Karyopharm Therapeutics Inc. (KPTI)

NASDAQ: KPTI · Real-Time Price · USD
9.08
+0.01 (0.11%)
At close: Jun 5, 2026, 4:00 PM EDT
8.81
-0.27 (-2.97%)
After-hours: Jun 5, 2026, 5:28 PM EDT
Market Cap204.77M +404.3%
Revenue (ttm)151.12M +6.3%
Net Income-194.97M
EPS-14.19
Shares Out 22.55M
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume262,513
Open9.04
Previous Close9.07
Day's Range8.85 - 9.23
52-Week Range3.65 - 10.99
Beta0.82
AnalystsBuy
Price Target13.50 (+48.68%)
Earnings DateMay 14, 2026

About KPTI

Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myelom... [Read more]

Industry Biotechnology
Sector Healthcare
IPO Date Nov 6, 2013
Employees 228
Stock Exchange NASDAQ
Ticker Symbol KPTI
Full Company Profile

Financial Performance

In 2025, Karyopharm Therapeutics's revenue was $146.07 million, an increase of 0.57% compared to the previous year's $145.24 million. Losses were -$196.04 million, 156.5% more than in 2024.

Financial Statements

Analyst Summary

According to 7 analysts, the average rating for KPTI stock is "Buy." The 12-month stock price target is $13.5, which is an increase of 48.68% from the latest price.

Price Target
$13.5
(48.68% upside)
Analyst Consensus: Buy
Stock Forecasts

News

Karyopharm Therapeutics Transcript: Jefferies Global Healthcare Conference 2026

Significant progress reported in myelofibrosis and endometrial cancer programs, with phase III SENTRY data showing strong efficacy and survival signals in myelofibrosis and EC-042 readout expected mid-year. Regulatory and commercial strategies are in place, with cash runway into late Q3.

3 days ago - Transcripts

Karyopharm to Participate in Webcast Featuring Endometrial Cancer Key Opinion Leader on June 8, 2026

NEWTON, Mass., June 3, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that it will parti...

4 days ago - PRNewsWire

Karyopharm Therapeutics Transcript: Study result

The phase III SENTRY trial showed selinexor plus ruxolitinib significantly improved spleen volume reduction and provided an early survival benefit in JAK inhibitor-naive myelofibrosis patients, with manageable safety and consistent efficacy across subgroups. SVR35 correlated with survival, and the combination may address real-world dosing challenges.

5 days ago - Transcripts

Karyopharm Therapeutics Press release: Study result

Karyopharm Therapeutics issued a press release on June 2, 2026, disclosing material business information to investors.

5 days ago - Filings

Karyopharm Therapeutics Slides: Study result

Karyopharm Therapeutics has posted slides in relation to its latest quarterly earnings report, which was published on June 2, 2026.

5 days ago - Filings

Karyopharm says Phase 3 SENTRY trial selected for presentation at EHA 2026

Karyopharm (KPTI) Therapeutics announced that its late-breaking abstract was accepted for an oral presentation at the 2026 European Hematology Association Congress, taking place June 11 to 14 in Stock...

5 days ago - TheFly

Karyopharm’s selinexor combination shows efficacy in myelofibrosis

Karyopharm (KPTI) will present the results of its Phase 3 SENTRY trial in a presentation at the 2026 ASCO Annual Meeting. The SENTRY results were also published this morning in…

5 days ago - TheFly

Karyopharm's Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis Selected for Late-Breaking Oral Presentation at EHA 2026

– New Data will Highlight a Post-Hoc Analysis from Phase 1 Portion of SENTRY Trial that Indicates Achievement of SVR35 with Selinexor plus Ruxolitinib May Predict Overall Survival – – Selected by EHA'...

5 days ago - PRNewsWire

Karyopharm to Present Results from Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis in Late-Breaking Oral Presentation at ASCO 2026 with Simultaneous Publication in the Journal of Clinical Oncology

– Selinexor in Combination with Ruxolitinib Demonstrated a Rapid and Near Doubling of Patients Achieving SVR35 at Week 24, versus Ruxolitinib, with a Consistent SVR35 Benefit Observed Across Prespecif...

5 days ago - PRNewsWire

Karyopharm Therapeutics Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

NEWTON, Mass., June 1, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company g...

6 days ago - PRNewsWire

Karyopharm to Host Investor Conference Call Featuring Expert Perspectives on the Phase 3 SENTRY Trial in Myelofibrosis Following 2026 ASCO Presentation

– Event To Feature Dr. John Mascarenhas, Principal Investigator of the Phase 3 SENTRY Trial – – Conference Call Scheduled for Tuesday, June 2, 2026 at 2:00 p.m. ET – NEWTON, Mass.

6 days ago - PRNewsWire

Karyopharm to Participate at the 2026 Jefferies Global Healthcare Conference

NEWTON, Mass., May 28, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company's...

10 days ago - PRNewsWire

Karyopharm Therapeutics Transcript: AGM 2026

The meeting confirmed a quorum and approved all five proposals, including director elections, plan amendments, executive compensation, and auditor ratification. No questions were raised by shareholders, and final voting results will be filed in a Form 8-K.

17 days ago - Transcripts

Karyopharm Therapeutics Transcript: RBC Capital Markets Global Healthcare Conference 2026

Phase III SENTRY data for selinexor plus ruxolitinib in myelofibrosis show rapid, deep responses and a strong early survival signal, with full results to be presented at ASCO. Regulatory and guideline engagement is progressing, and the endometrial cancer program targets a high unmet need subgroup.

19 days ago - Transcripts

Karyopharm Therapeutics Transcript: H.C. Wainwright 4th Annual BioConnect Investor Conference

Selinexor is advancing in myelofibrosis and endometrial cancer, with strong SENTRY trial results showing improved spleen volume reduction and early overall survival benefit. Regulatory flexibility and a robust commercial strategy position the drug for significant market impact.

19 days ago - Transcripts

Karyopharm Therapeutics Slides: Corporate presentation

Karyopharm Therapeutics has posted slides in relation to its latest quarterly earnings report, which was published on May 17, 2026.

21 days ago - Filings

Karyopharm reports Q1 EPS ($1.24), consensus ($1.44)

Reports Q1 revenue $35.1M, consensus $31.4M. “As we move through 2026, Karyopharm (KPTI) is in a pivotal period with meaningful clinical and regulatory milestones ahead,” said CEO Richard Paulson. “Th...

24 days ago - TheFly

Karyopharm sees 2026 revenue $130M-$150M, consensus $137.49M

07:33 EDT Karyopharm (KPTI) sees 2026 revenue $130M-$150M, consensus $137.49M

24 days ago - TheFly

Karyopharm Therapeutics Earnings Call Transcript: Q1 2026

Q1 2026 saw strong revenue growth and key clinical milestones, including positive SENTRY phase III results in myelofibrosis and completed enrollment in the XPORT-EC-042 endometrial cancer trial. Liquidity was strengthened with $50 million in new financing, supporting operations into late Q3 2026.

24 days ago - Transcripts

Karyopharm Therapeutics Earnings release: Q1 2026

Karyopharm Therapeutics released its Q1 2026 earnings on May 14, 2026, summarizing the period's financial results.

24 days ago - Filings

Karyopharm Therapeutics Slides: Q1 2026

Karyopharm Therapeutics has posted slides in relation to its Q1 2026 quarterly earnings report, which was published on May 14, 2026.

24 days ago - Filings

Karyopharm Therapeutics Quarterly report: Q1 2026

Karyopharm Therapeutics has published its Q1 2026 quarterly earnings report on May 14, 2026.

24 days ago - Filings

Karyopharm Reports First Quarter 2026 Financial Results and Completion of Phase 3 Endometrial Cancer Trial Enrollment

– Completed Enrollment of Phase 3 XPORT-EC-042 Trial in Endometrial Cancer; Topline Data Expected Mid-2026 – – Phase 3 SENTRY Results Selected for Late-Breaking Oral Presentation at ASCO on June 2 – –...

24 days ago - PRNewsWire

Karyopharm to Participate at Upcoming Investor Conferences

NEWTON, Mass., May 12, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company's...

26 days ago - PRNewsWire

Karyopharm to Report First Quarter 2026 Financial Results on May 14, 2026

-- Conference Call Scheduled for Thursday, May 14, 2026, at 8:00 a.m. ET -- NEWTON, Mass.

4 weeks ago - PRNewsWire