Spyre Therapeutics, Inc. (SYRE)
NASDAQ: SYRE · Real-Time Price · USD
85.69
-1.40 (-1.61%)
At close: Sep 25, 2026, 4:00 PM EDT
85.00
-0.69 (-0.81%)
After-hours: Sep 25, 2026, 6:12 PM EDT
Spyre Therapeutics Stock Forecast
Stock Price Forecast
According to 16 analysts polled by S&P Global, Spyre Therapeutics stock has a consensus rating of "Strong Buy" and an average price target of $120.08. The average 1-year stock price forecast is 40.13% higher than the current stock price, while the lowest is $97 (+13.20%) and the highest is $130 (+51.71%).
Price Target: $120.08 (+40.13%)
Analyst Consensus: Strong Buy
Price Target
ChartAnalyst Ratings
The average analyst rating for Spyre Therapeutics stock is "Strong Buy". This means that analysts believe this stock is likely to perform very well in the near future and significantly outperform the market.
Recommendation Trends
| Rating | Apr '26 | May '26 | Jun '26 | Jul '26 | Aug '26 | Sep '26 |
|---|---|---|---|---|---|---|
| Strong Buy | 17 | 17 | 17 | 16 | 16 | 15 |
| Buy | 0 | 0 | 0 | 0 | 0 | 0 |
| Hold | 0 | 0 | 0 | 1 | 1 | 1 |
| Sell | 0 | 0 | 0 | 0 | 0 | 0 |
| Strong Sell | 0 | 0 | 0 | 0 | 0 | 0 |
| Total | 17 | 17 | 17 | 17 | 17 | 16 |
Latest Forecasts
| Analyst | Firm | Rating | Rating | Action | Price Target | Upside | Date |
|---|---|---|---|---|---|---|---|
| Wedbush | Wedbush | Buy Maintains $123 | Buy | Maintains | $123 | +43.54% | Sep 9, 2026 |
| Jefferies | Jefferies | Buy Maintains $98 → $126 | Buy | Maintains | $98 → $126 | +47.04% | Sep 9, 2026 |
| Leerink Partners | Leerink Partners | Buy Reiterates $124 → $128 | Buy | Reiterates | $124 → $128 | +49.38% | Sep 9, 2026 |
| LifeSci Capital | LifeSci Capital | Buy Maintains $116 | Buy | Maintains | $116 | +35.37% | Sep 8, 2026 |
| Guggenheim | Guggenheim | Buy Reiterates $130 | Buy | Reiterates | $130 | +51.71% | Aug 27, 2026 |
Financial Forecast
Revenue This Year
n/a
Revenue Next Year
n/a
EPS This Year
-2.88
from -1.98
EPS Next Year
-3.52
from -2.88
EPS and Forward PE are based on non-GAAP adjusted numbers.