Ionis Pharmaceuticals Ratios and Metrics

Market cap in millions MXN. Fiscal year is January - December.

Millions MXN. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Sep '25 Sep 23, 2025	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Capitalization	235,488	230,689	115,024	122,707	104,655	88,091
Market Cap Growth	139.86%	100.56%	-6.26%	17.25%	18.80%	-44.00%
Enterprise Value	234,364	227,183	104,685	118,191	90,329	73,932
Last Close Price	1150.00	1150.00	743.00	737.51	877.25	621.80
PS Ratio	13.86	13.58	7.83	9.22	9.13	5.30
PB Ratio	26.74	26.20	9.38	18.77	9.37	5.57
P/TBV Ratio	26.74	26.20	9.38	18.77	9.37	5.57
P/FCF Ratio	-	-	-	-	-	228.03
P/OCF Ratio	-	-	-	-	-	139.52
EV/Sales Ratio	14.28	13.37	7.13	8.88	7.88	4.45
EV/FCF Ratio	-40.68	-	-	-	-	191.38
Debt / Equity Ratio	5.35	5.35	3.33	5.09	2.39	1.62
Debt / FCF Ratio	-	-	-	-	-	66.39
Net Debt / Equity Ratio	-0.13	-0.13	-0.58	-0.96	-1.10	-1.14
Net Debt / EBITDA Ratio	0.18	0.18	0.74	1.09	1.60	71.44
Net Debt / FCF Ratio	0.20	0.20	0.63	1.12	2.17	-46.81
Asset Turnover	0.29	0.29	0.24	0.28	0.23	0.32
Inventory Turnover	82.58	82.58	91.49	61.67	36.18	27.98
Quick Ratio	3.51	3.51	7.74	5.44	6.49	9.13
Current Ratio	3.83	3.83	8.47	5.90	7.07	9.75
Return on Equity (ROE)	-70.80%	-70.80%	-93.10%	-76.34%	-40.12%	-3.77%
Return on Assets (ROA)	-7.31%	-7.31%	-9.91%	-8.00%	-9.96%	-0.75%
Return on Invested Capital (ROIC)	-90.05%	-114.15%	-364.50%	-	-	-
Return on Capital Employed (ROCE)	-13.90%	-13.90%	-17.60%	-13.90%	-18.50%	-1.30%
Earnings Yield	-2.92%	-2.98%	-8.22%	-5.05%	-5.03%	-0.67%
FCF Yield	-2.45%	-2.50%	-9.89%	-4.57%	-5.41%	0.44%
Buyback Yield / Dilution	-7.02%	-7.02%	-4.42%	-0.95%	-0.59%	-1.01%

Source: S&P Global Market Intelligence. Standard template. Financial Sources.