Ionis Pharmaceuticals, Inc. (IONS)
NASDAQ: IONS · Real-Time Price · USD
57.00
+1.58 (2.85%)
Aug 12, 2026, 12:10 PM EDT - Market open
Ionis Pharmaceuticals Financials Overview
Financials in millions USD. Fiscal year is January - December.
Millions USD. Fiscal year is Jan - Dec.
| Fiscal Year | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 |
|---|---|---|---|---|---|---|
| Period Ending | Jun '26 Jun 30, 2026 | Dec '25 Dec 31, 2025 | Dec '24 Dec 31, 2024 | Dec '23 Dec 31, 2023 | Dec '22 Dec 31, 2022 | Dec '21 Dec 31, 2021 |
Revenue Revenue Growth | 874.09 | 943.71 | 705.14 | 787.65 | 587.37 | 810.46 |
Revenue Growth | -7.41% | 33.83% | -10.47% | 34.10% | -27.53% | 11.13% |
Gross Profit Gross Profit Growth | 858.07 | 927.8 | 693.92 | 778.51 | 573.25 | 799.61 |
Operating Income Operating Income Growth | -102.29 | -381.68 | -475.08 | -353.73 | -410.19 | -30.19 |
Net Income Net Income Growth | -114.65 | -381.39 | -453.9 | -366.29 | -269.72 | -28.6 |
Earnings Per Share EPS Growth | -3.46 | -2.38 | -3.04 | -2.56 | -1.90 | -0.20 |
EPS Growth | - | - | - | - | - | - |
| Fiscal Year | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 |
|---|---|---|---|---|---|---|
| Period Ending | Jun '26 Jun 30, 2026 | Dec '25 Dec 31, 2025 | Dec '24 Dec 31, 2024 | Dec '23 Dec 31, 2023 | Dec '22 Dec 31, 2022 | Dec '21 Dec 31, 2021 |
TRYNGOLZA TRYNGOLZA Growth | 113.6 | 107.5 | - | - | - | - |
DAWNZERA DAWNZERA Growth | - | 7.8 | - | - | - | - |
SPINRAZA Royalties SPINRAZA Royalties Growth | 207.2 | 212.3 | 216.1 | 240.4 | 242.3 | 267.8 |
WAINUA Royalties WAINUA Royalties Growth | 56.4 | 49.1 | 20.2 | - | - | - |
Other Royalties Other Royalties Growth | 24.7 | 35 | 34.2 | 34.9 | 30.1 | 55.5 |
Commercial Licensing and Other Royalty Commercial Licensing and Other Royalty Growth | 5.5 | 24.1 | 22.6 | 33.3 | 31 | 19.1 |
Amortization from Upfront Payments Amortization from Upfront Payments Growth | - | - | 131.4 | 125.3 | 68.6 | 77.5 |
Milestone Payments Milestone Payments Growth | - | - | 106.4 | 100.5 | 74 | 88.3 |
R&D License Fees R&D License Fees Growth | - | - | 71.3 | 116.8 | 37 | 291.3 |
Other R&D Services Other R&D Services Growth | - | - | 23.5 | 10 | 27.6 | 11 |
WAINUA Joint Development WAINUA Joint Development Growth | 53.1 | 42.1 | 79.4 | 126.4 | 76.8 | - |
Revenue (Total) Revenue (Total) Growth | 874.09 | 943.71 | 705.14 | 787.65 | 587.37 | 810.46 |
| Fiscal Year | Current | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 |
|---|---|---|---|---|---|---|
| Period Ending | Jun '26 Jun 30, 2026 | Dec '25 Dec 31, 2025 | Dec '24 Dec 31, 2024 | Dec '23 Dec 31, 2023 | Dec '22 Dec 31, 2022 | Dec '21 Dec 31, 2021 |
Cash & Investments Cash & Investments Growth | 2,055 | 2,677 | 2,298 | 2,331 | 1,987 | 2,115 |
Total Debt Total Debt Growth | 1,614 | 2,042 | 1,407 | 1,445 | 1,362 | 1,248 |
Net Cash (Debt) Net Cash Growth | 441.06 | 635.66 | 890.37 | 886.49 | 625.21 | 867.45 |
Net Cash Growth | -49.30% | -28.61% | 0.44% | 41.79% | -27.93% | -8.95% |
Net Cash Per Share Net Cash Per Share Growth | 2.71 | 3.97 | 5.96 | 6.19 | 4.41 | 6.15 |
| Fiscal Year | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 |
|---|---|---|---|---|---|---|
| Period Ending | Jun '26 Jun 30, 2026 | Dec '25 Dec 31, 2025 | Dec '24 Dec 31, 2024 | Dec '23 Dec 31, 2023 | Dec '22 Dec 31, 2022 | Dec '21 Dec 31, 2021 |
Operating Cash Flow Operating Cash Flow Growth | -496.43 | -268.58 | -500.95 | -307.51 | -274.37 | 30.8 |
Capital Expenditures CapEx Growth | -64.41 | -51.44 | -45.28 | -23.81 | -15.72 | -11.96 |
Free Cash Flow Free Cash Flow Growth | -560.84 | -320.03 | -546.23 | -331.32 | -290.09 | 18.84 |
Free Cash Flow Growth | - | - | - | - | - | 2340.93% |
| Fiscal Year | TTM | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 |
|---|---|---|---|---|---|---|
| Period Ending | Jun '26 Jun 30, 2026 | Dec '25 Dec 31, 2025 | Dec '24 Dec 31, 2024 | Dec '23 Dec 31, 2023 | Dec '22 Dec 31, 2022 | Dec '21 Dec 31, 2021 |
Gross Margin | 98.17% | 98.31% | 98.41% | 98.84% | 97.60% | 98.66% |
Operating Margin | -11.70% | -40.45% | -67.37% | -44.91% | -69.84% | -3.72% |
Pretax Margin | -23.53% | -40.22% | -65.25% | -42.40% | -43.92% | -3.60% |
Profit Margin | -13.12% | -40.41% | -64.37% | -46.50% | -45.92% | -3.53% |
FCF Margin | -64.16% | -33.91% | -77.46% | -42.06% | -49.39% | 2.33% |
| Fiscal Year | Current | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 |
|---|---|---|---|---|---|---|
| Period Ending | Aug '26 Aug 12, 2026 | Dec '25 Dec 31, 2025 | Dec '24 Dec 31, 2024 | Dec '23 Dec 31, 2023 | Dec '22 Dec 31, 2022 | Dec '21 Dec 31, 2021 |
Forward PE | - | 216.04 | 216.04 | 216.04 | 216.04 | 216.04 |
P/FCF Ratio | - | - | - | - | - | 228.03 |
PS Ratio | 10.54 | 13.69 | 7.83 | 9.27 | 9.13 | 5.30 |