Chemomab Therapeutics Earnings Call Transcripts
Fiscal Year 2026
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Nebokitug, a first-in-class antibody targeting CCL24, has shown strong anti-inflammatory and anti-fibrotic effects in PSC, with phase II data supporting an upcoming phase III trial focused on moderate to advanced disease. The company is seeking partners and has funding secured through 2026.
Fiscal Year 2025
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Positive phase II results for nebokitug in PSC showed strong anti-inflammatory and anti-fibrotic effects, with FDA alignment for a single pivotal phase III study. The drug is positioned as a potential first-in-class, disease-modifying therapy with significant commercial potential.
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CM-101 (Nebokitug) achieved clinical proof of concept in PSC, with significant efficacy and safety in Phase II, and is advancing to a global Phase III trial. Two major milestones—FDA feedback and open-label extension data—are expected in Q1 2025, with strong investor and partner interest.
Fiscal Year 2024
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The phase II SPRING trial of CM-101 in PSC met its primary safety endpoint and showed significant improvements in liver stiffness, ELF score, pruritus, and other key biomarkers, especially in patients with moderate to advanced disease. Plans are underway for a phase III trial and further strategic development.