Spero Therapeutics, Inc. (SPRO)

NASDAQ: SPRO · Real-Time Price · USD

1.155

-0.015 (-1.28%)

Oct 8, 2026, 11:44 AM EDT - Market open

Spero Therapeutics Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Total Valuation

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Oct '26 Oct 8, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Capitalization	67	131	56	78	90	518
Market Cap Growth	-42.81%	133.77%	-27.92%	-13.02%	-82.69%	-1.83%
Enterprise Value	19	86	-16	-10	46	401
Last Close Price	1.17	2.33	1.03	1.47	1.73	16.01

Price Ratios

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Oct '26 Oct 8, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
PE Ratio	9.04	15.31	-	3.42	-	-
Forward PE	-	4.88	-	-	-	-
PS Ratio	1.45	1.97	1.17	0.75	1.67	28.35
PB Ratio	1.54	2.22	1.22	0.73	1.18	5.86
P/TBV Ratio	1.54	2.22	1.22	0.73	1.18	5.86

EV Ratios

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Oct '26 Oct 8, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
EV/Sales Ratio	0.41	1.29	-	-	0.86	21.98
EV/EBITDA Ratio	-	12.01	-	-	-	-
EV/EBIT Ratio	2.93	12.01	-	-	-	-

Financial Efficiency

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Oct '26 Oct 8, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Debt / Equity Ratio	0.05	0.05	0.09	0.05	0.09	0.63
Debt / EBITDA Ratio	0.25	0.34	-	0.19	-	-
Net Debt / Equity Ratio	-1.10	-0.63	-1.05	-0.66	-1.35	-1.03
Net Debt / EBITDA Ratio	-	-5.22	0.67	-2.61	3.45	1.04
Net Debt / FCF Ratio	-2.49	2.96	2.07	2.15	13.25	1.41
Asset Turnover	0.82	0.74	0.33	0.68	0.36	0.11
Quick Ratio	6.03	7.40	2.15	3.42	5.09	7.98
Current Ratio	6.12	7.59	2.19	3.53	5.25	8.46
Return on Equity (ROE)	19.17%	16.30%	-89.62%	24.95%	-56.53%	-81.47%
Return on Assets (ROA)	7.19%	4.99%	-30.93%	10.90%	-12.91%	-33.88%
Return on Invested Capital (ROIC)	-	72.44%	-431.00%	502.14%	-	-1658.58%
Return on Capital Employed (ROCE)	14.90%	11.90%	-117.90%	18.40%	-29.60%	-57.70%

Yields

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Oct '26 Oct 8, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Earnings Yield	10.84%	6.53%	-122.10%	29.27%	-51.82%	-17.34%
FCF Yield	28.74%	-9.62%	-41.75%	-42.35%	-8.63%	-12.43%
Buyback Yield / Dilution	-9.05%	-9.25%	-1.98%	-40.98%	-21.65%	-38.01%

SEC Filings: 10-K · 10-Q