Xilio Therapeutics, Inc. (XLO)

NASDAQ: XLO · Real-Time Price · USD
8.28
-0.30 (-3.50%)
At close: May 22, 2026, 4:00 PM EDT
8.25
-0.03 (-0.36%)
After-hours: May 22, 2026, 4:10 PM EDT
Market Cap49.36M +32.4%
Revenue (ttm)53.48M +476.7%
Net Income-31.30M
EPS-5.41
Shares Out 5.98M
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume58,469
Open8.40
Previous Close8.58
Day's Range8.17 - 8.60
52-Week Range6.47 - 16.10
Beta-0.13
AnalystsStrong Buy
Price Target20.00 (+141.55%)
Earnings DateMay 12, 2026

About XLO

Xilio Therapeutics, Inc., a clinical-stage biotechnology company, engages in the discovery and development of masked immuno-oncology therapies. The company’s pipeline includes XTX501, a bispecific PD-1 / masked IL-2, for patients with metastatic non-small cell lung cancer; Efarindodekin alfa, an investigational, masked IL-12, that is in Phase 2 clinical trial for patients with advanced solid tumors; and Vilastobart, an investigational tumor-activated, Fc-enhanced, high affinity binding anti-CTLA-4 monoclonal antibody. The company was founded in... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date Oct 22, 2021
Employees 76
Stock Exchange NASDAQ
Ticker Symbol XLO
Full Company Profile

Financial Performance

In 2025, Xilio Therapeutics's revenue was $43.77 million, an increase of 589.88% compared to the previous year's $6.34 million. Losses were -$35.04 million, -39.84% less than in 2024.

Financial Statements

Analyst Summary

According to one analyst, the rating for XLO stock is "Strong Buy" and the 12-month stock price target is $20.0.

Price Target
$20.0
(141.55% upside)
Analyst Consensus: Strong Buy
Stock Forecasts

News

Xilio Therapeutics files $250M mixed securities shelf

07:50 EDT Xilio Therapeutics (XLO) files $250M mixed securities shelf

13 days ago - TheFly

Xilio Therapeutics Registration statement: Registration filing

Xilio Therapeutics filed a registration statement on May 12, 2026, providing details about a securities offering with the SEC.

13 days ago - Filings

Xilio Therapeutics Reports First Quarter 2026 Financial Results and Provides Pipeline and Business Updates

On track for planned IND submission in mid-2026 and Phase 1 initiation in the second half of 2026 for XTX501, a potential best-in-class bispecific PD-1 / masked IL-2

13 days ago - GlobeNewsWire

Xilio Therapeutics Earnings release: Q1 2026

Xilio Therapeutics released its Q1 2026 earnings on May 12, 2026, summarizing the period's financial results.

13 days ago - Filings

Xilio Therapeutics Quarterly report: Q1 2026

Xilio Therapeutics has published its Q1 2026 quarterly earnings report on May 12, 2026.

13 days ago - Filings

Xilio Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

WALTHAM, Mass., May 07, 2026 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing masked immuno-oncology therapies for people l...

18 days ago - GlobeNewsWire

Xilio Therapeutics Proxy statement: Proxy filing

Xilio Therapeutics filed a proxy statement on April 28, 2026, providing details for shareholder voting and corporate governance matters.

27 days ago - Filings

Xilio announces new preclinical data for XTX601 at AACR

Xilio Therapeutics (XLO) announced new preclinical data for XTX601, a masked T cell engager targeting claudin 18.2, at the American Association for Cancer Research Annual Meeting, taking place from Ap...

5 weeks ago - TheFly

Xilio Therapeutics Announces New Preclinical Data at AACR Annual Meeting for XTX601, a Masked T Cell Engager Targeting CLDN18.2

XTX601 demonstrated protease-dependent, tumor-selective activation and potent anti-tumor activity in multiple preclinical models

5 weeks ago - GlobeNewsWire

Xilio Therapeutics appoints Blanchard to its Board of Directors

Xilio Therapeutics (XLO) announced the appointment of Cheryl Blanchard, Ph.D. to the company’s board of directors. The company also announced that Christina Rossi has stepped down from its board of…

5 weeks ago - TheFly

Xilio Therapeutics Appoints Cheryl R. Blanchard, Ph.D.

WALTHAM, Mass., April 16, 2026 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing masked immuno-oncology therapies for people...

5 weeks ago - GlobeNewsWire

Xilio Therapeutics Announces Pipeline and Business Updates and Fourth Quarter and Full Year 2025 Financial Results

XTX501, a potential best-in-class bispecific PD-1 / masked IL-2, on track for planned IND submission in mid-2026 and Phase 1 initiation in the second half of 2026

2 months ago - GlobeNewsWire

Xilio Therapeutics Annual report: Q4 2025

Xilio Therapeutics has published its Q4 2025 annual report on March 23, 2026.

2 months ago - Filings

Xilio Therapeutics Earnings release: Q4 2025

Xilio Therapeutics released its Q4 2025 earnings on March 23, 2026, summarizing the period's financial results.

2 months ago - Filings

Xilio Therapeutics Annual report: Q4 2025

Xilio Therapeutics has published its Q4 2025 annual report on March 23, 2026.

2 months ago - Filings

Xilio Therapeutics to Present New Preclinical Data for its Masked T Cell Engager Program Targeting CLDN18.2 at the American Association for Cancer Research (AACR) Annual Meeting

WALTHAM, Mass., March 17, 2026 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing masked immuno-oncology therapies for people...

2 months ago - GlobeNewsWire

Xilio Therapeutics Inc trading halted, news pending

19:50 EDT Xilio Therapeutics (XLO) Inc trading halted, news pending

2 months ago - TheFly

Xilio Therapeutics announces 1-for-14 reverse stock split

Xilio Therapeutics (XLO) announced that it will implement a 1-for-14 reverse stock split of the issued shares of the company’s common stock, effective on March 13, 2026. Published first on…

2 months ago - TheFly

Xilio Therapeutics Announces 1-for-14 Reverse Stock Split

WALTHAM, Mass., March 12, 2026 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing masked immuno-oncology therapies for people...

2 months ago - GlobeNewsWire

Xilio Therapeutics Transcript: Leerink Global Healthcare Conference 2026

A new dual-targeted PSMA/STEAP1 cell engager with CD3 masking and CD2 co-stimulation was announced, aiming to address tumor heterogeneity and resistance in prostate cancer. INDs for this and the claudin 18.2 program are planned for 2027. The CTLA-4 and PD-1 IL-2 programs also showed promising progress.

2 months ago - Transcripts

Xilio Therapeutics to Present at the Leerink Partners Global Healthcare Conference

WALTHAM, Mass., March 02, 2026 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing masked immuno-oncology therapies for people...

3 months ago - GlobeNewsWire

Xilio Therapeutics announces inducement grants

Xilio Therapeutics (XLO) announced that, effective March 1, 2026, the company granted non-qualified stock options to purchase 50,050 shares of its common stock to two new employees under Xilio Therape...

3 months ago - TheFly

Xilio Therapeutics Announces Pricing of Underwritten Offering

WALTHAM, Mass., Feb. 11, 2026 (GLOBE NEWSWIRE) -- Xilio Therapeutics, Inc. (Nasdaq: XLO), a clinical-stage biotechnology company discovering and developing masked immuno-oncology therapies for people ...

3 months ago - GlobeNewsWire

Xilio Therapeutics Proxy statement: Proxy Filing

Xilio Therapeutics filed a proxy statement on January 26, 2026, providing details for shareholder voting and corporate governance matters.

4 months ago - Filings

Xilio Therapeutics Proxy statement: Proxy Filing

Xilio Therapeutics filed a proxy statement on January 16, 2026, providing details for shareholder voting and corporate governance matters.

4 months ago - Filings