Company Description
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States.
The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1).
Its lead compounds include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma; in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma; and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
It also develops Selinexor for treating hematological and solid tumor malignancies, including multiple myeloma, endometrial cancer, myelofibrosis, and DLBCL; and ELTANEXOR for treating other myeloproliferative neoplasms and TP53 wild-type solid tumors.
In addition, the company has license agreement with Menarini Group to develop and commercialize selinexor for human oncology indications; license agreement with Antengene Therapeutics Limited to develop and commercialize selinexor, eltanexor, and KPT-9274 for the treatment and/or prevention of human oncology indications, as well as verdinexor for the diagnosis, treatment, and/or prevention of human non-oncology indications; and distribution agreement for the commercialization of XPOVIO with FORUS Therapeutics Inc. Further, the company has a collaboration with Bristol Myers Squibb company to evaluate novel cereblon E3 ligase modulator agent mezigdomide in combination with Selinexor in patients with relapsed or refractory multiple myeloma.
Karyopharm Therapeutics Inc. was incorporated in 2008 and is headquartered in Newton, Massachusetts.
| Country | United States |
| Founded | 2008 |
| IPO Date | Nov 6, 2013 |
| Industry | Biotechnology |
| Sector | Healthcare |
| Employees | 279 |
| CEO | Richard Paulson |
Contact Details
Address: 85 Wells Avenue, 2nd Floor, Suite 210 Newton, Massachusetts 02459-3298 United States | |
| Phone | 617 658 0600 |
| Website | karyopharm.com |
Stock Details
| Ticker Symbol | KPTI |
| Exchange | NASDAQ |
| Stock Type | Common Stock |
| Fiscal Year | January - December |
| Reporting Currency | USD |
| CIK Code | 0001503802 |
| CUSIP Number | 48576U205 |
| ISIN Number | US48576U2050 |
| Employer ID | 26-3931704 |
| SIC Code | 2834 |
Key Executives
| Name | Position |
|---|---|
| Richard A. Paulson M.B.A. | President, Chief Executive Officer and Director |
| Dr. Sharon Shacham M.B.A., Ph.D. | Co-Founder and Chairman of Scientific Advisory Board |
| Kristin Abate | Vice President, Chief Accounting Officer and Assistant Treasurer |
| Brendan Twohig Strong | Senior Vice President of Investor Relations |
| Michael J. Mano J.D. | Executive Vice President, Chief Legal Officer and Secretary |
| James Accumanno J.D. | Chief Compliance Officer |
| Lisa DiPaolo | Executive Vice President and Chief Human Resource Officer |
| Dr. Amama Sadiq M.D., M.P.H. | Senior Vice President of Global Medical and Scientific Affairs |
Latest SEC Filings
| Date | Type | Title |
|---|---|---|
| Feb 19, 2026 | 8-K | Current Report |
| Feb 17, 2026 | SCHEDULE 13G/A | Filing |
| Feb 13, 2026 | 10-K | Annual Report |
| Feb 12, 2026 | SCHEDULE 13G/A | Filing |
| Feb 12, 2026 | 8-K | Current Report |
| Feb 10, 2026 | SCHEDULE 13G | Filing |
| Jan 29, 2026 | SCHEDULE 13G/A | Filing |
| Jan 12, 2026 | 8-K | Current Report |
| Jan 9, 2026 | DEF 14A | Other definitive proxy statements |
| Dec 30, 2025 | PRE 14A | Other preliminary proxy statements |