Upstream Bio, Inc. (UPB)

Upstream Bio Stock Forecast

Stock Price Forecast

The 3 analysts that cover Upstream Bio stock have a consensus rating of "Strong Buy" and an average price target of $46, which forecasts a 69.43% increase in the stock price over the next year. The lowest target is $40 and the highest is $51.

Price Target: $46 (+69.43%)

Analyst Consensus: Strong Buy

Target	Low	Average	Median	High
Price	$40	$46	$47	$51
Change	+47.33%	+69.43%	+73.11%	+87.85%

Analyst Ratings

The average analyst rating for Upstream Bio stock is "Strong Buy". This means that analysts believe this stock is likely to perform very well in the near future and significantly outperform the market.

Recommendation Trends

Rating	Aug '25	Sep '25	Oct '25	Nov '25	Dec '25	Jan '26
Strong Buy	1	1	2	1	1	1
Buy	3	3	3	1	2	2
Hold	0	0	0	0	0	0
Sell	0	0	0	0	0	0
Strong Sell	0	0	0	0	0	0
Total	4	4	5	2	3	3

Latest Forecasts

Analyst	Firm	Rating	Rating	Action	Price Target	Upside	Date
Joseph Catanzaro Mizuho	Mizuho	Buy Initiates $51	Buy	Initiates	$51	+87.85%	Dec 18, 2025
Cory Kasimov Evercore ISI Group	Evercore ISI Group	Buy Initiates $40	Buy	Initiates	$40	+47.33%	Nov 18, 2025
Danielle Brill Truist Securities	Truist Securities	Strong Buy Initiates $47	Strong Buy	Initiates	$47	+73.11%	Oct 14, 2025
Tessa Romero JP Morgan	JP Morgan	Buy Initiates $38	Buy	Initiates	$38	+39.96%	Nov 5, 2024
Matt Phipps William Blair	William Blair	Buy Initiates n/a	Buy	Initiates	n/a	n/a	Nov 5, 2024

More Analyst Ratings

Financial Forecast

Revenue This Year

2.77M

Increased by 16.92%

from 2.37M

Revenue Next Year

1.15M

Decreased by -58.39%

from 2.77M

EPS This Year

-2.59

from -5.58

EPS Next Year

-2.98

from -2.59

Fiscal Year	FY 2022	FY 2023	FY 2024	FY 2025	FY 2026	FY 2027	FY 2028
Period Ending	Dec 31, 2022	Dec 31, 2023	Dec 31, 2024	Dec 31, 2025	Dec 31, 2026	Dec 31, 2027	Dec 31, 2028
Revenue	1.21M	2.38M	2.37M	2.77M	1.15M	1.01M	5.71M
Revenue Growth	-	96.37%	-0.42%	16.92%	-58.39%	-12.66%	466.53%
EPS	-8.52	-12.95	-5.58	-2.59	-2.98	-3.03	-5.25
EPS Growth	-	-	-	-	-	-	-
Forward PE	-	-	-	-	-	-	-
No. Analysts	-	-	-	8	7	5	4

Historical EPS numbers are GAAP, while forecasted numbers may be non-GAAP.

Revenue Forecast

Revenue	2025	2026	2027	2028	2029	2030
High	3.2M	3.0M
Avg	2.8M	1.2M
Low	2.1M	n/a

Revenue Growth

Revenue Growth	2025	2026	2027	2028	2029	2030
High	32.9%	9.9%
Avg	16.9%	-58.4%
Low	-9.5%	-

EPS Forecast

EPS	2025	2026	2027	2028	2029	2030
High	-2.55	-2.71
Avg	-2.59	-2.98
Low	-2.72	-3.78

EPS Growth

EPS Growth	2025	2026	2027	2028	2029	2030
High	-	-
Avg	-	-
Low	-	-

Sources: Price targets and analyst ratings provided by Benzinga. Revenue and EPS forecast data provided by Finnhub. The data is sourced from Wall Street analysts. Data disclaimer.