Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ: IONS · Real-Time Price · USD
73.55
-0.55 (-0.74%)
At close: Nov 7, 2025, 4:00 PM EST
75.00
+1.45 (1.97%)
After-hours: Nov 7, 2025, 7:54 PM EST
-0.74%
Market Cap11.91B
Revenue (ttm)966.96M
Net Income (ttm)-256.34M
Shares Out 161.97M
EPS (ttm)-1.61
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume2,325,183
Open73.58
Previous Close74.10
Day's Range72.36 - 75.00
52-Week Range23.95 - 76.78
Beta0.31
AnalystsStrong Buy
Price Target80.24 (+9.1%)
Earnings DateOct 29, 2025

About IONS

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSE... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date May 17, 1991
Employees 1,069
Stock Exchange NASDAQ
Ticker Symbol IONS
Full Company Profile

Financial Performance

In 2024, Ionis Pharmaceuticals's revenue was $705.14 million, a decrease of -10.48% compared to the previous year's $787.65 million. Losses were -$453.90 million, 23.9% more than in 2023.

Financial Statements

Analyst Summary

According to 21 analysts, the average rating for IONS stock is "Strong Buy." The 12-month stock price target is $80.24, which is an increase of 9.10% from the latest price.

Price Target
$80.24
(9.10% upside)
Analyst Consensus: Strong Buy
Stock Forecasts

News

Ionis presents new data demonstrating long-term disease control with DAWNZERA™ (donidalorsen) at ACAAI 2025 Annual Meeting

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced new long-term data for DAWNZERA™ (donidalorsen), the first and only RNA-targeted prophylactic medicine for...

1 day ago - Business Wire

Ionis: What Upside Is Left After Shares Rocketed Higher Following Positive Trial Data?

Ionis Pharmaceuticals, Inc. has surged on strong phase-3 trial data and a robust pipeline, but much optimism is already priced in. IONS boasts recent drug launches (Wainua, Tryngolza, Dawnzera) with s...

3 days ago - Seeking Alpha

Ionis Pharmaceuticals, Inc. (IONS) Q3 2025 Earnings Call Transcript

Ionis Pharmaceuticals, Inc. ( IONS) Q3 2025 Earnings Call October 29, 2025 11:30 AM EDT Company Participants D. Walke - Senior Vice President of Investor Relations Brett Monia - Founder, CEO & Direct...

9 days ago - Seeking Alpha

Ionis reports third quarter 2025 financial results and highlights progress on key programs

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) (the “Company”) today reported financial results and provided key updates for the third quarter ended September 30, 2025. ...

10 days ago - Business Wire

Detailed data from the landmark CORE and CORE2 pivotal studies of olezarsen for sHTG to be presented as a late breaker at AHA Scientific Sessions

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that detailed data from the landmark pivotal Phase 3 CORE and CORE2 studies of olezarsen in people with se...

12 days ago - Business Wire

Ionis ranked #2 Top Employer by Science magazine, recognizing industry-leading scientific innovation and company culture

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced the company was named as a top employer to work for by Science magazine in its annual Top Employer survey ...

15 days ago - Business Wire

Ionis CEO Brett P. Monia receives 2025 Lifetime Achievement Award from the Oligonucleotide Therapeutics Society

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that Brett P. Monia, Ph.D., Ionis' chief executive officer, was awarded the 2025 Lifetime Achievement Awar...

17 days ago - Business Wire

Ionis to hold third quarter 2025 financial results webcast

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that it will host a live webcast on Wednesday, October 29th at 11:30 a.m. Eastern Time to discuss its thir...

23 days ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Shareholder/Analyst Call Transcript

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Shareholder/Analyst Call October 7, 2025 8:30 AM EDT Company Participants D. Walke - Senior Vice President of Investor Relations Brett Monia - Founder, CEO &...

4 weeks ago - Seeking Alpha

Ionis Pharmaceuticals CEO Brett Monia on the drugs they are focused on

Ionis Pharmaceuticals CEO Brett Monia joins CNBC's 'Squawk Box' to discuss RNA-targeted therapeutics, the drugs the company is focusing on, and more

4 weeks ago - CNBC Television

Ionis showcases transformational medicines and industry-leading pipeline at Innovation Day

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today is hosting its 2025 Innovation Day in New York City. Ionis leaders will highlight the company's recent and near-term...

4 weeks ago - Business Wire

Ionis Pharmaceuticals Reveals 'Unprecedented Results' From Rare Neurological Disease Trial

Ionis Pharmaceuticals, Inc. IONS released topline results on Monday from the pivotal study of zilganersen in children and adults living with Alexander disease (AxD), a rare, progressive, and often fat...

6 weeks ago - Benzinga

Ionis' brain disorder drug shows promise in clinical trial

Ionis Pharmaceuticals said on Monday its experimental brain disorder drug met the main goal in an early-to-late-stage study.

6 weeks ago - Reuters

Ionis announces positive topline results from pivotal study of zilganersen in Alexander disease

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced positive topline results from the pivotal study of zilganersen in children and adults living with Alexande...

6 weeks ago - Business Wire

TRYNGOLZA® (olezarsen) approved in the European Union for familial chylomicronemia syndrome (FCS)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) and Sobi® today announced that TRYNGOLZA® (olezarsen) has been approved in the European Union (EU) as an adjunct to diet i...

7 weeks ago - Business Wire

Ionis expands Surf Away+ event, marking 10 years of creating unique adaptive experiences for people with neurological diseases

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today celebrated 10 years of Surf Away+, an inclusive adaptive event for rare neurological disease communities. Originally...

2 months ago - Business Wire

Ionis: Recent Approvals, Upcoming Catalysts To Spur Strong Upside (Rating Upgrade)

After years of futility, Ionis' recent regulatory and clinical successes have spurred optimistic market attention. I review Q2/2025 earnings documents together with 09/04/2025 CEO Monia interview and ...

2 months ago - Seeking Alpha

Ionis Pharmaceuticals, Inc. (IONS) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference Transcript

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Morgan Stanley 23rd Annual Global Healthcare Conference September 9, 2025 12:20 PM EDT Company Participants Brett Monia - Founder, CEO & Director Conference ...

2 months ago - Seeking Alpha

Ionis Pharmaceuticals To Expedite Development Of Rare Neurological Disease Candidate With FDA Breakthrough Status

On Tuesday, the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy designation to Ionis Pharmaceuticals Inc.'s IONS ION582 for Angelman syndrome (AS), a rare neurological disorder.

2 months ago - Benzinga

Ionis receives U.S. FDA Breakthrough Therapy designation for ION582 in Angelman syndrome

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to ION582 fo...

2 months ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Presents At H.C. Wainwright 27th Annual Global Investment Conference (Transcript)

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) H.C. Wainwright 27th Annual Global Investment Conference September 8, 2025 3:00 PM EDT Company Participants Brett Monia - Founder, CEO & Director Conference ...

2 months ago - Seeking Alpha

Ionis to host investors and analysts for Innovation Day 2025

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that it will host Ionis Innovation Day on Tuesday, October 7, 2025, in New York. The agenda will feature p...

2 months ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Presents At Wells Fargo 20th Annual Healthcare Conference 2025 Transcript

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Wells Fargo 20th Annual Healthcare Conference 2025 September 4, 2025 10:15 AM EDT Company Participants Brett Monia - Founder, CEO & Director Conference Call ...

2 months ago - Seeking Alpha

Is The 35% Rally In IONS Stock Just The Beginning?

Ionis Pharmaceuticals' stock jumped 35% on September 2, 2025, after positive late-stage clinical trial results for olezarsen, a therapy for severe hypertriglyceridemia (sHTG). Investor enthusiasm is a...

2 months ago - Forbes

Ionis to present at upcoming investor conferences

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that management will participate in fireside chats at the following investor conferences: 2025 Wells Fargo...

2 months ago - Business Wire