Prime Medicine, Inc. (PRME)

Prime Medicine Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Apr 7, 2026	Dec 31, 2025	Dec 31, 2024	Dec 31, 2023	Dec 31, 2022	Dec 31, 2021
Market Cap	604	626	383	863	1,806	-
Market Cap Growth	142.56%	63.55%	-55.61%	-52.23%	-	-
Enterprise Value	542.59	556.99	229.73	745.45	1,529	0
Last Close Price	3.41	3.47	2.92	8.86	18.58	-
PE Ratio	-	-2.57	-1.77	-4.06	-4.43	-
PS Ratio	130.36	135.23	128.39	-	-	-
PB Ratio	4.99	5.18	2.50	6.48	5.71	-
P/TBV Ratio	4.22	4.27	2.26	6.06	1.99	-
P/FCF Ratio	-	-3.75	-2.94	-4.95	-12.21	-
P/OCF Ratio	-	-3.85	-3.12	-5.22	-13.70	-
EV/Sales Ratio	117.14	120.25	77.01	-	-	-
EV/EBITDA Ratio	-	-2.77	-1.17	-3.72	-13.38	-
EV/EBIT Ratio	-	-2.67	-1.13	-3.64	-13.12	-
EV/FCF Ratio	-	-3.33	-1.76	-4.28	-10.34	-
Debt / Equity Ratio	0.90	0.90	0.24	0.03	0.05	0.01
Debt / EBITDA Ratio	-0.58	-0.58	-0.21	-0.07	-0.25	-0.12
Debt / FCF Ratio	-0.70	-0.70	-0.31	-0.08	-0.19	-0.27
Net Debt / Equity Ratio	-0.51	-0.51	-0.98	-0.81	-0.84	1.66
Net Debt / EBITDA Ratio	0.31	0.31	0.76	0.54	2.32	3.09
Net Debt / FCF Ratio	0.37	0.37	1.15	0.62	1.79	6.78
Asset Turnover	0.01	0.01	0.01	0	0	0
Quick Ratio	4.74	4.74	5.02	2.16	11.00	4.65
Current Ratio	4.84	4.84	5.58	2.53	11.10	4.67
Return on Equity (ROE)	-146.81%	-146.81%	-136.88%	-88.44%	-44.52%	-121.13%
Return on Assets (ROA)	-65.08%	-65.08%	-82.41%	-74.01%	-35.47%	-47.23%
Return on Invested Capital (ROIC)	-186.55%	-186.55%	-342.15%	-456.18%	-522.18%	2803.81%
Return on Capital Employed (ROCE)	-73.77%	-73.77%	-102.00%	-86.96%	-40.36%	-60.51%
Earnings Yield	-33.31%	-38.90%	-56.51%	-24.60%	-22.55%	-
FCF Yield	-27.67%	-26.68%	-33.98%	-20.18%	-8.19%	-
Buyback Yield / Dilution	-25.43%	-25.43%	-30.37%	-168.42%	-161.23%	-391.47%
Total Shareholder Return	-25.43%	-25.43%	-30.37%	-168.42%	-161.23%	-391.47%

Updated Dec 31, 2025. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q