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Upstream Bio, Inc. (UPB)
NASDAQ: UPB · Real-Time Price · USD
2.780
-0.080 (-2.80%)
Nov 13, 2026, 4:00 PM EST - Market closed

Upstream Bio Financials Overview

Millions USD. Fiscal year is Jan - Dec.

Revenue & Profits
Chart
Fiscal Year
TTMFY 2025FY 2024FY 2023FY 2022
Period EndingSep '26 Dec '25 Dec '24 Dec '23 Dec '22
Revenue
2.872.852.372.381.21
Revenue Growth
2.54%20.42%-0.42%96.37%-
Gross Profit
2.872.852.372.381.21
Operating Income
-175.53-160.36-77.76-40.11-23.91
Net Income
-163.94-143.44-76.4-38.26-23.87
Earnings Per Share
-3.01-2.66-5.58-12.95-8.52
EPS Growth
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Cash & Debt
Chart
Fiscal Year
CurrentFY 2025FY 2024FY 2023FY 2022
Period EndingSep '26 Dec '25 Dec '24 Dec '23 Dec '22
Cash & Investments
207.37341.51470.45109.8117.05
Total Debt
0.791.271.830.050.09
Net Cash (Debt)
206.58340.24468.62109.7716.96
Net Cash Growth
-44.32%-27.40%326.93%547.31%-
Net Cash Per Share
3.796.3234.2537.166.06

Cash Flow & CapEx
Chart
Fiscal Year
TTMFY 2025FY 2024FY 2023FY 2022
Period EndingSep '26 Dec '25 Dec '24 Dec '23 Dec '22
Operating Cash Flow
-168.33-133.28-59.17-37.93-19.02
Capital Expenditures
-0.05-0.17-0.51-0.14-0.08
Free Cash Flow
-168.39-133.44-59.68-38.07-19.1
Free Cash Flow Growth
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Margins
Chart
Fiscal Year
TTMFY 2025FY 2024FY 2023FY 2022
Period EndingSep '26 Dec '25 Dec '24 Dec '23 Dec '22
Gross Margin
100.00%100.00%100.00%100.00%100.00%
Operating Margin
-6115.99%-5618.82%-3281.18%-1685.46%-1972.69%
Pretax Margin
-5712.33%-5026.03%-2650.04%-862.90%-1969.31%
Profit Margin
-5712.33%-5026.03%-3223.42%-1607.35%-1969.31%
FCF Margin
-5867.18%-4675.54%-2518.27%-1599.58%-1576.15%

Valuation
Chart
Fiscal Year
CurrentFY 2025FY 2024FY 2023FY 2022
Period EndingNov '26 Dec '25 Dec '24 Dec '23 Dec '22
PS Ratio
53.09514.07371.78--