SPDR S&P BIOTECH ETF (XBI)

XBI Holdings List

As of Apr 16, 2025

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No.	Symbol	Name	% Weight	Shares
1	NTRA	Natera, Inc.	2.91%	908,351
2	VRTX	Vertex Pharmaceuticals Incorporated	2.74%	264,924
3	ALNY	Alnylam Pharmaceuticals, Inc.	2.66%	541,447
4	INSM	Insmed Incorporated	2.65%	1,772,790
5	UTHR	United Therapeutics Corporation	2.60%	427,459
6	GILD	Gilead Sciences, Inc.	2.57%	1,151,448
7	NBIX	Neurocrine Biosciences, Inc.	2.57%	1,203,450
8	EXAS	Exact Sciences Corporation	2.55%	2,831,898
9	AMGN	Amgen Inc.	2.53%	420,043
10	INCY	Incyte Corporation	2.38%	1,937,902
11	MDGL	Madrigal Pharmaceuticals, Inc.	2.38%	363,156
12	BIIB	Biogen Inc.	2.30%	936,314
13	ABBV	AbbVie Inc.	2.26%	618,921
14	REGN	Regeneron Pharmaceuticals, Inc.	2.23%	190,360
15	EXEL	Exelixis, Inc.	2.15%	2,795,236
16	BPMC	Blueprint Medicines Corporation	2.11%	1,206,133
17	MRNA	Moderna, Inc.	2.01%	3,749,137
18	BMRN	BioMarin Pharmaceutical Inc.	1.99%	1,590,196
19	TGTX	TG Therapeutics, Inc.	1.80%	2,208,490
20	BBIO	BridgeBio Pharma, Inc.	1.77%	2,454,572
21	HALO	Halozyme Therapeutics, Inc.	1.69%	1,349,292
22	RVMD	Revolution Medicines, Inc.	1.53%	1,984,507
23	CYTK	Cytokinetics, Incorporated	1.49%	1,791,047
24	CRSP	CRISPR Therapeutics AG	1.43%	1,773,342
25	SMMT	Summit Therapeutics Inc.	1.37%	2,789,887
26	SRPT	Sarepta Therapeutics, Inc.	1.36%	1,183,593
27	IONS	Ionis Pharmaceuticals, Inc.	1.29%	2,140,286
28	ROIV	Roivant Sciences Ltd.	1.28%	6,020,178
29	ADMA	ADMA Biologics, Inc.	1.23%	2,712,151
30	VKTX	Viking Therapeutics, Inc.	1.12%	2,231,803
31	SWTX	SpringWorks Therapeutics, Inc.	1.08%	1,347,056
32	ALKS	Alkermes plc	1.06%	1,827,070
33	KRYS	Krystal Biotech, Inc.	1.03%	293,476
34	PCVX	Vaxcyte, Inc.	0.99%	1,600,691
35	TWST	Twist Bioscience Corporation	0.99%	1,205,632
36	RNA	Avidity Biosciences, Inc.	0.96%	1,758,671
37	NUVL	Nuvalent, Inc.	0.93%	621,680
38	ACLX	Arcellx, Inc.	0.92%	710,478
39	RYTM	Rhythm Pharmaceuticals, Inc.	0.92%	701,095
40	VCYT	Veracyte, Inc.	0.90%	1,347,567
41	SRRK	Scholar Rock Holding Corporation	0.86%	1,356,080
42	APLS	Apellis Pharmaceuticals, Inc.	0.85%	2,187,527
43	SLNO	Soleno Therapeutics, Inc.	0.84%	562,936
44	RXRX	Recursion Pharmaceuticals, Inc.	0.82%	7,267,128
45	RARE	Ultragenyx Pharmaceutical Inc.	0.80%	1,078,475
46	CRNX	Crinetics Pharmaceuticals, Inc.	0.78%	1,240,174
47	ACAD	ACADIA Pharmaceuticals Inc.	0.75%	2,432,317
48	AKRO	Akero Therapeutics, Inc.	0.72%	899,590
49	PTCT	PTC Therapeutics, Inc.	0.69%	693,038
50	AGIO	Agios Pharmaceuticals, Inc.	0.66%	1,137,009

As of Apr 16, 2025

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