Spero Therapeutics, Inc. (SPRO)

NASDAQ: SPRO · Real-Time Price · USD
2.630
+0.040 (1.54%)
May 20, 2026, 4:00 PM EDT - Market closed
Market Cap152.28M +361.5%
Revenue (ttm)61.19M +37.2%
Net Income15.24M
EPS0.26
Shares Out 57.90M
PE Ratio10.26
Forward PE3.93
Dividendn/a
Ex-Dividend Daten/a
Volume320,203
Open2.590
Previous Close2.590
Day's Range2.550 - 2.645
52-Week Range0.656 - 3.220
Beta1.43
AnalystsHold
Price Target4.00 (+52.09%)
Earnings DateMay 13, 2026

About SPRO

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company’s product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, man... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date Nov 2, 2017
Employees 25
Stock Exchange NASDAQ
Ticker Symbol SPRO
Full Company Profile

Financial Performance

Financial Statements

Analyst Summary

According to one analyst, the rating for SPRO stock is "Hold" and the 12-month stock price target is $4.0.

Price Target
$4.0
(52.09% upside)
Analyst Consensus: Hold
Stock Forecasts

News

Spero Therapeutics Announces First Quarter 2026 Operating Results and Provides Business Update

New Drug Application (NDA) for tebipenem HBr for complicated urinary tract infections (cUTI), including pyelonephritis, is under review at the FDA, with PDUFA date of June 18, 2026 Spero maintains its...

7 days ago - GlobeNewsWire

Spero Therapeutics Earnings release: Q1 2026

Spero Therapeutics released its Q1 2026 earnings on May 13, 2026, summarizing the period's financial results.

7 days ago - Filings

Spero Therapeutics Quarterly report: Q1 2026

Spero Therapeutics has published its Q1 2026 quarterly earnings report on May 13, 2026.

7 days ago - Filings

Spero Therapeutics to Report First Quarter 2026 Financial Results and Provide Business Update on May 13, 2026

CAMBRIDGE, Mass., May 05, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics , Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on identifying and developing novel treatments for rare ...

15 days ago - GlobeNewsWire

Spero Therapeutics Proxy statement: Proxy filing

Spero Therapeutics filed a proxy statement on April 27, 2026, providing details for shareholder voting and corporate governance matters.

23 days ago - Filings

Spero Therapeutics Proxy statement: Proxy filing

Spero Therapeutics filed a proxy statement on April 27, 2026, providing details for shareholder voting and corporate governance matters.

23 days ago - Filings

Spero Therapeutics Proxy statement: Proxy filing

Spero Therapeutics filed a proxy statement on April 13, 2026, providing details for shareholder voting and corporate governance matters.

5 weeks ago - Filings

Spero Therapeutics Announces Fourth Quarter and Full Year 2025 Operating Results and Provides a Business Update

CAMBRIDGE, Mass., March 26, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on identifying and developing novel treatments for rare...

7 weeks ago - GlobeNewsWire

Spero Therapeutics Earnings release: Q4 2025

Spero Therapeutics released its Q4 2025 earnings on March 26, 2026, summarizing the period's financial results.

7 weeks ago - Filings

Spero Therapeutics Annual report: Q4 2025

Spero Therapeutics has published its Q4 2025 annual report on March 26, 2026.

7 weeks ago - Filings

Spero Therapeutics to Report Fourth Quarter and Full Year 2025 Financial Results and Provide Business Update on March 26, 2026

CAMBRIDGE, Mass., March 18, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on identifying and developing novel treatments for rare...

2 months ago - GlobeNewsWire

Spero announces GSK filed NDA resubmission to FDA for tebipenem HBr

Spero Therapeutics (SPRO) announced that its development partner, GSK (GSK), filed a New Drug Application, NDA, resubmission to the U.S. Food and Drug Administration, FDA, for tebipenem HBr, an invest...

Other symbols: GSK
5 months ago - TheFly

Spero Announces NDA Resubmission of Tebipenem HBr by GSK to the FDA for the Treatment of Complicated Urinary Tract Infections, Including Pyelonephritis

CAMBRIDGE, Mass., Dec. 19, 2025 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on identifying and developing novel treatments for rare ...

5 months ago - GlobeNewsWire

Spero Therapeutics announces inducement grant under Nasdaq listing rule

Spero Therapeutics (SPRO) announced that on November 3, 2025, the Compensation Committee of Spero’s Board of Directors approved the grant of an aggregate of 90,000 restricted stock unit awards to…

6 months ago - TheFly

Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass., Nov. 28, 2025 (GLOBE NEWSWIRE) -- Spero Therapeutics , Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on identifying and developing novel treatments for rare...

6 months ago - GlobeNewsWire

Spero Therapeutics Announces Third Quarter 2025 Operating Results and Provides a Business Update

Results from PIVOT-PO Phase 3 trial evaluating tebipenem HBr in complicated urinary tract infection (cUTI) presented as IDWeek late-breaker in October 2025 Spero's development partner, GSK, plans to s...

6 months ago - GlobeNewsWire

Spero Therapeutics Earnings release: Q3 2025

Spero Therapeutics released its Q3 2025 earnings on November 13, 2025, summarizing the period's financial results.

6 months ago - Filings

Spero Therapeutics Quarterly report: Q3 2025

Spero Therapeutics has published its Q3 2025 quarterly earnings report on November 13, 2025.

6 months ago - Filings

Spero Therapeutics to Report Third Quarter 2025 Financial Results and Provide Business Update on November 13, 2025

CAMBRIDGE, Mass., Nov. 04, 2025 (GLOBE NEWSWIRE) -- Spero Therapeutics , Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company, focused on identifying and developing novel treatments for rar...

7 months ago - GlobeNewsWire

Spero Therapeutics, GSK announce PIVOT-PO trial efficacy and safety results

Spero Therapeutics (SPRO) and GSK plc (GSK) announced efficacy and safety results of the phase 3 PIVOT-PO trial evaluating tebipenem HBr, an investigational oral treatment for complicated urinary trac...

Other symbols: GSK
7 months ago - TheFly

PIVOT-PO Phase 3 Data Show Tebipenem HBr's Potential as the First Oral Carbapenem Antibiotic for Patients with Complicated Urinary Tract Infections (cUTIs)

CAMBRIDGE, Mass., Oct. 21, 2025 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO) and GSK plc (LSE/NYSE: GSK) today announced efficacy and safety results of the positive pivotal phase 3 PIVO...

7 months ago - GlobeNewsWire

Spero Therapeutics Announces Presentations on Tebipenem Hbr at IDWeek

CAMBRIDGE, Mass., Oct. 14, 2025 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on identifying and developing novel treatments for rare ...

7 months ago - GlobeNewsWire

Spero Therapeutics Earnings Call Transcript: Q2 2025

Phase III trial for tebipenem HBr in cUTI met its primary endpoint and was stopped early for efficacy, with regulatory submission planned by year-end 2025. Revenue rose 39% year-over-year, net loss narrowed, and cash runway now extends into 2028.

10 months ago - Transcripts

Spero Therapeutics Quarterly report: Q2 2025

Spero Therapeutics has published its Q2 2025 quarterly earnings report on August 12, 2025.

10 months ago - Filings

Spero Therapeutics Earnings release: Q2 2025

Spero Therapeutics released its Q2 2025 earnings on August 12, 2025, summarizing the period's financial results.

10 months ago - Filings