Ionis Pharmaceuticals, Inc. (IONS)
NASDAQ: IONS · Real-Time Price · USD
61.14
+1.26 (2.10%)
Sep 2, 2026, 2:00 PM EDT - Market open

Ionis Pharmaceuticals Financials Overview

Millions USD. Fiscal year is Jan - Dec.

Revenue & Profits

Fiscal YearTTMFY 2025FY 2024FY 2023FY 2022FY 2021
Period EndingJun '26 Dec '25 Dec '24 Dec '23 Dec '22 Dec '21
Revenue
874.09943.71705.14787.65587.37810.46
Revenue Growth
-7.41%33.83%-10.47%34.10%-27.53%11.13%
Gross Profit
-60.612.18-207.61-121.11-259.9156.16
Operating Income
-594.35-381.68-475.08-353.73-410.19-30.19
Net Income
-565.17-381.39-453.9-366.29-269.72-28.6
Earnings Per Share
-3.46-2.38-3.04-2.56-1.90-0.20
EPS Growth
------

Revenue by Segment

Fiscal YearTTMFY 2025FY 2024FY 2023FY 2022FY 2021
Period EndingJun '26 Dec '25 Dec '24 Dec '23 Dec '22 Dec '21
TRYNGOLZA
113.6107.5----
DAWNZERA
-7.8----
SPINRAZA Royalties
207.2212.3216.1240.4242.3267.8
WAINUA Royalties
56.449.120.2---
Other Commercial
34.13535.834.930.155.5
Other Royalties
22.124.12133.33119.1
Amortization from Upfront Payments
--131.4125.368.677.5
Milestone Payments
--106.4100.57488.3
R&D License Fees
--71.3116.837291.3
Other R&D Services
--23.51027.611
WAINUA Joint Development
53.142.179.4126.476.8-
Revenue (Total)
874.09943.71705.14787.65587.37810.46

Cash & Debt

Fiscal YearCurrentFY 2025FY 2024FY 2023FY 2022FY 2021
Period EndingJun '26 Dec '25 Dec '24 Dec '23 Dec '22 Dec '21
Cash & Investments
2,1022,6802,3032,3381,9972,133
Total Debt
2,1892,6161,9591,9671,3691,251
Net Cash (Debt)
-86.6764.58344.14370.23628.21882.13
Net Cash Growth
--81.23%-7.05%-41.07%-28.78%-8.06%
Net Cash Per Share
-0.530.402.302.594.436.26

Cash Flow & CapEx

Fiscal YearTTMFY 2025FY 2024FY 2023FY 2022FY 2021
Period EndingJun '26 Dec '25 Dec '24 Dec '23 Dec '22 Dec '21
Operating Cash Flow
-496.43-268.58-500.95-307.51-274.3730.8
Capital Expenditures
-64.41-51.44-45.28-23.81-15.72-11.96
Free Cash Flow
-560.84-320.03-546.23-331.32-290.0918.84
Free Cash Flow Growth
-----2340.93%

Margins

Fiscal YearTTMFY 2025FY 2024FY 2023FY 2022FY 2021
Period EndingJun '26 Dec '25 Dec '24 Dec '23 Dec '22 Dec '21
Gross Margin
-6.93%1.29%-29.44%-15.38%-44.25%19.27%
Operating Margin
-68.00%-40.45%-67.37%-44.91%-69.84%-3.72%
Pretax Margin
-64.30%-40.22%-65.25%-42.40%-43.92%-3.60%
Profit Margin
-64.66%-40.41%-64.37%-46.50%-45.92%-3.53%
FCF Margin
-64.16%-33.91%-77.46%-42.06%-49.39%2.33%

Valuation

Fiscal YearCurrentFY 2025FY 2024FY 2023FY 2022FY 2021
Period EndingSep '26 Dec '25 Dec '24 Dec '23 Dec '22 Dec '21
Forward PE
-216.04216.04216.04216.04216.04
P/FCF Ratio
-----228.03
PS Ratio
11.3813.587.839.229.135.30