Upstream Bio, Inc. (UPB)
NASDAQ: UPB · Real-Time Price · USD
2.870
+0.130 (4.74%)
Oct 26, 2026, 2:26 PM EDT - Market open

Upstream Bio Statistics

Total Valuation

Upstream Bio has a market cap or net worth of $157.19 million. The enterprise value is -$103.16 million.

Market Cap157.19M
Enterprise Value -103.16M

Important Dates

The next estimated earnings date is Monday, November 9, 2026, before market open.

Earnings Date Nov 9, 2026
Ex-Dividend Date n/a

Share Statistics

Upstream Bio has 54.77 million shares outstanding. The number of shares has increased by 38.95% in one year.

Current Share Class 54.77M
Shares Outstanding 54.77M
Shares Change (YoY) +38.95%
Shares Change (QoQ) +0.43%
Owned by Insiders (%) 0.07%
Owned by Institutions (%) 75.91%
Float 42.81M

Valuation Ratios

PE Ratio n/a
Forward PE n/a
PS Ratio 50.99
Forward PS 107.17
PB Ratio 0.55
P/TBV Ratio 0.59
P/FCF Ratio n/a
P/OCF Ratio n/a
PEG Ratio n/a
Financial Ratio History

Enterprise Valuation

EV / Earnings n/a
EV / Sales n/a
EV / EBITDA n/a
EV / EBIT n/a
EV / FCF n/a

Financial Position

The company has a current ratio of 27.99, with a Debt / Equity ratio of 0.00.

Current Ratio 27.99
Quick Ratio 26.38
Debt / Equity 0.00
Debt / EBITDA n/a
Debt / FCF n/a
Interest Coverage n/a

Financial Efficiency

Return on equity (ROE) is -46.05% and return on invested capital (ROIC) is -31.15%.

Return on Equity (ROE) -46.05%
Return on Assets (ROA) -30.28%
Return on Invested Capital (ROIC) -31.15%
Return on Capital Employed (ROCE) -62.68%
Weighted Average Cost of Capital (WACC) 11.83%
Revenue Per Employee $42,107
Profits Per Employee -$2.09M
Employee Count75
Asset Turnover 0.01
Inventory Turnover n/a

Taxes

Income Tax n/a
Effective Tax Rate n/a

Stock Price Statistics

The stock price has decreased by -86.55% in the last 52 weeks. The beta is 1.39, so Upstream Bio's price volatility has been higher than the market average.

Beta (5Y) 1.39
52-Week Price Change -86.55%
50-Day Moving Average 5.25
200-Day Moving Average 9.85
Relative Strength Index (RSI) 26.25
Average Volume (20 Days) 1,226,042

Short Selling Information

The latest short interest is 4.51 million, so 8.24% of the outstanding shares have been sold short.

Short Interest 4.51M
Short Previous Month 4.49M
Short % of Shares Out 8.24%
Short % of Float 10.55%
Short Ratio (days to cover) 7.05

Income Statement

In the last 12 months, Upstream Bio had revenue of $3.16 million and -$156.50 million in losses. Loss per share was -$2.89.

Revenue3.16M
Gross Profit 3.16M
Operating Income -169.98M
Pretax Income -156.50M
Net Income -156.50M
EBITDA -169.78M
EBIT -169.98M
Loss Per Share -$2.89
Full Income Statement

Balance Sheet

The company has $261.31 million in cash and $954,000 in debt, with a net cash position of $260.35 million or $4.75 per share.

Cash & Cash Equivalents 261.31M
Total Debt 954,000
Net Cash 260.35M
Net Cash Per Share $4.75
Equity (Book Value) 270.96M
Book Value Per Share 4.95
Working Capital 269.61M
Full Balance Sheet

Cash Flow

In the last 12 months, operating cash flow was -$136.34 million and capital expenditures -$118,000, giving a free cash flow of -$136.46 million.

Operating Cash Flow -136.34M
Capital Expenditures -118,000
Depreciation & Amortization 202,000
Net Borrowing n/a
Free Cash Flow -136.46M
FCF Per Share -$2.49
Full Cash Flow Statement

Margins

Gross Margin 100.00%
Operating Margin -5,382.65%
Pretax Margin -4,955.67%
Profit Margin n/a
EBITDA Margin n/a
EBIT Margin n/a
FCF Margin n/a

Dividends & Yields

Upstream Bio does not appear to pay any dividends at this time.

Dividend Per Share n/a
Dividend Yield n/a
Dividend Growth (YoY) n/a
Years of Dividend Growth n/a
Payout Ratio n/a
FCF Payout Ratio n/a
Buyback Yield -38.95%
Shareholder Yield -38.95%
Earnings Yield -100.55%
FCF Yield -84.74%

Analyst Forecast

The average price target for Upstream Bio is $29.83, which is 939.37% higher than the current price. The consensus rating is "Buy".

Price Target $29.83
Price Target Difference 939.37%
Analyst Consensus Buy
Analyst Count 8
Revenue Growth Forecast (3Y) -25.80%
EPS Growth Forecast (3Y) n/a
Stock Forecasts

Fair Value

There are several formulas that can be used to estimate the intrinsic value of a stock.

Lynch Fair Value n/a
Lynch Upside n/a
Graham Number n/a
Graham Upside n/a

Stock Splits

This stock does not have any record of stock splits.

Last Split Date n/a
Split Type n/a
Split Ratio n/a

Scores

Upstream Bio has an Altman Z-Score of 50.27 and a Piotroski F-Score of 2.

Altman Z-Score 50.27
Piotroski F-Score 2