Good day, ladies and gentlemen, and welcome to the First Quarter 2019 LabCorp Holdings Earnings Conference Call. At this time, all participants are in a listen only mode. Later, we will conduct a question and answer session and instructions will follow at that time. As a reminder, this call is being recorded. I would now like to introduce your host for today's conference, Clarissa Willett, Vice President of Investor Relations.
Please go ahead.
Good morning, and welcome to LabCorp's Q1 2019 conference call. As detailed in today's press release, there will be a replay of this conference call available via telephone and Internet. With me today are Dave King, Chairman and Chief Executive Officer Glenn Eisenberg, Executive Vice President and Chief Financial Officer and John Ratliff, CEO of Covance Drug Development. This morning, in the Investor Relations section of our website at www.labcorp.com, we posted both our press release and an Investor Relations presentation with additional information on our business and operations, which include a reconciliation of the non GAAP financial measures to the GAAP financial measures discussed during today's call. Historically, in connection with our earnings call, we have also furnished our Investor Relations slide deck on Form 8 ks.
Going forward, it is our expectation that we will only be posting these presentations on our website and not furnishing them on Form 8 ks. We encourage investors to monitor and regularly check the Investor Relations portion of our website for business and financial information about the company. Finally, we are making forward looking statements during today's call. These forward looking statements include, but are not limited to, statements with respect to estimated 2019 guidance and the related assumptions, the impact of various factors on operating and financial results, expected savings and synergies and the opportunity for future growth. Each of the forward looking statements is based upon current expectations and is subject to change based upon various factors that could affect our financial results.
Some of these factors are set forth in detail in our 2018 Form 10 ks and subsequent Forms 10 Q and in the company's other filings with the SEC. We have no obligation to provide any updates to these forward looking statements even if our expectations change. Now, I'll turn the call over to Dave King.
Thank you, Clarissa, and good morning. I'll begin by discussing financial highlights of the Q1. We are off to a very strong start in 2019 with 1st quarter revenue of $2,800,000,000 and adjusted EPS of $2.62 Our results were driven by strong underlying performance and organic revenue growth across both businesses and were the result of solid execution of our 3 foundational strategies: delivering world class diagnostics, bringing new medicines to patients faster and using technology to change the way care is delivered. Our diagnostics business grew organically during the quarter in both revenue and volume despite additional price reductions due to PAMA and the loss of exclusivity in 2 of our largest managed care contracts. Organic volume was broad based and increased by 80 basis points with some benefit from Aetna growth and weather, partially offset by the negative impact of the loss of exclusivity in the United and Horizon contracts and a one fewer revenue day than last year.
As a reminder, we do not count requisitions from our hospital lab management agreements in our volume due to a lack of similarity to our core business in terms of testing frequency. Had we included lab management requisitions in our volume calculation, organic volume growth would have been approximately 2.8%. I am very proud of the outstanding effort of every colleague in our diagnostics business from sales reps to couriers to phlebotomists to lab techs that enabled us to grow volume organically given the impact of the managed care changes. Covance continued to grow strongly. Excluding the negative impact of reduced pass throughs, the business grew organically consistent with our guidance of 5% to 9% full year revenue growth.
We are also pleased with the impressive 280 basis points of margin expansion. Consistent with our guidance, we deployed $100,000,000 of capital to share repurchase, executed several tuck in acquisitions and finalized the highly strategic Envigo transaction. We are pleased with our Q1 performance, which exceeded our internal expectations and are accordingly increasing our full year EPS guidance range to $11.05 to $11.45 Now I'll review the quarter's performance highlights. I'll start with enterprise wide activities that demonstrate the power of our combined scale, breadth of services, integration of capabilities and data and patient centricity. LabCorp was awarded a virtual trial by a top 20 pharma client focused on a long term follow-up safety study for an oncology gene therapy drug.
This trial will utilize diagnostics patient service centers, the Covance market access call center, Covance project management, study design and electronic data capture to reduce the patient burden. This is another example of pharma sponsors growing interest in innovative solutions that make trials faster, cheaper and more patient friendly. We continue to advance our leadership position in companion diagnostics and precision medicine. We bring up companion diagnostics through our dedicated companion diagnostics laboratory, validate their clinical utility in Covance trials and commercialize them through the diagnostic sales force. Revenue from all aspects of companion diagnostics grew more than 30% across the enterprise in the Q1 versus last year.
In January, we announced an agreement with Genfit that makes an innovative NASH liver diagnostic test available to the clinical research market. Covance is a recognized leader in NASH clinical trials and is currently supporting the Phase III NASH trial for Genfit. Diagnostics and Covance have been involved in the commercialization of NASH testing options for more than 10 years, seeking to move from invasive liver biopsies to blood based testing. Genfit cited LabCorp's enterprise wide expertise in this important therapeutic area as an important value add in selecting us for this partnership. In short, our enterprise wide offering uses our combined capabilities to deliver industry leading solutions focused on innovation, quality, efficiency and service.
In Diagnostics, January marked the official opening of the United, Horizon and Aetna exclusives, putting us in network with all major national plants. Although we saw expected volume decline in January, we are pleased with our performance and our ability to generate organic volume growth despite losing exclusivity with 2 major plants. As we projected, United and Horizon volumes declined in January, partially offset by Aetna gains, but were stable throughout the rest of the quarter. We're also pleased that LabCorp and all of its specialty branded laboratories were selected to be UnitedHealthcare preferred laboratory network providers. LabCorp selection reflects a long and deep partnership with United that has delivered industry changing innovations and value in laboratory services, while delivering outstanding quality, access and convenience to patients and providers.
We look forward to working closely with United to fully deliver on the promise of the preferred laboratory network. So the financial fundamentals of our Diagnostics business remain strong and patients and providers increasingly see benefits to choosing LabCorp. We continue our strategy of meeting patients where they want to be served. Our LabCorp Walgreens partnership is on track to have at least 125 sites by the end of this year, including locations in several new states and major metropolitan markets. We are also on track to achieve our target of at least 600 locations by 2022.
We continue to discuss a broader collaboration with Walgreens on patient engagement, health and wellness offerings and the creation of a next generation CRO. During the Q2, we will add consumer initiated phlebotomy based testing to Pixel by LabCorp. This new offering will expand the number of testing options available to consumers and will enable access and convenience and will enhance access and convenience by giving them the option to use an at home kit for sample collection or visit 1 of LabCorp patient service centers or LabCorp at Walgreens locations in states where Pixel by LabCorp is available. We also continue investing in tools and technology focused on consumer convenience to create an improved experience with LabCorp. Our new mobile optimized LabCorp PreCheck combined with the convenience of LabCorp Express in our PSCs has been well received by patients with 88% positive responses to point of service surveys overall and 94% positive when checking in with a reservation.
LabCorp Express is also standard in all LabCorp Walgreens locations. During the quarter, we further enhanced our value to our customers by acquiring NNG Diagnostics, a recognized leader in next generation sequencing and complex testing for neurology. We also expanded our collaboration with an investment in OmniSeq, which positions us for a major push into growing the combined assets of Covance and Diagnostics in the increasingly important oncology therapeutic area. Finally, we made significant progress in the quarter on our LaunchPad Phase II initiatives. We are on track to deliver a total of $200,000,000 of net savings by the end 2021 through initiatives focused on data analytics, digitizing the enterprise, process automation and improving overall productivity of the diagnostics operating model.
Covance's operating performance continues to validate acquisition. Investments in leadership, end to end capabilities, therapeutic expertise and global infrastructure have translated into $10,000,000,000 of backlog, a 1.24 book to bill over the last 12 months and mid to high single digit organic revenue growth, excluding pass throughs, plus margin expansion of 2 80 basis points. Our data capabilities, a critical asset for patient recruitment and site selection strategies, are much copied but nowhere near equal. We are the industry leader in companion diagnostics and are now seeing tremendous growth in other solutions, such as cell and gene therapy, immunology, immunotoxicology and genomic testing. During the quarter, we continued to enhance Covance's offerings through strategic acquisitions.
We acquired Mi Bio Research, which brings specialized preclinical capabilities in cell and gene therapy and oncology testing. This acquisition adds depth in an exciting and rapidly growing area of drug discovery today and creates the opportunity for more work to move from preclinical to clinical development. We also agreed to acquire Regulatory and Clinical Research Institute or RCRI, a device focused CRO with strong regulatory consulting expertise. In April, we announced an innovative business swap transaction with Envigo. The transaction provides Covance with enhanced global non clinical research capabilities while maintaining access to Envigo's research models and services through a multiyear renewable supply agreement.
This unique collaborative approach to early stage research demonstrates our commitment to providing clients with innovative end to end solutions. All of these acquisitions demonstrate how we are investing in Covance to enhance its capabilities and grow its market opportunities. We were recently awarded a Phase 3 cardiovascular study building on the work we did on the Phase 2 study supporting the same molecule. We are also awarded a molecule development program to provide strategic consulting to design the customer's clinical development program, oversee the development process and conduct the clinical trial once designed. This win in particular is an example of the growing demand for Covance's biotech solutions, which take advantage of our comprehensive capabilities and the design around you approach adopted as part of selecting the best of the best in the Chiltern integration.
Our medical device and diagnostics drive group recently earned its largest ever medical device study win due largely to our end to end device business. Our device CRO now includes the Chiltern device capabilities, preclinical med device innovation, a preclinical device CRO we acquired last year, our CRI and our legacy Covance Therapeutic expertise. It is a powerful combination for customers who have long been asking us for device trial capability. We continue to execute on key priorities in our Covance LaunchPad initiative and are on track to deliver $150,000,000 of net savings by the end of 2020. We are also on track to realize $30,000,000 in cost synergies from the integration of Chiltern by the end of 2019.
Our global service delivery model increasingly enables us to be more competitive in winning and delivering studies. Our Chiltern and Cyformix acquisitions added to our global footprint and brought Covance enhanced robotic process automation and artificial intelligence capabilities. The GSDM improved the efficiency of our operations, reducing costs and enhancing quality and speed for clients. In closing, these are challenging times for the laboratory industry, but our global life sciences capabilities give us tools we need to succeed despite the headwinds. As these remarks demonstrate, we possess unique and differentiated capabilities that our competitors cannot replicate.
In October, we will celebrate our 50th anniversary as a company, an amazing milestone and a great tribute to the visionary leaders who came before us. We are mindful that their inspired leadership and our relentless dedication to exceptional quality, service, value and innovation have been foundational to our success over these 5 decades. With those ideals and the daily commitment of our now 61,000 dedicated colleagues around the globe, we are well positioned to succeed in the next 50 years as well. Now I'll turn the call over to Glenn.
Thank you, Dave. My comments today will focus on the company's Q1 results as well as provide an update on our 2019 guidance. I'll conclude with additional commentary on our recently announced transaction with Envigo. Revenue for the quarter was $2,800,000,000 a decrease of 2% compared to last year. This decline was due to the impact from divestitures of 1.8% and unfavorable foreign currency translation of 0.9%.
Acquisitions added 0.5% of growth, while the organic revenue grew at 0.2%. Excluding the negative impact from PAMA of 90 basis points, organic revenue grew 1.1%. Operating income for the quarter was $318,000,000 or 11.4 percent of revenue compared to $305,000,000 or 10.7% last year. During the quarter, we had $36,000,000 of restructuring charges and special items, primarily related to LaunchPad initiatives and acquisition integration. Adjusted operating income, which excludes amortization of $57,000,000 as well as restructuring charges and special items, was $411,000,000 or 14.7 percent of revenue compared to $436,000,000 or 15.3 percent last year.
The decline in adjusted operating income and margin was primarily due to lower pricing as a result of PAMA and higher personnel costs, partially offset by demand and LaunchPad savings. The tax rate for the quarter was 27% compared to 28.6% last year. The adjusted tax rate excluding special charges and amortization was 26.3% compared to 22.9% last year. The higher adjusted tax rate was primarily due to the tax impact from stock based compensation. We continue to expect the company's adjusted tax rate for the full year to be between 25% 26%.
Net earnings for the quarter were $186,000,000 or $1.86 per diluted share. Adjusted EPS, which exclude amortization, restructuring charges and other special items, were $2.62 in the quarter, down 6% compared to last year. Operating cash flow was $166,000,000 in the quarter compared to $180,000,000 a year ago. The decrease in operating cash flow was primarily due to lower cash earnings, partially offset by favorable working capital. Capital expenditures totaled $94,000,000 or 3.4 percent of revenue compared to $73,000,000 or 2.5 percent last year.
The increase in capital expenditures was primarily due to investments in facility expansion, technology and automation to support increased demand and optimize margins. As a result, free cash flow was $72,000,000 in the quarter compared to $107,000,000 a year ago. We remained active throughout the quarter in terms of capital allocation. During the quarter, we invested $47,000,000 in acquisitions and repurchased $100,000,000 of stock. As of March 31, we had $1,250,000,000 of authorization remaining under our share repurchase program.
At quarter end, our cash balance was $349,000,000 down from $427,000,000 at the end of 2018. Total debt at quarter end was $6,000,000,000 and our leverage was 3x gross debt to last 12 months EBITDA. Now review our segment performance beginning with LabCorp Diagnostics. Revenue for the quarter was $1,700,000,000 a decrease of 2.7% compared to last year. The decline was due to divestitures of 2.9% and foreign currency translation of approximately 30 basis points.
Acquisitions added 0.1%, while organic revenue grew 0.4%. Excluding the negative impact from PAMA of 150 basis points, organic revenue increased by 1.9%. Organic volume increased 0.8% over last year and was constrained by managed care contract changes, which negatively impacted volume by approximately 70 basis points. Additionally, volume includes the unfavorable impact of 1 less revenue day of 1%, partially offset by favorable weather of 0.8%. Revenue per requisition excluding the impact from divestitures decreased by 0.4%.
Revenue per acquisition was negatively impacted by 150 basis points due to PAMA. Excluding divestitures in PAMA, revenue per acquisition 18% of revenue compared to $364,000,000 or 20.6 percent last year. The decline in adjusted operating income and margin primarily due to the negative impact from PAMA of approximately $27,000,000 divestitures, personnel costs and cybersecurity expenses, partially offset by LaunchPad savings. In addition, the negative impact of 1 less revenue day in the quarter, along with not having the one time benefit of the legal settlement realized last year, was partially offset by favorable weather and one less payroll day this quarter. While margins year over year are expected to decline throughout the year, primarily due to PAMA, they are expected to decline less each quarter as we benefit from increasing LaunchPad savings throughout the year.
We remain on track to deliver $200,000,000 of net savings from the 3 year LaunchPad initiative by the end of 2021. Now I'll review the performance of Covance Drug Development. Revenue for the quarter was $1,100,000,000 a decrease of 0.4% compared to last year due to the impact of unfavorable currency
translation of
2 of unfavorable currency translation of 2 10 basis points. On a constant currency basis, revenue increased by 1.7% as acquisitions added 1.2% and organic growth contributed 0.5%. As we noted on our Q4 earnings call, we expected Covance's 1st quarter revenue growth rate to be below our full year guidance range, primarily due to timing and the negative impact of foreign currency translation. Pass throughs, which were down in the quarter, negatively impacted organic volume growth. A variety of factors influence pass throughs, including study life cycle, client preferences, geographic mix and business mix.
And excluding pass throughs, organic revenue growth in the quarter was in line with the company's full year guidance range of 5% to 9%. Adjusted operating income for the segment was $138,000,000 or 12.8 percent of revenue compared to $108,000,000 or 10% last year. The $30,000,000 increase in adjusted operating income and 280 basis point improvement in margins was primarily due to organic demand, LaunchPad savings, acquisitions and currency translation, partially offset by higher personnel costs. While currency translation negatively impacted revenue, earnings and margin benefited slightly during the quarter given the origin of our cost structure relative to our revenue. We remain on track to deliver $150,000,000 of net savings from Covance's 3 year LaunchPad initiative by the end of 2020.
For the trailing 12 months, net order and net book to bill remained strong at $5,300,000,000 $1,240,000 respectively. Backlog at the end of the quarter was $9,900,000,000 an increase of approximately $185,000,000 from last quarter. We expect approximately $3,900,000,000 of this backlog to convert into revenue over the next 12 months. Now I'll discuss our 2019 guidance, which assumes foreign exchange rates as of March 31, 2019 for the remainder of the year and includes the impact from capital allocation with free cash flow being used for share repurchases and acquisitions. We expect revenue growth of 0.5% to 2.5% over 2018 revenue of $11,300,000,000 unchanged from our prior guidance.
This guidance includes the negative impact from 2018 divestitures of 1.2% and the negative impact from currency translation of 50 basis points. We expect LabCorp Diagnostics revenue to be down 2% to 4% as compared to 2018 revenue of $7,000,000,000 unchanged from our prior guidance. This guidance includes the negative impact from 20 18 divestitures of approximately 2% and the negative impact from currency translation of 20 basis points. We expect Covance Drug Development revenue growth of 5% to 9% over 2018 revenue of $4,300,000,000 unchanged from our prior guidance. This guidance includes the negative impact of currency translation of approximately 90 basis points, which is 30 basis points unfavorable compared to our prior guidance.
Organic revenue growth excluding pass throughs is also expected to be up 5% to 9% over 2018. Our adjusted EPS guidance is $11.05 to $11.45 an increase of 0% to 4% compared to $11.02 in 2018. This is an increase over our prior guidance of $11 to $11.40 Our free cash flow guidance is $950,000,000 to $1,050,000,000 compared to $926,000,000 last year, unchanged from our prior guidance. Now I'll provide some additional commentary on our recently announced transaction with Envigo. As Dave noted, the Envigo transaction is both strategically and financially attractive.
In this transaction, we will purchase Envigo's non clinical contract research service business, while selling them our research models and service business. The transaction's net purchase price of $485,000,000 is comprised of LabCorp paying $595,000,000 in cash and receiving $110,000,000 in the form of 3 year note. The Envigo transaction meets our stated financial criteria as we expect it to be accretive to earnings and cash flow in year 1 and to exceed our cost of capital by year 3. The company expects to deliver over $10,000,000 of net cost synergies during the 1st 2 years. The transaction, which is expected to close midyear, will be financed through cash on hand and bank debt.
This concludes our formal remarks and we will now take questions. Operator?
Thank you. Our first question comes from the line of Lisa Gill with JPMorgan. Your line is now open.
Good morning. Thank you. Glenn, can we just start with Envigo? Is there anything included if you expect it to close mid year, is there anything included in the updated guidance for the
transaction? Yes, Lisa. We have in the obviously the enterprise, but obviously also in Covance's guidance range of total revenue growth of 5% to 9% includes what we expect to be roughly half a year's worth of the Envigo revenues. And similarly, in the earnings EPS guidance range, if you will, the benefits of the accretion is there. As you know, as we've talked about earlier when we first established our guidance that we expected to use the $1,000,000,000 at the midpoint of our expected free cash flow guidance to be used for a combination of share repurchases and acquisitions with no debt looking to be paid down under that scenario.
So we had factored in M and A. Obviously, in the case of Envigo, we had been working on it well in advance of providing our guidance for the full year when we gave it initially. So the benefit of that was reflected as is our other capital allocation, which included repurchases and tuck ins that we did in the Q1 as well as still an additional, call it, $350,000,000 plus of additional capital allocation still to be realized through the remainder of the year.
Great. And then just as a follow-up, Dave, I didn't hear you talk a lot about PAMA being a big driver to drive consolidation and your closest competitor talked about that on the earnings call last week. Are you seeing that where we're starting to see that play out here in 2019? And as we think about allocating capital, how do you think about potential acquisitions now that PAMA is really being felt by those hospital outreach and other smaller labs?
Yes. Obviously, the impact of PAMA is significant, and it's more significant on smaller lab providers than on us. But and there is a very robust pipeline, Lisa, of potential acquisitions that we continue to look at. We evaluate every acquisition based on strategic fit and our stated financial criteria. And so as you saw in the quarter, we mentioned MNG, we mentioned RCRI, we mentioned the investment in OmniSeq, We mentioned Envigo.
So we allocate capital where the best strategic fit is and where we see the best opportunity to meet our stated financial criteria. The only other comment I would make on PAMA, which I think is important to underline is PAMA is regardless of how you feel about consolidation, PAMA overall is not a good thing for the lab industry or for patients. We know that the largest nursing home lab provider filed for bankruptcy. That's now going to be an unserved population. And the impact on smaller labs and even on us in terms of continued cuts, access points and services, is not going to be a positive for Medicare beneficiaries.
So even as we talk about the potential positives, we also have to remember there are significant negatives to PAMA beyond just reductions in our price.
I appreciate that. Thank you.
Thank you. Our next question comes from the line of Kevin Caliendo with UBS. Your line is now open.
Great. Thank you very much and thanks for the call. On Envigo, just kind of to get some details around sort of the cross sell opportunities there and also any overlap that might exist with existing customers. And if you can also maybe talk a little bit about Envigo's historical growth or expected growth profile and also their margin profile, especially compared to Covance's?
Sure. This is John and I'll take that. The overlap is minimal in terms of the customer side. They're much more concentrated on the biotech and even though my early development area has great percentage of that as well. If you look at customer side, not a lot of overlap.
We actually look at that as a positive in the sense that they have a level of capacity and we're tight on capacity. So we look at more of the revenue upside. I know you mentioned cross sell, but at the same time, there's cross selling opportunities. There's also capacity upticks. Their margin is higher than the Covance margin and higher than the early development because of the way that we did the deal, we did not take on any of the corporate overhead And so profitability wise, it will be a profitable area for the early development and Glenn gave you in terms of the revenues for the full year.
So obviously, gives you a feel for the guidance for a half year.
Got it. Got it. Great. And just one question, just thinking about the organic growth numbers that you provided on the diagnostic side, if I'm backing into it correctly, it looks like about 1.5%. I was a little bit surprised that the headwinds from the managed care contracts is only around 70 basis points.
If we back into that number, it's smaller than what we had anticipated. Is that how should we think about it between United and Aetna? I guess if we I guess my main point here is if we look at sort of what Quest talked about and sort of what you talked about in terms of these managed care contracts, it would imply that there's some share that's being taken from not from each other, but from other smaller existing in network labs. Is that a fair assessment?
Yes. I don't know what Quest talked about. I don't know what we talk about. I agree with you. I think Glenn gave you the number was a net impact of 70 basis points.
We were very pleased with the retention of the United business and our team, as I mentioned in my prepared remarks, did absolutely outstanding job in getting in front of our customers and continuing to demonstrate the value that LabCorp brings to retain that business. We are very pleased with the retention of the Horizon business and our team particularly in the Northeast division again an outstanding job from top to bottom, everybody in that division in retaining the business. And the ethnic growth was strong and actually has continued to increase throughout the quarter. So it's hard for me to hypothesize about where the volumes are coming from. But I would say, we are very pleased with where we are and particularly with the fact that we exited the quarter with the situation stable and with the overall broad based organic growth in areas like women's health, infectious disease, genetics, oncology.
So from our perspective, just a very strong quarter in terms of demand, which we're pleased about. Great. Thanks so much.
Thank you. Our next question comes from the line of Jack Meehan with Barclays. Your line is now open.
Thanks. Good morning. Dave, you mentioned the promise of the preferred lab network. I'm curious, what do you think happens on July 1st versus January 1st? And how strong do you think some of the economic incentives are going to be for physicians and patients to choose a preferred lab?
Well, the preferred lab network is initiating obviously in the middle of a year. And so the likelihood that there'll be any significant impact in year, I think, is minimal. And we haven't built anything into volumes or guidance that would anticipate a significant impact there. I think as we go through the managed Care selling cycle this summer and fall and as we see the implementation on January 1, Jack, A lot of it's going to depend on how the preferred lab network is tied into benefit design. What are the out of network benefits?
What are the benefits for employers of pushing their employees to the preferred lab network. But if benefit design and the preferred lab network are well tied together, in the long term, it's a significant opportunity for us.
Great. And then on the Covance side, just to nitpick a little bit, the bookings were a little lighter than what we were looking for. Can you talk about the health of the funding environment? Was there anything that maybe got pushed out a little bit? And anything notable on the cancellation front?
This is John, Jack. And so the health of the funding environment is still strong. Approvals up, biotech environment still strong, no measurable difference in the cancellations. And if you look, I know we ticked down a bit in terms of the 1.26 to the 1.24. I tend to look at things 80% half full.
We do lose a strong compare last year when you're looking at the last 12 months. In terms of certain bookings did rotate out of the quarter in terms of into the second, but that's kind of a normal phenomenon. We look to win more and bookings still very healthy environment and healthy across all of our areas, early development, our labs and in the clinical. So still positive about the environment.
Great. Thanks, John.
Thank you. Our next question comes from the line of Ross Muken with Evercore ISI. Your line is now open.
Good morning, guys. So just getting back to the Covance business, obviously, both in 4Q and this quarter, you had great margin progression, Seems like LaunchPad sort of really building its momentum. I guess, as you think about sort of in this quarter, obviously, a little hard to tease out some of the benefit that probably came from the lower pass through, but the underlying still feels very good. Where are we in sort of that progress in terms of ramping LaunchPad? And then as you think about layering on the infrastructure of Envigo, where historically these type of transactions in early phase have led to pretty good synergy capture, at least being able to leverage the new facility.
How are you thinking about that? Is kind of outside just a mix kind of margin enhancement and how it fits into kind of the LaunchPad plan?
Yes. I think in terms of the LaunchPad, we had an objective of $150,000,000 over the 3 years. We're well on our way into that. We don't break that out by year, but obviously our margins are up. I know in terms of you mentioned on the lower pass throughs, I invite you to do the math, even if you had $30,000,000 more in revenue, you'd still be up 2.50 basis points.
If you had $60,000,000 more in revenue, you'd be up 2.20. But bottom line is that margins are up. We expect margins to be up for the full year. Envigo will weight us up in terms of the profitability. And then finally, long term, we're looking to be at peer level margins.
Helpful. And then just on the lab side, probably for the better, but there really wasn't any comment on sort of DTC Genomics or at least anything of consequence. I guess any updated thoughts there? Obviously, that market has been pretty volatile and we've seen a bit of instability there. But obviously, you had forecasted for a decline just in terms of how that fits into sort of where your full year expectation is?
Yes, Ross, it's Dave. There was a slight benefit in the quarter from the direct consumer genomics business. We continue to forecast for the full year, it will be flat to slightly down. And so we don't anticipate that it will be a
Thank you. Our next question comes from the line of Dan Leonard with Deutsche Bank. Your line is now open.
Thank you. Just a couple of clarifications. First off on Covance, Glenn, you mentioned that the total revenue guide is 5% to 9%, the organic revenue guide is 5% to 9%, which would suggest M and A is about 100 bps. I would have thought Envigo would be a little bit more than that by itself and you did some other deals as well. So can you help bridge that for me?
Sure. Dan, you're right. If you just took the expected or half a year's worth of the, call it, 2018 pro form a in V Go that gets you around $80,000,000 of revenues rounded, which would be around 1.9% growth. So the issue that you're having is we're providing a range. So we're going to be benefiting from the M and A that we have done in Covance including Envigo.
We're going to benefit in the underlying organic growth of our business and then the headwind, if you will, you have currency as well as some of the pass through that occurred in the Q1, but still strong underlying organic growth in the business added by acquisitions and then the headwinds that we talked about.
Okay. Thank you. And then my follow-up, I'm trying to bridge to the $0.05 increase in EPS guide after you beat by $0.09 Did you pull anything back out of future periods in terms of pacing of share repurchase or anything like that?
No, I think it's Dan that as Dave commented in his remarks, we performed well across both businesses. We did better frankly on the managed care side than expected in the original guidance at least that we had. So the reflection of the improvement in our earnings guidance range is really a reflection of that we did well in the Q1 and that our outlook for the
remainder of
the year remains unchanged.
Okay. Thank
you. Thank you. Our next question comes from the line of Erin Wright with Credit Suisse. Your line is now open.
Great. On the Covance side, what was the quarterly book to bill trend on an ASC 606 basis? And how would you to RFP flow and demand trends across both large and small biopharma and just the broader nature of new business wins in the quarter? Thanks.
The RFP flow was good in all the segments. And in terms of kind of nice record levels in terms of early development, but upticks in clinical, nice strong on RFP flow on the lab side. We're not publishing the quarterly, but if you look 1.26 on the last 12 months, 1.24 in terms of this quarter, you can see that that's in line and that strength was across the different business segments.
Okay, great. And then on the lab side, how should we be thinking about the quarterly progression of the underlying organic volume trends here, particularly as it relates to United and the roll off and the 70 basis point impact that you were speaking to as well. Is this a more it seems to be a more measured rate than your initial internal expectations, if that's correct? And then also, is it should we be assuming here that the United Preferred Lab Network and pricing thereon was all contemplated in your previous guidance? Thanks.
Aaron, it's Dave. There was no price adjustment in terms of the United Preferred Lab Network. So the price that we have with United and had negotiated as part of the contract renewal remained the same. There's no further price adjustment. In terms of the progression of organic volume, I don't expect there to be any significant change in that progression.
I think that as we said, we came out of the quarter in terms of United and Horizon stable. We actually started again to see some growth at the end of the quarter in Aetna. And so I think what you've seen in the Q1 is probably pretty representative of what you'll see during the year.
Okay, great. Thank you.
Thank you. Our next question comes from the line of Ricky Goldwasser with Morgan Stanley. Your line is now open.
Yes. Hi, good morning. So Dave, just going back to the trends on the lab side in the quarter, I know that in the past you said that you expect most of the managed care share movement to happen earlier in the year. Your comments on the call suggest that this has happened that the retention or the share shifts that you're seeing are even more muted than you expected. On the other hand, your competitor said last week on the call that they anticipate the share move to pick up in the second half.
So what gives you kind of like confidence? What are you seeing in the marketplace that would suggest that we've seen kind of like the most of it or that the changes aren't going to be normalized versus accelerating later in the year?
Yes. Good morning, Ricky. As I said, I don't know what our competitor says. I just know what the numbers tell me. And what the numbers tell me is we monitor the United, Horizon and Aetna sessions every single day all across the country, and we see the progression based on where we were last year on a normalized basis to account for seasonality and holidays.
What we saw exactly as we projected was that the major drop off in the contracts that we're opening came in January in early January. And by the time we came out of January through February March, we were at a very stable run rate. In terms of Aetna, we probably started a little more slowly than I would have liked, but that volume progressed over the quarter, and we saw a nice increasing trend throughout. So I'm just looking at numbers and trends, and that's what gives me confidence for where we are and where I think we'll be for the balance of the year.
Okay. And then just a follow-up question on the relationship with Walgreens. I think you said that you can be at 125 sites by the end of the year. As you open these sites, are you in conjunction going to close standalone LabCorp drawing centers? And if that's the case, should we think about it as part of the LaunchPad savings?
Or is this kind of like a separate cost saving opportunity that we should think about for later in the year but also through 2022?
Yes. So we don't think about closing Patient Service Centers as part of opening the Walgreens locations. Again, we look at our patient service center network based on demand, so how many people are showing up based on wait times, based on staffing. And I would say that there may be some patient service centers that close in some areas based on part of our Walgreens strategy is looking at an isolated geographic area and seeing do we do better when we move volume from stand alone PSCs into Walgreens. But as a general proposition, think about this as 125 more access points rather than swapping them out.
In terms of cost savings, even if we close all the even if we close 125 stand alones and move them to Walgreens, there's no cost savings there. It's basically just a cost swap. So you shouldn't consider cost savings to be part of the equation on either side.
Understood. Thank you. Thank you. Our next question comes from the line of Stephen Baxter with Wolfe Research. Your line is now open.
Hi, thanks for the question. I was hoping to get a little more detail on the Envigo transaction. Can you help us understand how the multiple compares to what you paid for Chiltern? We estimated it was pretty comparable. And then maybe quantify the accretion expectations and what type of financing assumptions embedded in the commentary.
The split between cash and debt would be helpful. And we're estimating that the multiple is similar
to Chiltern, would have probably added at least $0.05 to the guidance. So trying to
square all the moving parts in the Covance side. Thanks.
Yes, Stephen, this is Glenn. Let me take the first cut. Couple of things. 1, the market multiple is comparable to deals in the drug development space. Obviously, we provided revenues and we provided obviously the net purchase price on the combined transaction.
But John also noted that the business has very strong margins stronger than or higher than what we have in our early total segment basis. So from a even an earnings multiple standpoint, you would see that it came up very much in line. The accretion, we would agree as well. We talked about that this deal meets our financial criteria. So it will be accretive to our earnings this year.
It is reflected in the guidance as is all the $1,000,000,000 that we said that we would deploy our free cash flow at the midpoint. We expect all of that $1,000,000,000 to be accretive. So that was obviously already into the guidance that we had already. And the financing of it, I think, was the last part of your question was at this stage, we'll use cash on hand and bank debt as we generate obviously the bulk of our free cash flow later in the year. So obviously we'll have the cash that would enable us to pay down any of the debt that we would use to finance the transaction.
In total, the net transaction is $45,000,000 $595,000,000 though will be cash. So 5 $95,000,000 arguably of the free cash flow in addition to call it $150,000,000 ish that we did in the Q1 still leaves some additional free cash flow for the rest of the year for continued capital deployment.
Great. Thank you.
Thank you. Our next question comes from the line of Patrick Donnelly with Goldman Sachs. Your line is now open.
Great, thanks. Dave, maybe one for you just on the hospital referral trends. Obviously, a little bit of noise there late last year. It seemed transitory in nature, but can you just give us an update how 1Q trended on that front and the visibility going forward?
Yes, Patrick. I agree with you. I think it was a transitory event that we saw in kind of October, November last year. We actually saw a pickup in December and continued stability throughout the quarter.
Okay, great. And then maybe just an update on the commercial pricing environment outside of PAMA and the commercial contract shifts. It seems stable just by looking at the margins, but can you just update us on some of the conversations you've had recently on the commercial side outside of those external factors?
Sure. Obviously, the big commercial deals are essentially completed. And I would say, yes, the pricing environment on commercial contracts is generally stable. Again, as we remind our commercial partners, demands for reduced pricing are a double edged sword because although there are price reductions for them, then that's going to roll through into the next data collection for PAMA, which obviously we're in the process of trying to delay, but it's going to roll through into the next data collection. And in the long run, as I mentioned before, more price cuts across the board lead to reduced access for patients and Medicare beneficiaries.
So I think we're I think the price the commercial pricing environment is stable and we're very comfortable with where we're coming out in the contract discussions.
Great. Appreciate it.
Thank you. Our next question comes from the line of Bill Quirk with Piper Jaffray. Your line is now open.
Great. Thanks. Good morning, everyone. First off, I guess Dave or John, would you mind elaborating on Dave, you had some comments about a potential next gen CRO that you mentioned with your Walgreens comments, just some additional details, timing, things like
Sure, Bill. This is obviously a topic that we're discussing with Walgreens. I don't want to spend a lot of time on it, because it's in the genesis. But the idea is the ability of our 2 companies to combine prescription data, laboratory data, global data, global site locations, particularly their significant overseas network, all to facilitate the things that we've talked about in terms of improving trial performance, which is speed, quality and reduced cost. So conceptually, this is something that we think that there's substantial opportunity on given our combined global size and scale, but it's early stages in terms of the discussions.
Understood. And then just as a follow-up, your comments about the recent build out of medical device capabilities at Covance, what else do you need at this point to look at capturing some additional share within that segment of the CRO space? Thanks.
We think we're in good shape based on that. If you look at the end to end capabilities of what we've now put together, PMI has preclinical, the Chiltern capabilities has the core of the later stage, if you want to call it device CRS. We added to that RCRI with respect to the regulatory consulting side as well as that core device capability. And then finally, we had in Covance, the legacy Covance, strong therapeutic expertise, cardiovascular is an example, putting that all together, really strengthened our hand and now has an end to end capability that is unmatched in the industry.
Got it. Thank you.
Thank you. Our next question comes from the line of Brian Tanquilut with Jefferies. Your line is now open.
All my questions were answered. Thank
you. Thank you.
Our next question comes from the line of Matt Larew with William Blair. Your line is now open.
Hey, good morning guys. This is Dan Waller on for Matt Larew. Thanks for taking my questions. I wanted to ask you guys about your in home strategy in Pixel. What are the key targets that you guys have in mind for this year and how are you measuring success there?
Thanks.
Good morning, Matt. Dan, it's Dave. Pixel is a screening and a wellness tool. And over time, our goal is to expand the test menu and to have the potential with collaborators to reach patients in the home. I think in the long run, it's going to be an important tool, especially when you think about, for example, our hospital partners that are at risk, and increasing their health system partners that are taking risk for some sort of the patient population, some set of the patient population or our health plan partners that have their own managed care plans.
And as a result, we're going to be acutely aware of the needs and the conditions of homebound patients. So again, we're playing the long game with pixel and with how we reach basis in the home, but we think it's a very important part of our strategy, which we referred to in the opening comments about meeting the patients where they want and where they need to be served.
Great. Thank you.
Thank you. Our next question comes from the line of Donald Hooker with KeyBanc. Your line is now open.
Hi, great. Good morning. I guess most of
my questions have been answered, but just maybe in a
brief Hey, Donna. Hello.
I'm going
to have to dial back in. There's a lot of static on the line. We'll take your question, but you may want to try disconnecting and dial back in. All right.
I'll try. Can you hear me now?
No. I'll drop I'm sorry. I'll drop off.
Our next question comes from the line of Kevin Ellich with Craig Hallum. Your line is now open.
Hey, Dave. Can you hear me? It's Kevin.
Yes.
Okay. Thanks. I know the call is going to get long here.
Yes. Just want to comment, we are at the top of the hour. We have 4, 3 people in the queue plus in fairness, we got to let Don back in if he dials back in. So if your questions have been answered, let's please try and keep it short.
Sure. So PAMA, and again, I hopped on late, sorry for that. But can you talk about any indirect impact on Medicaid or floating rate contracts that you're seeing from PAMA?
Yes. We said last quarter when we gave the guidance, our estimate for PAMA is all in and it includes the impact of the fee for service and managed Medicaid plans as well as whatever impact there is on for Medicare Advantage. So the impact that we have identified in the call out is the all in impact, both in terms of impact on revenue and the dollar amount.
Okay. Thanks.
Thank you. Our next question comes from the line of Ralph Giacobbe with Citi. Your line is now open.
Thanks. Good morning. I think there's some questions around ability to pay commissions to sales reps kind of going forward. I know there's been some debate on whether or not that will actually sort of take hold or whether there will be repercussions about that. But Dave, would love to just hear sort of thoughts on that and sort of your comfort level there?
Thanks.
Yes. So the changes that were made in the SUPPORT Act last year, we continue to believe were misguided and unintentional on Congress' part. It was a as I understand it, there was some floor language that was adopted that was aimed at what was perceived to be abusive tactics by some testing related to toxicology and pain management. We have been working with the legislative leadership in the Department of Justice. There has been legislative amendment language submitted to the congressional committees of jurisdiction.
It is being evaluated by the Department of Justice to make sure that the fix that would address the over inclusiveness of the language that was added would be acceptable to DOJ as well as the legislative sponsor. So we continue to be optimistic that we're going to get this resolved, Ralph, and we don't have a good estimate on the timing.
Okay. No problem. Thank you. Thank you. Our next question comes from the line of Derik De Bruin with Bank of America.
Your line is now open.
Hi, this is Eizong for Derik today. Just a couple of quick ones. Thank you for taking the question. So just want to confirm, if last year's organic revenue growth on the CRO side included the pass through that we talked about. If that's if the growth from CRO benefited from pass through last year, just want to get some clarity on what the CRO revenue growth guide looks like including the pass through.
So basically just trying to see if the growth is apples to apples in terms of coherence. And then just as a follow-up, I wanted to see if you can provide any color on the EBITDA incremental EBITDA from Envigo? Thank you.
This is Glenn. I'll take the first cut. The impact of the pass throughs were included in last year's numbers. When we adopted the new accounting standards ASC 606, we took a full retrospective method so that we have it in prior periods for comparative purposes, so they're included. With regard to the EBITDA of Envigo, the only thing would share with you at this time is that, again, we expect to close kind of mid year and that the adjusted operating income margins, but would also play in the EBITDA would be greater than the margins of the segment.
So to give you some perspective, they're pretty attractive margins and obviously upon closure, you'll start to see the benefit of that margin, as John alluded to earlier, reflected in the segment margins.
Sorry. And then just one follow-up.
No, no, no, no. You asked 1 and 1. I'm sorry, but we're past the time.
All right. Great. Thank you.
Thank you.
Thank you. We have no further questions in the queue at this time. I would now like to turn the call back to Dave King for any further remarks.
Thank you very much. We appreciate you joining us for the call this morning. I want to reemphasize how proud I am of the effort of both of our businesses this quarter in a challenging environment. I'm pleased and extremely proud of the performance of our 61,000 people around the world. So thank you very much, and have a great day.
Ladies and gentlemen, thank you for participating in today's conference. This does conclude today's program. You may all disconnect. Everyone have a