopharmaceutical collaborations provide strategic leverage to advance our pipeline and create new pathways for value creation.
We have already established a number of important biopharma relationships that leverage our focus on answering, through the use of RNA sequencing, clinical questions throughout the patient journey in a range of oncology and other indications. Our collaborations to date include Eli Lilly Loxo Oncology, in connection with Afirma in thyroid cancer; Johnson & Johnson, in connection with Percepta and our in-development nasal swab test in lung cancer; and Acerta and AstraZeneca, with LymphMark in lymphoma. We believe we can continue to expand our biopharma partnerships as we further advance our genomic testing business. I would like to remind you that the revenue from these partnerships will be difficult to predict and very lumpy by nature, clearly providing leverage with our investment and commercial presence in a portfolio of oncology and other clinical indications to drive additional value. Finally, we have a very strong cash position.
As of March 31st, 2020, we have $153.1 million in cash, giving us a long runway and flexibility. Note that we have also updated our business catalyst slide from our corporate deck, and you can find it for your reference at the end of our business and financial presentation from today. Before closing, I would like to give a huge shout-out to our employees who have done a tremendous job of rising to this unprecedented occasion. In the face of the pandemic, they've adapted to the new work structure, embraced new ways of collaborating, sought creative solutions to challenges, and maintained their positive attitudes, passion, and focus. I am truly honored to lead such a phenomenal team, and I look forward to weathering this storm and continuing to work to build Veracyte into a world-class global diagnostics company. I will now ask Sydney to open the call up for questions.
Thank you. Ladies and gentlemen, to ask a question, you will need to press star one on your telephone. To withdraw your question, please press the pound key. Once again, that's star one to ask a question. Our first question comes from the line of Tom Slatton with Lake Street Capital. Your line is open.
Great. Hi, guys. Thanks so much for taking the questions. Just going back to COVID, when you did your pre-release in mid-April, you had also used the 50%+ reduction in testing volumes. Did that stay pretty steady in the second half of April, or was there further deterioration? Because I know 50+ can mean a lot of things. I'm just curious if that was kind of a trough or if you saw further deterioration.
Thank you, Tom, for joining us today. No, that number pretty much continued through the period of April.
Great. One more with respect to your recovery framework. Sorry. The temporary furlough that you instituted earlier in April, do you think the totality of if we stay within your U-shaped scenario, or do you think there'll be additional furloughing as long as we stay within that U-shaped scenario that you're working from?
Yeah, I think that's why we put out the framework. I think that early on, a lot of people were thinking this would be a V-reaction. We go down deep, and then boom, everything's going to pop back. On the other end of the spectrum, there's still questions about maybe it's just a very, very long recovery.
I think in looking at all aspects of that and all the analytics and data that we have that we're kind of rerunning every day and have lots of people out there in the field giving us data as well, we're fairly comfortable that preparing and planning for a U-shaped recovery gave us the benefit of getting the cost savings but the flexibility to respond to either a more rapid recovery that might echo the shape of the V curve or a weather a longer recovery, such as indicated in that longer -term chart. I think we're comfortable that the steps we've taken give us the cash preservation we need to weather it. We have the easy ability to flex and respond more quickly if we need. The furloughing gives us the ability, we hope, to rebound and bring people back, hopefully quicker than we're planning for.
That's great. Just one final one. Could you give us maybe some insight in what we might expect to see over the balance of this year for nasal swabs, or are any data releases going to be in 2021?
We did put our catalyst slide in the deck, and as anyone who has seen this slide before will note, we've sort of pulled the implications around growth, because pulling our guidance, we really don't know what that growth will look like. Fortunately, because of the stage of these products and where we have been at, we already have clinical cohorts built. A lot of the pre-investment has been done over the last couple of years, and the collaborations with J&J are augmenting that. We are not, at the time, expecting to have any significant impact on any of our pipeline products. The nasal swab test is predicted to launch in 2021. Typically, final validation data comes out close to that launch timing; I don't think we would expect to see any kind of final validation data yet this year.
We typically do have interim sets of data , and as we come into some of the organizational meetings, which are all virtual this year, we hopefully will have an opportunity to share some of the interim data as that algorithm development moves forward. We are very excited and very pleased that our pipeline is strong. It remains on track; 2021's going to be a busy year of commercializing three products, one of those going to the international markets for the first time.
That's great. Thanks so much for taking the questions and congrats on everything.
Thanks, Tom. Appreciate you joining us today.
Thank you. Our next question comes from Sung Ji Nam with BTIG. Your line is open.
Hi. Thanks for taking the questions. Bonnie and Keith, obviously, had a very strong quarter despite COVID headwinds towards the end of the quarter. I was wondering if you may be able to parse out what the COVID impact may have been and if you were pacing ahead of expectations in terms of your core genomic testing volume. I was curious if there are any surprises that you might be able to highlight.
I think in our core pharma business, we felt really good about that. We ramped up our commercial team at the end of the year, and we're really on path to do great things on the testing side of the business. Our lung business did very well. We had about $2 million in revenue just in lungs alone in the quarter, and then our product business did $3.4 million. I'm always chuckling, but this $3.4 million, I think, is the best quarter Prosigna's ever had. I think even the people that sold it to us were like, How'd you all do that? We believe the product business has done very well. We think our products have in-network status. They're all Medicare-covered. We have a great sales team that really understands the products. They're leading tests in each of their markets.
It's just a lot of great things that were happening pre-pandemic. I think with what John Hanna's done on the commercial team to sort of get everybody engaged in retraining and getting in front of doctors and writing notes to doctors and things that just have a personal touch, that business will come back, and we feel good about that business coming back. We feel good about the fact that our tests essentially try to keep people from having invasive procedures, and we think that people are more and more understanding what diagnostics are and all the things we've been talking about, where we've been positioning companies, so we think that's really great.
Our biopharma and collaboration business, as Bonnie said, is probably not going to be impacted as much by this because we already have the cohorts and a lot of the investments made, and we can continue to progress that throughout all this. There are just a lot of things we feel very hopeful for.
Obviously, this is a struggle for a lot of people across the country and a lot of people that are out of work or physicians that aren't getting money, and they can't pay nurses and things like that. We feel for people across that business, and we feel for our employees that we've had to furlough, but we feel like there's a really good chance here that this thing gets back and we recover.
Yeah, I think just to close that out, in the biopharma collaboration area, we ended up booking revenue from all three of the clinical collaborations this quarter, which wasn't anticipated. Anyway, I think Keith said it well. Very strong quarter for us.
Great. That's very helpful. Also, thank you for the recovery framework, thinking through that for us. It's very helpful. Was curious, though, if you're expecting kind of the more normalized levels in the first and second quarters of next year, what do you think are the implications for the target patient populations in terms of patients delaying their diagnosis or treatment options? Do you think there will be pent-up demand or catching-up demand heading into next year? Are you prepared to accommodate or address potential I don't know if there might be a spike or a significant ramp in terms of demand early on in the recovery phase?
First of all, I'll just start by saying, quite frankly, we don't know. I think anyone that thinks they do know what's going to happen next year in the first and second quarter, I want to hire them as my advisor. Especially if they're right. We don't know, but I think that we chose the level of furloughing to kind of hit that balance of not going. Obviously, as Keith pointed out, we had a lot of commercial hiring in the very end of the year as we brought on the NanoString team. Keep in mind, part of that sales and marketing expense that we carried into Q1 included John's hiring here in the U.S. to ramp up for three products growing through the year.
In addition to that, we did have the NanoString and the European group that we brought over and wanted to keep in place. I think we went deep enough with the recovery plan to have a substantial cost savings from it, but not so deep that we can't, we believe, turn on a dime to get back in there to any site that our reps have access to. Maybe it's a good time to let John walk through some of the steps that they've taken to change the organizational readiness and a few other things that he's done, not only to take advantage of this slow time but also to be even more ready to do business in what we believe may be a little bit different paradigm when things return. John, why don't you just walk through that?
Sure, I'm happy to, and thanks for the question. Bonnie and Keith both touched on this in their prepared remarks in different places, but there are really three things we've been very focused on ever since the initial shelter-in-place policies were put out there. They are organizational readiness, really emphasizing the value proposition behind our products, and the third is digitizing customer engagement.
From a readiness perspective, we for some time now, as we've been ramping our multi-product selling structure in the U.S., have invested in and put in place a really strong virtual training platform for our field team members, and we were able to leverage this to double down on clinical knowledge, product knowledge, and selling skills across the country with our team members to really ensure that they are prepared as soon as the shelter-in-place policies lift to get back out into the field and sell and move the business rapidly.
The second is focusing on our value proposition and really emphasizing the value of our products in this COVID era around helping patients avoid unnecessary procedures that are at low risk of cancer or disease and then informing those patients that are at higher risk that they need to be prioritized for invasive procedures, as Bonnie talked about, such as the Afirma Xpression Atlas and thyroid cancer. Thirdly is digitizing engagement.
As Bonnie said, we took a balanced approach here of furloughing what we believe are the appropriate number of individuals to enable us to have a cash savings, but we don't think this in any way inhibits our ability to service our customers, given that like many other companies, we have put in place travel restrictions both for the safety of our employees, but also for that of the office staff and physicians that they service. We've focused on enabling our employees to digitally engage with customers, whether that be by email, text, phone, video, web conference, and we're seeing a really high level of engagement in peer-to-peer virtual programs in all of the specialties we service. We feel like we've taken the appropriate steps as an organization.
We have a high degree of engagement with customers today as they come back online, and they've really prepared the team to support those customers in the field in any way that they need to service their patients.
Great. Super helpful. Thanks. Thank you. I'll get back in the queue. Thank you.
Okay. Thanks, Sung Ji.
Thanks, Sung Ji.
for joining us today.
Thank you. Our next question comes from Puneet Souda with SVB Leerink. Your line is open.
Hi, guys. It's Wesley on for Puneet today.
Hi, Wesley.
Hey. We wanted to follow up on an earlier question about the product segment. It came in above our expectations as well, and I believe on the 4Q call, you guys had suggested $7 million-$9 million for the year. Obviously, that's been withdrawn at this point, but a strong start to the year for the segment. I guess maybe just can you explain a little more on just, I guess, what's worked well to start the year and, I guess, the impact in the near term that we can expect with the ongoing disruption and then moving forward through the rest of the year?
Yeah. I think that, obviously, with a $3.4 million quarter, that $8 million that we had predicted actually could be in line of sight, right? We don't know for sure; there isn't a huge leap of faith to be able to do that. I think we just got the year kicked off strong, bringing tremendous focus and really just the enthusiasm of getting everybody truly excited about not just that product, but what we're going to be able to do in the diagnostic global marketplace with access to this new platform. Beginning very early on, as early as December, at the breast cancer meeting in San Antonio, as well as other meetings virtually with key opinion leaders in Europe, being able to tell the vision of this isn't just going to be a story of Prosigna but a story of a portfolio of oncology products.
I think also, a lot of the momentum coming into the year was driven by a lot of the posters and presentations and data on that product that emerged at the San Antonio Breast Cancer Symposium in December. I mentioned it briefly in my prepared remarks, but in particular, what we are seeing just a lot of enthusiasm around with the product is its ability to report intrinsic subtypes for breast cancer. This is really over and above reporting of information that can literally guide treatment decisions and choices beyond just a risk of recurrence score that is the predominant answer given by other products on the market. We've seen a whole emergence of thought leaders wanting to engage, continue to do studies, and really lean into some of this very exciting data coming out on intrinsic subtypes.
I think that had a lot to do with the momentum entering Q1. Would've been great to be able to continue that. At the same time, when we think about, and I think maybe Sung Ji asked this and we skipped answering it specifically, we don't know exactly product by product how this will unfold, but I think we believe our early gut feel, if you will, is that the first market that is likely to begin to reemerge is probably in the U.S., the Afirma physician office segment for thyroid nodule evaluation. These doctors aren't living under the auspices of rules of a healthcare system or an institution that has more onerous rules around how they open up. The fact is, these doctors can manage patient volume through their offices and probably do it in a fairly safe environment.
Our team has seen early re-engagement coming from that segment specifically. You might recall that about 40% of our Afirma volume comes from the physician office market for that segment. The hospital business across all of our products has all been suppressed to the levels that we've mentioned, so we don't really have an early indication there. As we think long -term, outside of some of this work and enthusiasm on Prosigna for answering other clinical questions, patients that get tested with these early breast cancer tests, ours as well as others on the market, are having the testing performed following the detection of breast cancer that usually comes from mammograms and screening.
I've made comments a few times that as we emerge from this, with 22 million people losing their jobs, a lot of people being out of work, and people losing healthcare, I don't think any of us—and this is why we kind of leaned into this slower, maybe U-shaped recurve rather than a V—believe that women are going to wake up one day and this will all be over and the first thing they're going to think about doing is going back to have their mammograms done. It just isn't the way the psychology of these kinds of things work. We actually expect that that could impact a longer recovery on, for one example, Prosigna. I think each product will have its own nuances.
At the same time, if a patient with lung cancer gets detected, you're probably going to want to get a diagnosis for that cancer, because waiting a year might kill the patient. All of these will play in different ways. We'll keep our eyes on it. We think that we have diversified the business and now have new value coming from different segments of our own business, products with different value propositions and different recovery curves, perhaps. That, along with our very strong pipeline and our ability to deliver on that pipeline through this pandemic, we believe, positions us quite strongly to emerge well.
That's great. Thank you. You actually answered a number of my questions there as well.
Great.
If I could, I'd ask one quick follow-up on states that are starting to reopen already. I know it's still very early, but any high-level commentary you could provide on if trends have started to tick back up or if we're still sitting in that kind of 50% year-over-year reduction? Thanks.
Overall, you don't see the rounding errors. John does run data at every rep level, which is every state and every territory. John will probably say there's a few of those rural areas out there where we are seeing some reemergence. Is that right?
Yeah, I think Bonnie stated it the best we can say, which is in the community endocrinology practice segment, we're seeing a slight rebound. In general, the business remains down at that 50% reduction year-over-year, and we're not prepared to change that estimate at this time.
That's right.
Great. Thank you. Appreciate it.
Thank you for joining us. You bet.
Thanks a lot.
Thank you once again, ladies and gentlemen. That's star one to ask a question. Our next question comes from Paul Knight with Janney. Your line is open.
Hi, Paul.
Hi, Bonnie. Can you hear me?
I can.
Sorry.
Thanks for joining us.
Some of us on the East Coast were dropped, and we're all back live now.
Yeah. We've heard that from a few. Sorry to hear that.
Must be the rain.
Must be.
Regarding the volumes on Afirma, I know. Put it this way, they were below the corporate average on volume growth. Could you give us a little color on lung cancer diagnostics, specifically with Percepta, what the continuing comment from docs on Percepta?
I think Percepta is being received very well. We kind of group those into our lung volume all together. As Keith pointed out earlier, we actually booked over $2 million of revenue in lung, which was about 138% growth over the prior year. We're seeing both of those products really complement each other in the sales process because it's a common call point and a common setting within the hospital where these two products are collected. We're pleased with where that business came in in the first quarter, and Afirma was pretty much right on target with where we thought that would be as well, even in light of the last couple weeks of the quarter declining.
Yeah. Collaborations are a target for you to increase your revenue and relationships in that market. Can you talk about how that's going, and is it less difficult than clinical testing in this COVID world we're in?
Well, certainly, I just want to clarify what we're doing with biopharma collaborations, because we have not turned on a new channel to the company out searching for biopharma business. We're not entering deals with someone doing a pancreatic test that they want us to do, because we're not in that line of work. What we're doing is very aligned with what we're doing in the clinical business, and I believe it gives us a tremendous amount of strategic leverage to help drive the success of the diagnostic or prognostic tests while we're building the value creation lever of the biopharma partner. Which is not only adding value through revenue and milestones, et cetera, but it's being done in a clinical indication where we are driving our clinical assays. I think that is a little bit unique in the way that we at Veracyte have pulled that off.
As I said, we don't have it in the investor deck we put up today, but in our corporate deck, we have a really nice illustration of this, where just a year or so ago, we were a company with an Afirma thyroid product, a Percepta product, and an Envisia product, all answering diagnostic questions. We've extended our thyroid product now to inform on variants and fusions across an entire array of whole transcriptome data. We call this platform Xpression Atlas. We are now extending collaborations that are bringing additional value to us in thyroid cancer on the back of Xpression Atlas. We're also seeing a lot of enthusiasm in the field as these new drugs come along and there is an attempt to find rare patients that could benefit that would not maybe respond to the typical radioactive treatments.
We did the same thing in lung cancer, where we had Percepta to aid in the improved diagnosis and improved efficiency of bronchoscopy procedures, knowing we wanted to use that same field of injury science to go early and bring an early detection tool to market in the nose. That was the perfect segue to partner with J&J and be able to leverage the relationship to bring a lot of value to bear in clinical cohorts, in helping us get these products commercialized, et cetera. All the time that we're doing that, we are strategically getting leverage to advance our pipeline, which is going to bring new products to market.
In fact, the nasal swab launching next year in the U.S. and the year after that in international markets is very strategic and purposeful. With the acquisition of NanoString, we brought on two new oncology indications that, quite frankly, we're quite enthused about. I think that going to the breast cancer conference, hearing some of this new data emerging on subtypes and how important this data might be in helping to guide treatment decisions for patients, we believe we're at a great place in breast cancer now to play that same playbook, leveraging a diagnostic with informing treatment decisions, as well with lymphoma, a product that is still in development and not even commercialized yet, we've already secured a biopharma relationship to build value in the lymphoma testing space.
I think what we have done is really build a strategy that is lifting up everything we're doing clinically and doing it with funding, if you will, from very important strategic collaborations that help both the diagnostic and the treatment decision side of the equation. We're really excited about it. I think we entered that with that being the strategy. We talked on our call about the launch of Percepta Atlas next year, which is going to be kind of a play like thyroid Xpression Atlas but here into a market where patients depend on getting this data to help inform treatment decisions. That we can potentially answer these questions right at the time of diagnosis instead of two months later after another sample has to be collected through a surgical procedure to be able to answer it. It's all coming together nicely.
It's based around deep understanding and investment in the clinical indications we go into, the broadest and deepest scientific and technological platform that exists, and a focus around making sure we're not out chasing any collaboration but that we're bringing things on board that strategically are going to give us leverage to advance the pipeline.
Thank you, Bonnie.
You bet. Thanks for being on the call, Paul.
Thank you. Ladies and gentlemen, I'm not showing any further questions at this time. This concludes today's conference call. Thank you for your participation. You may now disconnect. Everyone, have a wonderful day.