Welcome to the 2026 annual meeting of stockholders of Spyre Therapeutics, Inc. The chair of today's meeting is Dr. Cameron Turtle, CEO and director of Spyre Therapeutics, Inc. At this time, all participants will be in a listen-only mode. I will now turn the call over to the chair of the meeting, Dr. Turtle. You may begin, sir.
Morning, everyone. It's my pleasure to welcome you to the 2026 annual meeting of stockholders of Spyre Therapeutics. It's now 12:01 P.M. Eastern Time, and I'd like to formally call the meeting to order. The polls are now open. Please note that this meeting is being recorded. However, the use of any recording devices by participants is prohibited. Today's meeting is being held virtually. Please note that while we welcome questions from our stockholders, questions should be limited to the business items under consideration today. If you would like to submit a question, you may do so by following the instructions on the meeting portal. As indicated in the rules of conduct, stockholders may vote or submit questions during the meeting by entering the 16-digit control number they received with their proxy materials.
Please remember that you may vote your shares online at any time during this meeting prior to the closing of the polls. The polls opened at the beginning of the meeting, and we will close the polls after the presentation and discussion of today's proposals. Now, I would like to introduce the other members of our board of directors who are joining us today. Jeffrey Albers, Tomas Kiselak, Sandra Milligan, Mark McKenna, and Laurie Stelzer. I would also like to introduce the other members of the management team who are joining us today.
Scott Burrows, Chief Financial Officer, Heidy King-Jones, Chief Legal Officer and Corporate Secretary, and Sheldon Sloan, Chief Medical Officer. Representatives of our independent registered public accounting firm, KPMG, and our outside legal counsel, Ropes & Gray, are also joining us today. Ms. King-Jones will act as secretary of the meeting.
Natalie Hairston of American Election Services has been appointed to serve as our inspector of elections. This meeting will be conducted in accordance with the agenda and rules of conduct that have been provided on the virtual meeting website. To maintain an informative, orderly, and constructive meeting, we ask that participants abide by these rules.
The company's agents have certified that the proxy materials were first made available to stockholders of record beginning on April 10, 2026. We will file copies of the notice and related affidavit of mailing with the minutes of this meeting. I've received an oath signed by the inspector of elections stating that they will faithfully execute with strict impartiality their duties, which will be filed with the minutes of this meeting. Our board of directors set April 2nd, 2026, as the record date for this meeting.
Only stockholders of record on that date are entitled to vote at this meeting. As of that date, there were 78,784,358 shares of the company's common stock issued and outstanding. I have been informed by the inspector of election that at least a majority of those shares are represented either virtually or by proxy for the meeting, and therefore, we have a quorum. Accordingly, I declare that this meeting is properly constituted and convened. We will now address the business items before the stockholders as set forth in the proxy statement. Following a discussion and vote on the business items, we will close the polls and conclude the formal business of the meeting. Will the secretary now please present the business items to be voted on at this meeting?
The first matter to be considered is to elect the following Class I directors to our board to serve until the 2029 annual meeting of stockholders and until their successors are duly elected and qualified. Mark McKenna, Dr. Cameron Turtle, and Laurie Seltzer. The second matter to be considered is to approve on a non-binding advisory basis the compensation of the company's named executive officers. The third matter to be considered is to ratify the appointment of KPMG LLP as the company's independent auditor. The fourth matter to be considered is to approve the amended and restated 2016 employee stock purchase plan.
Thank you, Heidy. As a reminder, the board of directors has recommended that you vote for each director nominee in Proposal one and for Proposals two, three, and four. Are there any stockholder questions or comments specifically related to these proposals? Seeing no questions on the proposals, we will close the polls shortly. If you wish to vote or to change your previously submitted vote, you should do so by following the instructions on the web portal now to ensure that your votes are counted. If you have previously voted, it is not necessary for you to vote today unless you wish to change your vote. We'll now pause for a brief period to allow stockholders to vote.
The time is now 12:06 P.M. Eastern Time, and the polls are closed for voting. Will the secretary please report the preliminary vote count?
Based on a preliminary tally of received votes and proxies by the inspector of elections, I declare that we have received votes and proxies sufficient to elect each of the director nominees and to approve each of the other proposals voted on today. The final vote count, including the validity of the votes received at this meeting, will be tabulated and filed with the Securities and Exchange Commission in a Form 8-K within four business days.
Thanks, Heidy. This concludes the business portion of the meeting. On behalf of the entire company, I want to thank you for attending and exercising your voting rights as stockholders and for your continued support of Spyre. There being no further business, the meeting is now adjourned.
The conference has now concluded. Thank you for attending today's presentation. You may now disconnect.