Upstream Bio, Inc. (UPB)
| Market Cap | 331.96M -33.1% |
| Revenue (ttm) | 3.32M +44.7% |
| Net Income | -156.76M |
| EPS | -2.90 |
| Shares Out | 54.42M |
| PE Ratio | n/a |
| Forward PE | n/a |
| Dividend | n/a |
| Ex-Dividend Date | n/a |
| Volume | 1,432,196 |
| Open | 6.03 |
| Previous Close | 6.38 |
| Day's Range | 5.85 - 6.47 |
| 52-Week Range | 5.85 - 33.68 |
| Beta | n/a |
| Analysts | Strong Buy |
| Price Target | 41.63 (+582.46%) |
| Earnings Date | May 13, 2026 |
About UPB
Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.
Financial Performance
In 2025, Upstream Bio's revenue was $2.85 million, an increase of 20.42% compared to the previous year's $2.37 million. Losses were -$143.44 million, 87.8% more than in 2024.
Financial StatementsAnalyst Summary
According to 9 analysts, the average rating for UPB stock is "Strong Buy." The 12-month stock price target is $41.63, which is an increase of 582.46% from the latest price.
News
KBRA Assigns Preliminary Ratings to OBX 2026-AHC2 Trust
NEW YORK--(BUSINESS WIRE)-- #creditratingagency--KBRA assigns preliminary ratings to 65 classes of mortgage pass-through notes from OBX 2026-AHC2 Trust, a prime agency-eligible RMBS transaction sponso...
Upstream Bio downgraded to Neutral from Overweight at JPMorgan
JPMorgan downgraded Upstream Bio (UPB) to Neutral from Overweight with a price target of $8, down from $35. There are other thymic stromal lymphopoietin competitors in asthma that will be…
Upstream Bio Transcript: Goldman Sachs 47th Annual Global Healthcare Conference 2026
Verekitug, a TSLP receptor-targeting antibody, showed strong phase II results in severe asthma and CRSwNP, supporting quarterly dosing and broad efficacy. Phase III trials in both indications are set for early next year, with a robust cash runway and plans for pipeline expansion.
Upstream Bio Transcript: AGM 2026
The meeting confirmed a quorum, elected two directors for three-year terms, and ratified the appointment of PricewaterhouseCoopers as auditor for 2026. All proposals were approved, with results to be filed in a Form 8-K.
Upstream Bio to Showcase Additional Efficacy Data from the Phase 2 VIBRANT Trial of Verekitug in CRSwNP in Oral Session at EAACI 2026
WALTHAM, Mass., June 08, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respirator...
Upstream Bio to Present at the Goldman Sachs 47th Annual Global Healthcare Conference
WALTHAM, Mass., June 03, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respirator...
Upstream Bio initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Matthew Caufield initiated coverage of Upstream Bio (UPB) with a Buy rating and $36 price target The company’s lead biologic candidate verekitug reflects a novel antibody antag...
Upstream Bio presents data from Phase 2 VIBRANT trial of verekitug
Upstream Bio (UPB) presented new data from the Phase 2 VIBRANT trial evaluating verekitug in participants with chronic rhinosinusitis with nasal polyps. The data, presented in two posters at the…
Upstream Bio Presents New Data from Phase 2 VIBRANT Trial of Verekitug Demonstrating Improvement in Asthma Symptom Control in Participants with CRSwNP and Comorbid Asthma at the ATS 2026 International Conference
– Verekitug led to statistically significant and clinically meaningful improvement in asthma symptom control as measured by the Asthma Control Questionnaire-6 (ACQ-6) in participants with CRSwNP and c...
Upstream Bio price target lowered to $50 from $51 at Mizuho
Mizuho lowered the firm’s price target on Upstream Bio (UPB) to $50 from $51 and keeps an Outperform rating on the shares. The firm updated the company’s model post the…
Upstream Bio Reports First Quarter 2026 Financial Results and Recent Business Highlights
– Company rapidly advancing Phase 3 programs designed to deliver best-in-class efficacy with convenient quarterly dosing in severe asthma and CRSwNP – – End-of-Phase 2 meetings with FDA planned for mi...
Upstream Bio Earnings release: Q1 2026
Upstream Bio released its Q1 2026 earnings on May 13, 2026, summarizing the period's financial results.
Upstream Bio Quarterly report: Q1 2026
Upstream Bio has published its Q1 2026 quarterly earnings report on May 13, 2026.
Upstream Bio Slides: Corporate presentation
Upstream Bio has posted slides in relation to its latest quarterly earnings report, which was published on May 13, 2026.
Upstream Bio to present new data from Phase 2 Vibrant trial of Verekitug
Upstream Bio (UPB) announced two upcoming poster presentations at the American Thoracic Society 2026 International Conference in Orlando, FL, on Monday, May 18, 2026. The presentations feature new dat...
Upstream Bio to Present New Data from Phase 2 VIBRANT Trial of Verekitug at the ATS 2026 International Conference
WALTHAM, Mass., April 17, 2026 (GLOBE NEWSWIRE) -- Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respirat...
Upstream Bio Proxy statement: Proxy filing
Upstream Bio filed a proxy statement on April 16, 2026, providing details for shareholder voting and corporate governance matters.
Upstream Bio Proxy statement: Proxy filing
Upstream Bio filed a proxy statement on April 16, 2026, providing details for shareholder voting and corporate governance matters.
Upstream Bio Slides: Corporate presentation
Upstream Bio has posted slides in relation to its latest quarterly earnings report, which was published on April 6, 2026.
Upstream Bio downgraded to In Line from Outperform at Evercore ISI
Evercore ISI downgraded Upstream Bio (UPB) to In Line from Outperform with a price target of $15, down from $40. While the firm remains “optimistic” on verekitug and believes the…
Upstream Bio Highlights Phase 3 Development Strategy for Verekitug and Reports Fourth Quarter and Full Year 2025 Financial Results
– Company to pursue Phase 3 development strategy designed to deliver best-in-class efficacy with a high-dose quarterly regimen in broad patient populations in both severe asthma and CRSwNP – – Company...
Upstream Bio Annual report: Q4 2025
Upstream Bio has published its Q4 2025 annual report on March 26, 2026.
Upstream Bio Earnings release: Q4 2025
Upstream Bio released its Q4 2025 earnings on March 26, 2026, summarizing the period's financial results.
Upstream Bio Slides: Corporate presentation
Upstream Bio has posted slides in relation to its latest quarterly earnings report, which was published on March 26, 2026.
Upstream Bio Transcript: Leerink Global Healthcare Conference 2026
Verekitug demonstrated strong efficacy and quarterly dosing in phase II asthma trials, with plans to start phase III in severe asthma and CRSwNP by early next year. The COPD program is over 60% enrolled, and device development is progressing in parallel. Cash runway extends through 2027.