Damora Therapeutics Earnings Call Transcripts
Fiscal Year 2026
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Damora, formerly Galecto, is refocusing on mutant CALR therapies for ET and MF, with a lead antibody asset entering clinical trials this year and a strong financial position. Their differentiated approach targets both Type 1 and Type 2 mutations, aiming for best-in-class efficacy and convenience.
Fiscal Year 2025
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The acquisition brings a robust pipeline of anti-mutant calreticulin therapies for myeloproliferative neoplasms, supported by $285 million in financing. Integration of complementary assets and leadership aims to accelerate clinical development, targeting a $5 billion-plus market opportunity.
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A novel dual ENL-YEATS and FLT3 inhibitor, BRM-1420, shows strong preclinical efficacy and safety in AML models, targeting high-risk genetic subsets and menin inhibitor resistance. Clinical trials are planned for 2026, with initial focus on relapsed/refractory AML and future combination strategies prioritized.