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Upstream Bio, Inc. (UPB)
NASDAQ: UPB · Real-Time Price · USD
6.50
+0.09 (1.40%)
Jul 30, 2026, 1:35 PM EDT - Market open

Upstream Bio Financials Overview

Millions USD. Fiscal year is Jan - Dec.

Revenue & Profits
Chart
Fiscal YearTTMFY 2025FY 2024FY 2023FY 2022
Period EndingMar '26 Dec '25 Dec '24 Dec '23 Dec '22
Revenue
3.322.852.372.381.21
Revenue Growth
44.69%20.42%-0.42%96.37%-
Gross Profit
3.322.852.372.381.21
Operating Income
-171.96-160.36-77.76-40.11-23.91
Net Income
-116.17-143.44-76.4-38.26-23.87
Earnings Per Share
-2.90-2.66-5.58-12.95-8.13
EPS Growth
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Cash & Debt
Chart
Fiscal YearCurrentFY 2025FY 2024FY 2023FY 2022
Period EndingMar '26 Dec '25 Dec '24 Dec '23 Dec '22
Cash & Investments
294.58341.51470.45109.8117.05
Total Debt
1.111.271.832.920.09
Net Cash (Debt)
293.47340.24468.62106.8916.96
Net Cash Growth
-31.70%-27.40%338.41%530.37%-
Net Cash Per Share
5.436.3234.2536.195.77

Cash Flow & CapEx
Chart
Fiscal YearTTMFY 2025FY 2024FY 2023FY 2022
Period EndingMar '26 Dec '25 Dec '24 Dec '23 Dec '22
Operating Cash Flow
-139.96-133.28-59.17-37.93-19.02
Capital Expenditures
--0.17-0.51-0.14-0.08
Free Cash Flow
-139.96-133.44-59.68-38.07-19.1
Free Cash Flow Growth
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Margins
Chart
Fiscal YearTTMFY 2025FY 2024FY 2023FY 2022
Period EndingMar '26 Dec '25 Dec '24 Dec '23 Dec '22
Gross Margin
100.00%100.00%100.00%100.00%100.00%
Operating Margin
-5176.49%-5618.82%-3281.18%-1685.46%-1972.69%
Pretax Margin
-4718.96%-5026.03%-2650.04%-862.90%-1969.31%
Profit Margin
-4718.96%-5026.03%-2650.04%-862.90%-1969.31%
FCF Margin
-4213.18%-4675.54%-2518.27%-1599.58%-1576.16%

Valuation
Chart
Fiscal YearCurrentFY 2025FY 2024FY 2023FY 2022
Period EndingJul '26 Dec '25 Dec '24 Dec '23 Dec '22
PS Ratio
107.96515.96371.83--