Spyre Therapeutics, Inc. (SYRE)
NASDAQ: SYRE · Real-Time Price · USD
103.86
+7.27 (7.53%)
At close: Nov 6, 2026, 4:00 PM EST
103.00
-0.86 (-0.83%)
After-hours: Nov 6, 2026, 7:30 PM EST

Spyre Therapeutics Statistics

Total Valuation

SYRE has a market cap or net worth of $9.86 billion. The enterprise value is $8.79 billion.

Market Cap9.86B
Enterprise Value 8.79B

Important Dates

The last earnings date was Tuesday, November 3, 2026, after market close.

Earnings Date Nov 3, 2026
Ex-Dividend Date n/a

Share Statistics

SYRE has 94.97 million shares outstanding. The number of shares has increased by 38.78% in one year.

Current Share Class 94.97M
Shares Outstanding 94.97M
Shares Change (YoY) +38.78%
Shares Change (QoQ) +4.34%
Owned by Insiders (%) 5.29%
Owned by Institutions (%) 104.07%
Float 88.95M

Valuation Ratios

PE Ratio n/a
Forward PE n/a
PS Ratio n/a
Forward PS n/a
PB Ratio 10.32
P/TBV Ratio 10.90
P/FCF Ratio n/a
P/OCF Ratio n/a
PEG Ratio n/a
Financial Ratio History

Enterprise Valuation

EV / Earnings n/a
EV / Sales n/a
EV / EBITDA n/a
EV / EBIT n/a
EV / FCF n/a

Financial Position

The company has a current ratio of 27.40, with zero debt.

Current Ratio 27.40
Quick Ratio 26.92
Debt / Equity n/a
Debt / EBITDA n/a
Debt / FCF n/a
Interest Coverage n/a

Financial Efficiency

Return on equity (ROE) is -35.03% and return on invested capital (ROIC) is -26.56%.

Return on Equity (ROE) -35.03%
Return on Assets (ROA) -24.95%
Return on Invested Capital (ROIC) -26.56%
Return on Capital Employed (ROCE) -30.22%
Weighted Average Cost of Capital (WACC) 22.00%
Revenue Per Employee n/a
Profits Per Employee -$1.72M
Employee Count130
Asset Turnover n/a
Inventory Turnover n/a

Taxes

Income Tax n/a
Effective Tax Rate n/a

Stock Price Statistics

The stock price has increased by +354.53% in the last 52 weeks. The beta is 3.23, so SYRE's price volatility has been higher than the market average.

Beta (5Y) 3.23
52-Week Price Change +354.53%
50-Day Moving Average 89.79
200-Day Moving Average 74.85
Relative Strength Index (RSI) 65.15
Average Volume (20 Days) 1,064,223

Short Selling Information

The latest short interest is 12.51 million, so 13.17% of the outstanding shares have been sold short.

Short Interest 12.51M
Short Previous Month 12.84M
Short % of Shares Out 13.17%
Short % of Float 14.06%
Short Ratio (days to cover) 7.98

Income Statement

Revenue n/a
Gross Profit -259.72M
Operating Income -320.17M
Pretax Income -263.86M
Net Income -224.01M
EBITDA n/a
EBIT -320.17M
Earnings Per Share (EPS) -$2.73
Full Income Statement

Balance Sheet

The company has $1.07 billion in cash and no debt, with a net cash position of $1.07 billion or $11.29 per share.

Cash & Cash Equivalents 1.07B
Total Debt n/a
Net Cash 1.07B
Net Cash Per Share $11.29
Equity (Book Value) 1.05B
Book Value Per Share 10.06
Working Capital 1.06B
Full Balance Sheet

Cash Flow

Operating Cash Flow -249.32M
Capital Expenditures n/a
Depreciation & Amortization n/a
Net Borrowing n/a
Free Cash Flow -249.32M
FCF Per Share -$2.63
Full Cash Flow Statement

Margins

Gross Margin n/a
Operating Margin n/a
Pretax Margin n/a
Profit Margin n/a
EBITDA Margin n/a
EBIT Margin n/a
FCF Margin n/a

Dividends & Yields

SYRE does not appear to pay any dividends at this time.

Dividend Per Share n/a
Dividend Yield n/a
Dividend Growth (YoY) n/a
Years of Dividend Growth n/a
Payout Ratio n/a
FCF Payout Ratio n/a
Buyback Yield -38.78%
Shareholder Yield -38.78%
Earnings Yield -2.63%
FCF Yield -2.53%

Analyst Forecast

The average price target for SYRE is $123.20, which is 18.62% higher than the current price. The consensus rating is "Strong Buy".

Price Target $123.20
Price Target Difference 18.62%
Analyst Consensus Strong Buy
Analyst Count 18
Revenue Growth Forecast (3Y) n/a
EPS Growth Forecast (3Y) n/a
Stock Forecasts

Fair Value

There are several formulas that can be used to estimate the intrinsic value of a stock.

Lynch Fair Value n/a
Lynch Upside n/a
Graham Number n/a
Graham Upside n/a
Graham Formula Value n/a
Graham Formula Upside n/a

Stock Splits

The last stock split was on September 8, 2023. It was a reverse split with a ratio of 1:25.

Last Split Date Sep 8, 2023
Split Type Reverse
Split Ratio 1:25

Scores

Altman Z-Score n/a
Piotroski F-Score 1