ALPS Medical Breakthroughs ETF (SBIO)

SBIO Holdings List

As of May 16, 2025

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No.	Symbol	Name	% Weight	Shares
1	VRNA	Verona Pharma plc	5.28%	59,430
2	ALKS	Alkermes plc	4.47%	114,014
3	AXSM	Axsome Therapeutics, Inc.	4.26%	31,800
4	RYTM	Rhythm Pharmaceuticals, Inc.	3.41%	45,601
5	ACAD	ACADIA Pharmaceuticals Inc.	3.26%	117,453
6	RNA	Avidity Biosciences, Inc.	3.26%	86,140
7	PTCT	PTC Therapeutics, Inc.	3.24%	56,568
8	ZLAB	Zai Lab Limited	2.90%	75,268
9	AKRO	Akero Therapeutics, Inc.	2.78%	57,289
10	MRUS	Merus N.V.	2.61%	50,330
11	CRNX	Crinetics Pharmaceuticals, Inc.	2.58%	66,329
12	PTGX	Protagonist Therapeutics, Inc.	2.52%	45,391
13	MLTX	MoonLake Immunotherapeutics	2.18%	46,479
14	XENE	Xenon Pharmaceuticals Inc.	2.06%	54,568
15	MIRM	Mirum Pharmaceuticals, Inc.	1.96%	34,998
16	BCRX	BioCryst Pharmaceuticals, Inc.	1.92%	150,317
17	VCEL	Vericel Corporation	1.89%	35,691
18	DNLI	Denali Therapeutics Inc.	1.88%	109,433
19	NAMS	NewAmsterdam Pharma Company N.V.	1.80%	76,603
20	CGON	CG Oncology, Inc.	1.76%	55,615
21	FOLD	Amicus Therapeutics, Inc.	1.76%	218,976
22	APGE	Apogee Therapeutics, Inc.	1.66%	32,718
23	GLPG	Galapagos NV	1.65%	47,644
24	AGIO	Agios Pharmaceuticals, Inc.	1.52%	41,683
25	IRON	Disc Medicine, Inc.	1.51%	25,135
26	TARS	Tarsus Pharmaceuticals, Inc.	1.50%	27,550
27	LQDA	Liquidia Corporation	1.45%	61,564
28	IDYA	IDEAYA Biosciences, Inc.	1.34%	60,466
29	IMCR	Immunocore Holdings plc	1.34%	35,410
30	GPCR	Structure Therapeutics Inc.	1.34%	42,628
31	CLDX	Celldex Therapeutics, Inc.	1.25%	49,066
32	EWTX	Edgewise Therapeutics, Inc.	1.24%	67,091
33	VERA	Vera Therapeutics, Inc.	1.21%	45,701
34	MNKD	MannKind Corporation	1.18%	216,928
35	AUPH	Aurinia Pharmaceuticals Inc.	0.99%	97,098
36	VRDN	Viridian Therapeutics, Inc.	0.97%	60,406
37	NVAX	Novavax, Inc.	0.94%	112,239
38	RCUS	Arcus Biosciences, Inc.	0.81%	75,763
39	NTLA	Intellia Therapeutics, Inc.	0.81%	75,980
40	PHVS	Pharvaris N.V.	0.74%	35,995
41	NUVB	Nuvation Bio Inc.	0.68%	240,852
42	PRAX	Praxis Precision Medicines, Inc.	0.68%	14,678
43	MLYS	Mineralys Therapeutics, Inc.	0.65%	34,060
44	IMNM	Immunome, Inc.	0.62%	61,454
45	AVXL	Anavex Life Sciences Corp.	0.61%	59,170
46	AVBP	ArriVent BioPharma, Inc.	0.60%	24,729
47	VIR	Vir Biotechnology, Inc.	0.58%	101,036
48	ANAB	AnaptysBio, Inc.	0.57%	22,724
49	DNTH	Dianthus Therapeutics, Inc.	0.57%	23,272
50	FLGT	Fulgent Genetics, Inc.	0.57%	22,356
51	DAWN	Day One Biopharmaceuticals, Inc.	0.56%	72,065
52	REPL	Replimune Group, Inc.	0.54%	55,346
53	KROS	Keros Therapeutics, Inc.	0.51%	29,216
54	XNCR	Xencor, Inc.	0.51%	50,561
55	STOK	Stoke Therapeutics, Inc.	0.48%	39,196
56	SVRA	Savara Inc.	0.44%	113,734
57	UPB	Upstream Bio, Inc.	0.41%	38,397
58	TBPH	Theravance Biopharma, Inc.	0.41%	35,451
59	AMLX	Amylyx Pharmaceuticals, Inc.	0.40%	66,419
60	CAPR	Capricor Therapeutics, Inc.	0.38%	32,650
61	CELC	Celcuity Inc.	0.37%	28,296
62	ZBIO	Zenas BioPharma, Inc.	0.36%	27,642
63	MBX	MBX Biosciences, Inc.	0.36%	25,580
64	TRML	Tourmaline Bio, Inc.	0.35%	17,195
65	PRTA	Prothena Corporation plc	0.33%	37,294
66	ERAS	Erasca, Inc.	0.33%	206,609
67	AUTL	Autolus Therapeutics plc	0.33%	196,227
68	CMPS	COMPASS Pathways plc	0.32%	65,077
69	RAPP	Rapport Therapeutics, Inc.	0.32%	25,672
70	RIGL	Rigel Pharmaceuticals, Inc.	0.32%	12,872
71	URGN	UroGen Pharma Ltd.	0.29%	32,190
72	OLMA	Olema Pharmaceuticals, Inc.	0.29%	49,604
73	ARCT	Arcturus Therapeutics Holdings Inc.	0.28%	19,601
74	ITOS	iTeos Therapeutics, Inc.	0.27%	28,148
75	AURA	Aura Biosciences, Inc.	0.27%	36,512
76	RNAC	Cartesian Therapeutics, Inc.	0.24%	19,054
77	VNDA	Vanda Pharmaceuticals Inc.	0.21%	41,261
78	ATXS	Astria Therapeutics, Inc.	0.21%	42,686
79	SLRN	Acelyrin, Inc.	0.21%	73,354
80	ANNX	Annexon, Inc.	0.20%	81,186
81	RZLT	Rezolute, Inc.	0.19%	42,326
82	CRGX	CARGO Therapeutics, Inc.	0.17%	32,580
83	YMAB	Y-mAbs Therapeutics, Inc.	0.17%	32,723
84	ELDN	Eledon Pharmaceuticals, Inc.	0.16%	43,658
85	FDMT	4D Molecular Therapeutics, Inc.	0.14%	32,239
86	ACRS	Aclaris Therapeutics, Inc.	0.13%	77,408
87	ALDX	Aldeyra Therapeutics, Inc.	0.12%	43,039
88	LRMR	Larimar Therapeutics, Inc.	0.12%	46,638
89	ENTA	Enanta Pharmaceuticals, Inc.	0.11%	15,973
90	ALEC	Alector, Inc.	0.11%	73,627
91	NMRA	Neumora Therapeutics, Inc.	0.10%	112,377
92	MGNX	MacroGenics, Inc.	0.09%	47,798
93	PROK	ProKidney Corp.	0.09%	93,522
94	KYTX	Kyverna Therapeutics, Inc.	0.09%	31,580
95	ZNTL	Zentalis Pharmaceuticals, Inc.	0.08%	54,075
96	IRWD	Ironwood Pharmaceuticals, Inc.	0.08%	114,822
97	PLRX	Pliant Therapeutics, Inc.	0.08%	44,467
98	STRO	Sutro Biopharma, Inc.	0.07%	60,163
99	n/a	State Street Instl Trs Pls MMkt Premier	0.05%	41,312
100	LON: AZN	AstraZeneca PLC	0.00%	36,586
101	n/a	Azn Ln - Cvr	0.00%	29,054
102	n/a	Omniab	0.00%	3,653
103	n/a	Omniab	0.00%	3,653
104	n/a	Radius Health Cvr	0.00%	28,640
105	n/a	Chinook Therapeutics, Inc.	0.00%	20,700
106	n/a	Cash	-0.01%	n/a

As of May 16, 2025

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