Spyre Therapeutics, Inc. (SYRE)
NASDAQ: SYRE · Real-Time Price · USD
63.27
+11.98 (23.36%)
At close: Apr 13, 2026, 4:00 PM EDT
62.29
-0.98 (-1.55%)
After-hours: Apr 13, 2026, 7:57 PM EDT

Spyre Therapeutics Statistics

Total Valuation

SYRE has a market cap or net worth of $4.97 billion. The enterprise value is $4.21 billion.

Market Cap4.97B
Enterprise Value 4.21B

Important Dates

The next estimated earnings date is Thursday, May 7, 2026, after market close.

Earnings Date May 7, 2026
Ex-Dividend Date n/a

Share Statistics

SYRE has 78.54 million shares outstanding. The number of shares has increased by 36.21% in one year.

Current Share Class 78.54M
Shares Outstanding 78.54M
Shares Change (YoY) +36.21%
Shares Change (QoQ) +24.29%
Owned by Insiders (%) 6.64%
Owned by Institutions (%) 93.52%
Float 64.39M

Valuation Ratios

PE Ratio n/a
Forward PE n/a
PS Ratio n/a
Forward PS n/a
PB Ratio 8.84
P/TBV Ratio 8.88
P/FCF Ratio n/a
P/OCF Ratio n/a
PEG Ratio n/a
Financial Ratio History

Enterprise Valuation

EV / Earnings n/a
EV / Sales n/a
EV / EBITDA n/a
EV / EBIT n/a
EV / FCF n/a

Financial Position

The company has a current ratio of 13.25

Current Ratio 13.25
Quick Ratio 12.94
Debt / Equity n/a
Debt / EBITDA n/a
Debt / FCF n/a
Interest Coverage n/a

Financial Efficiency

Return on equity (ROE) is -25.17% and return on invested capital (ROIC) is -22.26%.

Return on Equity (ROE) -25.17%
Return on Assets (ROA) -19.80%
Return on Invested Capital (ROIC) -22.26%
Return on Capital Employed (ROCE) -30.53%
Weighted Average Cost of Capital (WACC) 20.43%
Revenue Per Employee n/a
Profits Per Employee -$1.24M
Employee Count102
Asset Turnover n/a
Inventory Turnover n/a

Taxes

Income Tax -15,000
Effective Tax Rate n/a

Stock Price Statistics

The stock price has increased by +417.76% in the last 52 weeks. The beta is 2.94, so SYRE's price volatility has been higher than the market average.

Beta (5Y) 2.94
52-Week Price Change +417.76%
50-Day Moving Average 42.04
200-Day Moving Average 27.38
Relative Strength Index (RSI) 79.96
Average Volume (20 Days) 1,043,424

Short Selling Information

The latest short interest is 10.44 million, so 13.29% of the outstanding shares have been sold short.

Short Interest 10.44M
Short Previous Month 10.00M
Short % of Shares Out 13.29%
Short % of Float 16.21%
Short Ratio (days to cover) 12.10

Income Statement

Revenue n/a
Gross Profit -171.65M
Operating Income -219.56M
Pretax Income -155.22M
Net Income -126.54M
EBITDA n/a
EBIT -219.56M
Earnings Per Share (EPS) -$1.98
Full Income Statement

Balance Sheet

The company has $756.53 million in cash and n/a in debt, with a net cash position of $756.53 million or $9.63 per share.

Cash & Cash Equivalents 756.53M
Total Debt n/a
Net Cash 756.53M
Net Cash Per Share $9.63
Equity (Book Value) 715.24M
Book Value Per Share 7.15
Working Capital 719.10M
Full Balance Sheet

Cash Flow

Operating Cash Flow -169.25M
Capital Expenditures n/a
Depreciation & Amortization n/a
Net Borrowing n/a
Free Cash Flow -169.25M
FCF Per Share -$2.15
Full Cash Flow Statement

Margins

Gross Margin n/a
Operating Margin n/a
Pretax Margin n/a
Profit Margin n/a
EBITDA Margin n/a
EBIT Margin n/a
FCF Margin n/a

Dividends & Yields

SYRE does not appear to pay any dividends at this time.

Dividend Per Share n/a
Dividend Yield n/a
Dividend Growth (YoY) n/a
Years of Dividend Growth n/a
Payout Ratio n/a
Buyback Yield -36.21%
Shareholder Yield -36.21%
Earnings Yield -2.55%
FCF Yield -3.41%

Analyst Forecast

The average price target for SYRE is $72.78, which is 15.03% higher than the current price. The consensus rating is "Strong Buy".

Price Target $72.78
Price Target Difference 15.03%
Analyst Consensus Strong Buy
Analyst Count 9
Revenue Growth Forecast (5Y) n/a
EPS Growth Forecast (5Y) 12.69%
Stock Forecasts

Fair Value

There are several formulas that can be used to estimate the intrinsic value of a stock.

Lynch Fair Value n/a
Lynch Upside n/a
Graham Number n/a
Graham Upside n/a

Stock Splits

The last stock split was on September 8, 2023. It was a reverse split with a ratio of 1:25.

Last Split Date Sep 8, 2023
Split Type Reverse
Split Ratio 1:25

Scores

Altman Z-Score n/a
Piotroski F-Score 1