Upstream Bio, Inc. (UPB)
NASDAQ: UPB · Real-Time Price · USD
8.21
-0.16 (-1.91%)
May 26, 2026, 4:00 PM EDT - Market closed

Upstream Bio Statistics

Total Valuation

Upstream Bio has a market cap or net worth of $446.79 million. The enterprise value is $153.32 million.

Market Cap446.79M
Enterprise Value 153.32M

Important Dates

The last earnings date was Wednesday, May 13, 2026, before market open.

Earnings Date May 13, 2026
Ex-Dividend Date n/a

Share Statistics

Upstream Bio has 54.42 million shares outstanding. The number of shares has increased by 105.15% in one year.

Current Share Class 54.42M
Shares Outstanding 54.42M
Shares Change (YoY) +105.15%
Shares Change (QoQ) +0.45%
Owned by Insiders (%) 0.29%
Owned by Institutions (%) 66.75%
Float 35.01M

Valuation Ratios

PE Ratio n/a
Forward PE n/a
PS Ratio 134.49
Forward PS 226.16
PB Ratio 1.47
P/TBV Ratio 1.47
P/FCF Ratio n/a
P/OCF Ratio n/a
PEG Ratio n/a
Financial Ratio History

Enterprise Valuation

EV / Earnings n/a
EV / Sales 46.15
EV / EBITDA n/a
EV / EBIT n/a
EV / FCF n/a

Financial Position

The company has a current ratio of 23.14, with a Debt / Equity ratio of 0.00.

Current Ratio 23.14
Quick Ratio 21.74
Debt / Equity 0.00
Debt / EBITDA n/a
Debt / FCF n/a
Interest Coverage n/a

Financial Efficiency

Return on equity (ROE) is -41.83% and return on invested capital (ROIC) is -28.57%.

Return on Equity (ROE) -41.83%
Return on Assets (ROA) -27.76%
Return on Invested Capital (ROIC) -28.57%
Return on Capital Employed (ROCE) -56.50%
Weighted Average Cost of Capital (WACC) n/a
Revenue Per Employee $44,293
Profits Per Employee -$2.09M
Employee Count75
Asset Turnover 0.01
Inventory Turnover n/a

Taxes

Income Tax n/a
Effective Tax Rate n/a

Stock Price Statistics

The stock price has decreased by -10.37% in the last 52 weeks.

Beta (5Y) n/a
52-Week Price Change -10.37%
50-Day Moving Average 9.25
200-Day Moving Average 18.48
Relative Strength Index (RSI) 37.98
Average Volume (20 Days) 521,475

Short Selling Information

The latest short interest is 3.22 million, so 5.92% of the outstanding shares have been sold short.

Short Interest 3.22M
Short Previous Month 3.02M
Short % of Shares Out 5.92%
Short % of Float 9.21%
Short Ratio (days to cover) 5.29

Income Statement

In the last 12 months, Upstream Bio had revenue of $3.32 million and -$156.76 million in losses. Loss per share was -$2.90.

Revenue3.32M
Gross Profit 3.32M
Operating Income -171.96M
Pretax Income -156.76M
Net Income -156.76M
EBITDA -171.77M
EBIT -171.96M
Loss Per Share -$2.90
Full Income Statement

Balance Sheet

The company has $294.58 million in cash and $1.11 million in debt, with a net cash position of $293.47 million or $5.39 per share.

Cash & Cash Equivalents 294.58M
Total Debt 1.11M
Net Cash 293.47M
Net Cash Per Share $5.39
Equity (Book Value) 304.00M
Book Value Per Share 5.59
Working Capital 302.61M
Full Balance Sheet

Cash Flow

In the last 12 months, operating cash flow was -$139.96 million and capital expenditures -$165,000, giving a free cash flow of -$140.13 million.

Operating Cash Flow -139.96M
Capital Expenditures -165,000
Depreciation & Amortization 194,000
Net Borrowing n/a
Free Cash Flow -140.13M
FCF Per Share -$2.57
Full Cash Flow Statement

Margins

Gross Margin 100.00%
Operating Margin -5,176.49%
Pretax Margin -4,718.96%
Profit Margin n/a
EBITDA Margin n/a
EBIT Margin n/a
FCF Margin n/a

Dividends & Yields

Upstream Bio does not appear to pay any dividends at this time.

Dividend Per Share n/a
Dividend Yield n/a
Dividend Growth (YoY) n/a
Years of Dividend Growth n/a
Payout Ratio n/a
Buyback Yield -105.15%
Shareholder Yield -105.15%
Earnings Yield -35.09%
FCF Yield -31.36%

Analyst Forecast

The average price target for Upstream Bio is $42.43, which is 416.81% higher than the current price. The consensus rating is "Buy".

Price Target $42.43
Price Target Difference 416.81%
Analyst Consensus Buy
Analyst Count 8
Revenue Growth Forecast (5Y) 102.06%
EPS Growth Forecast (5Y) n/a
Stock Forecasts

Fair Value

There are several formulas that can be used to estimate the intrinsic value of a stock.

Lynch Fair Value n/a
Lynch Upside n/a
Graham Number n/a
Graham Upside n/a

Stock Splits

This stock does not have any record of stock splits.

Last Split Date n/a
Split Type n/a
Split Ratio n/a

Scores

Upstream Bio has an Altman Z-Score of 36.77 and a Piotroski F-Score of 1.

Altman Z-Score 36.77
Piotroski F-Score 1