Upstream Bio Stock Forecast

Stock Price Forecast

According to 9 analysts polled by S&P Global, Upstream Bio stock has a consensus rating of "Buy" and an average price target of $38.25. The average 1-year stock price forecast is 521.95% higher than the current stock price, while the lowest is $8.00 (+30.08%) and the highest is $75 (+1,119.51%).

Price Target: $38.25 (+521.95%)

Analyst Consensus: Buy

Target	Low	Average	Median	High
Price	$8.00	$38.25	$39.5	$75
Change	+30.08%	+521.95%	+542.28%	+1119.5%

Analyst Ratings

The average analyst rating for Upstream Bio stock is "Buy". This means that analysts believe this stock is likely to outperform the market over the next twelve months.

Recommendation Trends

Rating	Jan '26	Feb '26	Mar '26	Apr '26	May '26	Jun '26
Strong Buy	6	6	5	5	5	6
Buy	2	2	2	2	2	1
Hold	0	0	1	1	1	2
Sell	0	0	0	0	0	0
Strong Sell	0	0	0	0	0	0
Total	8	8	8	8	8	9

Latest Forecasts

Analyst	Firm	Rating	Rating	Action	Price Target	Upside	Date
Tessa Romero J.P. Morgan	J.P. Morgan	Hold Downgrades $35 → $8	Hold	Downgrades	$35 → $8	+30.08%	Jun 12, 2026
Matthew Caufield H.C. Wainwright	H.C. Wainwright	Buy Initiates $36	Buy	Initiates	$36	+485.37%	Jun 3, 2026
Matt Phipps William Blair	William Blair	Buy Maintains n/a	Buy	Maintains	n/a	n/a	May 19, 2026
Kate Dellorusso LifeSci Capital	LifeSci Capital	Buy Maintains $42	Buy	Maintains	$42	+582.93%	May 19, 2026
Joseph Catanzaro Mizuho Securities	Mizuho Securities	Buy Maintains $51 → $50	Buy	Maintains	$51 → $50	+713.01%	May 14, 2026

More Analyst Ratings

Financial Forecast

Revenue This Year

2.04M

from 2.85M

-28.58%

from 2.85M

Revenue Next Year

1.65M

from 2.04M

-19.01%

from 2.04M

EPS This Year

-2.84

from -2.66

EPS Next Year

-2.89

from -2.84

Fiscal Year	FY 2022	FY 2023	FY 2024	FY 2025	FY 2026
Period Ending	Dec 31, 2022	Dec 31, 2023	Dec 31, 2024	Dec 31, 2025	Dec 31, 2026
Revenue	1.21M	2.38M	2.37M	2.85M	2.04M
Revenue Growth	-	96.37%	-0.42%	20.42%	-28.58%
Gross Profit	1.21M	2.38M	2.37M	2.85M	2.04M
Gross Margin	100.00%	100.00%	100.00%	100.00%	100.00%
Operating Income	-23.91M	-40.11M	-77.76M	-160.36M	-180.70M
Net Income	-23.87M	-20.54M	-62.81M	-143.44M	-170.90M
EPS	-	-	-	-2.66	-2.84
Free Cash Flow	-	-25.96M	-40.98M	-88.75M	-166.88M
No. Analysts	-	-	-	-	8

EPS and Forward PE are based on non-GAAP adjusted numbers.

Revenue Forecast

Revenue	2026	2027	2028
High	3.7M
Avg	2.0M
Low	n/a

Revenue Growth

Revenue Growth	2026	2027	2028
High	28.2%
Avg	-28.6%
Low	-100.0%

EPS Forecast

EPS	2026	2027	2028
High	-2.25
Avg	-2.84
Low	-3.37

EPS Growth

EPS Growth	2026	2027	2028
High	-
Avg	-
Low	-