State Street SPDR S&P Biotech ETF (XBI)

NYSEARCA: XBI · Real-Time Price · USD

155.05

-1.85 (-1.18%)

At close: Nov 10, 2026, 4:00 PM EST

155.19

+0.14 (0.09%)

After-hours: Nov 10, 2026, 5:32 PM EST

XBI Holdings Information

XBI is an equity ETF with a total of 167 individual holdings. The top holdings are Moderna stock at 2.86%, Spyre Therapeutics at 1.81%, Exelixis at 1.78%, Biogen at 1.75%, and Amgen at 1.72%.

Total Holdings

167

Top 10 Percentage

18.26%

Asset Class

Equity

ETF Category

Health

Assets

10.06B

PE Ratio

20.29

Breakdown by Sector

Top 25 Holdings

Updated Nov 9, 2026

No.	Symbol	Name	Weight% Weight	Shares	Stock Price	% Change
1	MRNA	Moderna, Inc.	2.86%	1,131,454	250.56	-6.86%
2	SYRE	Spyre Therapeutics, Inc.	1.81%	1,764,946	104.46	-4.17%
3	EXEL	Exelixis, Inc.	1.78%	2,630,409	70.57	-1.63%
4	BIIB	Biogen Inc.	1.75%	728,105	253.32	-0.61%
5	AMGN	Amgen Inc.	1.72%	392,175	465.22	-
6	ABBV	AbbVie Inc.	1.69%	611,560	293.91	0.21%
7	GILD	Gilead Sciences, Inc.	1.68%	1,053,470	170.91	0.94%
8	TGTX	TG Therapeutics, Inc.	1.67%	2,807,552	64.25	1.37%
9	UTHR	United Therapeutics Corporation	1.66%	302,774	588.51	1.04%
10	ORKA	Oruka Therapeutics, Inc.	1.65%	1,676,857	109.87	5.08%
11	REGN	Regeneron Pharmaceuticals, Inc.	1.64%	189,964	916.03	-0.43%
12	NBIX	Neurocrine Biosciences, Inc.	1.57%	988,985	169.11	0.15%
13	TWST	Twist Bioscience Corporation	1.56%	1,222,381	132.19	-2.33%
14	VRTX	Vertex Pharmaceuticals Incorporated	1.53%	294,466	547.70	-0.58%
15	BBIO	BridgeBio Pharma, Inc.	1.48%	2,016,729	78.61	0.87%
16	ALKS	Alkermes plc	1.47%	3,379,564	46.50	0.71%
17	KYMR	Kymera Therapeutics, Inc.	1.45%	1,111,109	136.60	-1.63%
18	ROIV	Roivant Sciences Ltd.	1.40%	3,669,817	41.17	1.23%
19	NTRA	Natera, Inc.	1.40%	464,520	312.08	-2.59%
20	INCY	Incyte Corporation	1.40%	1,217,563	120.39	-1.23%
21	PRAX	Praxis Precision Medicines, Inc.	1.39%	444,349	337.89	1.48%
22	RVMD	Revolution Medicines, Inc.	1.39%	738,872	193.10	-3.52%
23	PTCT	PTC Therapeutics, Inc.	1.39%	2,270,753	64.11	-1.41%
24	HALO	Halozyme Therapeutics, Inc.	1.38%	1,428,699	103.03	0.11%
25	PTGX	Protagonist Therapeutics, Inc.	1.35%	1,052,352	136.28	0.28%

Showing 25 of 167 holdings

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