Spero Therapeutics Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2024	FY 2023	FY 2022	FY 2021	FY 2020
Period Ending	Mar '26 Mar 26, 2026	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021	Dec '20 Dec 31, 2020
Market Cap	134	56	78	91	621	567
Market Cap Growth	233.55%	-27.82%	-14.15%	-85.38%	9.38%	207.32%
Enterprise Value	88.82	5.89	5.4	-13.4	528.55	447.34
Last Close Price	2.38	1.03	1.47	1.73	16.01	19.39
PE Ratio	-	-0.81	3.42	-1.41	-5.50	-5.51
PS Ratio	3.31	1.17	0.75	1.70	33.99	60.81
PB Ratio	5.12	1.22	0.73	1.20	7.03	4.30
P/TBV Ratio	4.99	1.21	0.73	0.86	5.60	3.29
P/FCF Ratio	-	-2.40	-2.36	-11.74	-9.64	-6.59
P/OCF Ratio	-	-2.40	-2.36	-11.74	-9.64	-6.61
EV/Sales Ratio	2.19	0.12	0.05	-0.25	28.95	47.95
EV/EBITDA Ratio	-	-0.08	0.25	0.32	-6.05	-5.71
EV/EBIT Ratio	-	-0.08	0.25	0.32	-6.01	-5.65
EV/FCF Ratio	-	-0.25	-0.16	1.73	-8.21	-5.20
Debt / Equity Ratio	0.05	0.06	0.04	0.07	0.62	0.05
Debt / EBITDA Ratio	-0.07	-0.06	0.25	-0.16	-0.64	-0.10
Debt / FCF Ratio	-0.12	-0.18	-0.17	-0.86	-0.87	-0.09
Net Debt / Equity Ratio	-1.71	-1.05	-0.66	-1.35	-1.03	-0.90
Net Debt / EBITDA Ratio	0.97	0.66	-3.24	2.48	1.04	1.52
Net Debt / FCF Ratio	1.64	2.07	2.15	13.25	1.41	1.38
Asset Turnover	0.49	0.33	0.68	0.36	0.11	0.07
Quick Ratio	3.74	2.15	4.67	5.09	7.98	9.28
Current Ratio	3.83	2.19	3.53	5.25	8.46	9.70
Return on Equity (ROE)	-119.13%	-89.62%	30.63%	-56.53%	-81.47%	-75.77%
Return on Assets (ROA)	-56.47%	-50.09%	15.42%	-28.52%	-54.22%	-60.96%
Return on Invested Capital (ROIC)	-321.01%	-112.22%	45.44%	-550.73%	-786.58%	-1379.24%
Return on Capital Employed (ROCE)	-91.81%	-70.98%	17.30%	-33.02%	-60.36%	-72.40%
Earnings Yield	-32.69%	-123.30%	29.25%	-71.10%	-18.18%	-18.15%
FCF Yield	-20.64%	-41.69%	-42.35%	-8.52%	-10.37%	-15.16%
Buyback Yield / Dilution	-	0.00%	-0.28%	-27.47%	-13.95%	-14.25%

Updated Nov 13, 2025. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q