Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ: IONS · Real-Time Price · USD
63.16
-0.88 (-1.37%)
At close: Sep 12, 2025, 4:00 PM EDT
62.87
-0.29 (-0.46%)
After-hours: Sep 12, 2025, 7:30 PM EDT
-1.37%
Market Cap10.07B
Revenue (ttm)944.05M
Net Income (ttm)-268.22M
Shares Out 159.39M
EPS (ttm)-1.73
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume1,471,495
Open63.85
Previous Close64.04
Day's Range63.07 - 64.61
52-Week Range23.95 - 64.72
Beta0.28
AnalystsBuy
Price Target67.88 (+7.47%)
Earnings DateNov 5, 2025

About IONS

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSE... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date May 17, 1991
Employees 1,069
Stock Exchange NASDAQ
Ticker Symbol IONS
Full Company Profile

Financial Performance

In 2024, Ionis Pharmaceuticals's revenue was $705.14 million, a decrease of -10.48% compared to the previous year's $787.65 million. Losses were -$453.90 million, 23.9% more than in 2023.

Financial Statements

Analyst Summary

According to 17 analysts, the average rating for IONS stock is "Buy." The 12-month stock price target is $67.88, which is an increase of 7.47% from the latest price.

Price Target
$67.88
(7.47% upside)
Analyst Consensus: Buy
Stock Forecasts

News

Ionis expands Surf Away+ event, marking 10 years of creating unique adaptive experiences for people with neurological diseases

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today celebrated 10 years of Surf Away+, an inclusive adaptive event for rare neurological disease communities. Originally...

2 days ago - Business Wire

Ionis: Recent Approvals, Upcoming Catalysts To Spur Strong Upside (Rating Upgrade)

After years of futility, Ionis' recent regulatory and clinical successes have spurred optimistic market attention. I review Q2/2025 earnings documents together with 09/04/2025 CEO Monia interview and ...

3 days ago - Seeking Alpha

Ionis Pharmaceuticals, Inc. (IONS) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference Transcript

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Morgan Stanley 23rd Annual Global Healthcare Conference September 9, 2025 12:20 PM EDT Company Participants Brett Monia - Founder, CEO & Director Conference ...

4 days ago - Seeking Alpha

Ionis Pharmaceuticals To Expedite Development Of Rare Neurological Disease Candidate With FDA Breakthrough Status

On Tuesday, the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy designation to Ionis Pharmaceuticals Inc.'s IONS ION582 for Angelman syndrome (AS), a rare neurological disorder.

5 days ago - Benzinga

Ionis receives U.S. FDA Breakthrough Therapy designation for ION582 in Angelman syndrome

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to ION582 fo...

5 days ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Presents At H.C. Wainwright 27th Annual Global Investment Conference (Transcript)

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) H.C. Wainwright 27th Annual Global Investment Conference September 8, 2025 3:00 PM EDT Company Participants Brett Monia - Founder, CEO & Director Conference ...

5 days ago - Seeking Alpha

Ionis to host investors and analysts for Innovation Day 2025

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that it will host Ionis Innovation Day on Tuesday, October 7, 2025, in New York. The agenda will feature p...

6 days ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Presents At Wells Fargo 20th Annual Healthcare Conference 2025 Transcript

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Wells Fargo 20th Annual Healthcare Conference 2025 September 4, 2025 10:15 AM EDT Company Participants Brett Monia - Founder, CEO & Director Conference Call ...

10 days ago - Seeking Alpha

Is The 35% Rally In IONS Stock Just The Beginning?

Ionis Pharmaceuticals' stock jumped 35% on September 2, 2025, after positive late-stage clinical trial results for olezarsen, a therapy for severe hypertriglyceridemia (sHTG). Investor enthusiasm is a...

11 days ago - Forbes

Ionis to present at upcoming investor conferences

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that management will participate in fireside chats at the following investor conferences: 2025 Wells Fargo...

12 days ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Positive CORE And CORE2 Topline Results (Transcript)

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Positive CORE and CORE2 Topline Results Company Participants D. Walke - Senior Vice President of Investor Relations Brett Monia - Founder, CEO & Director Sot...

12 days ago - Seeking Alpha

Ionis Pharmaceuticals stock rockets 31% to new 52-week high on breakthrough news

Ionis Pharmaceuticals stock jumped 31% on Tuesday hitting a new 52-week high after breakthrough news that lit up investor interest and boosted confidence across the biotech sector.

12 days ago - Invezz

Ionis Pharma's Investigational Drug Shows Promise For Triglyceride And Pancreatitis Reduction

Ionis Pharmaceuticals, Inc. IONS on Tuesday released topline results from the pivotal Phase 3 CORE and CORE2 studies of olezarsen for severe hypertriglyceridemia (sHTG).

12 days ago - Benzinga

Ionis shares jump after drug lowers blood fat levels in advanced trials

Ionis Pharmaceuticals' shares surged on Tuesday before the bell after the drugmaker said its experimental treatment significantly reduced levels of blood fats called triglycerides and reduced pancreat...

12 days ago - Reuters

Olezarsen significantly reduces triglycerides and acute pancreatitis events in landmark pivotal studies for people with severe hypertriglyceridemia (sHTG)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced positive topline results from the pivotal Phase 3 CORE and CORE2 studies of olezarsen in people with sever...

12 days ago - Business Wire

mRNA Biotechs - Long-Term Value Risks Abound

mRNA vaccine companies are overhyped post-pandemic, facing scientific, operational, and regulatory headwinds that limit long-term investment appeal. Scientific and business risks, including delivery c...

17 days ago - Seeking Alpha

Ionis: Dawnzera Approval Kicks Off New Era For Strikingly Undervalued Pharma

Ionis Pharmaceuticals remains a Buy after Dawnzera's FDA approval, which strengthens its pipeline and revenue outlook despite a history of operating losses. Dawnzera's market opportunity in hereditary...

19 days ago - Seeking Alpha

US FDA approves Ionis' drug for rare genetic disorder

The U.S. Food and Drug Administration on Thursday approved Ionis Pharmaceuticals' drug to prevent instances of severe swelling in various parts of the body of patients with a rare genetic disorder.

24 days ago - Reuters

DAWNZERA™ (donidalorsen) approved in the U.S. as first and only RNA-targeted prophylactic treatment for hereditary angioedema

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that the U.S. Food and Drug Administration (FDA) has approved DAWNZERA™ (donidalorsen) for prophylaxis to ...

24 days ago - Business Wire

Ionis Pharmaceuticals, Inc. (IONS) Q2 2025 Earnings Call Transcript

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) Q2 2025 Earnings Conference Call July 30, 2025 11:30 AM ET Company Participants Brett P. Monia - Founder, CEO & Director D.

6 weeks ago - Seeking Alpha

Ionis Posts Surprise Q2 Profit, Double Revenues On Stronger Sales From Newly Approved Genetic Disease Drug

Ionis Pharmaceuticals Inc. IONS reported second-quarter adjusted earnings of 85 cents on Wednesday. The company reported an adjusted loss of $35 million a year ago.

6 weeks ago - Benzinga

Ionis reports second quarter 2025 financial results and highlights progress on key programs

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) (the “Company”) today reported financial results and provided key updates for the second quarter ended June 30, 2025. “Dur...

6 weeks ago - Business Wire

TRYNGOLZA® (olezarsen) recommended for approval in the EU by CHMP for familial chylomicronemia syndrome (FCS)

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) and Sobi® today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency ...

7 weeks ago - Business Wire

Ionis Pharmaceuticals founder Stanley Crooke on the fight against rare diseases

Stanley Crooke, Ionis Pharmaceuticals founder and n-Lorem founder, joins 'Squawk Box' to discuss the fight against rare diseases, the development of ASO technology, and more.

7 weeks ago - CNBC Television

Phase 3 OASISplus data demonstrating benefit of donidalorsen for HAE patients who switched from other prophylactics published in JACI In Practice

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that positive results from the Phase 3 OASISplus prospective switch study of donidalorsen in patients with...

7 weeks ago - Business Wire