Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ: IONS · Real-Time Price · USD
75.90
-0.95 (-1.24%)
May 7, 2026, 2:31 PM EDT - Market open
Market Cap12.54B +177.8%
Revenue (ttm)1.06B +47.5%
Net Income-326.98M
EPS-2.02
Shares Out 165.26M
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume1,052,195
Open76.56
Previous Close76.85
Day's Range74.87 - 76.56
52-Week Range31.66 - 86.74
Beta0.38
AnalystsStrong Buy
Price Target94.00 (+23.85%)
Earnings DateApr 29, 2026

About IONS

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also ... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date May 17, 1991
Employees 1,402
Stock Exchange NASDAQ
Ticker Symbol IONS
Full Company Profile

Financial Performance

In 2025, Ionis Pharmaceuticals's revenue was $943.71 million, an increase of 33.83% compared to the previous year's $705.14 million. Losses were -$381.39 million, -15.97% less than in 2024.

Financial Statements

Analyst Summary

According to 22 analysts, the average rating for IONS stock is "Strong Buy." The 12-month stock price target is $94.0, which is an increase of 23.85% from the latest price.

Price Target
$94.0
(23.85% upside)
Analyst Consensus: Strong Buy
Stock Forecasts

News

Ionis to host 2026 virtual Annual Meeting of Stockholders

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that management will conduct its 2026 virtual Annual Meeting of Stockholders followed by a general corpora...

3 days ago - Business Wire

Ionis to present at upcoming investor conferences

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that management will participate in fireside chats at the following investor conferences: Bank of America ...

6 days ago - Business Wire

Ionis Pharmaceuticals price target raised to $111 from $104 at Oppenheimer

Oppenheimer raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $111 from $104 and keeps an Outperform rating on the shares. The firm notes the stock traded higher following

7 days ago - TheFly

Ionis Pharmaceuticals price target raised to $86 from $83 at Stifel

Stifel raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $86 from $83 and keeps a Hold rating on the shares. Published first on TheFly – the ultimate source

7 days ago - TheFly

Ionis Pharmaceuticals price target raised to $100 from $95 at RBC Capital

RBC Capital raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $100 from $95 and keeps an Outperform rating on the shares. The firm cites the company’s better-than-expected Q1

7 days ago - TheFly

Ionis Pharmaceuticals price target raised to $125 from $120 at H.C. Wainwright

H.C. Wainwright raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $125 from $120 and keeps a Buy rating on the shares. The firm says management commentary strengthens its

7 days ago - TheFly

Ionis Pharmaceuticals price target raised to $115 from $106 at Barclays

Barclays analyst Eliana Merle raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $115 from $106 and keeps an Overweight rating on the shares. Published first on TheFly –

7 days ago - TheFly

Ionis Pharmaceuticals Earnings Call Transcript: Q1 2026

Q1 2026 saw 87% revenue growth, driven by strong TRYNGOLZA and DAWNZERA launches and milestone payments. Guidance for 2026 was raised, with robust commercial and R&D revenue expected, and two major independent launches on track.

8 days ago - Transcripts

Ionis Pharmaceuticals reports Q1 EPS (56c), consensus (77c)

Reports Q1 revenue $246M, consensus $196.01M. “Ionis’ strong performance in the first quarter of 2026 underscores the strength of our commercial and R&D engines. Our independent launches are increasin...

8 days ago - TheFly

Ionis Pharmaceuticals raises FY26 revenue view $875M-$900M from $800M-$825M

Consensus $811.3M. “Ionis entered 2026 with strong momentum. We continued this momentum with the first quarter financial results reflecting increased commercial revenue from our independent launches a...

8 days ago - TheFly

Ionis reports first quarter 2026 financial results and highlights progress on key programs

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) (the “Company”) today reported financial results and provided key updates for the first quarter ended March 31, 2026. “Ion...

8 days ago - Business Wire

Ionis partner GSK announces bepirovirsen NDA accepted for priority review

Ionis Pharmaceuticals (IONS) partner GSK (GSK) announced the FDA has accepted for priority review the new drug application, or NDA, for bepirovirsen, an investigational antisense oligonucleotide, or A...

Other symbols: GSK
9 days ago - TheFly

Ionis partner GSK announces bepirovirsen accepted for Priority Review and granted Breakthrough Therapy Designation by U.S. FDA as a potential first-in-class medicine for chronic hepatitis B

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) partner GSK today announced the U.S. Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Appl...

9 days ago - Business Wire

Ionis Pharmaceuticals price target lowered to $108 from $110 at TD Cowen

TD Cowen lowered the firm’s price target on Ionis Pharmaceuticals (IONS) to $108 from $110 and keeps a Buy rating on the shares. The firm updated its model while trimming

14 days ago - TheFly

Ionis Pharmaceuticals price target raised to $130 from $95 at Morgan Stanley

Morgan Stanley raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $130 from $95 and keeps an Overweight rating on the shares. The firm believes the market opportunity for

16 days ago - TheFly

Ionis announces additional results from zilganersen study in AxD

Ionis Pharmaceuticals (IONS) announced additional results from the pivotal study of zilganersen in children and adults living with Alexander disease, a rare, progressive and often fatal neurological c...

16 days ago - TheFly

Ionis presents new data from pivotal study of zilganersen in Alexander disease (AxD) at AAN 2026 Annual Meeting

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced additional positive results from the pivotal study of zilganersen in children and adults living with Alexa...

16 days ago - Business Wire

Ionis Pharmaceuticals initiated with a Buy at Canaccord

Canaccord last night initiated coverage of Ionis Pharmaceuticals (IONS) with a Buy rating and $110 price target The firm says the company is executing “very well” in its transition to

16 days ago - TheFly

Ionis Pharmaceuticals initiated with a Buy at Canaccord

Canaccord initiated coverage of Ionis Pharmaceuticals (IONS) with a Buy rating and $110 price target Published first on TheFly – the ultimate source for real-time, market-moving breaking financial new...

16 days ago - TheFly

Ionis to hold first quarter 2026 financial results webcast

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that it will host a live webcast on Wednesday, April 29 at 8:30 a.m. Eastern Time to discuss its first qua...

22 days ago - Business Wire

Ionis Pharmaceuticals resumed with an Outperform at Raymond James

Raymond James analyst Tiago Fauth resumed coverage of Ionis Pharmaceuticals (IONS) with an Outperform rating and $104 price target The firm sees further upside in the shares given the company’s

27 days ago - TheFly

Ionis Pharmaceuticals price target raised to $111 from $100 at BofA

BofA raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $111 from $100 and keeps a Buy rating on the shares. The firm adjusted several targets in conjunction with

4 weeks ago - TheFly

Ionis Pharmaceuticals management to meet with Oppenheimer

Meeting to be held on April 7 hosted by Oppenheimer. Published first on TheFly – the ultimate source for real-time, market-moving breaking financial news. Try Now>> See today’s best-performing stocks

5 weeks ago - TheFly

FDA Approves New High Dose Regimen of SPINRAZA® (nusinersen) for Spinal Muscular Atrophy

The approval was anchored on data from the pivotal DEVOTE study that investigated the efficacy and safety of the High Dose Regimen of SPINRAZA in treatment-naïve and previously treated SPINRAZA patien...

Other symbols: BIIB
5 weeks ago - GlobeNewsWire

Ionis Pharmaceuticals price target raised to $106 from $95 at Barclays

Barclays raised the firm’s price target on Ionis Pharmaceuticals (IONS) to $106 from $95 and keeps an Overweight rating on the shares. The firm boosted its 2034 Tryngolza in severe

6 weeks ago - TheFly