Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ: IONS · Real-Time Price · USD
80.60
-0.33 (-0.41%)
At close: Feb 26, 2026, 4:00 PM EST
80.60
0.00 (0.00%)
After-hours: Feb 26, 2026, 4:00 PM EST
Market Cap13.06B +162.7%
Revenue (ttm)944.00M +33.9%
Net Income-381.00M
EPS-2.38
Shares Out 161.97M
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume2,185,716
Open80.32
Previous Close80.93
Day's Range78.92 - 82.44
52-Week Range23.95 - 86.74
Beta0.31
AnalystsStrong Buy
Price Target85.14 (+5.62%)
Earnings DateFeb 25, 2026

About IONS

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSE... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date May 17, 1991
Employees 1,069
Stock Exchange NASDAQ
Ticker Symbol IONS
Full Company Profile

Financial Performance

In 2025, Ionis Pharmaceuticals's revenue was $944.00 million, an increase of 33.87% compared to the previous year's $705.14 million. Losses were -$381.00 million, -16.06% less than in 2024.

Financial Statements

Analyst Summary

According to 22 analysts, the average rating for IONS stock is "Strong Buy." The 12-month stock price target is $85.14, which is an increase of 5.62% from the latest price.

Price Target
$85.14
(5.62% upside)
Analyst Consensus: Strong Buy
Stock Forecasts

News

Olezarsen sNDA accepted by the FDA for Priority Review for the treatment of severe hypertriglyceridemia (sHTG)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the U.S. Food and Drug Administration (FDA) has accepted for Priority Review the supplemental New Dru...

10 hours ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Q4 2025 Earnings Call Transcript

Ionis Pharmaceuticals, Inc. (IONS) Q4 2025 Earnings Call Transcript

1 day ago - Seeking Alpha

Ionis Guides Below 2026 Sales Views Despite Strong Growth From Lead Drug

Ionis Pharmaceuticals Inc. (NASDAQ: IONS) on Wednesday reported a fourth quarter adjusted loss of $1.15, better than the Wall Street loss estimate of $1.32

1 day ago - Benzinga

Ionis reports fourth quarter and full year 2025 financial results and highlights progress on key programs

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) (the “Company”) today reported financial results and provided key updates for the fourth quarter and year ended December 3...

1 day ago - Business Wire

Ionis to present at upcoming investor conferences

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that management will participate in fireside chats at the following investor conferences: Oppenheimer 36th...

7 days ago - Business Wire

Ionis updates time for fourth quarter and full year 2025 financial results webcast

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced a change in the start time for its fourth quarter and full year 2025 financial results webcast. The live w...

9 days ago - Business Wire

Ionis to hold fourth quarter and full year 2025 financial results webcast

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that it will host a live webcast on Wednesday, February 25 at 11:30 a.m. Eastern Time to discuss its fourt...

15 days ago - Business Wire

DAWNZERA™ (donidalorsen) approved in the European Union for hereditary angioedema (HAE)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) and Otsuka Pharmaceutical Co., Ltd. (Otsuka) today announced that the European Commission (EC) has approved DAWNZERA™ (don...

5 weeks ago - Business Wire

Ionis: Expected 2026 Launch Of Olezarsen In SHTG To Spur Leap In Revenue Growth

Ionis Pharmaceuticals (IONS) has appreciated ~25% since my last upgrade, reflecting strong momentum. This article spotlights Olezarsen, Ionis's wholly owned molecule, as a key driver of future upside....

5 weeks ago - Seeking Alpha

Ionis Pharmaceuticals, Inc. (IONS) Presents at 44th Annual J.P. Morgan Healthcare Conference Transcript

Ionis Pharmaceuticals, Inc. (IONS) Presents at 44th Annual J.P. Morgan Healthcare Conference Transcript

6 weeks ago - Seeking Alpha

Ionis well-positioned for continued momentum and substantial value creation in 2026 with two new independent launches and several pivotal data readouts

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced highlights from the Company's 2025 achievements and provided additional updates on key milestones expected...

6 weeks ago - Business Wire

GSK/Ionis Partnered Investigational Drug Shows Strong Results In Large Hepatitis B Studies

Ionis Pharmaceuticals Inc. (NASDAQ: IONS) partner GSK Plc (NYSE: GSK) on Wednesday shared data from two pivotal Phase 3 studies, B-Well 1 and B-Well 2, of bepirovirsen, an investigational antisense ol...

Other symbols: GSK
7 weeks ago - Benzinga

Ionis partner GSK announces positive topline results from B-Well 1 and B-Well 2 Phase 3 studies for bepirovirsen, a potential first-in-class medicine for chronic hepatitis B

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) partner GSK today announced positive results from two pivotal Phase 3 studies, B-Well 1 and B-Well 2, evaluating the safet...

7 weeks ago - Business Wire

Ionis to present at 44th Annual J.P. Morgan Healthcare Conference

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that Brett P. Monia, Ph.D., chief executive officer, will present a company overview at the 44th Annual J....

7 weeks ago - Business Wire

Ionis receives U.S. FDA Breakthrough Therapy designation for zilganersen for Alexander disease (AxD)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to zilganers...

3 months ago - Business Wire

Ionis receives U.S. FDA Breakthrough Therapy designation for olezarsen for severe hypertriglyceridemia (sHTG)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to olezarsen...

3 months ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Presents at Jefferies London Healthcare Conference 2025 Transcript

Ionis Pharmaceuticals, Inc. ( IONS) Jefferies London Healthcare Conference 2025 November 18, 2025 8:30 AM EST Company Participants Brett Monia - Founder, CEO & Director Conference Call Participants A...

3 months ago - Seeking Alpha

Biogen Completes Acquisition of Alcyone Therapeutics

CAMBRIDGE, Mass., Nov. 14, 2025 (GLOBE NEWSWIRE) -- Biogen Inc. (Nasdaq: BIIB) has completed the acquisition of Alcyone Therapeutics, a clinical-stage biotechnology company known for its innovative CN...

Other symbols: BIIB
3 months ago - GlobeNewsWire

DAWNZERA™ (donidalorsen) receives positive opinion from CHMP, recommended for approval in EU for hereditary angioedema (HAE)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) and Otsuka Pharmaceutical Co., Ltd. (Otsuka) today announced that the Committee for Medicinal Products for Human Use (CHMP...

3 months ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Presents at Stifel 2025 Healthcare Conference Transcript

Ionis Pharmaceuticals, Inc. ( IONS) Stifel 2025 Healthcare Conference November 13, 2025 8:00 AM EST Company Participants Kyle Jenne - Executive VP & Chief Global Product Strategy Officer Elizabeth L....

3 months ago - Seeking Alpha

Ionis Prices Convertible Notes Offering to Refinance 2026 Convertible Notes

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) announced today the pricing of $700.0 million aggregate principal amount of 0.00% Convertible Senior Notes due 2030 (the “...

3 months ago - Business Wire

Ionis Announces Proposed Convertible Offering to Refinance 2026 Convertible Notes

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (NASDAQ: IONS) announced today that it intends to offer, subject to market conditions and other factors, $700.0 million aggregate princip...

3 months ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Discusses Detailed Phase III Results for Olezarsen in Severe Hypertriglyceridemia Transcript

Ionis Pharmaceuticals, Inc. ( IONS) Discusses Detailed Phase III Results for Olezarsen in Severe Hypertriglyceridemia November 8, 2025 3:00 PM EST Company Participants D. Walke - Senior Vice Presiden...

3 months ago - Seeking Alpha

Ionis: Near-Term Launches With Blockbuster Potential Boosts Upside Despite Stock Rally

Ionis Pharmaceuticals maintains a Buy rating as its transformation to a commercial company accelerates, driven by wholly-owned product launches and revenue growth. Q3 results highlight a revenue shift...

3 months ago - Seeking Alpha

Ionis Reports Substantial Drop In Acute Pancreatitis Events With Cholesterol Lowering Drug

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) on Sunday shared results from the pivotal Phase 3 CORE and CORE2 studies of olezarsen for severe hypertriglyceridemia (sHTG), a condition characterized by dan...

3 months ago - Benzinga