Protagonist Therapeutics Ratios and Metrics

Market cap in millions USD. Fiscal year is January - December.

Millions USD. Fiscal year is Jan - Dec.

Fiscal Year	Current	FY 2025	FY 2024	FY 2023	FY 2022	FY 2021
Period Ending	Apr '26 Apr 9, 2026	Dec '25 Dec 31, 2025	Dec '24 Dec 31, 2024	Dec '23 Dec 31, 2023	Dec '22 Dec 31, 2022	Dec '21 Dec 31, 2021
Market Cap	6,642	5,466	2,356	1,323	538	1,636
Market Cap Growth	105.97%	131.99%	78.04%	145.83%	-67.10%	85.52%
Enterprise Value	6,006	4,906	1,947	981.64	302.08	1,313
Last Close Price	104.09	87.34	38.60	22.93	10.91	34.20
PE Ratio	-	-42.60	9.13	-16.50	-4.20	-12.62
Forward PE	34.74	59.76	-	-	-	-
PS Ratio	144.33	118.78	5.42	22.05	20.25	59.80
PB Ratio	10.60	8.89	3.49	3.93	2.50	5.45
P/TBV Ratio	10.76	9.03	3.72	3.87	2.48	5.28
P/FCF Ratio	118.43	97.46	12.89	-18.68	-4.94	-15.01
P/OCF Ratio	115.16	94.77	12.79	-18.84	-4.98	-15.17
EV/Sales Ratio	130.52	106.62	4.48	16.36	11.36	47.99
EV/EBITDA Ratio	-	-31.28	7.68	-10.59	-2.32	-10.50
EV/EBIT Ratio	-	-31.03	7.70	-10.48	-2.30	-10.43
EV/FCF Ratio	107.09	87.48	10.65	-13.86	-2.77	-12.05
Debt / Equity Ratio	0.01	0.01	0.02	0	0.01	0.01
Debt / EBITDA Ratio	-0.07	-0.07	0.04	-0.01	-0.03	-0.05
Debt / FCF Ratio	0.18	0.18	0.06	-0.02	-0.03	-0.05
Net Debt / Equity Ratio	-0.91	-0.91	-0.60	-1.01	-1.08	-1.07
Net Debt / EBITDA Ratio	3.55	3.55	-1.61	3.67	1.79	2.57
Net Debt / FCF Ratio	-9.93	-9.93	-2.23	4.81	2.15	2.95
Asset Turnover	0.07	0.07	0.79	0.20	0.09	0.08
Quick Ratio	12.49	12.49	12.32	16.53	7.61	7.53
Current Ratio	12.71	12.71	12.48	16.71	7.80	7.74
Return on Equity (ROE)	-20.18%	-20.18%	54.39%	-28.59%	-49.41%	-43.32%
Return on Assets (ROA)	-22.53%	-22.53%	45.17%	-30.91%	-44.11%	-37.44%
Return on Invested Capital (ROIC)	-86.56%	-86.56%	167.86%	855.66%	700.45%	1004.11%
Return on Capital Employed (ROCE)	-23.96%	-23.96%	48.91%	-33.84%	-50.49%	-42.81%
Earnings Yield	-1.96%	-2.35%	10.96%	-6.06%	-23.83%	-7.92%
FCF Yield	0.84%	1.03%	7.76%	-5.35%	-20.24%	-6.66%
Buyback Yield / Dilution	2.31%	2.31%	-14.65%	-15.74%	-5.87%	-34.67%
Total Shareholder Return	2.31%	2.31%	-14.65%	-15.74%	-5.87%	-34.67%

Updated Dec 31, 2025. Data Source: Fiscal.ai. Standard template. Financial Sources.

SEC Filings: 10-K · 10-Q