SPDR S&P BIOTECH ETF (XBI)

XBI Holdings Information

XBI is an equity ETF with a total of 129 individual holdings. The top holdings are Alnylam Pharmaceuticals stock at 3.55%, Insmed at 3.31%, United Therapeutics at 3.21%, Halozyme Therapeutics at 3.11%, and Incyte at 2.74%.

• Total Holdings: 129
• Top 10 Percentage: 28.20%
• Asset Class: Equity
• ETF Category: Health
• Assets: 5.48B
• PE Ratio: n/a

Top 25 Holdings

As of Sep 9, 2025

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No.	Symbol	Name	% Weight	Shares
1	ALNY	Alnylam Pharmaceuticals, Inc.	3.55%	403,745
2	INSM	Insmed Incorporated	3.31%	1,230,381
3	UTHR	United Therapeutics Corporation	3.21%	435,981
4	HALO	Halozyme Therapeutics, Inc.	3.11%	2,238,668
5	INCY	Incyte Corporation	2.74%	1,751,032
6	NBIX	Neurocrine Biosciences, Inc.	2.55%	970,844
7	MDGL	Madrigal Pharmaceuticals, Inc.	2.52%	307,768
8	ABBV	AbbVie Inc.	2.42%	629,527
9	BBIO	BridgeBio Pharma, Inc.	2.41%	2,467,844
10	BIIB	Biogen Inc.	2.37%	905,965
11	REGN	Regeneron Pharmaceuticals, Inc.	2.36%	232,447
12	GILD	Gilead Sciences, Inc.	2.33%	1,103,054
13	NTRA	Natera, Inc.	2.33%	722,949
14	EXAS	Exact Sciences Corporation	2.19%	2,166,008
15	BMRN	BioMarin Pharmaceutical Inc.	2.14%	2,109,046
16	IONS	Ionis Pharmaceuticals, Inc.	2.13%	1,815,793
17	AMGN	Amgen Inc.	2.11%	413,056
18	EXEL	Exelixis, Inc.	2.03%	2,909,864
19	CYTK	Cytokinetics, Incorporated	2.00%	2,125,876
20	MRNA	Moderna, Inc.	1.94%	4,344,228
21	VRTX	Vertex Pharmaceuticals Incorporated	1.93%	266,517
22	ROIV	Roivant Sciences Ltd.	1.82%	7,410,782
23	RVMD	Revolution Medicines, Inc.	1.43%	1,918,756
24	CRSP	CRISPR Therapeutics AG	1.41%	1,434,090
25	TGTX	TG Therapeutics, Inc.	1.38%	2,360,621

Showing 25 of 129 holdings

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